Eintrag weiter verarbeiten
Verfügbar über Online-Ressource

Exploring regulatory mechanisms of CD8 + T cell contraction

Gespeichert in:

Bibliographische Detailangaben
Zeitschriftentitel: Proceedings of the National Academy of Sciences
Personen und Körperschaften: Prlic, Martin, Bevan, Michael J.
In: Proceedings of the National Academy of Sciences, 105, 2008, 43, S. 16689-16694
Format: E-Article
Sprache: Englisch
veröffentlicht:
Proceedings of the National Academy of Sciences
Schlagwörter:
Multidisciplinary
author_facet Prlic, Martin
Bevan, Michael J.
Prlic, Martin
Bevan, Michael J.
author Prlic, Martin
Bevan, Michael J.
spellingShingle Prlic, Martin
Bevan, Michael J.
Proceedings of the National Academy of Sciences
Exploring regulatory mechanisms of CD8 + T cell contraction
Multidisciplinary
author_sort prlic, martin
spelling Prlic, Martin Bevan, Michael J. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.0808997105 <jats:p>A small fraction of the CD8 T cell effector population that responds to an infection progresses through the contraction phase to the memory stage. The factors regulating the extent of contraction are poorly understood. Competition for limited resources has been widely postulated to be the cause of cell death during the contraction phase, but our data show that competition does not affect contraction kinetics. We go on to demonstrate that all effector cells present at the peak of the response have the potential to become bona fide memory cells, thus excluding selection on the basis of functionality. We propose that the fate of a CD8 effector cell is predetermined before the onset of contraction and discuss possible mechanisms of regulation.</jats:p> Exploring regulatory mechanisms of CD8 <sup>+</sup> T cell contraction Proceedings of the National Academy of Sciences
doi_str_mv 10.1073/pnas.0808997105
facet_avail Online
Free
format ElectronicArticle
fullrecord blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjA4MDg5OTcxMDU
id ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjA4MDg5OTcxMDU
institution DE-D275
DE-Bn3
DE-Brt1
DE-Zwi2
DE-D161
DE-Zi4
DE-Gla1
DE-15
DE-Pl11
DE-Rs1
DE-14
DE-105
DE-Ch1
DE-L229
imprint Proceedings of the National Academy of Sciences, 2008
imprint_str_mv Proceedings of the National Academy of Sciences, 2008
issn 0027-8424
1091-6490
issn_str_mv 0027-8424
1091-6490
language English
mega_collection Proceedings of the National Academy of Sciences (CrossRef)
match_str prlic2008exploringregulatorymechanismsofcd8tcellcontraction
publishDateSort 2008
publisher Proceedings of the National Academy of Sciences
recordtype ai
record_format ai
series Proceedings of the National Academy of Sciences
source_id 49
title Exploring regulatory mechanisms of CD8 + T cell contraction
title_unstemmed Exploring regulatory mechanisms of CD8 + T cell contraction
title_full Exploring regulatory mechanisms of CD8 + T cell contraction
title_fullStr Exploring regulatory mechanisms of CD8 + T cell contraction
title_full_unstemmed Exploring regulatory mechanisms of CD8 + T cell contraction
title_short Exploring regulatory mechanisms of CD8 + T cell contraction
title_sort exploring regulatory mechanisms of cd8 <sup>+</sup> t cell contraction
topic Multidisciplinary
url http://dx.doi.org/10.1073/pnas.0808997105
publishDate 2008
physical 16689-16694
description <jats:p>A small fraction of the CD8 T cell effector population that responds to an infection progresses through the contraction phase to the memory stage. The factors regulating the extent of contraction are poorly understood. Competition for limited resources has been widely postulated to be the cause of cell death during the contraction phase, but our data show that competition does not affect contraction kinetics. We go on to demonstrate that all effector cells present at the peak of the response have the potential to become bona fide memory cells, thus excluding selection on the basis of functionality. We propose that the fate of a CD8 effector cell is predetermined before the onset of contraction and discuss possible mechanisms of regulation.</jats:p>
container_issue 43
container_start_page 16689
container_title Proceedings of the National Academy of Sciences
container_volume 105
format_de105 Article, E-Article
format_de14 Article, E-Article
format_de15 Article, E-Article
format_de520 Article, E-Article
format_de540 Article, E-Article
format_dech1 Article, E-Article
format_ded117 Article, E-Article
format_degla1 E-Article
format_del152 Buch
format_del189 Article, E-Article
format_dezi4 Article
format_dezwi2 Article, E-Article
format_finc Article, E-Article
format_nrw Article, E-Article
_version_ 1792339676851339274
geogr_code not assigned
last_indexed 2024-03-01T15:51:38.565Z
geogr_code_person not assigned
