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A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity
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| Veröffentlicht in: | The journal of biological chemistry 287(2012), 4, Seite 2926-2934 |
|---|---|
| Personen und Körperschaften: | , |
| Titel: | A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity/ Mototada Shichiri, Nozomu Kono, Yuta Shimanaka, Masaki Tanito, Daisy E. Rotzoll, Yasukazu Yoshida, Yoshihisa Hagihara, Hiroshi Tamai, and Hiroyuki Arai |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
2012
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| Gesamtaufnahme: |
: The journal of biological chemistry, 287(2012), 4, Seite 2926-2934
, volume:287 |
| Schlagwörter: | |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 2 | |a A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity |c Mototada Shichiri, Nozomu Kono, Yuta Shimanaka, Masaki Tanito, Daisy E. Rotzoll, Yasukazu Yoshida, Yoshihisa Hagihara, Hiroshi Tamai, and Hiroyuki Arai |
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| 520 | |a Chloroquine (CQ) is a widely prescribed anti-malarial agent and is also prescribed to treat autoimmune diseases. Clinical treatment with CQ is often accompanied by serious side effects such as hepatitis and retinopathy. As a weak base, CQ accumulates in intracellular acidic organelles, raises the pH, and induces osmotic swelling and permeabilization of acidic organelles, which account for CQ-induced cytotoxicity. We reported previously that CQ treatment caused α-tocopherol transfer protein (α-TTP), a gene product of familial vitamin E deficiency, to change its location from the cytosol to the surface of acidic organelles. Here we show that α-TTP plays a novel role in protecting against CQ toxicity both in vitro and in vivo. In the presence of CQ, rat hepatoma McARH7777 cells, which do not express α-TTP endogenously, showed more severe cytotoxicity, such as larger vacuolation of acidic organelles and caspase activation, than α-TTP transfectant cells. Similarly, α-TTP knockout mice showed more severe CQ toxicity, such as hepatotoxicity and retinopathy, than wild-type mice. These effects were not ameliorated by vitamin E supplementation. In contrast to bafilomycin A1 treatment, which prevents CQ accumulation in cells by raising the pH of acidic organelles, α-TTP expression prevented CQ accumulation without affecting the pH of acidic organelles. Taken together, our data suggest that α-TTP protects against CQ toxicity by preventing CQ accumulation in acidic organelles through a mechanism distinct from vitamin E transport. | ||
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| 650 | 4 | |a Chloroquine | |
| 650 | 4 | |a Lipid Binding Protein | |
| 650 | 4 | |a Lysosomal Acidification | |
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| 650 | 4 | |a Vacuolar Acidification | |
| 650 | 4 | |a Vacuolar ATPase | |
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| 650 | 4 | |a α-Tocopherol Transfer Protein | |
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| contents | Chloroquine (CQ) is a widely prescribed anti-malarial agent and is also prescribed to treat autoimmune diseases. Clinical treatment with CQ is often accompanied by serious side effects such as hepatitis and retinopathy. As a weak base, CQ accumulates in intracellular acidic organelles, raises the pH, and induces osmotic swelling and permeabilization of acidic organelles, which account for CQ-induced cytotoxicity. We reported previously that CQ treatment caused α-tocopherol transfer protein (α-TTP), a gene product of familial vitamin E deficiency, to change its location from the cytosol to the surface of acidic organelles. Here we show that α-TTP plays a novel role in protecting against CQ toxicity both in vitro and in vivo. In the presence of CQ, rat hepatoma McARH7777 cells, which do not express α-TTP endogenously, showed more severe cytotoxicity, such as larger vacuolation of acidic organelles and caspase activation, than α-TTP transfectant cells. Similarly, α-TTP knockout mice showed more severe CQ toxicity, such as hepatotoxicity and retinopathy, than wild-type mice. These effects were not ameliorated by vitamin E supplementation. In contrast to bafilomycin A1 treatment, which prevents CQ accumulation in cells by raising the pH of acidic organelles, α-TTP expression prevented CQ accumulation without affecting the pH of acidic organelles. Taken together, our data suggest that α-TTP protects against CQ toxicity by preventing CQ accumulation in acidic organelles through a mechanism distinct from vitamin E transport. |
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| spelling | Shichiri, Mototada VerfasserIn (DE-588)1163847534 (DE-627)1028184298 (DE-576)508249368 aut, A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity Mototada Shichiri, Nozomu Kono, Yuta Shimanaka, Masaki Tanito, Daisy E. Rotzoll, Yasukazu Yoshida, Yoshihisa Hagihara, Hiroshi Tamai, and Hiroyuki Arai, alpha, 2012, 9, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Published, JBC Papers in Press, December 6, 2011, Gesehen am 03.08.2018, Chloroquine (CQ) is a widely prescribed anti-malarial agent and is also prescribed to treat autoimmune diseases. Clinical treatment with CQ is often accompanied by serious side effects such as hepatitis and retinopathy. As a weak base, CQ accumulates in intracellular acidic organelles, raises the pH, and induces osmotic swelling and permeabilization of acidic organelles, which