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Varying immunizations with plasmodium radiation-attenuated sporozoites alter tissue-specific CD8+ T cell dynamics
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| Veröffentlicht in: | Frontiers in immunology 9(2018) Artikel-Nummer 1137, 13 Seiten |
|---|---|
| Personen und Körperschaften: | , , , , |
| Titel: | Varying immunizations with plasmodium radiation-attenuated sporozoites alter tissue-specific CD8+ T cell dynamics/ Roland Frank, Michael Gabel, Kirsten Heiss, Ann-Kristin Mueller and Frederik Graw |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
28 May 2018
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| Gesamtaufnahme: |
: Frontiers in immunology, 9(2018) Artikel-Nummer 1137, 13 Seiten
, volume:9 |
| Schlagwörter: | |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 0 | |a Varying immunizations with plasmodium radiation-attenuated sporozoites alter tissue-specific CD8+ T cell dynamics |c Roland Frank, Michael Gabel, Kirsten Heiss, Ann-Kristin Mueller and Frederik Graw |
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| 520 | |a Whole sporozoite vaccines (WSV) represent one of the most promising strategies to induce protection against malaria. However, the development of efficient vaccination protocols still remains a major challenge. To understand how the generation of immunity is affected by variations in vaccination dosage and frequency, we systematically analyzed intrasplenic and intrahepatic CD8+ T cell responses following varied immunizations of mice with radiation-attenuated sporozoites (RAS). By combining experimental data and mathematical modeling, our analysis indicates a reversing role of spleen and liver in the generation of protective liver-resident CD8+ T cells during priming and booster injections: While the spleen acts as a critical source compartment during priming, the increase in vaccine-induced hepatic T cell levels is likely due to local reactivation in the liver in response to subsequent booster injections. Higher dosing accelerates the efficient generation of liver-resident CD8+ T cells by especially affecting their local reactivation. In addition, we determine the differentiation and migration pathway from splenic precursors towards hepatic memory cells thereby presenting a mechanistic framework for the impact of various vaccination protocols on these dynamics. Thus, our work provides important insights into organ-specific CD8+ T cell dynamics and their role and interplay in the formation of protective immunity against malaria. | ||
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| 650 | 4 | |a Malaria | |
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| 650 | 4 | |a Plasmodium berghei | |
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| author | Frank, Roland, Gabel, Michael, Heiß, Kirsten, Müller, Ann-Kristin, Graw, Frederik |
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| contents | Whole sporozoite vaccines (WSV) represent one of the most promising strategies to induce protection against malaria. However, the development of efficient vaccination protocols still remains a major challenge. To understand how the generation of immunity is affected by variations in vaccination dosage and frequency, we systematically analyzed intrasplenic and intrahepatic CD8+ T cell responses following varied immunizations of mice with radiation-attenuated sporozoites (RAS). By combining experimental data and mathematical modeling, our analysis indicates a reversing role of spleen and liver in the generation of protective liver-resident CD8+ T cells during priming and booster injections: While the spleen acts as a critical source compartment during priming, the increase in vaccine-induced hepatic T cell levels is likely due to local reactivation in the liver in response to subsequent booster injections. Higher dosing accelerates the efficient generation of liver-resident CD8+ T cells by especially affecting their local reactivation. In addition, we determine the differentiation and migration pathway from splenic precursors towards hepatic memory cells thereby presenting a mechanistic framework for the impact of various vaccination protocols on these dynamics. Thus, our work provides important insights into organ-specific CD8+ T cell dynamics and their role and interplay in the formation of protective immunity against malaria. |
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| spelling | Frank, Roland VerfasserIn (DE-588)104981598X (DE-627)782732283 (DE-576)403822181 aut, Varying immunizations with plasmodium radiation-attenuated sporozoites alter tissue-specific CD8+ T cell dynamics Roland Frank, Michael Gabel, Kirsten Heiss, Ann-Kristin Mueller and Frederik Graw, 28 May 2018, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Das Pluszeichen ist im Titel hochgestellt, Gesehen am 24.07.2018, Whole sporozoite vaccines (WSV) represent one of the most promising strategies to induce protection against malaria. However, the development of efficient vaccination protocols still remains a major challenge. To understand how the generation of immunity is affected by variations in vaccination dosage and frequency, we systematically analyzed intrasplenic and intrahepatic CD8+ T cell responses following varied immunizations of mice with radiation-attenuated sporozoites (RAS). By combining experimental data and mathematical modeling, our analysis indicates a reversing role of spleen