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Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma
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| Veröffentlicht in: | Scientific reports 9(2019) Artikel-Nummer 11326, 9 Seiten |
|---|---|
| Personen und Körperschaften: | , , , , , |
| Titel: | Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma/ Carl Maximilian Thielmann, Milene Costa da Silva, Thomas Muley, Michael Meister, Esther Herpel, & Martina U. Muckenthaler |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
05 August 2019
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| Gesamtaufnahme: |
: Scientific reports, 9(2019) Artikel-Nummer 11326, 9 Seiten
, volume:9 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 520 | |a Iron-loaded tumor-associated macrophages (iTAMs) show a pro-inflammatory phenotype, hallmarked by anti-tumorigenic activity and an ability to attenuate tumor growth. Here we explored the relevance of these findings in lung cancer patients by investigating the impact of the iTAM content in the tumor microenvironment (TME) on patient survival. We analyzed 102 human non-small cell lung cancer (NSCLC) paraffin-embedded archival tissue samples for iron levels and macrophage numbers. Interestingly, patients with lung adenocarcinoma accumulating iron in the TME show higher numbers of M1-like pro-inflammatory TAMs and a survival advantage compared to iron-negative patients. By contrast, in patients with lung squamous cell carcinoma iron in the TME does not affect survival, suggesting a unique influence of iron on different histological subtypes of non-small cell lung cancer (NSCLC). We conclude that in lung adenocarcinoma iron may serve as a prognostic marker for patient survival and as a potential therapeutic target for anti-cancer therapy. | ||
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| contents | Iron-loaded tumor-associated macrophages (iTAMs) show a pro-inflammatory phenotype, hallmarked by anti-tumorigenic activity and an ability to attenuate tumor growth. Here we explored the relevance of these findings in lung cancer patients by investigating the impact of the iTAM content in the tumor microenvironment (TME) on patient survival. We analyzed 102 human non-small cell lung cancer (NSCLC) paraffin-embedded archival tissue samples for iron levels and macrophage numbers. Interestingly, patients with lung adenocarcinoma accumulating iron in the TME show higher numbers of M1-like pro-inflammatory TAMs and a survival advantage compared to iron-negative patients. By contrast, in patients with lung squamous cell carcinoma iron in the TME does not affect survival, suggesting a unique influence of iron on different histological subtypes of non-small cell lung cancer (NSCLC). We conclude that in lung adenocarcinoma iron may serve as a prognostic marker for patient survival and as a potential therapeutic target for anti-cancer therapy. |
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| spelling | Thielmann, Carl Maximilian 1991- VerfasserIn (DE-588)1160054266 (DE-627)1023153114 (DE-576)505472368 aut, Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma Carl Maximilian Thielmann, Milene Costa da Silva, Thomas Muley, Michael Meister, Esther Herpel, & Martina U. Muckenthaler, 05 August 2019, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 28.02.2020, Iron-loaded tumor-associated macrophages (iTAMs) show a pro-inflammatory phenotype, hallmarked by anti-tumorigenic activity and an ability to attenuate tumor growth. Here we explored the relevance of these findings in lung cancer patients by investigating the impact of the iTAM content in the tumor microenvironment (TME) on patient survival. We analyzed 102 human non-small cell lung cancer (NSCLC) paraffin-embedded archival tissue samples for iron levels and macrophage numbers. Interestingly, patients with lung adenocarcinoma accumulating iron in the TME show higher numbers of M1-like pro-inflammatory TAMs and a survival advantage compared to iron-negative patients. By contrast, in patients with lung squamous cell carcinoma iron in the TME does not affect survival, suggesting a unique influence of iron on different histological subtypes of non-small cell lung cancer (NSCLC). We conclude that in lung adenocarcinoma iron may serve as a prognostic marker for patient survival and as a potential therapeutic target for anti-cancer therapy., Costa da Silva, Milene VerfasserIn (DE-588)116005231X (DE-627)1023148838 (DE-576)505468735 aut, Muley, Thomas VerfasserIn (DE-588)1056885432 (DE-627)794179169 (DE-576)16759284X aut, Meister, Michael VerfasserIn (DE-588)1078792046 (DE-627)839461402 (DE-576)451890108 aut, Herpel, Esther 1973- VerfasserIn (DE-588)12965227X (DE-627)476593662 (DE-576)297767984 aut, Muckenthaler, Martina VerfasserIn (DE-588)1046124595 (DE-627)775766496 (DE-576)173146813 aut, Enthalten in Scientific reports [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 9(2019) Artikel-Nummer 11326, 9 Seiten Online-Ressource (DE-627)663366712 (DE-600)2615211-3 (DE-576)346641179 2045-2322 nnns, volume:9 year:2019, https://doi.org/10.1038/s41598-019-47833-x Verlag Resolving-System kostenfrei Volltext, https://www.nature.com/articles/s41598-019-47833-x Verlag kostenfrei Volltext, https://doi.org/10.1038/s41598-019-47833-x LFER, https://www.nature.com/articles/s41598-019-47833-x LFER, LFER 2020-03-09T00:00:00Z |
| spellingShingle | Thielmann, Carl Maximilian, Costa da Silva, Milene, Muley, Thomas, Meister, Michael, Herpel, Esther, Muckenthaler, Martina, Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma, Iron-loaded tumor-associated macrophages (iTAMs) show a pro-inflammatory phenotype, hallmarked by anti-tumorigenic activity and an ability to attenuate tumor growth. Here we explored the relevance of these findings in lung cancer patients by investigating the impact of the iTAM content in the tumor microenvironment (TME) on patient survival. We analyzed 102 human non-small cell lung cancer (NSCLC) paraffin-embedded archival tissue samples for iron levels and macrophage numbers. Interestingly, patients with lung adenocarcinoma accumulating iron in the TME show higher numbers of M1-like pro-inflammatory TAMs and a survival advantage compared to iron-negative patients. By contrast, in patients with lung squamous cell carcinoma iron in the TME does not affect survival, suggesting a unique influence of iron on different histological subtypes of non-small cell lung cancer (NSCLC). We conclude that in lung adenocarcinoma iron may serve as a prognostic marker for patient survival and as a potential therapeutic target for anti-cancer therapy. |
| title | Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma |
| title_auth | Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma |
| title_full | Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma Carl Maximilian Thielmann, Milene Costa da Silva, Thomas Muley, Michael Meister, Esther Herpel, & Martina U. Muckenthaler |
| title_fullStr | Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma Carl Maximilian Thielmann, Milene Costa da Silva, Thomas Muley, Michael Meister, Esther Herpel, & Martina U. Muckenthaler |
| title_full_unstemmed | Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma Carl Maximilian Thielmann, Milene Costa da Silva, Thomas Muley, Michael Meister, Esther Herpel, & Martina U. Muckenthaler |
| title_in_hierarchy | Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma / Carl Maximilian Thielmann, Milene Costa da Silva, Thomas Muley, Michael Meister, Esther Herpel, & Martina U. Muckenthaler, |
| title_short | Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma |
| title_sort | iron accumulation in tumor associated macrophages marks an improved overall survival in patients with lung adenocarcinoma |
| url | https://doi.org/10.1038/s41598-019-47833-x, https://www.nature.com/articles/s41598-019-47833-x |