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Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors
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| Veröffentlicht in: | Hepatology 56(2012), 5, Seite 1817-1827 |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , |
| Titel: | Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors/ Olaf Neumann, Miriam Kesselmeier, Robert Geffers, Rossella Pellegrino, Bernhard Radlwimmer, Katrin Hoffmann, Volker Ehemann, Peter Schemmer, Peter Schirmacher, Justo Lorenzo Bermejo, and Thomas Longerich |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
2012
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| Gesamtaufnahme: |
: Hepatology, 56(2012), 5, Seite 1817-1827
, volume:56 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| author | Neumann, Olaf, Kesselmeier, Miriam, Pellegrino, Rossella, Radlwimmer, Bernhard, Hoffmann, Katrin, Ehemann, Volker, Schemmer, Peter, Schirmacher, Peter, Lorenzo Bermejo, Justo, Longerich, Thomas |
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| contents | To identify new tumor-suppressor gene candidates relevant for human hepatocarcinogenesis, we performed genome-wide methylation profiling and vertical integration with array-based comparative genomic hybridization (aCGH), as well as expression data from a cohort of well-characterized human hepatocellular carcinomas (HCCs). Bisulfite-converted DNAs from 63 HCCs and 10 healthy control livers were analyzed for the methylation status of more than 14,000 genes. |
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| spelling | Neumann, Olaf VerfasserIn (DE-588)1033375632 (DE-627)741119498 (DE-576)380962381 aut, Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors Olaf Neumann, Miriam Kesselmeier, Robert Geffers, Rossella Pellegrino, Bernhard Radlwimmer, Katrin Hoffmann, Volker Ehemann, Peter Schemmer, Peter Schirmacher, Justo Lorenzo Bermejo, and Thomas Longerich, 2012, 11, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, First published: 11 June 2012, Gesehen am 15.06.2018, To identify new tumor-suppressor gene candidates relevant for human hepatocarcinogenesis, we performed genome-wide methylation profiling and vertical integration with array-based comparative genomic hybridization (aCGH), as well as expression data from a cohort of well-characterized human hepatocellular carcinomas (HCCs). Bisulfite-converted DNAs from 63 HCCs and 10 healthy control livers were analyzed for the methylation status of more than 14,000 genes., Kesselmeier, Miriam 1983- VerfasserIn (DE-588)1093868643 (DE-627)853887896 (DE-576)462777642 aut, Pellegrino, Rossella VerfasserIn (DE-588)1078935327 (DE-627)839825439 (DE-576)45208315X aut, Radlwimmer, Bernhard VerfasserIn (DE-588)1078935513 (DE-627)839825560 (DE-576)452084423 aut, Hoffmann, Katrin 1980- VerfasserIn (DE-588)131774417 (DE-627)513946950 (DE-576)252913078 aut, Ehemann, Volker VerfasserIn (DE-588)1022298747 (DE-627)716950391 (DE-576)365104566 aut, Schemmer, Peter 1967- VerfasserIn (DE-588)1022604244 (DE-627)717006794 (DE-576)365668230 aut, Schirmacher, Peter 1961- VerfasserIn (DE-588)1020440112 (DE-627)691221197 (DE-576)360427448 aut, Lorenzo Bermejo, Justo 1972- VerfasserIn (DE-588)124754619 (DE-627)706705572 (DE-576)294483632 aut, Longerich, Thomas 1974- VerfasserIn (DE-588)128494514 (DE-627)373916124 (DE-576)297178059 aut, Enthalten in Hepatology New York [u.a.] : Wiley Interscience, 1981 56(2012), 5, Seite 1817-1827 Online-Ressource (DE-627)268132003 (DE-600)1472120-X (DE-576)077450183 1527-3350 nnns, volume:56 year:2012 number:5 pages:1817-1827 extent:11, http://dx.doi.org/10.1002/hep.25870 Verlag Resolving-System kostenfrei Volltext, https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.25870 Verlag kostenfrei Volltext, http://dx.doi.org/10.1002/hep.25870 LFER, LFER 2018-07-10T00:00:00Z |
| spellingShingle | Neumann, Olaf, Kesselmeier, Miriam, Pellegrino, Rossella, Radlwimmer, Bernhard, Hoffmann, Katrin, Ehemann, Volker, Schemmer, Peter, Schirmacher, Peter, Lorenzo Bermejo, Justo, Longerich, Thomas, Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors, To identify new tumor-suppressor gene candidates relevant for human hepatocarcinogenesis, we performed genome-wide methylation profiling and vertical integration with array-based comparative genomic hybridization (aCGH), as well as expression data from a cohort of well-characterized human hepatocellular carcinomas (HCCs). Bisulfite-converted DNAs from 63 HCCs and 10 healthy control livers were analyzed for the methylation status of more than 14,000 genes. |
| swb_id_str | 506413829 |
| title | Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors |
| title_auth | Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors |
| title_full | Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors Olaf Neumann, Miriam Kesselmeier, Robert Geffers, Rossella Pellegrino, Bernhard Radlwimmer, Katrin Hoffmann, Volker Ehemann, Peter Schemmer, Peter Schirmacher, Justo Lorenzo Bermejo, and Thomas Longerich |
| title_fullStr | Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors Olaf Neumann, Miriam Kesselmeier, Robert Geffers, Rossella Pellegrino, Bernhard Radlwimmer, Katrin Hoffmann, Volker Ehemann, Peter Schemmer, Peter Schirmacher, Justo Lorenzo Bermejo, and Thomas Longerich |
| title_full_unstemmed | Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors Olaf Neumann, Miriam Kesselmeier, Robert Geffers, Rossella Pellegrino, Bernhard Radlwimmer, Katrin Hoffmann, Volker Ehemann, Peter Schemmer, Peter Schirmacher, Justo Lorenzo Bermejo, and Thomas Longerich |
| title_in_hierarchy | Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors / Olaf Neumann, Miriam Kesselmeier, Robert Geffers, Rossella Pellegrino, Bernhard Radlwimmer, Katrin Hoffmann, Volker Ehemann, Peter Schemmer, Peter Schirmacher, Justo Lorenzo Bermejo, and Thomas Longerich, |
| title_short | Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors |
| title_sort | methylome analysis and integrative profiling of human hccs identify novel protumorigenic factors |
| url | http://dx.doi.org/10.1002/hep.25870, https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.25870 |