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Interventional left atrial appendage closure affects the metabolism of acylcarnitines
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| Veröffentlicht in: | International journal of molecular sciences 19(2018,2) Artikel-Nummer 500, 12 Seiten |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , |
| Titel: | Interventional left atrial appendage closure affects the metabolism of acylcarnitines/ Christian Fastner, Michael Behnes, Benjamin Sartorius, Annika Wenke, Siegfried Lang, Gökhan Yücel, Katherine Sattler, Jonas Rusnak, Ahmad Saleh, Christian Barth, Kambis Mashayekhi, Ursula Hoffmann, Martin Borggrefe and Ibrahim Akin |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
7 February 2018
|
| Gesamtaufnahme: |
: International journal of molecular sciences, 19(2018,2) Artikel-Nummer 500, 12 Seiten
, volume:19 |
| Schlagwörter: | |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 0 | |a Interventional left atrial appendage closure affects the metabolism of acylcarnitines |c Christian Fastner, Michael Behnes, Benjamin Sartorius, Annika Wenke, Siegfried Lang, Gökhan Yücel, Katherine Sattler, Jonas Rusnak, Ahmad Saleh, Christian Barth, Kambis Mashayekhi, Ursula Hoffmann, Martin Borggrefe and Ibrahim Akin |
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| 520 | |a Background: Left atrial appendage closure (LAAC) represents the interventional alternative to oral anticoagulation for stroke prevention in atrial fibrillation (AF). The metabolism of acylcarnitines was shown to affect cardiovascular diseases. This study evaluates the influence of successful LAAC on the metabolism of acylcarnitines. Methods: Patients undergoing successful LAAC were enrolled prospectively. Peripheral blood samples for metabolomics measurements were collected immediately before (i.e., index) and six months after LAAC (i.e., mid-term). A targeted metabolomics analysis based on electrospray ionization-liquid chromatography-mass spectrometry (ESI-LC-MS/MS) and MS/MS measurements was performed. Results: 44 patients with non-valvular AF (median CHA2DS2-VASc score 4, median HAS-BLED score 4) and successful LAAC were included. Significant changes in acylcarnitine levels were found in the total cohort, which were mainly attributed to patients with impaired left ventricular and renal function, elevated amino-terminal pro-brain natriuretic peptide (NT-proBNP) and diabetes mellitus. Adjusted multivariable regression models revealed significant changes of five metabolites over mid-term follow-up: C2, C14:1, C16, and C18:1 decreased significantly (each p < 0.05); short-chain C5 acylcarnitine plasma levels increased significantly (p < 0.05). Conclusion: This study demonstrates that successful LAAC affects the metabolism of acylcarnitines at mid-term follow-up. | ||
| 650 | 4 | |a acylcarnitines | |
| 650 | 4 | |a atrial fibrillation | |
| 650 | 4 | |a left atrial appendage | |
| 650 | 4 | |a left atrial appendage closure | |
| 650 | 4 | |a metabolomics | |
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| 900 | |a Saleh, A. | ||
| 900 | |a Rusnak, Jonas Christopher | ||
| 900 | |a Rusnak, J. | ||
| 900 | |a Borggrefe, M. | ||
| 900 | |a Wenke, Annika Karina | ||
| 900 | |a Wenke, A. | ||
| 900 | |a Sartorius, B. | ||
| 900 | |a Lang, S. | ||
| 900 | |a Fastner, C. | ||
| 900 | |a Sattler, Katherine Johanna Elise | ||
| 900 | |a Sattler, K. | ||
| 900 | |a Hoffmann, U. | ||
| 900 | |a Barth, C. | ||
| 900 | |a Barth, Christian Willi | ||
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| author | Fastner, Christian, Behnes, Michael, Sartorius, Benjamin, Wenke, Annika, Lang, Siegfried, Yücel, Gökhan, Sattler, Katherine, Rusnak, Jonas, Saleh, Ahmad, Barth, Christian, Hoffmann, Ursula, Borggrefe, Martin, Akın, Ibrahim |
| author_facet | Fastner, Christian, Behnes, Michael, Sartorius, Benjamin, Wenke, Annika, Lang, Siegfried, Yücel, Gökhan, Sattler, Katherine, Rusnak, Jonas, Saleh, Ahmad, Barth, Christian, Hoffmann, Ursula, Borggrefe, Martin, Akın, Ibrahim |
