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Ruxolitinib is effective in the treatment of a patient with refractory T-ALL
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Veröffentlicht in: | eJHaem 2(2021), 1, Seite 139-142 |
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Personen und Körperschaften: | , , , , , , , , , , , , |
Titel: | Ruxolitinib is effective in the treatment of a patient with refractory T-ALL/ Sonia Jaramillo, Hannah Hennemann, Peter Horak, Veronica Teleanu, Christoph E. Heilig, Barbara Hutter, Albrecht Stenzinger, Hanno Glimm, Benjamin Goeppert, Carsten Müller-Tidow, Stefan Fröhling, Stefan Schönland, Richard F. Schlenk |
Format: | E-Book-Kapitel |
Sprache: | Englisch |
veröffentlicht: |
2021
|
Gesamtaufnahme: |
: eJHaem, 2(2021), 1, Seite 139-142
, volume:2 |
Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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author | Jaramillo Segura, Sonia, Hennemann, Hannah Mai, Horak, Peter, Teleanu, Maria-Veronica, Heilig, Christoph E., Hutter, Barbara, Stenzinger, Albrecht, Glimm, Hanno, Goeppert, Benjamin, Müller-Tidow, Carsten, Fröhling, Stefan, Schönland, Stefan, Schlenk, Richard Friedrich |
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contents | T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive T-cell malignancy. Chemotherapy alone cures only 25-45% of the cases, thus, novel treatment agents and strategies are urgently needed. We assessed the efficacy of ruxolitinib in a patient with a cutaneous relapse after allogeneic blood cell transplantation of a refractory T-ALL with a Janus kinase 3 (JAK3) mutation. In this case report, we were able to show the potential benefit of the JAK inhibitor ruxolitinib in JAK3-mutated refractory T-ALL and emphasize the importance of integrating molecular markers in current treatment decision making for patients with T-ALL. |
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spelling | Jaramillo Segura, Sonia VerfasserIn (DE-588)1149855606 (DE-627)1010162772 (DE-576)496412213 aut, Ruxolitinib is effective in the treatment of a patient with refractory T-ALL Sonia Jaramillo, Hannah Hennemann, Peter Horak, Veronica Teleanu, Christoph E. Heilig, Barbara Hutter, Albrecht Stenzinger, Hanno Glimm, Benjamin Goeppert, Carsten Müller-Tidow, Stefan Fröhling, Stefan Schönland, Richard F. Schlenk, 2021, 4, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, First published: 04 December 2020, Gesehen am 07.09.2021, T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive T-cell malignancy. Chemotherapy alone cures only 25-45% of the cases, thus, novel treatment agents and strategies are urgently needed. We assessed the efficacy of ruxolitinib in a patient with a cutaneous relapse after allogeneic blood cell transplantation of a refractory T-ALL with a Janus kinase 3 (JAK3) mutation. In this case report, we were able to show the potential benefit of the JAK inhibitor ruxolitinib in JAK3-mutated refractory T-ALL and emphasize the importance of integrating molecular markers in current treatment decision making for patients with T-ALL., Hennemann, Hannah Mai VerfasserIn (DE-588)1214672329 (DE-627)1725692104 aut, Horak, Peter VerfasserIn (DE-588)1156426111 (DE-627)1019252839 (DE-576)502179961 aut, Teleanu, Maria-Veronica 1977- VerfasserIn (DE-588)1136788557 (DE-627)893574074 (DE-576)49028566X aut, Heilig, Christoph E. 1981- VerfasserIn (DE-588)141951141 (DE-627)632539798 (DE-576)325796440 aut, Hutter, Barbara VerfasserIn (DE-588)14009752X (DE-627)61602293X (DE-576)314588760 aut, Stenzinger, Albrecht VerfasserIn (DE-588)139606106 (DE-627)703395238 (DE-576)312432755 aut, Glimm, Hanno 1967- VerfasserIn (DE-588)113880677 (DE-627)51985120X (DE-576)289777879 