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Saturation-recovery myocardial T 1 -mapping during systole: accurate and robust quantification in the presence of arrhythmia
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| Veröffentlicht in: | Scientific reports 8(2018) Artikel-Nummer 5251, 9 Seiten |
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| Personen und Körperschaften: | , , , , , , |
| Titel: | Saturation-recovery myocardial T 1 -mapping during systole: accurate and robust quantification in the presence of arrhythmia/ Nadja M. Meßner, Johannes Budjan, Dirk Loßnitzer, Theano Papavassiliu, Lothar R. Schad, Sebastian Weingärtner & Frank G. Zöllner |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
27 March 2018
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| Gesamtaufnahme: |
: Scientific reports, 8(2018) Artikel-Nummer 5251, 9 Seiten
, volume:8 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
| Zusammenfassung: | Myocardial T1-mapping, a cardiac magnetic resonance imaging technique, facilitates a quantitative measure of fibrosis which is linked to numerous cardiovascular symptoms. To overcome the problems of common techniques, including lack of accuracy and robustness against partial-voluming and heart-rate variability, we introduce a systolic saturation-recovery T1-mapping method. The Saturation-Pulse Prepared Heart-rate independent Inversion-Recovery (SAPPHIRE) T1-mapping method was modified to enable imaging during systole. Phantom measurements were used to evaluate the insensitivity of systolic T1-mapping towards heart-rate variability. In-vivo feasibility and accuracy were demonstrated in ten healthy volunteers with native and post-contrast T1-mappping during systole and diastole. To show benefits in the presence of RR-variability, six arrhythmic patients underwent native T1-mapping. Resulting systolic SAPPHIRE T1-values showed no dependence on arrhythmia in phantom (CoV < 1%). In-vivo, significantly lower T1 (1563 ± 56 ms, precision: 84.8 ms) and ECV-values (0.20 ± 0.03) than during diastole (T1 = 1580 ± 62 ms, p = 0.0124; precision: 60.2 ms, p = 0.03; ECV = 0.21 ± 0.03, p = 0.0098) were measured, with a strong correlation of systolic and diastolic T1 (r = 0.89). In patients, mis-triggering-induced motion caused significant imaging artifacts in diastolic T1-maps, whereas systolic T1-maps displayed resilience to arrythmia. In conclusion, the proposed method enables saturation-recovery T1-mapping during systole, providing increased robustness against partial-voluming compared to diastolic imaging, for the benefit of T1-measurements in arrhythmic patients. |
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| Beschreibung: |
Gesehen am 24.07.2018 Die 1 ist im Titel tiefgestellt |
| Umfang: | 9 |
| ISSN: |
2045-2322
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| DOI: | 10.1038/s41598-018-23506-z |