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Uptake and effects of copper in rat liver mitochondria
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| Zeitschriftentitel: | Biochemical Journal |
|---|---|
| Personen und Körperschaften: | , |
| In: | Biochemical Journal, 160, 1976, 3, S. 707-714 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
Portland Press Ltd.
|
| Schlagwörter: |
| author_facet |
Zaba, B N Harris, E J Zaba, B N Harris, E J |
|---|---|
| author |
Zaba, B N Harris, E J |
| spellingShingle |
Zaba, B N Harris, E J Biochemical Journal Uptake and effects of copper in rat liver mitochondria Cell Biology Molecular Biology Biochemistry |
| author_sort |
zaba, b n |
| spelling |
Zaba, B N Harris, E J 0264-6021 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1042/bj1600707 <jats:p>The rate and extent of Cu2+ uptake by rat liver mitochondria was measured under various conditions. 1. The uptake is both greater and faster without an energy supply. 2. The uptake, when occuring in ionic media, has a biphasic character, that is it always slows down after an initial burst, and then re-accelerates. 3. Uptake of Cu2+ in the presence of energy initiates K+ uptake from K+-containing media with accompanying swelling and respiratory stimulation. Depending on the amounts of Cu2+ added and the K+ concentration, an inhibition of respiration later ensues. 4. Chelation of the Cu2+ by substrates (notably glutamate) decreases the effects. 5. Prior exposure to Cu2+ decreases or prevents energy-dependent Ca2+ uptake.</jats:p> Uptake and effects of copper in rat liver mitochondria Biochemical Journal |
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Portland Press Ltd., 1976 |
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1976 |
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Biochemical Journal |
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| title |
Uptake and effects of copper in rat liver mitochondria |
| title_unstemmed |
Uptake and effects of copper in rat liver mitochondria |
| title_full |
Uptake and effects of copper in rat liver mitochondria |
| title_fullStr |
Uptake and effects of copper in rat liver mitochondria |
| title_full_unstemmed |
Uptake and effects of copper in rat liver mitochondria |
| title_short |
Uptake and effects of copper in rat liver mitochondria |
| title_sort |
uptake and effects of copper in rat liver mitochondria |
| topic |
Cell Biology Molecular Biology Biochemistry |
| url |
http://dx.doi.org/10.1042/bj1600707 |
| publishDate |
1976 |
| physical |
707-714 |
| description |
<jats:p>The rate and extent of Cu2+ uptake by rat liver mitochondria was measured under various conditions. 1. The uptake is both greater and faster without an energy supply. 2. The uptake, when occuring in ionic media, has a biphasic character, that is it always slows down after an initial burst, and then re-accelerates. 3. Uptake of Cu2+ in the presence of energy initiates K+ uptake from K+-containing media with accompanying swelling and respiratory stimulation. Depending on the amounts of Cu2+ added and the K+ concentration, an inhibition of respiration later ensues. 4. Chelation of the Cu2+ by substrates (notably glutamate) decreases the effects. 5. Prior exposure to Cu2+ decreases or prevents energy-dependent Ca2+ uptake.</jats:p> |
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| author | Zaba, B N, Harris, E J |
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| description | <jats:p>The rate and extent of Cu2+ uptake by rat liver mitochondria was measured under various conditions. 1. The uptake is both greater and faster without an energy supply. 2. The uptake, when occuring in ionic media, has a biphasic character, that is it always slows down after an initial burst, and then re-accelerates. 3. Uptake of Cu2+ in the presence of energy initiates K+ uptake from K+-containing media with accompanying swelling and respiratory stimulation. Depending on the amounts of Cu2+ added and the K+ concentration, an inhibition of respiration later ensues. 4. Chelation of the Cu2+ by substrates (notably glutamate) decreases the effects. 5. Prior exposure to Cu2+ decreases or prevents energy-dependent Ca2+ uptake.</jats:p> |
| doi_str_mv | 10.1042/bj1600707 |
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| id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA0Mi9iajE2MDA3MDc |
| imprint | Portland Press Ltd., 1976 |
| imprint_str_mv | Portland Press Ltd., 1976 |
| institution | DE-Gla1, DE-Zi4, DE-15, DE-Rs1, DE-Pl11, DE-105, DE-14, DE-Ch1, DE-L229, DE-D275, DE-Bn3, DE-Brt1, DE-Zwi2, DE-D161 |
| issn | 0264-6021 |
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| language | English |
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| physical | 707-714 |
| publishDate | 1976 |
| publishDateSort | 1976 |
| publisher | Portland Press Ltd. |
| record_format | ai |
| recordtype | ai |
| series | Biochemical Journal |
| source_id | 49 |
| spelling | Zaba, B N Harris, E J 0264-6021 Portland Press Ltd. Cell Biology Molecular Biology Biochemistry http://dx.doi.org/10.1042/bj1600707 <jats:p>The rate and extent of Cu2+ uptake by rat liver mitochondria was measured under various conditions. 1. The uptake is both greater and faster without an energy supply. 2. The uptake, when occuring in ionic media, has a biphasic character, that is it always slows down after an initial burst, and then re-accelerates. 3. Uptake of Cu2+ in the presence of energy initiates K+ uptake from K+-containing media with accompanying swelling and respiratory stimulation. Depending on the amounts of Cu2+ added and the K+ concentration, an inhibition of respiration later ensues. 4. Chelation of the Cu2+ by substrates (notably glutamate) decreases the effects. 5. Prior exposure to Cu2+ decreases or prevents energy-dependent Ca2+ uptake.</jats:p> Uptake and effects of copper in rat liver mitochondria Biochemical Journal |
| spellingShingle | Zaba, B N, Harris, E J, Biochemical Journal, Uptake and effects of copper in rat liver mitochondria, Cell Biology, Molecular Biology, Biochemistry |
| title | Uptake and effects of copper in rat liver mitochondria |
| title_full | Uptake and effects of copper in rat liver mitochondria |
| title_fullStr | Uptake and effects of copper in rat liver mitochondria |
| title_full_unstemmed | Uptake and effects of copper in rat liver mitochondria |
| title_short | Uptake and effects of copper in rat liver mitochondria |
| title_sort | uptake and effects of copper in rat liver mitochondria |
| title_unstemmed | Uptake and effects of copper in rat liver mitochondria |
| topic | Cell Biology, Molecular Biology, Biochemistry |
| url | http://dx.doi.org/10.1042/bj1600707 |