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A plasmodium cross-stage antigen contributes to the development of experimental cerebral malaria
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Veröffentlicht in: | Frontiers in immunology 9(2018) Artikel-Nummer 1875, 20 Seiten |
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Titel: | A plasmodium cross-stage antigen contributes to the development of experimental cerebral malaria/ Priyanka Fernandes, Shanshan W. Howland, Kirsten Heiss, Angelika Hoffmann, Maria A. Hernández-Castañeda, Klára Obrová, Roland Frank, Philipp Wiedemann, Martin Bendzus, Laurent Rénia and Ann-Kristin Mueller |
Format: | E-Book-Kapitel |
Sprache: | Englisch |
veröffentlicht: |
14 August 2018
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Gesamtaufnahme: |
: Frontiers in immunology, 9(2018) Artikel-Nummer 1875, 20 Seiten
, volume:9 |
Schlagwörter: | |
Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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author | Fernandes, Priyanka, Howland, Shanshan W., Heiß, Kirsten, Hoffmann, Angelika, Hernández-Castañeda, Maria Andrea, Obrová, Klára, Frank, Roland, Wiedemann, Philipp, Bendszus, Martin, Rénia, Laurent, Müller, Ann-Kristin |
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contents | Cerebral malaria is a complex neurological syndrome caused by an infection with Plasmodium falciparum parasites and is exclusively attributed to a series of host-parasite interactions at the pathological blood-stage of infection. In contrast, the preceding intra-hepatic phase of replication is generally considered clinically silent and thereby excluded from playing any role in the development of neurological symptoms. In this study however, we present an antigen PbmaLS_05 that is presented to the host immune system by both pre-erythrocytic and intra-erythrocytic stages and contributes to the development of cerebral malaria in mice. Although deletion of the endogenous PbmaLS_05 prevented the development of Experimental Cerebral Malaria (ECM) in susceptible mice after both sporozoite and infected red blood cell (iRBC) infections, we observed significant differences in contribution of the host immune response between both modes of inoculation. Moreover, PbmaLS_05-specific CD8+ T cells contributed to the development of ECM after sporozoite but not iRBC-infection, suggesting that pre-erythrocytic antigens like PbmaLS_05 can also contribute to the development of cerebral symptoms. Our data thus highlights the importance of the natural route of infection in the study of ECM, with potential implications for vaccine and therapeutic strategies against malaria. |
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spelling | Fernandes, Priyanka VerfasserIn (DE-588)1075511917 (DE-627)833375652 (DE-576)443612765 aut, A plasmodium cross-stage antigen contributes to the development of experimental cerebral malaria Priyanka Fernandes, Shanshan W. Howland, Kirsten Heiss, Angelika Hoffmann, Maria A. Hernández-Castañeda, Klára Obrová, Roland Frank, Philipp Wiedemann, Martin Bendzus, Laurent Rénia and Ann-Kristin Mueller, 14 August 2018, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 26.09.2018, Cerebral malaria is a complex neurological syndrome caused by an infection with Plasmodium falciparum parasites and is exclusively attributed to a series of host-parasite interactions at the pathological blood-stage of infection. In contrast, the preceding intra-hepatic phase of replication is generally considered clinically silent and thereby excluded from playing any role in the development of neurological symptoms. In this study however, we present an antigen PbmaLS_05 that is presented to the host immune system by both pre-erythrocytic and intra-erythrocytic stages and contributes to the development of cerebral malaria in mice. Although deletion of the endogenous PbmaLS_05 prevented the development of Experimental Cerebral Malaria (ECM) in susceptible mice after both sporozoite and infected red blood cell (iRBC) infections, we observed significant differences in contribution of the host immune response between both modes of inoculation. Moreover, PbmaLS_05-specific CD8+ T cells contributed to the development of ECM after sporozoite but not iRBC-infection, suggesting that pre-erythrocytic antigens like PbmaLS_05 can also contribute to the development of cerebral symptoms. Our data thus highlights the importance of the natural route of infection in the study of ECM, with potential implications for vaccine and therapeutic strategies against malaria., CD8 T cells, cross-presentation, experimental cerebral malaria, Malaria, Plasmodium berghei, Pre-erythrocytic stages, Howland, Shanshan W. VerfasserIn aut, Heiß, Kirsten VerfasserIn (DE-588)131455044 (DE-627)509454275 (DE-576)298488698 aut, Hoffmann, Angelika VerfasserIn (DE-588)1036902080 (DE-627)751406759 (DE-576)38950372X aut, Hernández-Castañeda, Maria Andrea 1885- VerfasserIn (DE-588)1230438629 (DE-627)1752772091 aut, Obrová, Klára VerfasserIn (DE-588)1175244481 (DE-627)1046182021 (DE-576)516140604 aut, Frank, Roland VerfasserIn (DE-588)104981598X (DE-627)782732283 (DE-576)403822181 aut, Wiedemann, Philipp 1968- VerfasserIn (DE-588)122752821 (DE-627)706028805 (DE-576)293407134 aut, Bendszus, Martin VerfasserIn (DE-588)1032676426 (DE-627)738634131 (DE-576)175567697 aut, Rénia, Laurent VerfasserIn aut, Müller, Ann-Kristin VerfasserIn (DE-588)1068939419 (DE-627)821077988 (DE-576)428315046 aut, Enthalten in Frontiers in immunology Lausanne : Frontiers Media, 2010 9(2018) Artikel-Nummer 1875, 20 Seiten Online-Ressource (DE-627)657998354 (DE-600)2606827-8 (DE-576)343624834 1664-3224 nnns, volume:9 year:2018, http://dx.doi.org/10.3389/fimmu.2018.01875 Verlag Resolving-System kostenfrei Volltext, https://www.frontiersin.org/articles/10.3389/fimmu.2018.01875/full Verlag kostenfrei Volltext, http://dx.doi.org/10.3389/fimmu.2018.01875 LFER, LFER 2018-10-10T00:00:00Z |
spellingShingle | Fernandes, Priyanka, Howland, Shanshan W., Heiß, Kirsten, Hoffmann, Angelika, Hernández-Castañeda, Maria Andrea, Obrová, Klára, Frank, Roland, Wiedemann, Philipp, Bendszus, Martin, Rénia, Laurent, Müller, Ann-Kristin, A plasmodium cross-stage antigen contributes to the development of experimental cerebral malaria, Cerebral malaria is a complex neurological syndrome caused by an infection with Plasmodium falciparum parasites and is exclusively attributed to a series of host-parasite interactions at the pathological blood-stage of infection. In contrast, the preceding intra-hepatic phase of replication is generally considered clinically silent and thereby excluded from playing any role in the development of neurological symptoms. In this study however, we present an antigen PbmaLS_05 that is presented to the host immune system by both pre-erythrocytic and intra-erythrocytic stages and contributes to the development of cerebral malaria in mice. Although deletion of the endogenous PbmaLS_05 prevented the development of Experimental Cerebral Malaria (ECM) in susceptible mice after both sporozoite and infected red blood cell (iRBC) infections, we observed significant differences in contribution of the host immune response between both modes of inoculation. Moreover, PbmaLS_05-specific CD8+ T cells contributed to the development of ECM after sporozoite but not iRBC-infection, suggesting that pre-erythrocytic antigens like PbmaLS_05 can also contribute to the development of cerebral symptoms. Our data thus highlights the importance of the natural route of infection in the study of ECM, with potential implications for vaccine and therapeutic strategies against malaria., CD8 T cells, cross-presentation, experimental cerebral malaria, Malaria, Plasmodium berghei, Pre-erythrocytic stages |
swb_id_str | 511337353 |
title | A plasmodium cross-stage antigen contributes to the development of experimental cerebral malaria |
title_auth | A plasmodium cross-stage antigen contributes to the development of experimental cerebral malaria |
title_full | A plasmodium cross-stage antigen contributes to the development of experimental cerebral malaria Priyanka Fernandes, Shanshan W. Howland, Kirsten Heiss, Angelika Hoffmann, Maria A. Hernández-Castañeda, Klára Obrová, Roland Frank, Philipp Wiedemann, Martin Bendzus, Laurent Rénia and Ann-Kristin Mueller |
title_fullStr | A plasmodium cross-stage antigen contributes to the development of experimental cerebral malaria Priyanka Fernandes, Shanshan W. Howland, Kirsten Heiss, Angelika Hoffmann, Maria A. Hernández-Castañeda, Klára Obrová, Roland Frank, Philipp Wiedemann, Martin Bendzus, Laurent Rénia and Ann-Kristin Mueller |
title_full_unstemmed | A plasmodium cross-stage antigen contributes to the development of experimental cerebral malaria Priyanka Fernandes, Shanshan W. Howland, Kirsten Heiss, Angelika Hoffmann, Maria A. Hernández-Castañeda, Klára Obrová, Roland Frank, Philipp Wiedemann, Martin Bendzus, Laurent Rénia and Ann-Kristin Mueller |
title_in_hierarchy | A plasmodium cross-stage antigen contributes to the development of experimental cerebral malaria / Priyanka Fernandes, Shanshan W. Howland, Kirsten Heiss, Angelika Hoffmann, Maria A. Hernández-Castañeda, Klára Obrová, Roland Frank, Philipp Wiedemann, Martin Bendzus, Laurent Rénia and Ann-Kristin Mueller, |
title_short | A plasmodium cross-stage antigen contributes to the development of experimental cerebral malaria |
title_sort | plasmodium cross stage antigen contributes to the development of experimental cerebral malaria |
topic | CD8 T cells, cross-presentation, experimental cerebral malaria, Malaria, Plasmodium berghei, Pre-erythrocytic stages |
topic_facet | CD8 T cells, cross-presentation, experimental cerebral malaria, Malaria, Plasmodium berghei, Pre-erythrocytic stages |
url | http://dx.doi.org/10.3389/fimmu.2018.01875, https://www.frontiersin.org/articles/10.3389/fimmu.2018.01875/full |