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Tandem high‐dose therapy (HDT) for multiple myeloma: recombinant human erythropoietin therapy given between first and second HDT allows second peripheral blood stem cell transplant...
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| Zeitschriftentitel: | British Journal of Haematology |
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| Personen und Körperschaften: | , , , |
| In: | British Journal of Haematology, 123, 2003, 1, S. 103-105 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| Zusammenfassung: | <jats:p><jats:bold>Summary.</jats:bold> We evaluated the ability of recombinant human erythropoietin (rHuEpo) therapy, given before high‐dose therapy (HDT), to allow autologous peripheral blood stem cell transplantation (PBSCT) without red blood cell (RBC) transfusions. Eleven multiple myeloma patients underwent tandem HDT and autologous PBSC, receiving 500 U/kg/week rHuEpo from d 30 after initial transplant. Haemoglobin levels were 9·5 <jats:italic>±</jats:italic> 1·1 g/dl and 12·5 <jats:italic>±</jats:italic> 0·9 g/dl at the first and second transplant respectively (<jats:italic>P</jats:italic> < 0·001). RBC transfusions were required for 10/11 patients for the first transplant versus 1/11 for the second (<jats:italic>P</jats:italic> < 0·001). To conclude, a short course of rHuEpo therapy before HDT facilitates the performance of an autologous transplant without RBC transfusions.</jats:p> |
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| Umfang: | 103-105 |
| ISSN: |
0007-1048
1365-2141 |
| DOI: | 10.1046/j.1365-2141.2003.04556.x |