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The binding sites of miR-619-5p in the mRNAs of human and orthologous genes
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| Veröffentlicht in: | BMC genomics 18(2017) Artikel-Nummer 428, 10 Seiten |
|---|---|
| Personen und Körperschaften: | , |
| Titel: | The binding sites of miR-619-5p in the mRNAs of human and orthologous genes/ Shara Atambayeva, Raigul Niyazova, Anatoliy Ivashchenko, Anna Pyrkova, Ilya Pinsky, Aigul Akimniyazova and Siegfried Labeit |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
1 June 2017
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| Gesamtaufnahme: |
: BMC genomics, 18(2017) Artikel-Nummer 428, 10 Seiten
, volume:18 |
| Schlagwörter: | |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 4 | |a The binding sites of miR-619-5p in the mRNAs of human and orthologous genes |c Shara Atambayeva, Raigul Niyazova, Anatoliy Ivashchenko, Anna Pyrkova, Ilya Pinsky, Aigul Akimniyazova and Siegfried Labeit |
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| 520 | |a BACKGROUND: Normally, one miRNA interacts with the mRNA of one gene. However, there are miRNAs that can bind to many mRNAs, and one mRNA can be the target of many miRNAs. This significantly complicates the study of the properties of miRNAs and their diagnostic and medical applications. RESULTS: The search of 2,750 human microRNAs (miRNAs) binding sites in 12,175 mRNAs of human genes using the MirTarget program has been completed. For the binding sites of the miR-619-5p the hybridization free energy of the bonds was equal to 100% of the maximum potential free energy. The mRNAs of 201 human genes have complete complementary binding sites of miR-619-5p in the 3'UTR (214 sites), CDS (3 sites), and 5'UTR (4 sites). The mRNAs of CATAD1, ICA1L, GK5, POLH, and PRR11 genes have six miR-619-5p binding sites, and the mRNAs of OPA3 and CYP20A1 genes have eight and ten binding sites, respectively. All of these miR-619-5p binding sites are located in the 3'UTRs. The miR-619-5p binding site in the 5'UTR of mRNA of human USP29 gene is found in the mRNAs of orthologous genes of primates. Binding sites of miR-619-5p in the coding regions of mRNAs of C8H8orf44, C8orf44, and ISY1 genes encode the WLMPVIP oligopeptide, which is present in the orthologous proteins. Binding sites of miR-619-5p in the mRNAs of transcription factor genes ZNF429 and ZNF429 encode the AHACNP oligopeptide in another reading frame. Binding sites of miR-619-5p in the 3'UTRs of all human target genes are also present in the 3'UTRs of orthologous genes of mammals. The completely complementary binding sites for miR-619-5p are conservative in the orthologous mammalian genes. CONCLUSIONS: The majority of miR-619-5p binding sites are located in the 3'UTRs but some genes have miRNA binding sites in the 5'UTRs of mRNAs. Several genes have binding sites for miRNAs in the CDSs that are read in different open reading frames. Identical nucleotide sequences of binding sites encode different amino acids in different proteins. The binding sites of miR-619-5p in 3'UTRs, 5'UTRs and CDSs are conservative in the orthologous mammalian genes. | ||
| 650 | 4 | |a 3' Untranslated Regions | |
| 650 | 4 | |a 5' Untranslated Regions | |
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Binding Sites | |
| 650 | 4 | |a Gene | |
| 650 | 4 | |a Human | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a MicroRNAs | |
| 650 | 4 | |a miR-619-5p | |
| 650 | 4 | |a miRNA | |
| 650 | 4 | |a mRNA | |
| 650 | 4 | |a Orthologous genes | |
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| 650 | 4 | |a Sequence Homology, Nucleic Acid | |
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| contents | BACKGROUND: Normally, one miRNA interacts with the mRNA of one gene. However, there are miRNAs that can bind to many mRNAs, and one mRNA can be the target of many miRNAs. This significantly complicates the study of the properties of miRNAs and their diagnostic and medical applications. RESULTS: The search of 2,750 human microRNAs (miRNAs) binding sites in 12,175 mRNAs of human genes using the MirTarget program has been completed. For the binding sites of the miR-619-5p the hybridization free energy of the bonds was equal to 100% of the maximum potential free energy. The mRNAs of 201 human genes have complete complementary binding sites of miR-619-5p in the 3'UTR (214 sites), CDS (3 sites), and 5'UTR (4 sites). The mRNAs of CATAD1, ICA1L, GK5, POLH, and PRR11 genes have six miR-619-5p binding sites, and the mRNAs of OPA3 and CYP20A1 genes have eight and ten binding sites, respectively. All of these miR-619-5p binding sites are located in the 3'UTRs. The miR-619-5p binding site in the 5'UTR of mRNA of human USP29 gene is found in the mRNAs of orthologous genes of primates. Binding sites of miR-619-5p in the coding regions of mRNAs of C8H8orf44, C8orf44, and ISY1 genes encode the WLMPVIP oligopeptide, which is present in the orthologous proteins. Binding sites of miR-619-5p in the mRNAs of transcription factor genes ZNF429 and ZNF429 encode the AHACNP oligopeptide in another reading frame. Binding sites of miR-619-5p in the 3'UTRs of all human target genes are also present in the 3'UTRs of orthologous genes of mammals. The completely complementary binding sites for miR-619-5p are conservative in the orthologous mammalian genes. CONCLUSIONS: The majority of miR-619-5p binding sites are located in the 3'UTRs but some genes have miRNA binding sites in the 5'UTRs of mRNAs. Several genes have binding sites for miRNAs in the CDSs that are read in different open reading frames. Identical nucleotide sequences of binding sites encode different amino acids in different proteins. The binding sites of miR-619-5p in 3'UTRs, 5'UTRs and CDSs are conservative in the orthologous mammalian genes. |
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| spelling | Atambayeva, Shara VerfasserIn (DE-588)116499509X (DE-627)1029204640 (DE-576)510187803 aut, The binding sites of miR-619-5p in the mRNAs of human and orthologous genes Shara Atambayeva, Raigul Niyazova, Anatoliy Ivashchenko, Anna Pyrkova, Ilya Pinsky, Aigul Akimniyazova and Siegfried Labeit, 1 June 2017, 10, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 20.08.2018, BACKGROUND: Normally, one miRNA interacts with the mRNA of one gene. However, there are miRNAs that can bind to many mRNAs, and one mRNA can be the target of many miRNAs. This significantly complicates the study of the properties of miRNAs and their diagnostic and medical applications. RESULTS: The search of 2,750 human microRNAs (miRNAs) binding sites in 12,175 mRNAs of human genes using the MirTarget program has been completed. For the binding sites of the miR-619-5p the hybridization free energy of the bonds was equal to 100% of the maximum potential free energy. The mRNAs of 201 human genes have complete complementary binding sites of miR-619-5p in the 3'UTR (214 sites), CDS (3 sites), and 5'UTR (4 sites). The mRNAs of CATAD1, ICA1L, GK5, POLH, and PRR11 genes have six miR-619-5p binding sites, and the mRNAs of OPA3 and CYP20A1 genes have eight and ten binding sites, respectively. All of these miR-619-5p binding sites are located in the 3'UTRs. The miR-619-5p binding site in the 5'UTR of mRNA of human USP29 gene is found in the mRNAs of orthologous genes of primates. Binding sites of miR-619-5p in the coding regions of mRNAs of C8H8orf44, C8orf44, and ISY1 genes encode the WLMPVIP oligopeptide, which is present in the orthologous proteins. Binding sites of miR-619-5p in the mRNAs of transcription factor genes ZNF429 and ZNF429 encode the AHACNP oligopeptide in another reading frame. Binding sites of miR-619-5p in the 3'UTRs of all human target genes are also present in the 3'UTRs of orthologous genes of mammals. The completely complementary binding sites for miR-619-5p are conservative in the orthologous mammalian genes. CONCLUSIONS: The majority of miR-619-5p binding sites are located in the 3'UTRs but some genes have miRNA binding sites in the 5'UTRs of mRNAs. Several genes have binding sites for miRNAs in the CDSs that are read in different open reading frames. Identical nucleotide sequences of binding sites encode different amino acids in different proteins. The binding sites of miR-619-5p in 3'UTRs, 5'UTRs and CDSs are conservative in the orthologous mammalian genes., 3' Untranslated Regions, 5' Untranslated Regions, Animals, Binding Sites, Gene, Human, Humans, MicroRNAs, miR-619-5p, miRNA, mRNA, Orthologous genes, RNA, Messenger, Sequence Homology, Nucleic Acid, Labeit, Siegfried 1960- VerfasserIn (DE-588)1033566837 (DE-627)741562375 (DE-576)381187314 aut, Enthalten in BMC genomics London : BioMed Central, 2000 18(2017) Artikel-Nummer 428, 10 Seiten Online-Ressource (DE-627)326644954 (DE-600)2041499-7 (DE-576)107014750 1471-2164 nnns, volume:18 year:2017 extent:10, http://dx.doi.org/10.1186/s12864-017-3811-6 Verlag Resolving-System kostenfrei Volltext, http://dx.doi.org/10.1186/s12864-017-3811-6 LFER, LFER 2018-09-13T00:00:00Z |
