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Supplementation with 45S5 bioactive glass reduces in vivo resorption of the β-tricalcium-phosphate-based bone substitute material Vitoss
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| Veröffentlicht in: | International journal of molecular sciences 20(2019,17) Artikel-Nummer 4253, 18 Seiten |
|---|---|
| Personen und Körperschaften: | , , , , , , |
| Titel: | Supplementation with 45S5 bioactive glass reduces in vivo resorption of the β-tricalcium-phosphate-based bone substitute material Vitoss/ Fabian Westhauser, Christopher Essers, Maria Karadjian, Bruno Reible, Gerhard Schmidmaier, Sébastien Hagmann and Arash Moghaddam |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
30 August 2019
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| Gesamtaufnahme: |
: International journal of molecular sciences, 20(2019,17) Artikel-Nummer 4253, 18 Seiten
, volume:20 |
| Schlagwörter: | |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 0 | |a Supplementation with 45S5 bioactive glass reduces in vivo resorption of the β-tricalcium-phosphate-based bone substitute material Vitoss |c Fabian Westhauser, Christopher Essers, Maria Karadjian, Bruno Reible, Gerhard Schmidmaier, Sébastien Hagmann and Arash Moghaddam |
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| 520 | |a Compared to other materials such as 45S5 bioactive glass (BG), β-tricalcium phosphate (β-TCP)-based bone substitutes such as Vitoss show limited material-driven stimulation of osteogenesis and/or angiogenesis. The unfavorable degradation kinetics of β-TCP-based bone substitutes may result in an imbalance between resorption and osseous regeneration. Composite materials like Vitoss BA (Vitoss supplemented with 20 wt % 45S5-BG particles) might help to overcome these limitations. However, the influence of BG particles in Vitoss BA compared to unsupplemented Vitoss on osteogenesis, resorption behavior, and angiogenesis is not yet described. In this study, Vitoss and Vitoss BA scaffolds were seeded with human mesenchymal stromal cells before subcutaneous implantation in immunodeficient mice for 10 weeks. Scaffold resorption was monitored by micro-computed tomography, while osteoid formation and vascularization were assessed by histomorphometry and gene expression analysis. Whilst slightly more osteoid and improved angiogenesis were found in Vitoss BA, maturation of the osteoid was more advanced in Vitoss scaffolds. The volume of Vitoss implants decreased significantly, combined with a significantly increased presence of resorbing cells, whilst the volume remained stable in Vitoss BA scaffolds. Future studies should evaluate the interaction of 45S5-BG with resorbing cells and bone precursor cells in greater detail to improve the understanding and application of β-TCP/45S5-BG composite bone substitute materials. | ||
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| author | Westhauser, Fabian, Essers, Christopher, Karadjian, Maria, Reible, Bruno, Schmidmaier, Gerhard, Hagmann, Sébastien, Moghaddam-Alvandi, Arash |
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| contents | Compared to other materials such as 45S5 bioactive glass (BG), β-tricalcium phosphate (β-TCP)-based bone substitutes such as Vitoss show limited material-driven stimulation of osteogenesis and/or angiogenesis. The unfavorable degradation kinetics of β-TCP-based bone substitutes may result in an imbalance between resorption and osseous regeneration. Composite materials like Vitoss BA (Vitoss supplemented with 20 wt % 45S5-BG particles) might help to overcome these limitations. However, the influence of BG particles in Vitoss BA compared to unsupplemented Vitoss on osteogenesis, resorption behavior, and angiogenesis is not yet described. In this study, Vitoss and Vitoss BA scaffolds were seeded with human mesenchymal stromal cells before subcutaneous implantation in immunodeficient mice for 10 weeks. Scaffold resorption was monitored by