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Hair cortisol in twins: heritability and genetic overlap with psychological variables and stress-system genes
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| Veröffentlicht in: | Scientific reports 7(2017) Artikel-Nummer 15351, 15 Seiten |
|---|---|
| Personen und Körperschaften: | , , , |
| Titel: | Hair cortisol in twins: heritability and genetic overlap with psychological variables and stress-system genes/ Liz Rietschel, Fabian Streit, Gu Zhu, Kerrie McAloney, Josef Frank, Baptiste Couvy-Duchesne, Stephanie H. Witt, Tina M. Binz, John McGrath, Ian B. Hickie, Narelle K. Hansell, Margaret J. Wright, Nathan A. Gillespie, Andreas J. Forstner, Thomas G. Schulze, Stefan Wüst, Markus M. Nöthen, Markus R. Baumgartner, Brian R. Walker, Andrew A. Crawford, Lucía Colodro-Conde, Sarah E. Medland, Nicholas G. Martin and Marcella Rietschel |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
10 November 2017
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| Gesamtaufnahme: |
: Scientific reports, 7(2017) Artikel-Nummer 15351, 15 Seiten
, volume:7 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 0 | |a Hair cortisol in twins |b heritability and genetic overlap with psychological variables and stress-system genes |c Liz Rietschel, Fabian Streit, Gu Zhu, Kerrie McAloney, Josef Frank, Baptiste Couvy-Duchesne, Stephanie H. Witt, Tina M. Binz, John McGrath, Ian B. Hickie, Narelle K. Hansell, Margaret J. Wright, Nathan A. Gillespie, Andreas J. Forstner, Thomas G. Schulze, Stefan Wüst, Markus M. Nöthen, Markus R. Baumgartner, Brian R. Walker, Andrew A. Crawford, Lucía Colodro-Conde, Sarah E. Medland, Nicholas G. Martin and Marcella Rietschel |
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| 520 | |a Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables. | ||
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| contents | Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables. |
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| spelling | Rietschel, Liz VerfasserIn (DE-588)1028849087 (DE-627)731659910 (DE-576)376287403 aut, Hair cortisol in twins heritability and genetic overlap with psychological variables and stress-system genes Liz Rietschel, Fabian Streit, Gu Zhu, Kerrie McAloney, Josef Frank, Baptiste Couvy-Duchesne, Stephanie H. Witt, Tina M. Binz, John McGrath, Ian B. Hickie, Narelle K. Hansell, Margaret J. Wright, Nathan A. Gillespie, Andreas J. Forstner, Thomas G. Schulze, Stefan Wüst, Markus M. Nöthen, Markus R. Baumgartner, Brian R. Walker, Andrew A. Crawford, Lucía Colodro-Conde, Sarah E. Medland, Nicholas G. Martin and Marcella Rietschel, 10 November 2017, 15, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Published online: 10 November 2017, Gesehen am 05.07.2018, Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables., Witt, Stephanie 1970- VerfasserIn (DE-588)132177897 (DE-627)519022432 (DE-576)298988399 aut, Wüst, Stefan 1967- VerfasserIn (DE-588)118124129 (DE-627)079257704 (DE-576)291727492 aut, Rietschel, Marcella 1957- VerfasserIn (DE-588)112785751 (DE-627)505574020 (DE-576)289742307 aut, Enthalten in Scientific reports [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 7(2017) Artikel-Nummer 15351, 15 Seiten Online-Ressource (DE-627)663366712 (DE-600)2615211-3 (DE-576)346641179 2045-2322 nnns, volume:7 year:2017 extent:15, http://dx.doi.org/10.1038/s41598-017-11852-3 Verlag Resolving-System kostenfrei Volltext, http://www-nature-com/articles/s41598-017-11852-3 Verlag kostenfrei Volltext, http://dx.doi.org/10.1038/s41598-017-11852-3 LFER, LFER 2018-07-10T00:00:00Z |
| spellingShingle | Rietschel, Liz, Witt, Stephanie, Wüst, Stefan, Rietschel, Marcella, Hair cortisol in twins: heritability and genetic overlap with psychological variables and stress-system genes, Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables. |
| swb_id_str | 507304411 |
| title | Hair cortisol in twins: heritability and genetic overlap with psychological variables and stress-system genes |
| title_auth | Hair cortisol in twins heritability and genetic overlap with psychological variables and stress-system genes |
| title_full | Hair cortisol in twins heritability and genetic overlap with psychological variables and stress-system genes Liz Rietschel, Fabian Streit, Gu Zhu, Kerrie McAloney, Josef Frank, Baptiste Couvy-Duchesne, Stephanie H. Witt, Tina M. Binz, John McGrath, Ian B. Hickie, Narelle K. Hansell, Margaret J. Wright, Nathan A. Gillespie, Andreas J. Forstner, Thomas G. Schulze, Stefan Wüst, Markus M. Nöthen, Markus R. Baumgartner, Brian R. Walker, Andrew A. Crawford, Lucía Colodro-Conde, Sarah E. Medland, Nicholas G. Martin and Marcella Rietschel |
| title_fullStr | Hair cortisol in twins heritability and genetic overlap with psychological variables and stress-system genes Liz Rietschel, Fabian Streit, Gu Zhu, Kerrie McAloney, Josef Frank, Baptiste Couvy-Duchesne, Stephanie H. Witt, Tina M. Binz, John McGrath, Ian B. Hickie, Narelle K. Hansell, Margaret J. Wright, Nathan A. Gillespie, Andreas J. Forstner, Thomas G. Schulze, Stefan Wüst, Markus M. Nöthen, Markus R. Baumgartner, Brian R. Walker, Andrew A. Crawford, Lucía Colodro-Conde, Sarah E. Medland, Nicholas G. Martin and Marcella Rietschel |
| title_full_unstemmed | Hair cortisol in twins heritability and genetic overlap with psychological variables and stress-system genes Liz Rietschel, Fabian Streit, Gu Zhu, Kerrie McAloney, Josef Frank, Baptiste Couvy-Duchesne, Stephanie H. Witt, Tina M. Binz, John McGrath, Ian B. Hickie, Narelle K. Hansell, Margaret J. Wright, Nathan A. Gillespie, Andreas J. Forstner, Thomas G. Schulze, Stefan Wüst, Markus M. Nöthen, Markus R. Baumgartner, Brian R. Walker, Andrew A. Crawford, Lucía Colodro-Conde, Sarah E. Medland, Nicholas G. Martin and Marcella Rietschel |
| title_in_hierarchy | Hair cortisol in twins: heritability and genetic overlap with psychological variables and stress-system genes / Liz Rietschel, Fabian Streit, Gu Zhu, Kerrie McAloney, Josef Frank, Baptiste Couvy-Duchesne, Stephanie H. Witt, Tina M. Binz, John McGrath, Ian B. Hickie, Narelle K. Hansell, Margaret J. Wright, Nathan A. Gillespie, Andreas J. Forstner, Thomas G. Schulze, Stefan Wüst, Markus M. Nöthen, Markus R. Baumgartner, Brian R. Walker, Andrew A. Crawford, Lucía Colodro-Conde, Sarah E. Medland, Nicholas G. Martin and Marcella Rietschel, |
| title_short | Hair cortisol in twins |
| title_sort | hair cortisol in twins heritability and genetic overlap with psychological variables and stress system genes |
| title_sub | heritability and genetic overlap with psychological variables and stress-system genes |
| url | http://dx.doi.org/10.1038/s41598-017-11852-3, http://www-nature-com/articles/s41598-017-11852-3 |