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The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization
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| Veröffentlicht in: | Scientific reports 7(2017) Artikel-Nummer 38172, 9 Seiten |
|---|---|
| Personen und Körperschaften: | , , , |
| Titel: | The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization/ Yao V. Zhang, Shabab B. Hannan, Jeannine V. Kern, Doychin T. Stanchev, Baran Koç, Thomas R. Jahn & Tobias M. Rasse |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
27 March 2017
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| Gesamtaufnahme: |
: Scientific reports, 7(2017) Artikel-Nummer 38172, 9 Seiten
, volume:7 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 4 | |a The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization |c Yao V. Zhang, Shabab B. Hannan, Jeannine V. Kern, Doychin T. Stanchev, Baran Koç, Thomas R. Jahn & Tobias M. Rasse |
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| 520 | |a The kinesin-3 family member KIF1A has been shown to be important for experience dependent neuroplasticity. In Drosophila, amorphic mutations in the KIF1A homolog unc-104 disrupt the formation of mature boutons. Disease associated KIF1A mutations have been associated with motor and sensory dysfunctions as well as non-syndromic intellectual disability in humans. A hypomorphic mutation in the forkhead-associated domain of Unc-104, unc-104bris, impairs active zone maturation resulting in an increased fraction of post-synaptic glutamate receptor fields that lack the active zone scaffolding protein Bruchpilot. Here, we show that the unc-104brismutation causes defects in synaptic transmission as manifested by reduced amplitude of both evoked and miniature excitatory junctional potentials. Structural defects observed in the postsynaptic compartment of mutant NMJs include reduced glutamate receptor field size, and altered glutamate receptor composition. In addition, we observed marked loss of postsynaptic scaffolding proteins and reduced complexity of the sub-synaptic reticulum, which could be rescued by pre- but not postsynaptic expression of unc-104. Our results highlight the importance of kinesin-3 based axonal transport in synaptic transmission and provide novel insights into the role of Unc-104 in synapse maturation. | ||
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| author | Zhang, Yao, Jahn, Thomas R., Hannan, Shabab B., Rasse, Tobias M. |
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| contents | The kinesin-3 family member KIF1A has been shown to be important for experience dependent neuroplasticity. In Drosophila, amorphic mutations in the KIF1A homolog unc-104 disrupt the formation of mature boutons. Disease associated KIF1A mutations have been associated with motor and sensory dysfunctions as well as non-syndromic intellectual disability in humans. A hypomorphic mutation in the forkhead-associated domain of Unc-104, unc-104bris, impairs active zone maturation resulting in an increased fraction of post-synaptic glutamate receptor fields that lack the active zone scaffolding protein Bruchpilot. Here, we show that the unc-104brismutation causes defects in synaptic transmission as manifested by reduced amplitude of both evoked and miniature excitatory junctional potentials. Structural defects observed in the postsynaptic compartment of mutant NMJs include reduced glutamate receptor field size, and altered glutamate receptor composition. In addition, we observed marked loss of postsynaptic scaffolding proteins and reduced complexity of the sub-synaptic reticulum, which could be rescued by pre- but not postsynaptic expression of unc-104. Our results highlight the importance of kinesin-3 based axonal transport in synaptic transmission and provide novel insights into the role of Unc-104 in synapse maturation. |
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| spelling | Zhang, Yao 1984- VerfasserIn (DE-588)1036620859 (DE-627)750611995 (DE-576)384896111 aut, The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization Yao V. Zhang, Shabab B. Hannan, Jeannine V. Kern, Doychin T. Stanchev, Baran Koç, Thomas R. Jahn & Tobias M. Rasse, 27 March 2017, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 01.08.2018, The kinesin-3 family member KIF1A has been shown to be important for experience dependent neuroplasticity. In Drosophila, amorphic mutations in the KIF1A homolog unc-104 disrupt the formation of mature boutons. Disease associated KIF1A mutations have been associated with motor and