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Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population
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| Zeitschriftentitel: | Bioscience Reports |
|---|---|
| Personen und Körperschaften: | , , , , , |
| In: | Bioscience Reports, 39, 2019, 4 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
|
| Schlagwörter: |
| author_facet |
Liu, Lun Zheng, Jie Xu, Yajing Gao, Jian Fan, Lingling Xu, Dong Liu, Lun Zheng, Jie Xu, Yajing Gao, Jian Fan, Lingling Xu, Dong |
|---|---|
| author |
Liu, Lun Zheng, Jie Xu, Yajing Gao, Jian Fan, Lingling Xu, Dong |
| spellingShingle |
Liu, Lun Zheng, Jie Xu, Yajing Gao, Jian Fan, Lingling Xu, Dong Bioscience Reports Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population Cell Biology Molecular Biology Biochemistry Biophysics |
| author_sort |
liu, lun |
| spelling |
Liu, Lun Zheng, Jie Xu, Yajing Gao, Jian Fan, Lingling Xu, Dong 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20181382 <jats:title>Abstract</jats:title> <jats:p>The levels of cytokines, inflammatory cells, and angiogenic factors increase following diabetic retinopathy (DR), and the association between interleukin-10 (IL-10) gene rs1800896 polymorphism (IL-10 -1082G/A polymorphism) and DR in different populations has been extensively studied. However, the findings are conflicting, and there is no relevant research in Chinese subjects. Therefore, this case–control study involving 327 cases (type 2 diabetes patients with proliferative DR (PDR)) and 461 controls (type 2 diabetes patients without DR) was conducted to address the relationship between IL-10 gene rs1800896 polymorphism and risk of PDR in Chinese population. Genotyping was performed using PCR-based restriction fragment length polymorphism (PCR-RFLP) assay. It was found that GG genotype or G allele of the IL-10 gene rs1800896 polymorphism was associated with decreased risk for PDR. In conclusion, IL-10 gene rs1800896 polymorphism decreases the risk of PDR.</jats:p> Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population Bioscience Reports |
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Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population |
| title_unstemmed |
Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population |
| title_full |
Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population |
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Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population |
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Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population |
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Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population |
| title_sort |
association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a chinese han population |
| topic |
Cell Biology Molecular Biology Biochemistry Biophysics |
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http://dx.doi.org/10.1042/bsr20181382 |
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2019 |
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| description |
<jats:title>Abstract</jats:title>
<jats:p>The levels of cytokines, inflammatory cells, and angiogenic factors increase following diabetic retinopathy (DR), and the association between interleukin-10 (IL-10) gene rs1800896 polymorphism (IL-10 -1082G/A polymorphism) and DR in different populations has been extensively studied. However, the findings are conflicting, and there is no relevant research in Chinese subjects. Therefore, this case–control study involving 327 cases (type 2 diabetes patients with proliferative DR (PDR)) and 461 controls (type 2 diabetes patients without DR) was conducted to address the relationship between IL-10 gene rs1800896 polymorphism and risk of PDR in Chinese population. Genotyping was performed using PCR-based restriction fragment length polymorphism (PCR-RFLP) assay. It was found that GG genotype or G allele of the IL-10 gene rs1800896 polymorphism was associated with decreased risk for PDR. In conclusion, IL-10 gene rs1800896 polymorphism decreases the risk of PDR.</jats:p> |
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| description | <jats:title>Abstract</jats:title> <jats:p>The levels of cytokines, inflammatory cells, and angiogenic factors increase following diabetic retinopathy (DR), and the association between interleukin-10 (IL-10) gene rs1800896 polymorphism (IL-10 -1082G/A polymorphism) and DR in different populations has been extensively studied. However, the findings are conflicting, and there is no relevant research in Chinese subjects. Therefore, this case–control study involving 327 cases (type 2 diabetes patients with proliferative DR (PDR)) and 461 controls (type 2 diabetes patients without DR) was conducted to address the relationship between IL-10 gene rs1800896 polymorphism and risk of PDR in Chinese population. Genotyping was performed using PCR-based restriction fragment length polymorphism (PCR-RFLP) assay. It was found that GG genotype or G allele of the IL-10 gene rs1800896 polymorphism was associated with decreased risk for PDR. In conclusion, IL-10 gene rs1800896 polymorphism decreases the risk of PDR.</jats:p> |
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| spelling | Liu, Lun Zheng, Jie Xu, Yajing Gao, Jian Fan, Lingling Xu, Dong 0144-8463 1573-4935 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry Biophysics http://dx.doi.org/10.1042/bsr20181382 <jats:title>Abstract</jats:title> <jats:p>The levels of cytokines, inflammatory cells, and angiogenic factors increase following diabetic retinopathy (DR), and the association between interleukin-10 (IL-10) gene rs1800896 polymorphism (IL-10 -1082G/A polymorphism) and DR in different populations has been extensively studied. However, the findings are conflicting, and there is no relevant research in Chinese subjects. Therefore, this case–control study involving 327 cases (type 2 diabetes patients with proliferative DR (PDR)) and 461 controls (type 2 diabetes patients without DR) was conducted to address the relationship between IL-10 gene rs1800896 polymorphism and risk of PDR in Chinese population. Genotyping was performed using PCR-based restriction fragment length polymorphism (PCR-RFLP) assay. It was found that GG genotype or G allele of the IL-10 gene rs1800896 polymorphism was associated with decreased risk for PDR. In conclusion, IL-10 gene rs1800896 polymorphism decreases the risk of PDR.</jats:p> Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population Bioscience Reports |
| spellingShingle | Liu, Lun, Zheng, Jie, Xu, Yajing, Gao, Jian, Fan, Lingling, Xu, Dong, Bioscience Reports, Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population, Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| title | Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population |
| title_full | Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population |
| title_fullStr | Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population |
| title_full_unstemmed | Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population |
| title_short | Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population |
| title_sort | association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a chinese han population |
| title_unstemmed | Association between interleukin-10 gene rs1800896 polymorphism and diabetic retinopathy in a Chinese Han population |
| topic | Cell Biology, Molecular Biology, Biochemistry, Biophysics |
| url | http://dx.doi.org/10.1042/bsr20181382 |