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Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk
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| Zeitschriftentitel: | Biochemical Journal |
|---|---|
| Personen und Körperschaften: | , |
| In: | Biochemical Journal, 170, 1978, 2, S. 407-413 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
|
| Schlagwörter: |
| author_facet |
Dickson, J J Messer, M Dickson, J J Messer, M |
|---|---|
| author |
Dickson, J J Messer, M |
| spellingShingle |
Dickson, J J Messer, M Biochemical Journal Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk General Medicine |
| author_sort |
dickson, j j |
| spelling |
Dickson, J J Messer, M 0306-3283 Portland Press Ltd. General Medicine http://dx.doi.org/10.1042/bj1700407 <jats:p>1. The neuraminidase activity of homogenates of the mucosa of the middle and distal thirds of the small intestine of rats increased about 5-fold between birth and 4 to 8 days of age, and then gradually declined to the much lower adult activity by 24 days. No comparable changes occurred in the proximal third. 2. In 8-day-old rats, the neuraminidase activity of the middle and distal thirds of the small intestine was about 10 times greater than that of the proximal third, 20 times greater than that of the colon and at least 100 times greater than that of the liver, brain, gastric mucosa or pancreas. 3. In all other species investigated (mice, rabbits, cats and guinea pigs), the neuraminidase activity of the middle and distal thirds of the small intestine was greater in suckling animals than in adults. 4. The sialic acid content of rat milk increased about 2-fold between birth and 8 days post partum and then declined. 5. There was a highly significant positive correlation between the intestinal neuraminidase activity of suckling animals of various species and ages and the sialic acid content of milk obtained from the corresponding species and stage of lactation. 6. It is suggested that the intestinal neuraminidase of suckling mammals functions primarily to remove sialic acid from various components of milk, thus providing sialic acid for the synthesis of sialoglycoproteins and gangliosides by the young.</jats:p> Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk Biochemical Journal |
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Portland Press Ltd., 1978 |
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1978 |
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Portland Press Ltd. |
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Biochemical Journal |
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49 |
| title |
Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk |
| title_unstemmed |
Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk |
| title_full |
Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk |
| title_fullStr |
Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk |
| title_full_unstemmed |
Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk |
| title_short |
Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk |
| title_sort |
intestinal neuraminidase activity of suckling rats and other mammals. relationship to the sialic acid content of milk |
| topic |
General Medicine |
| url |
http://dx.doi.org/10.1042/bj1700407 |
| publishDate |
1978 |
| physical |
407-413 |
| description |
<jats:p>1. The neuraminidase activity of homogenates of the mucosa of the middle and distal thirds of the small intestine of rats increased about 5-fold between birth and 4 to 8 days of age, and then gradually declined to the much lower adult activity by 24 days. No comparable changes occurred in the proximal third. 2. In 8-day-old rats, the neuraminidase activity of the middle and distal thirds of the small intestine was about 10 times greater than that of the proximal third, 20 times greater than that of the colon and at least 100 times greater than that of the liver, brain, gastric mucosa or pancreas. 3. In all other species investigated (mice, rabbits, cats and guinea pigs), the neuraminidase activity of the middle and distal thirds of the small intestine was greater in suckling animals than in adults. 4. The sialic acid content of rat milk increased about 2-fold between birth and 8 days post partum and then declined. 5. There was a highly significant positive correlation between the intestinal neuraminidase activity of suckling animals of various species and ages and the sialic acid content of milk obtained from the corresponding species and stage of lactation. 6. It is suggested that the intestinal neuraminidase of suckling mammals functions primarily to remove sialic acid from various components of milk, thus providing sialic acid for the synthesis of sialoglycoproteins and gangliosides by the young.</jats:p> |
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| description | <jats:p>1. The neuraminidase activity of homogenates of the mucosa of the middle and distal thirds of the small intestine of rats increased about 5-fold between birth and 4 to 8 days of age, and then gradually declined to the much lower adult activity by 24 days. No comparable changes occurred in the proximal third. 2. In 8-day-old rats, the neuraminidase activity of the middle and distal thirds of the small intestine was about 10 times greater than that of the proximal third, 20 times greater than that of the colon and at least 100 times greater than that of the liver, brain, gastric mucosa or pancreas. 3. In all other species investigated (mice, rabbits, cats and guinea pigs), the neuraminidase activity of the middle and distal thirds of the small intestine was greater in suckling animals than in adults. 4. The sialic acid content of rat milk increased about 2-fold between birth and 8 days post partum and then declined. 5. There was a highly significant positive correlation between the intestinal neuraminidase activity of suckling animals of various species and ages and the sialic acid content of milk obtained from the corresponding species and stage of lactation. 6. It is suggested that the intestinal neuraminidase of suckling mammals functions primarily to remove sialic acid from various components of milk, thus providing sialic acid for the synthesis of sialoglycoproteins and gangliosides by the young.</jats:p> |
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| imprint | Portland Press Ltd., 1978 |
| imprint_str_mv | Portland Press Ltd., 1978 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2 |
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| physical | 407-413 |
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| series | Biochemical Journal |
| source_id | 49 |
| spelling | Dickson, J J Messer, M 0306-3283 Portland Press Ltd. General Medicine http://dx.doi.org/10.1042/bj1700407 <jats:p>1. The neuraminidase activity of homogenates of the mucosa of the middle and distal thirds of the small intestine of rats increased about 5-fold between birth and 4 to 8 days of age, and then gradually declined to the much lower adult activity by 24 days. No comparable changes occurred in the proximal third. 2. In 8-day-old rats, the neuraminidase activity of the middle and distal thirds of the small intestine was about 10 times greater than that of the proximal third, 20 times greater than that of the colon and at least 100 times greater than that of the liver, brain, gastric mucosa or pancreas. 3. In all other species investigated (mice, rabbits, cats and guinea pigs), the neuraminidase activity of the middle and distal thirds of the small intestine was greater in suckling animals than in adults. 4. The sialic acid content of rat milk increased about 2-fold between birth and 8 days post partum and then declined. 5. There was a highly significant positive correlation between the intestinal neuraminidase activity of suckling animals of various species and ages and the sialic acid content of milk obtained from the corresponding species and stage of lactation. 6. It is suggested that the intestinal neuraminidase of suckling mammals functions primarily to remove sialic acid from various components of milk, thus providing sialic acid for the synthesis of sialoglycoproteins and gangliosides by the young.</jats:p> Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk Biochemical Journal |
| spellingShingle | Dickson, J J, Messer, M, Biochemical Journal, Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk, General Medicine |
| title | Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk |
| title_full | Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk |
| title_fullStr | Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk |
| title_full_unstemmed | Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk |
| title_short | Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk |
| title_sort | intestinal neuraminidase activity of suckling rats and other mammals. relationship to the sialic acid content of milk |
| title_unstemmed | Intestinal neuraminidase activity of suckling rats and other mammals. Relationship to the sialic acid content of milk |
| topic | General Medicine |
| url | http://dx.doi.org/10.1042/bj1700407 |