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Ruxolitinib is effective in the treatment of a patient with refractory T-ALL

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Veröffentlicht in: eJHaem 2(2021), 1, Seite 139-142
Personen und Körperschaften: Jaramillo Segura, Sonia (VerfasserIn), Hennemann, Hannah Mai (VerfasserIn), Horak, Peter (VerfasserIn), Teleanu, Maria-Veronica (VerfasserIn), Heilig, Christoph E. (VerfasserIn), Hutter, Barbara (VerfasserIn), Stenzinger, Albrecht (VerfasserIn), Glimm, Hanno (VerfasserIn), Goeppert, Benjamin (VerfasserIn), Müller-Tidow, Carsten (VerfasserIn), Fröhling, Stefan (VerfasserIn), Schönland, Stefan (VerfasserIn), Schlenk, Richard Friedrich (VerfasserIn)
Titel: Ruxolitinib is effective in the treatment of a patient with refractory T-ALL/ Sonia Jaramillo, Hannah Hennemann, Peter Horak, Veronica Teleanu, Christoph E. Heilig, Barbara Hutter, Albrecht Stenzinger, Hanno Glimm, Benjamin Goeppert, Carsten Müller-Tidow, Stefan Fröhling, Stefan Schönland, Richard F. Schlenk
Format: E-Book-Kapitel
Sprache: Englisch
veröffentlicht:
2021
Gesamtaufnahme: : eJHaem, 2(2021), 1, Seite 139-142
, volume:2
Quelle: Verbunddaten SWB
Lizenzfreie Online-Ressourcen
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author Jaramillo Segura, Sonia, Hennemann, Hannah Mai, Horak, Peter, Teleanu, Maria-Veronica, Heilig, Christoph E., Hutter, Barbara, Stenzinger, Albrecht, Glimm, Hanno, Goeppert, Benjamin, Müller-Tidow, Carsten, Fröhling, Stefan, Schönland, Stefan, Schlenk, Richard Friedrich
author_facet Jaramillo Segura, Sonia, Hennemann, Hannah Mai, Horak, Peter, Teleanu, Maria-Veronica, Heilig, Christoph E., Hutter, Barbara, Stenzinger, Albrecht, Glimm, Hanno, Goeppert, Benjamin, Müller-Tidow, Carsten, Fröhling, Stefan, Schönland, Stefan, Schlenk, Richard Friedrich
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contents T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive T-cell malignancy. Chemotherapy alone cures only 25-45% of the cases, thus, novel treatment agents and strategies are urgently needed. We assessed the efficacy of ruxolitinib in a patient with a cutaneous relapse after allogeneic blood cell transplantation of a refractory T-ALL with a Janus kinase 3 (JAK3) mutation. In this case report, we were able to show the potential benefit of the JAK inhibitor ruxolitinib in JAK3-mutated refractory T-ALL and emphasize the importance of integrating molecular markers in current treatment decision making for patients with T-ALL.
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spelling Jaramillo Segura, Sonia VerfasserIn (DE-588)1149855606 (DE-627)1010162772 (DE-576)496412213 aut, Ruxolitinib is effective in the treatment of a patient with refractory T-ALL Sonia Jaramillo, Hannah Hennemann, Peter Horak, Veronica Teleanu, Christoph E. Heilig, Barbara Hutter, Albrecht Stenzinger, Hanno Glimm, Benjamin Goeppert, Carsten Müller-Tidow, Stefan Fröhling, Stefan Schönland, Richard F. Schlenk, 2021, 4, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, First published: 04 December 2020, Gesehen am 07.09.2021, T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive T-cell malignancy. Chemotherapy alone cures only 25-45% of the cases, thus, novel treatment agents and strategies are urgently needed. We assessed the efficacy of ruxolitinib in a patient with a cutaneous relapse after allogeneic blood cell transplantation of a refractory T-ALL with a Janus kinase 3 (JAK3) mutation. In this case report, we were able to show the potential benefit of the JAK inhibitor ruxolitinib in JAK3-mutated refractory T-ALL and emphasize the importance of integrating molecular markers in current treatment decision making for patients with T-ALL., Hennemann, Hannah Mai VerfasserIn (DE-588)1214672329 (DE-627)1725692104 aut, Horak, Peter VerfasserIn (DE-588)1156426111 (DE-627)1019252839 (DE-576)502179961 aut, Teleanu, Maria-Veronica 1977- VerfasserIn (DE-588)1136788557 (DE-627)893574074 (DE-576)49028566X aut, Heilig, Christoph E. 1981- VerfasserIn (DE-588)141951141 (DE-627)632539798 (DE-576)325796440 aut, Hutter, Barbara VerfasserIn (DE-588)14009752X (DE-627)61602293X (DE-576)314588760 aut, Stenzinger, Albrecht VerfasserIn (DE-588)139606106 (DE-627)703395238 (DE-576)312432755 aut, Glimm, Hanno 1967- VerfasserIn (DE-588)113880677 (DE-627)51985120X (DE-576)289777879 aut, Goeppert, Benjamin 1977- VerfasserIn (DE-588)1022581635 (DE-627)717004244 (DE-576)365641324 aut, Müller-Tidow, Carsten VerfasserIn (DE-588)1015101798 (DE-627)705330230 (DE-576)351197893 aut, Fröhling, Stefan 1969- VerfasserIn (DE-588)120890046 (DE-627)080950302 (DE-576)188733930 aut, Schönland, Stefan 1969- VerfasserIn (DE-588)122405226 (DE-627)705896137 (DE-576)293255792 aut, Schlenk, Richard Friedrich 1965- VerfasserIn (DE-588)129025380 (DE-627)387778004 (DE-576)297454102 aut, Enthalten in eJHaem Hoboken, NJ : Wiley, 2020 2(2021), 1, Seite 139-142 Online-Ressource (DE-627)1698060459 (DE-600)3021452-X 2688-6146 nnns, volume:2 year:2021 number:1 pages:139-142 extent:4, https://doi.org/10.1002/jha2.143 Verlag Resolving-System kostenfrei Volltext, https://onlinelibrary.wiley.com/doi/abs/10.1002/jha2.143 Verlag kostenfrei Volltext, https://doi.org/10.1002/jha2.143 LFER, https://onlinelibrary.wiley.com/doi/abs/10.1002/jha2.143 LFER, LFER 2021-10-06T11:27:50Z
spellingShingle Jaramillo Segura, Sonia, Hennemann, Hannah Mai, Horak, Peter, Teleanu, Maria-Veronica, Heilig, Christoph E., Hutter, Barbara, Stenzinger, Albrecht, Glimm, Hanno, Goeppert, Benjamin, Müller-Tidow, Carsten, Fröhling, Stefan, Schönland, Stefan, Schlenk, Richard Friedrich, Ruxolitinib is effective in the treatment of a patient with refractory T-ALL, T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive T-cell malignancy. Chemotherapy alone cures only 25-45% of the cases, thus, novel treatment agents and strategies are urgently needed. We assessed the efficacy of ruxolitinib in a patient with a cutaneous relapse after allogeneic blood cell transplantation of a refractory T-ALL with a Janus kinase 3 (JAK3) mutation. In this case report, we were able to show the potential benefit of the JAK inhibitor ruxolitinib in JAK3-mutated refractory T-ALL and emphasize the importance of integrating molecular markers in current treatment decision making for patients with T-ALL.
title Ruxolitinib is effective in the treatment of a patient with refractory T-ALL
title_auth Ruxolitinib is effective in the treatment of a patient with refractory T-ALL
title_full Ruxolitinib is effective in the treatment of a patient with refractory T-ALL Sonia Jaramillo, Hannah Hennemann, Peter Horak, Veronica Teleanu, Christoph E. Heilig, Barbara Hutter, Albrecht Stenzinger, Hanno Glimm, Benjamin Goeppert, Carsten Müller-Tidow, Stefan Fröhling, Stefan Schönland, Richard F. Schlenk
title_fullStr Ruxolitinib is effective in the treatment of a patient with refractory T-ALL Sonia Jaramillo, Hannah Hennemann, Peter Horak, Veronica Teleanu, Christoph E. Heilig, Barbara Hutter, Albrecht Stenzinger, Hanno Glimm, Benjamin Goeppert, Carsten Müller-Tidow, Stefan Fröhling, Stefan Schönland, Richard F. Schlenk
title_full_unstemmed Ruxolitinib is effective in the treatment of a patient with refractory T-ALL Sonia Jaramillo, Hannah Hennemann, Peter Horak, Veronica Teleanu, Christoph E. Heilig, Barbara Hutter, Albrecht Stenzinger, Hanno Glimm, Benjamin Goeppert, Carsten Müller-Tidow, Stefan Fröhling, Stefan Schönland, Richard F. Schlenk
title_in_hierarchy Ruxolitinib is effective in the treatment of a patient with refractory T-ALL / Sonia Jaramillo, Hannah Hennemann, Peter Horak, Veronica Teleanu, Christoph E. Heilig, Barbara Hutter, Albrecht Stenzinger, Hanno Glimm, Benjamin Goeppert, Carsten Müller-Tidow, Stefan Fröhling, Stefan Schönland, Richard F. Schlenk,
title_short Ruxolitinib is effective in the treatment of a patient with refractory T-ALL
title_sort ruxolitinib is effective in the treatment of a patient with refractory t all
url https://doi.org/10.1002/jha2.143, https://onlinelibrary.wiley.com/doi/abs/10.1002/jha2.143