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A multi-network comparative analysis of transcriptome and translatome identifies novel hub genes in cardiac remodeling
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| Veröffentlicht in: | Frontiers in genetics 11(2020) Artikel-Nummer 583124, 11 Seiten |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| Titel: | A multi-network comparative analysis of transcriptome and translatome identifies novel hub genes in cardiac remodeling/ Etienne Boileau, Shirin Doroudgar, Eva Riechert, Lonny Jürgensen, Thanh Cao Ho, Hugo A. Katus, Mirko Völkers and Christoph Dieterich |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
16 November 2020
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| Gesamtaufnahme: |
: Frontiers in genetics, 11(2020) Artikel-Nummer 583124, 11 Seiten
, volume:11 |
| Schlagwörter: | |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
| Errata: |
Boileau, Etienne: Corrigendum: A multi-network comparative analysis of transcriptome and translatome identifies novel hub genes in cardiac remodeling |
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| author | Boileau, Etienne, Doroudgar, Shirin, Riechert, Eva, Jürgensen, Lonny, Ho, Thanh Cao, Katus, Hugo, Völkers, Mirko, Dieterich, Christoph |
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| contents | Our understanding of the transition from physiological to pathological cardiac hypertrophy remains elusive and largely based on reductionist hypotheses. Here, we profiled the translatomes of 15 mouse hearts to provide a molecular blueprint of altered gene networks in early cardiac remodeling. Using co-expression analysis, we showed how sub-networks are orchestrated into functional modules associated with pathological phenotypes. We discovered unappreciated hub genes, many undocumented for their role in cardiac hypertrophy, and genes in the transcriptional network that were rewired in the translational network, and associated with semantically different subsets of enriched functional terms, such as Fam210a, a novel musculoskeletal modulator, or Psmd12, implicated in protein quality control. Using their correlation structure, we found that transcriptome networks are only partially reproducible at the translatome level, providing further evidence of post-transcriptional control at the level of translation. Our results provides novel insights into the complexity of the organization of in vivo cardiac regulatory networks. |
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| spelling | Boileau, Etienne VerfasserIn (DE-588)1194473482 (DE-627)1676464018 aut, A multi-network comparative analysis of transcriptome and translatome identifies novel hub genes in cardiac remodeling Etienne Boileau, Shirin Doroudgar, Eva Riechert, Lonny Jürgensen, Thanh Cao Ho, Hugo A. Katus, Mirko Völkers and Christoph Dieterich, 16 November 2020, 11, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 25.11.2020, Our understanding of the transition from physiological to pathological cardiac hypertrophy remains elusive and largely based on reductionist hypotheses. Here, we profiled the translatomes of 15 mouse hearts to provide a molecular blueprint of altered gene networks in early cardiac remodeling. Using co-expression analysis, we showed how sub-networks are orchestrated into functional modules associated with pathological phenotypes. We discovered unappreciated hub genes, many undocumented for their role in cardiac hypertrophy, and genes in the transcriptional network that were rewired in the translational network, and associated with semantically different subsets of enriched functional terms, such as Fam210a, a novel musculoskeletal modulator, or Psmd12, implicated in protein quality control. Using their correlation structure, we found that transcriptome networks are only partially reproducible at the translatome level, providing further evidence of post-transcriptional control at the level of translation. Our results provides novel insights into the complexity of the organization of in vivo cardiac regulatory networks., cardiac hypertrophy, cardiovascular, co-expression networks, transcription/RNA-seq, translation/Ribo-seq, Doroudgar, Shirin VerfasserIn (DE-588)1139390260 (DE-627)897138023 (DE-576)493250972 aut, Riechert, Eva 1988- VerfasserIn (DE-588)1192937465 (DE-627)1671457323 aut, Jürgensen, Lonny VerfasserIn (DE-588)1074309189 (DE-627)831992107 (DE-576)442582455 aut, Ho, Thanh Cao VerfasserIn aut, Katus, Hugo 