micro-computed tomography, while osteoid formation and vascularization were assessed by histomorphometry and gene expression analysis. Whilst slightly more osteoid and improved angiogenesis were found in Vitoss BA, maturation of the osteoid was more advanced in Vitoss scaffolds. The volume of Vitoss implants decreased significantly, combined with a significantly increased presence of resorbing cells, whilst the volume remained stable in Vitoss BA scaffolds. Future studies should evaluate the interaction of 45S5-BG with resorbing cells and bone precursor cells in greater detail to improve the understanding and application of β-TCP/45S5-BG composite bone substitute materials. |
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| spelling | Westhauser, Fabian 1990- VerfasserIn (DE-588)1121326501 (DE-627)874251060 (DE-576)480821496 aut, Supplementation with 45S5 bioactive glass reduces in vivo resorption of the β-tricalcium-phosphate-based bone substitute material Vitoss Fabian Westhauser, Christopher Essers, Maria Karadjian, Bruno Reible, Gerhard Schmidmaier, Sébastien Hagmann and Arash Moghaddam, 30 August 2019, 18, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 18.11.2019, Compared to other materials such as 45S5 bioactive glass (BG), β-tricalcium phosphate (β-TCP)-based bone substitutes such as Vitoss show limited material-driven stimulation of osteogenesis and/or angiogenesis. The unfavorable degradation kinetics of β-TCP-based bone substitutes may result in an imbalance between resorption and osseous regeneration. Composite materials like Vitoss BA (Vitoss supplemented with 20 wt % 45S5-BG particles) might help to overcome these limitations. However, the influence of BG particles in Vitoss BA compared to unsupplemented Vitoss on osteogenesis, resorption behavior, and angiogenesis is not yet described. In this study, Vitoss and Vitoss BA scaffolds were seeded with human mesenchymal stromal cells before subcutaneous implantation in immunodeficient mice for 10 weeks. Scaffold resorption was monitored by micro-computed tomography, while osteoid formation and vascularization were assessed by histomorphometry and gene expression analysis. Whilst slightly more osteoid and improved angiogenesis were found in Vitoss BA, maturation of the osteoid was more advanced in Vitoss scaffolds. The volume of Vitoss implants decreased significantly, combined with a significantly increased presence of resorbing cells, whilst the volume remained stable in Vitoss BA scaffolds. Future studies should evaluate the interaction of 45S5-BG with resorbing cells and bone precursor cells in greater detail to improve the understanding and application of β-TCP/45S5-BG composite bone substitute materials., 45S5 bioactive glass, bone tissue engineering, calcium phosphate, composite bone substitute materials, in vivo, resorption, Essers, Christopher VerfasserIn (DE-588)1189088134 (DE-627)1667821873 aut, Karadjian, Maria VerfasserIn (DE-588)1189087863 (DE-627)1667821571 aut, Reible, Bruno VerfasserIn (DE-588)112367745X (DE-627)877361002 (DE-576)481895558 aut, Schmidmaier, Gerhard 1970- VerfasserIn (DE-588)121147207 (DE-627)394702662 (DE-576)292558600 aut, Hagmann, Sébastien 1979- VerfasserIn (DE-588)137429312 (DE-627)695818457 (DE-576)303557850 aut, Moghaddam-Alvandi, Arash 1973- VerfasserIn (DE-588)13162458X (DE-627)511709080 (DE-576)298633140 aut, Enthalten in International journal of molecular sciences Basel : Molecular Diversity Preservation International, 2000 20(2019,17) Artikel-Nummer 4253, 18 Seiten Online-Ressource (DE-627)316340715 (DE-600)2019364-6 (DE-576)281194653 1422-0067 nnns, volume:20 year:2019 number:17 extent:18, https://doi.org/10.3390/ijms20174253 Verlag Resolving-System kostenfrei Volltext, https://www.mdpi.com/1422-0067/20/17/4253 Verlag kostenfrei Volltext, https://doi.org/10.3390/ijms20174253 LFER, https://www.mdpi.com/1422-0067/20/17/4253 LFER, LFER 2019-12-05T00:00:00Z |