and liver in the generation of protective liver-resident CD8+ T cells during priming and booster injections: While the spleen acts as a critical source compartment during priming, the increase in vaccine-induced hepatic T cell levels is likely due to local reactivation in the liver in response to subsequent booster injections. Higher dosing accelerates the efficient generation of liver-resident CD8+ T cells by especially affecting their local reactivation. In addition, we determine the differentiation and migration pathway from splenic precursors towards hepatic memory cells thereby presenting a mechanistic framework for the impact of various vaccination protocols on these dynamics. Thus, our work provides important insights into organ-specific CD8+ T cell dynamics and their role and interplay in the formation of protective immunity against malaria., Experimental vaccination, liver-resident CD8+ T cells, Malaria, mathematical modeling, Plasmodium berghei, Radiation attenuated sporozoites, Gabel, Michael VerfasserIn (DE-588)1160604061 (DE-627)1023961490 (DE-576)506027031 aut, Heiß, Kirsten VerfasserIn (DE-588)131455044 (DE-627)509454275 (DE-576)298488698 aut, Müller, Ann-Kristin VerfasserIn (DE-588)1068939419 (DE-627)821077988 (DE-576)428315046 aut, Graw, Frederik VerfasserIn (DE-588)1133583717 (DE-627)889501750 (DE-576)488591945 aut, Enthalten in Frontiers in immunology Lausanne : Frontiers Media, 2010 9(2018) Artikel-Nummer 1137, 13 Seiten Online-Ressource (DE-627)657998354 (DE-600)2606827-8 (DE-576)343624834 1664-3224 nnns, volume:9 year:2018, http://dx.doi.org/10.3389/fimmu.2018.01137 Verlag Resolving-System kostenfrei Volltext, https://www.frontiersin.org/articles/10.3389/fimmu.2018.01137/full Verlag kostenfrei Volltext, http://dx.doi.org/10.3389/fimmu.2018.01137 LFER, LFER 2018-08-13T00:00:00Z |
| spellingShingle | Frank, Roland, Gabel, Michael, Heiß, Kirsten, Müller, Ann-Kristin, Graw, Frederik, Varying immunizations with plasmodium radiation-attenuated sporozoites alter tissue-specific CD8+ T cell dynamics, Whole sporozoite vaccines (WSV) represent one of the most promising strategies to induce protection against malaria. However, the development of efficient vaccination protocols still remains a major challenge. To understand how the generation of immunity is affected by variations in vaccination dosage and frequency, we systematically analyzed intrasplenic and intrahepatic CD8+ T cell responses following varied immunizations of mice with radiation-attenuated sporozoites (RAS). By combining experimental data and mathematical modeling, our analysis indicates a reversing role of spleen and liver in the generation of protective liver-resident CD8+ T cells during priming and booster injections: While the spleen acts as a critical source compartment during priming, the increase in vaccine-induced hepatic T cell levels is likely due to local reactivation in the liver in response to subsequent booster injections. Higher dosing accelerates the efficient generation of liver-resident CD8+ T cells by especially affecting their local reactivation. In addition, we determine the differentiation and migration pathway from splenic precursors towards hepatic memory cells thereby presenting a mechanistic framework for the impact of various vaccination protocols on these dynamics. Thus, our work provides important insights into organ-specific CD8+ T cell dynamics and their role and interplay in the formation of protective immunity against malaria., Experimental vaccination, liver-resident CD8+ T cells, Malaria, mathematical modeling, Plasmodium berghei, Radiation attenuated sporozoites |
| swb_id_str | 507887999 |
| title | Varying immunizations with plasmodium radiation-attenuated sporozoites alter tissue-specific CD8+ T cell dynamics |
| title_auth | Varying immunizations with plasmodium radiation-attenuated sporozoites alter tissue-specific CD8+ T cell dynamics |
| title_full | Varying immunizations with plasmodium radiation-attenuated sporozoites alter tissue-specific CD8+ T cell dynamics Roland Frank, Michael Gabel, Kirsten Heiss, Ann-Kristin Mueller and Frederik Graw |
| title_fullStr | Varying immunizations with plasmodium radiation-attenuated sporozoites alter tissue-specific CD8+ T cell dynamics Roland Frank, Michael Gabel, Kirsten Heiss, Ann-Kristin Mueller and Frederik Graw |
| title_full_unstemmed | Varying immunizations with plasmodium radiation-attenuated sporozoites alter tissue-specific CD8+ T cell dynamics Roland Frank, Michael Gabel, Kirsten Heiss, Ann-Kristin Mueller and Frederik Graw |
| title_in_hierarchy | Varying immunizations with plasmodium radiation-attenuated sporozoites alter tissue-specific CD8+ T cell dynamics / Roland Frank, Michael Gabel, Kirsten Heiss, Ann-Kristin Mueller and Frederik Graw, |
| title_short | Varying immunizations with plasmodium radiation-attenuated sporozoites alter tissue-specific CD8+ T cell dynamics |
| title_sort | varying immunizations with plasmodium radiation attenuated sporozoites alter tissue specific cd8 t cell dynamics |
| topic | Experimental vaccination, liver-resident CD8+ T cells, Malaria, mathematical modeling, Plasmodium berghei, Radiation attenuated sporozoites |
| topic_facet | Experimental vaccination, liver-resident CD8+ T cells, Malaria, mathematical modeling, Plasmodium berghei, Radiation attenuated sporozoites |
| url | http://dx.doi.org/10.3389/fimmu.2018.01137, https://www.frontiersin.org/articles/10.3389/fimmu.2018.01137/full |