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Neural stem cells induce the formation of their physical niche during organogenesis
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| Veröffentlicht in: | eLife 6(2017) Artikel-Nummer e29173, 30 Seiten |
|---|---|
| Personen und Körperschaften: | , , , , , , , |
| Titel: | Neural stem cells induce the formation of their physical niche during organogenesis/ Ali Seleit, Isabel Krämer, Bea F Riebesehl, Elizabeth M Ambrosio, Julian S Stolper, Colin Q Lischik, Nicolas Dross, Lazaro Centanin |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
27 September 2017
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| Gesamtaufnahme: |
: eLife, 6(2017) Artikel-Nummer e29173, 30 Seiten
, volume:6 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| contents | Most organs rely on stem cells to maintain homeostasis during post-embryonic life. Typically, stem cells of independent lineages work coordinately within mature organs to ensure proper ratios of cell types. Little is known, however, on how these different stem cells locate to forming organs during development. Here we show that neuromasts of the posterior lateral line in medaka are composed of two independent life-long lineages with different embryonic origins. Clonal analysis and 4D imaging revealed a hierarchical organisation with instructing and responding roles: an inner, neural lineage induces the formation of an outer, border cell lineage (nBC) from the skin epithelium. Our results demonstrate that the neural lineage is necessary and sufficient to generate nBCs highlighting self-organisation principles at the level of the entire embryo. We hypothesise that induction of surrounding tissues plays a major role during the establishment of vertebrate stem cell niches. |
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| spelling | Seleit, Ali VerfasserIn (DE-588)1162220066 (DE-627)102569256X (DE-576)507275209 aut, Neural stem cells induce the formation of their physical niche during organogenesis Ali Seleit, Isabel Krämer, Bea F Riebesehl, Elizabeth M Ambrosio, Julian S Stolper, Colin Q Lischik, Nicolas Dross, Lazaro Centanin, 27 September 2017, 30, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 04.07.2018, Most organs rely on stem cells to maintain homeostasis during post-embryonic life. Typically, stem cells of independent lineages work coordinately within mature organs to ensure proper ratios of cell types. Little is known, however, on how these different stem cells locate to forming organs during development. Here we show that neuromasts of the posterior lateral line in medaka are composed of two independent life-long lineages with different embryonic origins. Clonal analysis and 4D imaging revealed a hierarchical organisation with instructing and responding roles: an inner, neural lineage induces the formation of an outer, border cell lineage (nBC) from the skin epithelium. Our results demonstrate that the neural lineage is necessary and sufficient to generate nBCs highlighting self-organisation principles at the level of the entire embryo. We hypothesise that induction of surrounding tissues plays a major role during the establishment of vertebrate stem cell niches., Krämer, Isabel VerfasserIn (DE-588)1124863575 (DE-627)879196645 (DE-576)483202134 aut, Riebesehl, Bea VerfasserIn (DE-588)1162224770 (DE-627)1025696689 (DE-576)507278038 aut, Ambrosio, Elizabeth VerfasserIn (DE-588)1162220414 (DE-627)1025692942 (DE-576)507275136 aut, Stolper, Julian VerfasserIn (DE-588)1162225785 (DE-627)1025697057 (DE-576)507279077 aut, Lischik, Colin Q. VerfasserIn (DE-588)1162226153 (DE-627)1025697375 (DE-576)507278984 aut, Dross, Nicolas VerfasserIn (DE-588)140690123 (DE-627)620889071 (DE-576)319432041 aut, Centanin, Lázaro VerfasserIn (DE-588)105927664X (DE-627)798228431 (DE-576)415156548 aut, Enthalten in eLife Cambridge : eLife Sciences Publications, 2012 6(2017) Artikel-Nummer e29173, 30 Seiten Online-Ressource (DE-627)728518384 (DE-600)2687154-3 (DE-576)372567576 2050-084X nnns, volume:6 year:2017 extent:30, http://dx.doi.org/10.7554/eLife.29173 Verlag Resolving-System kostenfrei Volltext, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617629/ Verlag kostenfrei Volltext, http://dx.doi.org/10.7554/eLife.29173 LFER, LFER 2018-07-10T00:00:00Z |
| spellingShingle | Seleit, Ali, Krämer, Isabel, Riebesehl, Bea, Ambrosio, Elizabeth, Stolper, Julian, Lischik, Colin Q., Dross, Nicolas, Centanin, Lázaro, Neural stem cells induce the formation of their physical niche during organogenesis, Most organs rely on stem cells to maintain homeostasis during post-embryonic life. Typically, stem cells of independent lineages work coordinately within mature organs to ensure proper ratios of cell types. Little is known, however, on how these different stem cells locate to forming organs during development. Here we show that neuromasts of the posterior lateral line in medaka are composed of two independent life-long lineages with different embryonic origins. Clonal analysis and 4D imaging revealed a hierarchical organisation with instructing and responding roles: an inner, neural lineage induces the formation of an outer, border cell lineage (nBC) from the skin epithelium. Our results demonstrate that the neural lineage is necessary and sufficient to generate nBCs highlighting self-organisation principles at the level of the entire embryo. We hypothesise that induction of surrounding tissues plays a major role during the establishment of vertebrate stem cell niches. |
| swb_id_str | 507279956 |
| title | Neural stem cells induce the formation of their physical niche during organogenesis |
| title_auth | Neural stem cells induce the formation of their physical niche during organogenesis |
| title_full | Neural stem cells induce the formation of their physical niche during organogenesis Ali Seleit, Isabel Krämer, Bea F Riebesehl, Elizabeth M Ambrosio, Julian S Stolper, Colin Q Lischik, Nicolas Dross, Lazaro Centanin |
| title_fullStr | Neural stem cells induce the formation of their physical niche during organogenesis Ali Seleit, Isabel Krämer, Bea F Riebesehl, Elizabeth M Ambrosio, Julian S Stolper, Colin Q Lischik, Nicolas Dross, Lazaro Centanin |
| title_full_unstemmed | Neural stem cells induce the formation of their physical niche during organogenesis Ali Seleit, Isabel Krämer, Bea F Riebesehl, Elizabeth M Ambrosio, Julian S Stolper, Colin Q Lischik, Nicolas Dross, Lazaro Centanin |
| title_in_hierarchy | Neural stem cells induce the formation of their physical niche during organogenesis / Ali Seleit, Isabel Krämer, Bea F Riebesehl, Elizabeth M Ambrosio, Julian S Stolper, Colin Q Lischik, Nicolas Dross, Lazaro Centanin, |
| title_short | Neural stem cells induce the formation of their physical niche during organogenesis |
| title_sort | neural stem cells induce the formation of their physical niche during organogenesis |
| url | http://dx.doi.org/10.7554/eLife.29173, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617629/ |