| spellingShingle | Westhauser, Fabian, Essers, Christopher, Karadjian, Maria, Reible, Bruno, Schmidmaier, Gerhard, Hagmann, Sébastien, Moghaddam-Alvandi, Arash, Supplementation with 45S5 bioactive glass reduces in vivo resorption of the β-tricalcium-phosphate-based bone substitute material Vitoss, Compared to other materials such as 45S5 bioactive glass (BG), β-tricalcium phosphate (β-TCP)-based bone substitutes such as Vitoss show limited material-driven stimulation of osteogenesis and/or angiogenesis. The unfavorable degradation kinetics of β-TCP-based bone substitutes may result in an imbalance between resorption and osseous regeneration. Composite materials like Vitoss BA (Vitoss supplemented with 20 wt % 45S5-BG particles) might help to overcome these limitations. However, the influence of BG particles in Vitoss BA compared to unsupplemented Vitoss on osteogenesis, resorption behavior, and angiogenesis is not yet described. In this study, Vitoss and Vitoss BA scaffolds were seeded with human mesenchymal stromal cells before subcutaneous implantation in immunodeficient mice for 10 weeks. Scaffold resorption was monitored by micro-computed tomography, while osteoid formation and vascularization were assessed by histomorphometry and gene expression analysis. Whilst slightly more osteoid and improved angiogenesis were found in Vitoss BA, maturation of the osteoid was more advanced in Vitoss scaffolds. The volume of Vitoss implants decreased significantly, combined with a significantly increased presence of resorbing cells, whilst the volume remained stable in Vitoss BA scaffolds. Future studies should evaluate the interaction of 45S5-BG with resorbing cells and bone precursor cells in greater detail to improve the understanding and application of β-TCP/45S5-BG composite bone substitute materials., 45S5 bioactive glass, bone tissue engineering, calcium phosphate, composite bone substitute materials, in vivo, resorption |
| title | Supplementation with 45S5 bioactive glass reduces in vivo resorption of the β-tricalcium-phosphate-based bone substitute material Vitoss |
| title_auth | Supplementation with 45S5 bioactive glass reduces in vivo resorption of the β-tricalcium-phosphate-based bone substitute material Vitoss |
| title_full | Supplementation with 45S5 bioactive glass reduces in vivo resorption of the β-tricalcium-phosphate-based bone substitute material Vitoss Fabian Westhauser, Christopher Essers, Maria Karadjian, Bruno Reible, Gerhard Schmidmaier, Sébastien Hagmann and Arash Moghaddam |
| title_fullStr | Supplementation with 45S5 bioactive glass reduces in vivo resorption of the β-tricalcium-phosphate-based bone substitute material Vitoss Fabian Westhauser, Christopher Essers, Maria Karadjian, Bruno Reible, Gerhard Schmidmaier, Sébastien Hagmann and Arash Moghaddam |
| title_full_unstemmed | Supplementation with 45S5 bioactive glass reduces in vivo resorption of the β-tricalcium-phosphate-based bone substitute material Vitoss Fabian Westhauser, Christopher Essers, Maria Karadjian, Bruno Reible, Gerhard Schmidmaier, Sébastien Hagmann and Arash Moghaddam |
| title_in_hierarchy | Supplementation with 45S5 bioactive glass reduces in vivo resorption of the β-tricalcium-phosphate-based bone substitute material Vitoss / Fabian Westhauser, Christopher Essers, Maria Karadjian, Bruno Reible, Gerhard Schmidmaier, Sébastien Hagmann and Arash Moghaddam, |
| title_short | Supplementation with 45S5 bioactive glass reduces in vivo resorption of the β-tricalcium-phosphate-based bone substitute material Vitoss |
| title_sort | supplementation with 45s5 bioactive glass reduces in vivo resorption of the β tricalcium phosphate based bone substitute material vitoss |
| topic | 45S5 bioactive glass, bone tissue engineering, calcium phosphate, composite bone substitute materials, in vivo, resorption |
| topic_facet | 45S5 bioactive glass, bone tissue engineering, calcium phosphate, composite bone substitute materials, in vivo, resorption |
| url | https://doi.org/10.3390/ijms20174253, https://www.mdpi.com/1422-0067/20/17/4253 |