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Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance
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| Zeitschriftentitel: | British Journal of Haematology |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| In: | British Journal of Haematology, 103, 1998, 4, S. 1161-1163 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Wiley
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| Schlagwörter: |
| author_facet |
Ackermann, Jutta Meidlinger, Petra Zojer, Niklas Gisslinger, Heinz Ludwig, Heinz Huber, Heinz Drach, Johannes Ackermann, Jutta Meidlinger, Petra Zojer, Niklas Gisslinger, Heinz Ludwig, Heinz Huber, Heinz Drach, Johannes |
|---|---|
| author |
Ackermann, Jutta Meidlinger, Petra Zojer, Niklas Gisslinger, Heinz Ludwig, Heinz Huber, Heinz Drach, Johannes |
| spellingShingle |
Ackermann, Jutta Meidlinger, Petra Zojer, Niklas Gisslinger, Heinz Ludwig, Heinz Huber, Heinz Drach, Johannes British Journal of Haematology Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance Hematology |
| author_sort |
ackermann, jutta |
| spelling |
Ackermann, Jutta Meidlinger, Petra Zojer, Niklas Gisslinger, Heinz Ludwig, Heinz Huber, Heinz Drach, Johannes 0007-1048 1365-2141 Wiley Hematology http://dx.doi.org/10.1046/j.1365-2141.1998.01124.x <jats:p>We have recently shown that presence of a p53 deletion in multiple myleoma is an independent predictor for short survival. We therefore investigated whether or not this chromosomal abnormality can be identified in patients with monoclonal gammopathy of undetermined significance (MGUS). Using a triple staining method combining staining for cytoplasmic immunoglobulins and fluorescence <jats:italic>in situ</jats:italic> hybridization (FISH) with chromosome 17‐centromere and p53‐gene specific probes, we studied plasma cells from 15 patients with MGUS. In all patients, concordant signal numbers with both probes were obtained (including one patient with trisomy 17), indicating that allelic loss of p53 does not occur in MGUS.</jats:p> Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance British Journal of Haematology |
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| title |
Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance |
| title_unstemmed |
Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance |
| title_full |
Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance |
| title_fullStr |
Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance |
| title_full_unstemmed |
Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance |
| title_short |
Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance |
| title_sort |
absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance |
| topic |
Hematology |
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http://dx.doi.org/10.1046/j.1365-2141.1998.01124.x |
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1998 |
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1161-1163 |
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<jats:p>We have recently shown that presence of a p53 deletion in multiple myleoma is an independent predictor for short survival. We therefore investigated whether or not this chromosomal abnormality can be identified in patients with monoclonal gammopathy of undetermined significance (MGUS). Using a triple staining method combining staining for cytoplasmic immunoglobulins and fluorescence <jats:italic>in situ</jats:italic> hybridization (FISH) with chromosome 17‐centromere and p53‐gene specific probes, we studied plasma cells from 15 patients with MGUS. In all patients, concordant signal numbers with both probes were obtained (including one patient with trisomy 17), indicating that allelic loss of p53 does not occur in MGUS.</jats:p> |
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| description | <jats:p>We have recently shown that presence of a p53 deletion in multiple myleoma is an independent predictor for short survival. We therefore investigated whether or not this chromosomal abnormality can be identified in patients with monoclonal gammopathy of undetermined significance (MGUS). Using a triple staining method combining staining for cytoplasmic immunoglobulins and fluorescence <jats:italic>in situ</jats:italic> hybridization (FISH) with chromosome 17‐centromere and p53‐gene specific probes, we studied plasma cells from 15 patients with MGUS. In all patients, concordant signal numbers with both probes were obtained (including one patient with trisomy 17), indicating that allelic loss of p53 does not occur in MGUS.</jats:p> |
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| imprint_str_mv | Wiley, 1998 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| spelling | Ackermann, Jutta Meidlinger, Petra Zojer, Niklas Gisslinger, Heinz Ludwig, Heinz Huber, Heinz Drach, Johannes 0007-1048 1365-2141 Wiley Hematology http://dx.doi.org/10.1046/j.1365-2141.1998.01124.x <jats:p>We have recently shown that presence of a p53 deletion in multiple myleoma is an independent predictor for short survival. We therefore investigated whether or not this chromosomal abnormality can be identified in patients with monoclonal gammopathy of undetermined significance (MGUS). Using a triple staining method combining staining for cytoplasmic immunoglobulins and fluorescence <jats:italic>in situ</jats:italic> hybridization (FISH) with chromosome 17‐centromere and p53‐gene specific probes, we studied plasma cells from 15 patients with MGUS. In all patients, concordant signal numbers with both probes were obtained (including one patient with trisomy 17), indicating that allelic loss of p53 does not occur in MGUS.</jats:p> Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance British Journal of Haematology |
| spellingShingle | Ackermann, Jutta, Meidlinger, Petra, Zojer, Niklas, Gisslinger, Heinz, Ludwig, Heinz, Huber, Heinz, Drach, Johannes, British Journal of Haematology, Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance, Hematology |
| title | Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance |
| title_full | Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance |
| title_fullStr | Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance |
| title_full_unstemmed | Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance |
| title_short | Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance |
| title_sort | absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance |
| title_unstemmed | Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance |
| topic | Hematology |
| url | http://dx.doi.org/10.1046/j.1365-2141.1998.01124.x |