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| contents | Background: Left atrial appendage closure (LAAC) represents the interventional alternative to oral anticoagulation for stroke prevention in atrial fibrillation (AF). The metabolism of acylcarnitines was shown to affect cardiovascular diseases. This study evaluates the influence of successful LAAC on the metabolism of acylcarnitines. Methods: Patients undergoing successful LAAC were enrolled prospectively. Peripheral blood samples for metabolomics measurements were collected immediately before (i.e., index) and six months after LAAC (i.e., mid-term). A targeted metabolomics analysis based on electrospray ionization-liquid chromatography-mass spectrometry (ESI-LC-MS/MS) and MS/MS measurements was performed. Results: 44 patients with non-valvular AF (median CHA2DS2-VASc score 4, median HAS-BLED score 4) and successful LAAC were included. Significant changes in acylcarnitine levels were found in the total cohort, which were mainly attributed to patients with impaired left ventricular and renal function, elevated amino-terminal pro-brain natriuretic peptide (NT-proBNP) and diabetes mellitus. Adjusted multivariable regression models revealed significant changes of five metabolites over mid-term follow-up: C2, C14:1, C16, and C18:1 decreased significantly (each p < 0.05); short-chain C5 acylcarnitine plasma levels increased significantly (p < 0.05). Conclusion: This study demonstrates that successful LAAC affects the metabolism of acylcarnitines at mid-term follow-up. |
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| spelling | Fastner, Christian 1985- VerfasserIn (DE-588)1075156661 (DE-627)832943770 (DE-576)443267634 aut, Interventional left atrial appendage closure affects the metabolism of acylcarnitines Christian Fastner, Michael Behnes, Benjamin Sartorius, Annika Wenke, Siegfried Lang, Gökhan Yücel, Katherine Sattler, Jonas Rusnak, Ahmad Saleh, Christian Barth, Kambis Mashayekhi, Ursula Hoffmann, Martin Borggrefe and Ibrahim Akin, 7 February 2018, 12, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 07.10.2019, Background: Left atrial appendage closure (LAAC) represents the interventional alternative to oral anticoagulation for stroke prevention in atrial fibrillation (AF). The metabolism of acylcarnitines was shown to affect cardiovascular diseases. This study evaluates the influence of successful LAAC on the metabolism of acylcarnitines. Methods: Patients undergoing successful LAAC were enrolled prospectively. Peripheral blood samples for metabolomics measurements were collected immediately before (i.e., index) and six months after LAAC (i.e., mid-term). A targeted metabolomics analysis based on electrospray ionization-liquid chromatography-mass spectrometry (ESI-LC-MS/MS) and MS/MS measurements was performed. Results: 44 patients with non-valvular AF (median CHA2DS2-VASc score 4, median HAS-BLED score 4) and successful LAAC were included. Significant changes in acylcarnitine levels were found in the total cohort, which were mainly attributed to patients with impaired left ventricular and renal function, elevated amino-terminal pro-brain natriuretic peptide (NT-proBNP) and diabetes mellitus. Adjusted multivariable regression models revealed significant changes of five metabolites over mid-term follow-up: C2, C14:1, C16, and C18:1 decreased significantly (each p < 0.05); short-chain C5 acylcarnitine plasma levels increased significantly (p < 0.05). Conclusion: This study demonstrates that successful LAAC affects the metabolism of acylcarnitines at mid-term follow-up., acylcarnitines, atrial fibrillation, left atrial appendage, left atrial appendage closure, metabolomics, Behnes, Michael 1982- VerfasserIn (DE-588)138373361 (DE-627)696560518 (DE-576)307333949 aut, Sartorius, Benjamin 1991- VerfasserIn (DE-588)1100544607 (DE-627)859458571 (DE-576)469750618 aut, Wenke, Annika 1994- VerfasserIn (DE-588)1161950621 (DE-627)1025460499 (DE-576)507029380 aut, Lang, Siegfried 1955- VerfasserIn (DE-588)1026112613 (DE-627)726109290 (DE-576)371365473 aut, Yücel, Gökhan 1985- VerfasserIn (DE-588)1123528063 (DE-627)876733259 (DE-576)481781145 aut, Sattler, Katherine 1976- VerfasserIn (DE-588)129625884 (DE-627)475212509 (DE-576)297755153 aut, Rusnak, Jonas 1987- VerfasserIn (DE-588)1115487876 (DE-627)869815806 (DE-576)477795110 aut, Saleh, Ahmad 1986- VerfasserIn (DE-588)119638469X (DE-627)1678165638 aut, Barth, Christian 1983- VerfasserIn (DE-588)1162299304 (DE-627)1025820134 (DE-576)507321642 aut, Hoffmann, Ursula 1962- VerfasserIn (DE-588)115587098 (DE-627)691432406 (DE-576)289964113 aut, Borggrefe, Martin VerfasserIn (DE-588)1025920546 (DE-627)725574232 (DE-576)370913426 aut, Akın, Ibrahim 1978- VerfasserIn (DE-588)132322293 (DE-627)521039010 (DE-576)299074366 aut, Enthalten in International journal of molecular sciences Basel : Molecular Diversity Preservation International, 2000 19(2018,2) Artikel-Nummer 500, 12 Seiten Online-Ressource (DE-627)316340715 (DE-600)2019364-6 (DE-576)281194653 1422-0067 nnns, volume:19 year:2018 number:2 extent:12, https://doi.org/10.3390/ijms19020500 Verlag Resolving-System kostenfrei Volltext, https://www.mdpi.com/1422-0067/19/2/500 Verlag Resolving-System kostenfrei Volltext, https://doi.org/10.3390/ijms19020500 LFER, https://www.mdpi.com/1422-0067/19/2/500 LFER, LFER 2019-12-05T00:00:00Z |