openURL url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Exploring+regulatory+mechanisms+of+CD8++++++++++++%2B++++++++++++T+cell+contraction&rft.date=2008-10-28&genre=article&issn=1091-6490&volume=105&issue=43&spage=16689&epage=16694&pages=16689-16694&jtitle=Proceedings+of+the+National+Academy+of+Sciences&atitle=Exploring+regulatory+mechanisms+of+CD8%0A++++++++++++%3Csup%3E%2B%3C%2Fsup%3E%0A++++++++++++T+cell+contraction&aulast=Bevan&aufirst=Michael+J.&rft_id=info%3Adoi%2F10.1073%2Fpnas.0808997105&rft.language%5B0%5D=eng
SOLR
_version_ 1792339676851339274
author Prlic, Martin, Bevan, Michael J.
author_facet Prlic, Martin, Bevan, Michael J., Prlic, Martin, Bevan, Michael J.
author_sort prlic, martin
container_issue 43
container_start_page 16689
container_title Proceedings of the National Academy of Sciences
container_volume 105
description <jats:p>A small fraction of the CD8 T cell effector population that responds to an infection progresses through the contraction phase to the memory stage. The factors regulating the extent of contraction are poorly understood. Competition for limited resources has been widely postulated to be the cause of cell death during the contraction phase, but our data show that competition does not affect contraction kinetics. We go on to demonstrate that all effector cells present at the peak of the response have the potential to become bona fide memory cells, thus excluding selection on the basis of functionality. We propose that the fate of a CD8 effector cell is predetermined before the onset of contraction and discuss possible mechanisms of regulation.</jats:p>
doi_str_mv 10.1073/pnas.0808997105
facet_avail Online, Free
format ElectronicArticle
format_de105 Article, E-Article
format_de14 Article, E-Article
format_de15 Article, E-Article
format_de520 Article, E-Article
format_de540 Article, E-Article
format_dech1 Article, E-Article
format_ded117 Article, E-Article
format_degla1 E-Article
format_del152 Buch
format_del189 Article, E-Article
format_dezi4 Article
format_dezwi2 Article, E-Article
format_finc Article, E-Article
format_nrw Article, E-Article
geogr_code not assigned
geogr_code_person not assigned
id ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA3My9wbmFzLjA4MDg5OTcxMDU
imprint Proceedings of the National Academy of Sciences, 2008
imprint_str_mv Proceedings of the National Academy of Sciences, 2008
institution DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Zi4, DE-Gla1, DE-15, DE-Pl11, DE-Rs1, DE-14, DE-105, DE-Ch1, DE-L229
issn 0027-8424, 1091-6490
issn_str_mv 0027-8424, 1091-6490
language English
last_indexed 2024-03-01T15:51:38.565Z
match_str prlic2008exploringregulatorymechanismsofcd8tcellcontraction
mega_collection Proceedings of the National Academy of Sciences (CrossRef)
physical 16689-16694
publishDate 2008
publishDateSort 2008
publisher Proceedings of the National Academy of Sciences
record_format ai
recordtype ai
series Proceedings of the National Academy of Sciences
source_id 49
spelling Prlic, Martin Bevan, Michael J. 0027-8424 1091-6490 Proceedings of the National Academy of Sciences Multidisciplinary http://dx.doi.org/10.1073/pnas.0808997105 <jats:p>A small fraction of the CD8 T cell effector population that responds to an infection progresses through the contraction phase to the memory stage. The factors regulating the extent of contraction are poorly understood. Competition for limited resources has been widely postulated to be the cause of cell death during the contraction phase, but our data show that competition does not affect contraction kinetics. We go on to demonstrate that all effector cells present at the peak of the response have the potential to become bona fide memory cells, thus excluding selection on the basis of functionality. We propose that the fate of a CD8 effector cell is predetermined before the onset of contraction and discuss possible mechanisms of regulation.</jats:p> Exploring regulatory mechanisms of CD8 <sup>+</sup> T cell contraction Proceedings of the National Academy of Sciences
spellingShingle Prlic, Martin, Bevan, Michael J., Proceedings of the National Academy of Sciences, Exploring regulatory mechanisms of CD8 + T cell contraction, Multidisciplinary
title Exploring regulatory mechanisms of CD8 + T cell contraction
title_full Exploring regulatory mechanisms of CD8 + T cell contraction
title_fullStr Exploring regulatory mechanisms of CD8 + T cell contraction
title_full_unstemmed Exploring regulatory mechanisms of CD8 + T cell contraction
title_short Exploring regulatory mechanisms of CD8 + T cell contraction
title_sort exploring regulatory mechanisms of cd8 <sup>+</sup> t cell contraction
title_unstemmed Exploring regulatory mechanisms of CD8 + T cell contraction
topic Multidisciplinary
url http://dx.doi.org/10.1073/pnas.0808997105