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Bedside-measurement of serum cholinesterase activity predicts patient morbidity and length of the intensive care unit stay following major traumatic injury
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| Veröffentlicht in: | Scientific reports 9(2019) Artikel-Nummer 10437, 9 Seiten |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| Titel: | Bedside-measurement of serum cholinesterase activity predicts patient morbidity and length of the intensive care unit stay following major traumatic injury/ Aleksandar R. Zivkovic, Karsten Schmidt, Thomas Stein, Matthias Münzberg, Thorsten Brenner, Markus A. Weigand, Stefan Kleinschmidt & Stefan Hofer |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
18 July 2019
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| Gesamtaufnahme: |
: Scientific reports, 9(2019) Artikel-Nummer 10437, 9 Seiten
, volume:9 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 0 | |a Bedside-measurement of serum cholinesterase activity predicts patient morbidity and length of the intensive care unit stay following major traumatic injury |c Aleksandar R. Zivkovic, Karsten Schmidt, Thomas Stein, Matthias Münzberg, Thorsten Brenner, Markus A. Weigand, Stefan Kleinschmidt & Stefan Hofer |
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| 520 | |a Major traumatic injury (MTI), a life-threatening condition requiring prompt medical intervention, is associated with an extensive inflammatory response often resulting in multiple organ dysfunction. Early stratification of trauma severity and the corresponding inflammation may help optimize resources at the intensive care unit (ICU). The cholinergic system counters inflammation by quickly modulating the immune response. Serum cholinesterase (butyrylcholinesterase, BChE) is an enzyme that hydrolyses acetylcholine. We tested whether a change in the BChE activity correlates with the morbidity and the length of ICU stay. Blood samples from 10 healthy volunteers and 44 patients with MTI were gathered at hospital admission, followed by measurements 12, 24 and 48 hours later. Point-of-care approach was used to determine the BChE activity. Disease severity was assessed by clinical scoring performed within 24 hours following hospital admission. BChE activity, measured at hospital admission, showed a significant and sustained reduction and correlated with disease severity scores obtained 24 hours following admission. BChE activity, obtained at hospital admission, correlated with the length of ICU stay. Bedside measurement of BChE activity, as a complementary addition to established procedures, might prove useful in the primary assessment of the disease severity and might therefore optimize therapy in the ICU. | ||
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| author | Živković, Aleksandar, Schmidt, Karsten, Stein, Thomas, Münzberg, Matthias, Brenner, Thorsten, Weigand, Markus A., Kleinschmidt, Stefan, Hofer, Stefan |
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| contents | Major traumatic injury (MTI), a life-threatening condition requiring prompt medical intervention, is associated with an extensive inflammatory response often resulting in multiple organ dysfunction. Early stratification of trauma severity and the corresponding inflammation may help optimize resources at the intensive care unit (ICU). The cholinergic system counters inflammation by quickly modulating the immune response. Serum cholinesterase (butyrylcholinesterase, BChE) is an enzyme that hydrolyses acetylcholine. We tested whether a change in the BChE activity correlates with the morbidity and the length of ICU stay. Blood samples from 10 healthy volunteers and 44 patients with MTI were gathered at hospital admission, followed by measurements 12, 24 and 48 hours later. Point-of-care approach was used to determine the BChE activity. Disease severity was assessed by clinical scoring performed within 24 hours following hospital admission. BChE activity, measured at hospital admission, showed a significant and sustained reduction and correlated with disease severity scores obtained 24 hours following admission. BChE activity, obtained at hospital admission, correlated with the length of ICU stay. Bedside measurement of BChE activity, as a complementary addition to established procedures, might prove useful in the primary assessment of the disease severity and might therefore optimize therapy in the ICU. |
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| spelling | Živković, Aleksandar 1976- VerfasserIn (DE-588)133065200 (DE-627)533317223 (DE-576)265580633 aut, Bedside-measurement of serum cholinesterase activity predicts patient morbidity and length of the intensive care unit stay following major traumatic injury Aleksandar R. Zivkovic, Karsten Schmidt, Thomas Stein, Matthias Münzberg, Thorsten Brenner, Markus A. Weigand, Stefan Kleinschmidt & Stefan Hofer, 18 July 2019, 9, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 17.10.2019, Major traumatic injury (MTI), a life-threatening condition requiring prompt medical intervention, is associated with an extensive inflammatory response often resulting in multiple organ dysfunction. Early stratification of trauma severity and the corresponding inflammation may help optimize resources at the intensive care unit (ICU). The cholinergic system counters inflammation by quickly modulating the immune response. Serum cholinesterase (butyrylcholinesterase, BChE) is an enzyme that hydrolyses acetylcholine. We tested whether a change in the BChE activity correlates with the morbidity and the length of ICU stay. Blood samples from 10 healthy