| spellingShingle | Atambayeva, Shara, Labeit, Siegfried, The binding sites of miR-619-5p in the mRNAs of human and orthologous genes, BACKGROUND: Normally, one miRNA interacts with the mRNA of one gene. However, there are miRNAs that can bind to many mRNAs, and one mRNA can be the target of many miRNAs. This significantly complicates the study of the properties of miRNAs and their diagnostic and medical applications. RESULTS: The search of 2,750 human microRNAs (miRNAs) binding sites in 12,175 mRNAs of human genes using the MirTarget program has been completed. For the binding sites of the miR-619-5p the hybridization free energy of the bonds was equal to 100% of the maximum potential free energy. The mRNAs of 201 human genes have complete complementary binding sites of miR-619-5p in the 3'UTR (214 sites), CDS (3 sites), and 5'UTR (4 sites). The mRNAs of CATAD1, ICA1L, GK5, POLH, and PRR11 genes have six miR-619-5p binding sites, and the mRNAs of OPA3 and CYP20A1 genes have eight and ten binding sites, respectively. All of these miR-619-5p binding sites are located in the 3'UTRs. The miR-619-5p binding site in the 5'UTR of mRNA of human USP29 gene is found in the mRNAs of orthologous genes of primates. Binding sites of miR-619-5p in the coding regions of mRNAs of C8H8orf44, C8orf44, and ISY1 genes encode the WLMPVIP oligopeptide, which is present in the orthologous proteins. Binding sites of miR-619-5p in the mRNAs of transcription factor genes ZNF429 and ZNF429 encode the AHACNP oligopeptide in another reading frame. Binding sites of miR-619-5p in the 3'UTRs of all human target genes are also present in the 3'UTRs of orthologous genes of mammals. The completely complementary binding sites for miR-619-5p are conservative in the orthologous mammalian genes. CONCLUSIONS: The majority of miR-619-5p binding sites are located in the 3'UTRs but some genes have miRNA binding sites in the 5'UTRs of mRNAs. Several genes have binding sites for miRNAs in the CDSs that are read in different open reading frames. Identical nucleotide sequences of binding sites encode different amino acids in different proteins. The binding sites of miR-619-5p in 3'UTRs, 5'UTRs and CDSs are conservative in the orthologous mammalian genes., 3' Untranslated Regions, 5' Untranslated Regions, Animals, Binding Sites, Gene, Human, Humans, MicroRNAs, miR-619-5p, miRNA, mRNA, Orthologous genes, RNA, Messenger, Sequence Homology, Nucleic Acid |
| swb_id_str | 510186149 |
| title | The binding sites of miR-619-5p in the mRNAs of human and orthologous genes |
| title_auth | The binding sites of miR-619-5p in the mRNAs of human and orthologous genes |
| title_full | The binding sites of miR-619-5p in the mRNAs of human and orthologous genes Shara Atambayeva, Raigul Niyazova, Anatoliy Ivashchenko, Anna Pyrkova, Ilya Pinsky, Aigul Akimniyazova and Siegfried Labeit |
| title_fullStr | The binding sites of miR-619-5p in the mRNAs of human and orthologous genes Shara Atambayeva, Raigul Niyazova, Anatoliy Ivashchenko, Anna Pyrkova, Ilya Pinsky, Aigul Akimniyazova and Siegfried Labeit |
| title_full_unstemmed | The binding sites of miR-619-5p in the mRNAs of human and orthologous genes Shara Atambayeva, Raigul Niyazova, Anatoliy Ivashchenko, Anna Pyrkova, Ilya Pinsky, Aigul Akimniyazova and Siegfried Labeit |
| title_in_hierarchy | The binding sites of miR-619-5p in the mRNAs of human and orthologous genes / Shara Atambayeva, Raigul Niyazova, Anatoliy Ivashchenko, Anna Pyrkova, Ilya Pinsky, Aigul Akimniyazova and Siegfried Labeit, |
| title_short | The binding sites of miR-619-5p in the mRNAs of human and orthologous genes |
| title_sort | binding sites of mir 619 5p in the mrnas of human and orthologous genes |
| topic | 3' Untranslated Regions, 5' Untranslated Regions, Animals, Binding Sites, Gene, Human, Humans, MicroRNAs, miR-619-5p, miRNA, mRNA, Orthologous genes, RNA, Messenger, Sequence Homology, Nucleic Acid |
| topic_facet | 3' Untranslated Regions, 5' Untranslated Regions, Animals, Binding Sites, Gene, Human, Humans, MicroRNAs, miR-619-5p, miRNA, mRNA, Orthologous genes, RNA, Messenger, Sequence Homology, Nucleic Acid |
| url | http://dx.doi.org/10.1186/s12864-017-3811-6 |