sensory dysfunctions as well as non-syndromic intellectual disability in humans. A hypomorphic mutation in the forkhead-associated domain of Unc-104, unc-104bris, impairs active zone maturation resulting in an increased fraction of post-synaptic glutamate receptor fields that lack the active zone scaffolding protein Bruchpilot. Here, we show that the unc-104brismutation causes defects in synaptic transmission as manifested by reduced amplitude of both evoked and miniature excitatory junctional potentials. Structural defects observed in the postsynaptic compartment of mutant NMJs include reduced glutamate receptor field size, and altered glutamate receptor composition. In addition, we observed marked loss of postsynaptic scaffolding proteins and reduced complexity of the sub-synaptic reticulum, which could be rescued by pre- but not postsynaptic expression of unc-104. Our results highlight the importance of kinesin-3 based axonal transport in synaptic transmission and provide novel insights into the role of Unc-104 in synapse maturation., Jahn, Thomas R. VerfasserIn (DE-588)116368953X (DE-627)1028067844 (DE-576)508167027 aut, Hannan, Shabab B. VerfasserIn (DE-588)1163735205 (DE-627)1028098863 (DE-576)508180368 aut, Rasse, Tobias M. 1977- VerfasserIn (DE-588)133367770 (DE-627)543665054 (DE-576)299800172 aut, Enthalten in Scientific reports [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 7(2017) Artikel-Nummer 38172, 9 Seiten Online-Ressource (DE-627)663366712 (DE-600)2615211-3 (DE-576)346641179 2045-2322 nnns, volume:7 year:2017 pages:38172, http://dx.doi.org/10.1038/srep38172 Verlag Resolving-System kostenfrei Volltext, https://www.nature.com/articles/srep38172 Verlag kostenfrei Volltext, http://dx.doi.org/10.1038/srep38172 LFER, LFER 2018-08-13T00:00:00Z |
| spellingShingle | Zhang, Yao, Jahn, Thomas R., Hannan, Shabab B., Rasse, Tobias M., The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization, The kinesin-3 family member KIF1A has been shown to be important for experience dependent neuroplasticity. In Drosophila, amorphic mutations in the KIF1A homolog unc-104 disrupt the formation of mature boutons. Disease associated KIF1A mutations have been associated with motor and sensory dysfunctions as well as non-syndromic intellectual disability in humans. A hypomorphic mutation in the forkhead-associated domain of Unc-104, unc-104bris, impairs active zone maturation resulting in an increased fraction of post-synaptic glutamate receptor fields that lack the active zone scaffolding protein Bruchpilot. Here, we show that the unc-104brismutation causes defects in synaptic transmission as manifested by reduced amplitude of both evoked and miniature excitatory junctional potentials. Structural defects observed in the postsynaptic compartment of mutant NMJs include reduced glutamate receptor field size, and altered glutamate receptor composition. In addition, we observed marked loss of postsynaptic scaffolding proteins and reduced complexity of the sub-synaptic reticulum, which could be rescued by pre- but not postsynaptic expression of unc-104. Our results highlight the importance of kinesin-3 based axonal transport in synaptic transmission and provide novel insights into the role of Unc-104 in synapse maturation. |
| swb_id_str | 508167221 |
| title | The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization |
| title_auth | The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization |
| title_full | The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization Yao V. Zhang, Shabab B. Hannan, Jeannine V. Kern, Doychin T. Stanchev, Baran Koç, Thomas R. Jahn & Tobias M. Rasse |
| title_fullStr | The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization Yao V. Zhang, Shabab B. Hannan, Jeannine V. Kern, Doychin T. Stanchev, Baran Koç, Thomas R. Jahn & Tobias M. Rasse |
| title_full_unstemmed | The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization Yao V. Zhang, Shabab B. Hannan, Jeannine V. Kern, Doychin T. Stanchev, Baran Koç, Thomas R. Jahn & Tobias M. Rasse |
| title_in_hierarchy | The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization / Yao V. Zhang, Shabab B. Hannan, Jeannine V. Kern, Doychin T. Stanchev, Baran Koç, Thomas R. Jahn & Tobias M. Rasse, |
| title_short | The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization |
| title_sort | kif1a homolog unc 104 is important for spontaneous release postsynaptic density maturation and perisynaptic scaffold organization |
| url | http://dx.doi.org/10.1038/srep38172, https://www.nature.com/articles/srep38172 |