volunteers and 44 patients with MTI were gathered at hospital admission, followed by measurements 12, 24 and 48 hours later. Point-of-care approach was used to determine the BChE activity. Disease severity was assessed by clinical scoring performed within 24 hours following hospital admission. BChE activity, measured at hospital admission, showed a significant and sustained reduction and correlated with disease severity scores obtained 24 hours following admission. BChE activity, obtained at hospital admission, correlated with the length of ICU stay. Bedside measurement of BChE activity, as a complementary addition to established procedures, might prove useful in the primary assessment of the disease severity and might therefore optimize therapy in the ICU., Schmidt, Karsten 1983- VerfasserIn (DE-588)141624841 (DE-627)63039475X (DE-576)324449690 aut, Stein, Thomas VerfasserIn aut, Münzberg, Matthias 1977- VerfasserIn (DE-588)132228254 (DE-627)519546385 (DE-576)299017656 aut, Brenner, Thorsten 1978- VerfasserIn (DE-588)130125709 (DE-627)491713363 (DE-576)189360607 aut, Weigand, Markus A. 1967- VerfasserIn (DE-588)1064970435 (DE-627)815375239 (DE-576)424658666 aut, Kleinschmidt, Stefan VerfasserIn aut, Hofer, Stefan 1971- VerfasserIn (DE-588)122418506 (DE-627)70590072X (DE-576)187683867 aut, Enthalten in Scientific reports [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 9(2019) Artikel-Nummer 10437, 9 Seiten Online-Ressource (DE-627)663366712 (DE-600)2615211-3 (DE-576)346641179 2045-2322 nnns, volume:9 year:2019 extent:9, https://doi.org/10.1038/s41598-019-46995-y Verlag Resolving-System kostenfrei Volltext, https://www.nature.com/articles/s41598-019-46995-y Verlag kostenfrei Volltext, https://doi.org/10.1038/s41598-019-46995-y LFER, https://www.nature.com/articles/s41598-019-46995-y LFER, LFER 2019-12-05T00:00:00Z |
| spellingShingle | Živković, Aleksandar, Schmidt, Karsten, Stein, Thomas, Münzberg, Matthias, Brenner, Thorsten, Weigand, Markus A., Kleinschmidt, Stefan, Hofer, Stefan, Bedside-measurement of serum cholinesterase activity predicts patient morbidity and length of the intensive care unit stay following major traumatic injury, Major traumatic injury (MTI), a life-threatening condition requiring prompt medical intervention, is associated with an extensive inflammatory response often resulting in multiple organ dysfunction. Early stratification of trauma severity and the corresponding inflammation may help optimize resources at the intensive care unit (ICU). The cholinergic system counters inflammation by quickly modulating the immune response. Serum cholinesterase (butyrylcholinesterase, BChE) is an enzyme that hydrolyses acetylcholine. We tested whether a change in the BChE activity correlates with the morbidity and the length of ICU stay. Blood samples from 10 healthy volunteers and 44 patients with MTI were gathered at hospital admission, followed by measurements 12, 24 and 48 hours later. Point-of-care approach was used to determine the BChE activity. Disease severity was assessed by clinical scoring performed within 24 hours following hospital admission. BChE activity, measured at hospital admission, showed a significant and sustained reduction and correlated with disease severity scores obtained 24 hours following admission. BChE activity, obtained at hospital admission, correlated with the length of ICU stay. Bedside measurement of BChE activity, as a complementary addition to established procedures, might prove useful in the primary assessment of the disease severity and might therefore optimize therapy in the ICU. |
| title | Bedside-measurement of serum cholinesterase activity predicts patient morbidity and length of the intensive care unit stay following major traumatic injury |
| title_auth | Bedside-measurement of serum cholinesterase activity predicts patient morbidity and length of the intensive care unit stay following major traumatic injury |
| title_full | Bedside-measurement of serum cholinesterase activity predicts patient morbidity and length of the intensive care unit stay following major traumatic injury Aleksandar R. Zivkovic, Karsten Schmidt, Thomas Stein, Matthias Münzberg, Thorsten Brenner, Markus A. Weigand, Stefan Kleinschmidt & Stefan Hofer |
| title_fullStr | Bedside-measurement of serum cholinesterase activity predicts patient morbidity and length of the intensive care unit stay following major traumatic injury Aleksandar R. Zivkovic, Karsten Schmidt, Thomas Stein, Matthias Münzberg, Thorsten Brenner, Markus A. Weigand, Stefan Kleinschmidt & Stefan Hofer |
| title_full_unstemmed | Bedside-measurement of serum cholinesterase activity predicts patient morbidity and length of the intensive care unit stay following major traumatic injury Aleksandar R. Zivkovic, Karsten Schmidt, Thomas Stein, Matthias Münzberg, Thorsten Brenner, Markus A. Weigand, Stefan Kleinschmidt & Stefan Hofer |
| title_in_hierarchy | Bedside-measurement of serum cholinesterase activity predicts patient morbidity and length of the intensive care unit stay following major traumatic injury / Aleksandar R. Zivkovic, Karsten Schmidt, Thomas Stein, Matthias Münzberg, Thorsten Brenner, Markus A. Weigand, Stefan Kleinschmidt & Stefan Hofer, |
| title_short | Bedside-measurement of serum cholinesterase activity predicts patient morbidity and length of the intensive care unit stay following major traumatic injury |
| title_sort | bedside measurement of serum cholinesterase activity predicts patient morbidity and length of the intensive care unit stay following major traumatic injury |
| url | https://doi.org/10.1038/s41598-019-46995-y, https://www.nature.com/articles/s41598-019-46995-y |