account for CQ-induced cytotoxicity. We reported previously that CQ treatment caused α-tocopherol transfer protein (α-TTP), a gene product of familial vitamin E deficiency, to change its location from the cytosol to the surface of acidic organelles. Here we show that α-TTP plays a novel role in protecting against CQ toxicity both in vitro and in vivo. In the presence of CQ, rat hepatoma McARH7777 cells, which do not express α-TTP endogenously, showed more severe cytotoxicity, such as larger vacuolation of acidic organelles and caspase activation, than α-TTP transfectant cells. Similarly, α-TTP knockout mice showed more severe CQ toxicity, such as hepatotoxicity and retinopathy, than wild-type mice. These effects were not ameliorated by vitamin E supplementation. In contrast to bafilomycin A1 treatment, which prevents CQ accumulation in cells by raising the pH of acidic organelles, α-TTP expression prevented CQ accumulation without affecting the pH of acidic organelles. Taken together, our data suggest that α-TTP protects against CQ toxicity by preventing CQ accumulation in acidic organelles through a mechanism distinct from vitamin E transport., 2011, Chloroquine, Lipid Binding Protein, Lysosomal Acidification, Lysosomes, Niemann-Pick Type C1, Vacuolar Acidification, Vacuolar ATPase, Vitamin E, α-Tocopherol Transfer Protein, Rotzoll, Daisy E. VerfasserIn (DE-588)107649837X (DE-627)834993511 (DE-576)171491408 aut, Enthalten in The journal of biological chemistry Bethesda, Md. : ASBMB Publications, 1905 287(2012), 4, Seite 2926-2934 Online-Ressource (DE-627)269247025 (DE-600)1474604-9 (DE-576)077883837 1083-351X nnns, volume:287 year:2012 number:4 pages:2926-2934 extent:9, http://dx.doi.org/10.1074/jbc.M111.321281 Verlag Resolving-System kostenfrei Volltext, http://www.jbc.org/content/287/4/2926 Verlag kostenfrei Volltext, http://dx.doi.org/10.1074/jbc.M111.321281 LFER, LFER 2018-08-13T00:00:00Z |
| spellingShingle | Shichiri, Mototada, Rotzoll, Daisy E., A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity, Chloroquine (CQ) is a widely prescribed anti-malarial agent and is also prescribed to treat autoimmune diseases. Clinical treatment with CQ is often accompanied by serious side effects such as hepatitis and retinopathy. As a weak base, CQ accumulates in intracellular acidic organelles, raises the pH, and induces osmotic swelling and permeabilization of acidic organelles, which account for CQ-induced cytotoxicity. We reported previously that CQ treatment caused α-tocopherol transfer protein (α-TTP), a gene product of familial vitamin E deficiency, to change its location from the cytosol to the surface of acidic organelles. Here we show that α-TTP plays a novel role in protecting against CQ toxicity both in vitro and in vivo. In the presence of CQ, rat hepatoma McARH7777 cells, which do not express α-TTP endogenously, showed more severe cytotoxicity, such as larger vacuolation of acidic organelles and caspase activation, than α-TTP transfectant cells. Similarly, α-TTP knockout mice showed more severe CQ toxicity, such as hepatotoxicity and retinopathy, than wild-type mice. These effects were not ameliorated by vitamin E supplementation. In contrast to bafilomycin A1 treatment, which prevents CQ accumulation in cells by raising the pH of acidic organelles, α-TTP expression prevented CQ accumulation without affecting the pH of acidic organelles. Taken together, our data suggest that α-TTP protects against CQ toxicity by preventing CQ accumulation in acidic organelles through a mechanism distinct from vitamin E transport., Chloroquine, Lipid Binding Protein, Lysosomal Acidification, Lysosomes, Niemann-Pick Type C1, Vacuolar Acidification, Vacuolar ATPase, Vitamin E, α-Tocopherol Transfer Protein |
| swb_id_str | 508249538 |
| title | A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity |
| title_alt | alpha |
| title_auth | A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity |
| title_full | A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity Mototada Shichiri, Nozomu Kono, Yuta Shimanaka, Masaki Tanito, Daisy E. Rotzoll, Yasukazu Yoshida, Yoshihisa Hagihara, Hiroshi Tamai, and Hiroyuki Arai |
| title_fullStr | A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity Mototada Shichiri, Nozomu Kono, Yuta Shimanaka, Masaki Tanito, Daisy E. Rotzoll, Yasukazu Yoshida, Yoshihisa Hagihara, Hiroshi Tamai, and Hiroyuki Arai |
| title_full_unstemmed | A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity Mototada Shichiri, Nozomu Kono, Yuta Shimanaka, Masaki Tanito, Daisy E. Rotzoll, Yasukazu Yoshida, Yoshihisa Hagihara, Hiroshi Tamai, and Hiroyuki Arai |
| title_in_hierarchy | A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity / Mototada Shichiri, Nozomu Kono, Yuta Shimanaka, Masaki Tanito, Daisy E. Rotzoll, Yasukazu Yoshida, Yoshihisa Hagihara, Hiroshi Tamai, and Hiroyuki Arai, |
| title_short | A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity |
| title_sort | novel role for α tocopherol transfer protein α ttp in protecting against chloroquine toxicity |
| topic | Chloroquine, Lipid Binding Protein, Lysosomal Acidification, Lysosomes, Niemann-Pick Type C1, Vacuolar Acidification, Vacuolar ATPase, Vitamin E, α-Tocopherol Transfer Protein |
| topic_facet | Chloroquine, Lipid Binding Protein, Lysosomal Acidification, Lysosomes, Niemann-Pick Type C1, Vacuolar Acidification, Vacuolar ATPase, Vitamin E, α-Tocopherol Transfer Protein |
| url | http://dx.doi.org/10.1074/jbc.M111.321281, http://www.jbc.org/content/287/4/2926 |