1951- VerfasserIn (DE-588)108916618 (DE-627)577155040 (DE-576)289625076 aut, Völkers, Mirko 1978- VerfasserIn (DE-588)133026442 (DE-627)530939932 (DE-576)299573753 aut, Dieterich, Christoph 1975- VerfasserIn (DE-588)130054844 (DE-627)494359269 (DE-576)297972448 aut, Enthalten in Frontiers in genetics Lausanne : Frontiers Media, 2010 11(2020) Artikel-Nummer 583124, 11 Seiten Online-Ressource (DE-627)65799829X (DE-600)2606823-0 (DE-576)343624826 1664-8021 nnns, volume:11 year:2020 extent:11, Errata Boileau, Etienne Corrigendum: A multi-network comparative analysis of transcriptome and translatome identifies novel hub genes in cardiac remodeling 2021 (DE-627)1777537762, https://doi.org/10.3389/fgene.2020.583124 Verlag Resolving-System kostenfrei Volltext, https://www.frontiersin.org/articles/10.3389/fgene.2020.583124/full Verlag kostenfrei Volltext, https://doi.org/10.3389/fgene.2020.583124 LFER, https://www.frontiersin.org/articles/10.3389/fgene.2020.583124/full LFER, LFER 2021-10-04T11:41:39Z |
| spellingShingle | Boileau, Etienne, Doroudgar, Shirin, Riechert, Eva, Jürgensen, Lonny, Ho, Thanh Cao, Katus, Hugo, Völkers, Mirko, Dieterich, Christoph, A multi-network comparative analysis of transcriptome and translatome identifies novel hub genes in cardiac remodeling, Our understanding of the transition from physiological to pathological cardiac hypertrophy remains elusive and largely based on reductionist hypotheses. Here, we profiled the translatomes of 15 mouse hearts to provide a molecular blueprint of altered gene networks in early cardiac remodeling. Using co-expression analysis, we showed how sub-networks are orchestrated into functional modules associated with pathological phenotypes. We discovered unappreciated hub genes, many undocumented for their role in cardiac hypertrophy, and genes in the transcriptional network that were rewired in the translational network, and associated with semantically different subsets of enriched functional terms, such as Fam210a, a novel musculoskeletal modulator, or Psmd12, implicated in protein quality control. Using their correlation structure, we found that transcriptome networks are only partially reproducible at the translatome level, providing further evidence of post-transcriptional control at the level of translation. Our results provides novel insights into the complexity of the organization of in vivo cardiac regulatory networks., cardiac hypertrophy, cardiovascular, co-expression networks, transcription/RNA-seq, translation/Ribo-seq |
| title | A multi-network comparative analysis of transcriptome and translatome identifies novel hub genes in cardiac remodeling |
| title_auth | A multi-network comparative analysis of transcriptome and translatome identifies novel hub genes in cardiac remodeling |
| title_full | A multi-network comparative analysis of transcriptome and translatome identifies novel hub genes in cardiac remodeling Etienne Boileau, Shirin Doroudgar, Eva Riechert, Lonny Jürgensen, Thanh Cao Ho, Hugo A. Katus, Mirko Völkers and Christoph Dieterich |
| title_fullStr | A multi-network comparative analysis of transcriptome and translatome identifies novel hub genes in cardiac remodeling Etienne Boileau, Shirin Doroudgar, Eva Riechert, Lonny Jürgensen, Thanh Cao Ho, Hugo A. Katus, Mirko Völkers and Christoph Dieterich |
| title_full_unstemmed | A multi-network comparative analysis of transcriptome and translatome identifies novel hub genes in cardiac remodeling Etienne Boileau, Shirin Doroudgar, Eva Riechert, Lonny Jürgensen, Thanh Cao Ho, Hugo A. Katus, Mirko Völkers and Christoph Dieterich |
| title_in_hierarchy | A multi-network comparative analysis of transcriptome and translatome identifies novel hub genes in cardiac remodeling / Etienne Boileau, Shirin Doroudgar, Eva Riechert, Lonny Jürgensen, Thanh Cao Ho, Hugo A. Katus, Mirko Völkers and Christoph Dieterich, |
| title_short | A multi-network comparative analysis of transcriptome and translatome identifies novel hub genes in cardiac remodeling |
| title_sort | multi network comparative analysis of transcriptome and translatome identifies novel hub genes in cardiac remodeling |
| topic | cardiac hypertrophy, cardiovascular, co-expression networks, transcription/RNA-seq, translation/Ribo-seq |
| topic_facet | cardiac hypertrophy, cardiovascular, co-expression networks, transcription/RNA-seq, translation/Ribo-seq |
| url | https://doi.org/10.3389/fgene.2020.583124, https://www.frontiersin.org/articles/10.3389/fgene.2020.583124/full |