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Tissue-driven hypothesis of genomic evolution and sequence-expression correlations
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| Zeitschriftentitel: | Proceedings of the National Academy of Sciences |
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| Personen und Körperschaften: | , |
| In: | Proceedings of the National Academy of Sciences, 104, 2007, 8, S. 2779-2784 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Proceedings of the National Academy of Sciences
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| Schlagwörter: |
| Zusammenfassung: | <jats:p> To maintain normal physiological functions, different tissues may have different developmental constraints on expressed genes. Consequently, the evolutionary tolerance for genomic evolution varies among tissues. Here, we formulate this argument as a “tissue-driven hypothesis” based on the stabilizing selection model. Moreover, several predicted genomic correlations are tested by the human–mouse microarray data. Our results are as follows. First, between the human and mouse, we have elaborated the among-tissue covariation between tissue expression distance ( <jats:italic>E</jats:italic> <jats:sub>ti</jats:sub> ) and tissue sequence distance ( <jats:italic>D</jats:italic> <jats:sub>ti</jats:sub> ). This highly significant <jats:italic>E</jats:italic> <jats:sub>ti</jats:sub> − <jats:italic>D</jats:italic> <jats:sub>ti</jats:sub> correlation emerges when the expression divergence and protein sequence divergence are under the same tissue constraints. Second, the tissue-driven hypothesis further explains the observed significant correlation between the tissue expression distance (between the human and mouse) and the duplicate tissue distance ( <jats:italic>T</jats:italic> <jats:sub>dup</jats:sub> ) between human (or mouse) paralogous genes. In other words, between-duplicate and interspecies expression divergences covary among tissues. Third, for genes with the same expression broadness, we found that genes expressed in more stringent tissues (e.g., neurorelated) generally tend to evolve more slowly than those in more relaxed tissues (e.g., hormone-related). We conclude that tissue factors should be considered as an important component in shaping the pattern of genomic evolution and correlations. </jats:p> |
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| Umfang: | 2779-2784 |
| ISSN: |
0027-8424
1091-6490 |
| DOI: | 10.1073/pnas.0610797104 |