| spellingShingle | Fastner, Christian, Behnes, Michael, Sartorius, Benjamin, Wenke, Annika, Lang, Siegfried, Yücel, Gökhan, Sattler, Katherine, Rusnak, Jonas, Saleh, Ahmad, Barth, Christian, Hoffmann, Ursula, Borggrefe, Martin, Akın, Ibrahim, Interventional left atrial appendage closure affects the metabolism of acylcarnitines, Background: Left atrial appendage closure (LAAC) represents the interventional alternative to oral anticoagulation for stroke prevention in atrial fibrillation (AF). The metabolism of acylcarnitines was shown to affect cardiovascular diseases. This study evaluates the influence of successful LAAC on the metabolism of acylcarnitines. Methods: Patients undergoing successful LAAC were enrolled prospectively. Peripheral blood samples for metabolomics measurements were collected immediately before (i.e., index) and six months after LAAC (i.e., mid-term). A targeted metabolomics analysis based on electrospray ionization-liquid chromatography-mass spectrometry (ESI-LC-MS/MS) and MS/MS measurements was performed. Results: 44 patients with non-valvular AF (median CHA2DS2-VASc score 4, median HAS-BLED score 4) and successful LAAC were included. Significant changes in acylcarnitine levels were found in the total cohort, which were mainly attributed to patients with impaired left ventricular and renal function, elevated amino-terminal pro-brain natriuretic peptide (NT-proBNP) and diabetes mellitus. Adjusted multivariable regression models revealed significant changes of five metabolites over mid-term follow-up: C2, C14:1, C16, and C18:1 decreased significantly (each p < 0.05); short-chain C5 acylcarnitine plasma levels increased significantly (p < 0.05). Conclusion: This study demonstrates that successful LAAC affects the metabolism of acylcarnitines at mid-term follow-up., acylcarnitines, atrial fibrillation, left atrial appendage, left atrial appendage closure, metabolomics |
| title | Interventional left atrial appendage closure affects the metabolism of acylcarnitines |
| title_auth | Interventional left atrial appendage closure affects the metabolism of acylcarnitines |
| title_full | Interventional left atrial appendage closure affects the metabolism of acylcarnitines Christian Fastner, Michael Behnes, Benjamin Sartorius, Annika Wenke, Siegfried Lang, Gökhan Yücel, Katherine Sattler, Jonas Rusnak, Ahmad Saleh, Christian Barth, Kambis Mashayekhi, Ursula Hoffmann, Martin Borggrefe and Ibrahim Akin |
| title_fullStr | Interventional left atrial appendage closure affects the metabolism of acylcarnitines Christian Fastner, Michael Behnes, Benjamin Sartorius, Annika Wenke, Siegfried Lang, Gökhan Yücel, Katherine Sattler, Jonas Rusnak, Ahmad Saleh, Christian Barth, Kambis Mashayekhi, Ursula Hoffmann, Martin Borggrefe and Ibrahim Akin |
| title_full_unstemmed | Interventional left atrial appendage closure affects the metabolism of acylcarnitines Christian Fastner, Michael Behnes, Benjamin Sartorius, Annika Wenke, Siegfried Lang, Gökhan Yücel, Katherine Sattler, Jonas Rusnak, Ahmad Saleh, Christian Barth, Kambis Mashayekhi, Ursula Hoffmann, Martin Borggrefe and Ibrahim Akin |
| title_in_hierarchy | Interventional left atrial appendage closure affects the metabolism of acylcarnitines / Christian Fastner, Michael Behnes, Benjamin Sartorius, Annika Wenke, Siegfried Lang, Gökhan Yücel, Katherine Sattler, Jonas Rusnak, Ahmad Saleh, Christian Barth, Kambis Mashayekhi, Ursula Hoffmann, Martin Borggrefe and Ibrahim Akin, |
| title_short | Interventional left atrial appendage closure affects the metabolism of acylcarnitines |
| title_sort | interventional left atrial appendage closure affects the metabolism of acylcarnitines |
| topic | acylcarnitines, atrial fibrillation, left atrial appendage, left atrial appendage closure, metabolomics |
| topic_facet | acylcarnitines, atrial fibrillation, left atrial appendage, left atrial appendage closure, metabolomics |
| url | https://doi.org/10.3390/ijms19020500, https://www.mdpi.com/1422-0067/19/2/500 |