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δ-Aminolaevulinate synthase expression in muscle after contractions and recovery
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| Zeitschriftentitel: | Biochemical Journal |
|---|---|
| Personen und Körperschaften: | , , , |
| In: | Biochemical Journal, 291, 1993, 1, S. 219-223 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
|
| Schlagwörter: |
| author_facet |
Takahashi, M McCurdy, D T M Essig, D A Hood, D A Takahashi, M McCurdy, D T M Essig, D A Hood, D A |
|---|---|
| author |
Takahashi, M McCurdy, D T M Essig, D A Hood, D A |
| spellingShingle |
Takahashi, M McCurdy, D T M Essig, D A Hood, D A Biochemical Journal δ-Aminolaevulinate synthase expression in muscle after contractions and recovery Cell Biology Molecular Biology Biochemistry |
| author_sort |
takahashi, m |
| spelling |
Takahashi, M McCurdy, D T M Essig, D A Hood, D A 0264-6021 1470-8728 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1042/bj2910219 <jats:p>The synthesis of haem has been postulated to be a key regulatory step in muscle mitochondrial biogenesis. We examined the expression of delta-aminolaevulinate synthase (ALAs), the regulatory enzyme of haem metabolism, in 10 Hz electrically stimulated and non-stimulated control rat tibialis anterior (TA) muscle. ALAs activity and mRNA levels were measured at 0, 18 and 48 h of recovery after 3 h of acute stimulation, or after 7 days of stimulation (3 h/day). ALAs activity in control muscles averaged 7.8 +/- 0.8 nmol/h per g (n = 30). After 3 h of stimulation and during recovery, no change in ALAs activity occurred. ALAs mRNA during the same time was unchanged except at 48 h of recovery, when it increased 1.3-fold above control (P &lt; 0.05). After 7 days of stimulation, ALAs activity was unchanged at 0 h, but increased at 18 and 48 h of recovery to 2.0- and 1.8-fold above control (P &lt; 0.05). ALAs mRNA was also increased, but to a level averaging 1.6-fold above control (P &lt; 0.05) at all times, indicating an increased mRNA stability or synthesis. No change in the haem-containing enzyme cytochrome c oxidase (CYTOX) activity occurred after 3 h of stimulation in the red section of the TA. After 7 days of stimulation, the increase in CYTOX activity averaged 1.7-fold above control (P &lt; 0.05) at all times. Thus the induction of ALAs during recovery after 7 days was regulated by factors which not only change ALAs mRNA content, but which also affect ALAs mRNA at translational or post-translational steps. This induction occurred despite a 1.7-fold increase in CYTOX, implying that a precursor-product relationship does not always exist.</jats:p> <i>δ</i>-Aminolaevulinate synthase expression in muscle after contractions and recovery Biochemical Journal |
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Portland Press Ltd., 1993 |
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Portland Press Ltd., 1993 |
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0264-6021 1470-8728 |
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1993 |
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Portland Press Ltd. |
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Biochemical Journal |
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49 |
| title |
δ-Aminolaevulinate synthase expression in muscle after contractions and recovery |
| title_unstemmed |
δ-Aminolaevulinate synthase expression in muscle after contractions and recovery |
| title_full |
δ-Aminolaevulinate synthase expression in muscle after contractions and recovery |
| title_fullStr |
δ-Aminolaevulinate synthase expression in muscle after contractions and recovery |
| title_full_unstemmed |
δ-Aminolaevulinate synthase expression in muscle after contractions and recovery |
| title_short |
δ-Aminolaevulinate synthase expression in muscle after contractions and recovery |
| title_sort |
<i>δ</i>-aminolaevulinate synthase expression in muscle after contractions and recovery |
| topic |
Cell Biology Molecular Biology Biochemistry |
| url |
http://dx.doi.org/10.1042/bj2910219 |
| publishDate |
1993 |
| physical |
219-223 |
| description |
<jats:p>The synthesis of haem has been postulated to be a key regulatory step in muscle mitochondrial biogenesis. We examined the expression of delta-aminolaevulinate synthase (ALAs), the regulatory enzyme of haem metabolism, in 10 Hz electrically stimulated and non-stimulated control rat tibialis anterior (TA) muscle. ALAs activity and mRNA levels were measured at 0, 18 and 48 h of recovery after 3 h of acute stimulation, or after 7 days of stimulation (3 h/day). ALAs activity in control muscles averaged 7.8 +/- 0.8 nmol/h per g (n = 30). After 3 h of stimulation and during recovery, no change in ALAs activity occurred. ALAs mRNA during the same time was unchanged except at 48 h of recovery, when it increased 1.3-fold above control (P &lt; 0.05). After 7 days of stimulation, ALAs activity was unchanged at 0 h, but increased at 18 and 48 h of recovery to 2.0- and 1.8-fold above control (P &lt; 0.05). ALAs mRNA was also increased, but to a level averaging 1.6-fold above control (P &lt; 0.05) at all times, indicating an increased mRNA stability or synthesis. No change in the haem-containing enzyme cytochrome c oxidase (CYTOX) activity occurred after 3 h of stimulation in the red section of the TA. After 7 days of stimulation, the increase in CYTOX activity averaged 1.7-fold above control (P &lt; 0.05) at all times. Thus the induction of ALAs during recovery after 7 days was regulated by factors which not only change ALAs mRNA content, but which also affect ALAs mRNA at translational or post-translational steps. This induction occurred despite a 1.7-fold increase in CYTOX, implying that a precursor-product relationship does not always exist.</jats:p> |
