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Graph based fusion of high-dimensional gene- and microRNA expression data
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| Personen und Körperschaften: | , , |
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| Titel: | Graph based fusion of high-dimensional gene- and microRNA expression data/ vorgelegt von Stephan Gade |
| Hochschulschriftenvermerk: | Göttingen, Univ., Diss., 2012 |
| Format: | E-Book Hochschulschrift |
| Sprache: | Englisch |
| veröffentlicht: |
2012
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| Schlagwörter: | |
| Druckausg.: | Gade, Stephan, Graph based fusion of high-dimensional gene- and microRNA expression data, 2012, 119 S. |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
| Zusammenfassung: | One of the main goals in cancer studies including high-throughput microRNA (miRNA) and mRNA data is to find and assess prognostic signatures capable of predicting clinical outcome. Both mRNA and miRNA expression changes in cancer diseases are described to reflect clinical characteristics like staging and prognosis. Furthermore, miRNA abundance can directly affect target transcripts and translation in tumor cells. Prediction models are trained to identify either mRNA or miRNA signatures for patient stratification. With the increasing number of microarray studies collecting mRNA and miRNA fro... |
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| Umfang: | Online-Ressource (PDF-Datei: 1,7 MB) |