aut, Goeppert, Benjamin 1977- VerfasserIn (DE-588)1022581635 (DE-627)717004244 (DE-576)365641324 aut, Müller-Tidow, Carsten VerfasserIn (DE-588)1015101798 (DE-627)705330230 (DE-576)351197893 aut, Fröhling, Stefan 1969- VerfasserIn (DE-588)120890046 (DE-627)080950302 (DE-576)188733930 aut, Schönland, Stefan 1969- VerfasserIn (DE-588)122405226 (DE-627)705896137 (DE-576)293255792 aut, Schlenk, Richard Friedrich 1965- VerfasserIn (DE-588)129025380 (DE-627)387778004 (DE-576)297454102 aut, Enthalten in eJHaem Hoboken, NJ : Wiley, 2020 2(2021), 1, Seite 139-142 Online-Ressource (DE-627)1698060459 (DE-600)3021452-X 2688-6146 nnns, volume:2 year:2021 number:1 pages:139-142 extent:4, https://doi.org/10.1002/jha2.143 Verlag Resolving-System kostenfrei Volltext, https://onlinelibrary.wiley.com/doi/abs/10.1002/jha2.143 Verlag kostenfrei Volltext, https://doi.org/10.1002/jha2.143 LFER, https://onlinelibrary.wiley.com/doi/abs/10.1002/jha2.143 LFER, LFER 2021-10-06T11:27:50Z |
spellingShingle | Jaramillo Segura, Sonia, Hennemann, Hannah Mai, Horak, Peter, Teleanu, Maria-Veronica, Heilig, Christoph E., Hutter, Barbara, Stenzinger, Albrecht, Glimm, Hanno, Goeppert, Benjamin, Müller-Tidow, Carsten, Fröhling, Stefan, Schönland, Stefan, Schlenk, Richard Friedrich, Ruxolitinib is effective in the treatment of a patient with refractory T-ALL, T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive T-cell malignancy. Chemotherapy alone cures only 25-45% of the cases, thus, novel treatment agents and strategies are urgently needed. We assessed the efficacy of ruxolitinib in a patient with a cutaneous relapse after allogeneic blood cell transplantation of a refractory T-ALL with a Janus kinase 3 (JAK3) mutation. In this case report, we were able to show the potential benefit of the JAK inhibitor ruxolitinib in JAK3-mutated refractory T-ALL and emphasize the importance of integrating molecular markers in current treatment decision making for patients with T-ALL. |
title | Ruxolitinib is effective in the treatment of a patient with refractory T-ALL |
title_auth | Ruxolitinib is effective in the treatment of a patient with refractory T-ALL |
title_full | Ruxolitinib is effective in the treatment of a patient with refractory T-ALL Sonia Jaramillo, Hannah Hennemann, Peter Horak, Veronica Teleanu, Christoph E. Heilig, Barbara Hutter, Albrecht Stenzinger, Hanno Glimm, Benjamin Goeppert, Carsten Müller-Tidow, Stefan Fröhling, Stefan Schönland, Richard F. Schlenk |
title_fullStr | Ruxolitinib is effective in the treatment of a patient with refractory T-ALL Sonia Jaramillo, Hannah Hennemann, Peter Horak, Veronica Teleanu, Christoph E. Heilig, Barbara Hutter, Albrecht Stenzinger, Hanno Glimm, Benjamin Goeppert, Carsten Müller-Tidow, Stefan Fröhling, Stefan Schönland, Richard F. Schlenk |
title_full_unstemmed | Ruxolitinib is effective in the treatment of a patient with refractory T-ALL Sonia Jaramillo, Hannah Hennemann, Peter Horak, Veronica Teleanu, Christoph E. Heilig, Barbara Hutter, Albrecht Stenzinger, Hanno Glimm, Benjamin Goeppert, Carsten Müller-Tidow, Stefan Fröhling, Stefan Schönland, Richard F. Schlenk |
title_in_hierarchy | Ruxolitinib is effective in the treatment of a patient with refractory T-ALL / Sonia Jaramillo, Hannah Hennemann, Peter Horak, Veronica Teleanu, Christoph E. Heilig, Barbara Hutter, Albrecht Stenzinger, Hanno Glimm, Benjamin Goeppert, Carsten Müller-Tidow, Stefan Fröhling, Stefan Schönland, Richard F. Schlenk, |
title_short | Ruxolitinib is effective in the treatment of a patient with refractory T-ALL |
title_sort | ruxolitinib is effective in the treatment of a patient with refractory t all |
url | https://doi.org/10.1002/jha2.143, https://onlinelibrary.wiley.com/doi/abs/10.1002/jha2.143 |