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| author | Takahashi, M, McCurdy, D T M, Essig, D A, Hood, D A |
| author_facet | Takahashi, M, McCurdy, D T M, Essig, D A, Hood, D A, Takahashi, M, McCurdy, D T M, Essig, D A, Hood, D A |
| author_sort | takahashi, m |
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| description | <jats:p>The synthesis of haem has been postulated to be a key regulatory step in muscle mitochondrial biogenesis. We examined the expression of delta-aminolaevulinate synthase (ALAs), the regulatory enzyme of haem metabolism, in 10 Hz electrically stimulated and non-stimulated control rat tibialis anterior (TA) muscle. ALAs activity and mRNA levels were measured at 0, 18 and 48 h of recovery after 3 h of acute stimulation, or after 7 days of stimulation (3 h/day). ALAs activity in control muscles averaged 7.8 +/- 0.8 nmol/h per g (n = 30). After 3 h of stimulation and during recovery, no change in ALAs activity occurred. ALAs mRNA during the same time was unchanged except at 48 h of recovery, when it increased 1.3-fold above control (P &lt; 0.05). After 7 days of stimulation, ALAs activity was unchanged at 0 h, but increased at 18 and 48 h of recovery to 2.0- and 1.8-fold above control (P &lt; 0.05). ALAs mRNA was also increased, but to a level averaging 1.6-fold above control (P &lt; 0.05) at all times, indicating an increased mRNA stability or synthesis. No change in the haem-containing enzyme cytochrome c oxidase (CYTOX) activity occurred after 3 h of stimulation in the red section of the TA. After 7 days of stimulation, the increase in CYTOX activity averaged 1.7-fold above control (P &lt; 0.05) at all times. Thus the induction of ALAs during recovery after 7 days was regulated by factors which not only change ALAs mRNA content, but which also affect ALAs mRNA at translational or post-translational steps. This induction occurred despite a 1.7-fold increase in CYTOX, implying that a precursor-product relationship does not always exist.</jats:p> |
| doi_str_mv | 10.1042/bj2910219 |
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| imprint | Portland Press Ltd., 1993 |
| imprint_str_mv | Portland Press Ltd., 1993 |
| institution | DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1 |
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| issn_str_mv | 0264-6021, 1470-8728 |
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| last_indexed | 2024-03-01T13:57:40.964Z |
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| physical | 219-223 |
| publishDate | 1993 |
| publishDateSort | 1993 |
| publisher | Portland Press Ltd. |
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| series | Biochemical Journal |
| source_id | 49 |
| spelling | Takahashi, M McCurdy, D T M Essig, D A Hood, D A 0264-6021 1470-8728 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1042/bj2910219 <jats:p>The synthesis of haem has been postulated to be a key regulatory step in muscle mitochondrial biogenesis. We examined the expression of delta-aminolaevulinate synthase (ALAs), the regulatory enzyme of haem metabolism, in 10 Hz electrically stimulated and non-stimulated control rat tibialis anterior (TA) muscle. ALAs activity and mRNA levels were measured at 0, 18 and 48 h of recovery after 3 h of acute stimulation, or after 7 days of stimulation (3 h/day). ALAs activity in control muscles averaged 7.8 +/- 0.8 nmol/h per g (n = 30). After 3 h of stimulation and during recovery, no change in ALAs activity occurred. ALAs mRNA during the same time was unchanged except at 48 h of recovery, when it increased 1.3-fold above control (P &lt; 0.05). After 7 days of stimulation, ALAs activity was unchanged at 0 h, but increased at 18 and 48 h of recovery to 2.0- and 1.8-fold above control (P &lt; 0.05). ALAs mRNA was also increased, but to a level averaging 1.6-fold above control (P &lt; 0.05) at all times, indicating an increased mRNA stability or synthesis. No change in the haem-containing enzyme cytochrome c oxidase (CYTOX) activity occurred after 3 h of stimulation in the red section of the TA. After 7 days of stimulation, the increase in CYTOX activity averaged 1.7-fold above control (P &lt; 0.05) at all times. Thus the induction of ALAs during recovery after 7 days was regulated by factors which not only change ALAs mRNA content, but which also affect ALAs mRNA at translational or post-translational steps. This induction occurred despite a 1.7-fold increase in CYTOX, implying that a precursor-product relationship does not always exist.</jats:p> <i>δ</i>-Aminolaevulinate synthase expression in muscle after contractions and recovery Biochemical Journal |
| spellingShingle | Takahashi, M, McCurdy, D T M, Essig, D A, Hood, D A, Biochemical Journal, δ-Aminolaevulinate synthase expression in muscle after contractions and recovery, Cell Biology, Molecular Biology, Biochemistry |
| title | δ-Aminolaevulinate synthase expression in muscle after contractions and recovery |
| title_full | δ-Aminolaevulinate synthase expression in muscle after contractions and recovery |
| title_fullStr | δ-Aminolaevulinate synthase expression in muscle after contractions and recovery |
| title_full_unstemmed | δ-Aminolaevulinate synthase expression in muscle after contractions and recovery |
| title_short | δ-Aminolaevulinate synthase expression in muscle after contractions and recovery |
| title_sort | <i>δ</i>-aminolaevulinate synthase expression in muscle after contractions and recovery |
| title_unstemmed | δ-Aminolaevulinate synthase expression in muscle after contractions and recovery |
| topic | Cell Biology, Molecular Biology, Biochemistry |
| url | http://dx.doi.org/10.1042/bj2910219 |