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Characterization of Saccharomyces cerevisiae strains displaying high-level or low-level resistance to trichothecene antibiotics
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| Zeitschriftentitel: | Biochemical Journal |
|---|---|
| Personen und Körperschaften: | , , , , |
| In: | Biochemical Journal, 267, 1990, 3, S. 709-713 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
|
| Schlagwörter: |
| author_facet |
Fernandez-Lobato, M Cannon, M Mitlin, J A Mount, R C Jimenez, A Fernandez-Lobato, M Cannon, M Mitlin, J A Mount, R C Jimenez, A |
|---|---|
| author |
Fernandez-Lobato, M Cannon, M Mitlin, J A Mount, R C Jimenez, A |
| spellingShingle |
Fernandez-Lobato, M Cannon, M Mitlin, J A Mount, R C Jimenez, A Biochemical Journal Characterization of Saccharomyces cerevisiae strains displaying high-level or low-level resistance to trichothecene antibiotics Cell Biology Molecular Biology Biochemistry |
| author_sort |
fernandez-lobato, m |
| spelling |
Fernandez-Lobato, M Cannon, M Mitlin, J A Mount, R C Jimenez, A 0264-6021 1470-8728 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1042/bj2670709 <jats:p>Biochemical and genetic analyses have been carried out on Saccharomyces cerevisiae strains characterized in vivo as sensitive, low-level-resistant or high-level-resistant to trichothecene antibiotics. Levels of drug resistance in vitro were determined for each strain and for suitable diploids derived from them. Ribosome biogenesis was also studied in selected haploids. It is suggested that resistance in all cases results from a mutation in the gene encoding ribosomal protein L3. If this is indeed the situation, then different mutations in this same gene not only can cause low-level or high-level resistance to trichothecene antibiotics but also can affect the maturation of either 40 S or 60 S ribosomal subunits.</jats:p> Characterization of <i>Saccharomyces cerevisiae</i> strains displaying high-level or low-level resistance to trichothecene antibiotics Biochemical Journal |
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Portland Press Ltd., 1990 |
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Portland Press Ltd., 1990 |
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0264-6021 1470-8728 |
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Biochemical Journal |
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49 |
| title |
Characterization of Saccharomyces cerevisiae strains displaying high-level or low-level resistance to trichothecene antibiotics |
| title_unstemmed |
Characterization of Saccharomyces cerevisiae strains displaying high-level or low-level resistance to trichothecene antibiotics |
| title_full |
Characterization of Saccharomyces cerevisiae strains displaying high-level or low-level resistance to trichothecene antibiotics |
| title_fullStr |
Characterization of Saccharomyces cerevisiae strains displaying high-level or low-level resistance to trichothecene antibiotics |
| title_full_unstemmed |
Characterization of Saccharomyces cerevisiae strains displaying high-level or low-level resistance to trichothecene antibiotics |
| title_short |
Characterization of Saccharomyces cerevisiae strains displaying high-level or low-level resistance to trichothecene antibiotics |
| title_sort |
characterization of <i>saccharomyces cerevisiae</i> strains displaying high-level or low-level resistance to trichothecene antibiotics |
| topic |
Cell Biology Molecular Biology Biochemistry |
| url |
http://dx.doi.org/10.1042/bj2670709 |
| publishDate |
1990 |
| physical |
709-713 |
| description |
<jats:p>Biochemical and genetic analyses have been carried out on Saccharomyces cerevisiae strains characterized in vivo as sensitive, low-level-resistant or high-level-resistant to trichothecene antibiotics. Levels of drug resistance in vitro were determined for each strain and for suitable diploids derived from them. Ribosome biogenesis was also studied in selected haploids. It is suggested that resistance in all cases results from a mutation in the gene encoding ribosomal protein L3. If this is indeed the situation, then different mutations in this same gene not only can cause low-level or high-level resistance to trichothecene antibiotics but also can affect the maturation of either 40 S or 60 S ribosomal subunits.</jats:p> |
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| author | Fernandez-Lobato, M, Cannon, M, Mitlin, J A, Mount, R C, Jimenez, A |
| author_facet | Fernandez-Lobato, M, Cannon, M, Mitlin, J A, Mount, R C, Jimenez, A, Fernandez-Lobato, M, Cannon, M, Mitlin, J A, Mount, R C, Jimenez, A |
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| description | <jats:p>Biochemical and genetic analyses have been carried out on Saccharomyces cerevisiae strains characterized in vivo as sensitive, low-level-resistant or high-level-resistant to trichothecene antibiotics. Levels of drug resistance in vitro were determined for each strain and for suitable diploids derived from them. Ribosome biogenesis was also studied in selected haploids. It is suggested that resistance in all cases results from a mutation in the gene encoding ribosomal protein L3. If this is indeed the situation, then different mutations in this same gene not only can cause low-level or high-level resistance to trichothecene antibiotics but also can affect the maturation of either 40 S or 60 S ribosomal subunits.</jats:p> |
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| imprint | Portland Press Ltd., 1990 |
| imprint_str_mv | Portland Press Ltd., 1990 |
| institution | DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
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| physical | 709-713 |
| publishDate | 1990 |
| publishDateSort | 1990 |
| publisher | Portland Press Ltd. |
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| series | Biochemical Journal |
| source_id | 49 |
| spelling | Fernandez-Lobato, M Cannon, M Mitlin, J A Mount, R C Jimenez, A 0264-6021 1470-8728 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1042/bj2670709 <jats:p>Biochemical and genetic analyses have been carried out on Saccharomyces cerevisiae strains characterized in vivo as sensitive, low-level-resistant or high-level-resistant to trichothecene antibiotics. Levels of drug resistance in vitro were determined for each strain and for suitable diploids derived from them. Ribosome biogenesis was also studied in selected haploids. It is suggested that resistance in all cases results from a mutation in the gene encoding ribosomal protein L3. If this is indeed the situation, then different mutations in this same gene not only can cause low-level or high-level resistance to trichothecene antibiotics but also can affect the maturation of either 40 S or 60 S ribosomal subunits.</jats:p> Characterization of <i>Saccharomyces cerevisiae</i> strains displaying high-level or low-level resistance to trichothecene antibiotics Biochemical Journal |
| spellingShingle | Fernandez-Lobato, M, Cannon, M, Mitlin, J A, Mount, R C, Jimenez, A, Biochemical Journal, Characterization of Saccharomyces cerevisiae strains displaying high-level or low-level resistance to trichothecene antibiotics, Cell Biology, Molecular Biology, Biochemistry |
| title | Characterization of Saccharomyces cerevisiae strains displaying high-level or low-level resistance to trichothecene antibiotics |
| title_full | Characterization of Saccharomyces cerevisiae strains displaying high-level or low-level resistance to trichothecene antibiotics |
| title_fullStr | Characterization of Saccharomyces cerevisiae strains displaying high-level or low-level resistance to trichothecene antibiotics |
| title_full_unstemmed | Characterization of Saccharomyces cerevisiae strains displaying high-level or low-level resistance to trichothecene antibiotics |
| title_short | Characterization of Saccharomyces cerevisiae strains displaying high-level or low-level resistance to trichothecene antibiotics |
| title_sort | characterization of <i>saccharomyces cerevisiae</i> strains displaying high-level or low-level resistance to trichothecene antibiotics |
| title_unstemmed | Characterization of Saccharomyces cerevisiae strains displaying high-level or low-level resistance to trichothecene antibiotics |
| topic | Cell Biology, Molecular Biology, Biochemistry |
| url | http://dx.doi.org/10.1042/bj2670709 |