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Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer: results of the FOGT-4 trial
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| Veröffentlicht in: | British journal of cancer 106(2012), 6, Seite 1239-1245 |
|---|---|
| Personen und Körperschaften: | , , |
| Titel: | Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer: results of the FOGT-4 trial/ A. Tikidzhieva, A. Benner, S. Michel, A. Formentini, K.-H. Link, W. Dippold, M. von Knebel Doeberitz, M. Kornmann and M. Kloor |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
21 February 2012
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| Gesamtaufnahme: |
: British journal of cancer, 106(2012), 6, Seite 1239-1245
, volume:106 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 0 | |a Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer |b results of the FOGT-4 trial |c A. Tikidzhieva, A. Benner, S. Michel, A. Formentini, K.-H. Link, W. Dippold, M. von Knebel Doeberitz, M. Kornmann and M. Kloor |
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| 520 | |a Background: High-level microsatellite instability (MSI-H) has been reported as a prognostic marker in colon cancer. We here analysed the prognostic significance of MSI and mutations of the Beta2-Microglobulin (B2M) gene, which occur in about 30% of MSI-H colon cancer, in the cohort of the prospective FOGT-4 (Forschungsruppe Onkologie Gastrointestinale Tumoren, FOGT) trial. Methods: Microsatellite instability status was determined using standard protocols (NCI/ICG-HNPCC panel and CAT25) in 223 colon cancer lesions. Beta2-Microglobulin mutation status was evaluated by exon-wise sequencing in all MSI-H lesions. Results: Patients with MSI-H (n=34) colon cancer presented with a significantly lower risk of relapse after 12 months of follow-up compared with MSS (n=189) colon cancer patients (5 year time to relapse: MSI-H 0.82 vs MSS 0.66, P=0.03). No significant difference in overall survival was detected. Beta2-Microglobulin mutations were identified in 10 (29.4%) out of 34 MSI-H colon cancers and were associated with a complete absence of disease relapse or tumour-related death events (P=0.09). Conclusion: The risk of late disease relapse was significantly lower in patients with MSI-H compared with MSS colon cancer. Moreover, B2M mutations may contribute to the favourable outcome of MSI-H colon cancer patients and should therefore be evaluated as a potential prognostic marker in future clinical trials. | ||
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| contents | Background: High-level microsatellite instability (MSI-H) has been reported as a prognostic marker in colon cancer. We here analysed the prognostic significance of MSI and mutations of the Beta2-Microglobulin (B2M) gene, which occur in about 30% of MSI-H colon cancer, in the cohort of the prospective FOGT-4 (Forschungsruppe Onkologie Gastrointestinale Tumoren, FOGT) trial. Methods: Microsatellite instability status was determined using standard protocols (NCI/ICG-HNPCC panel and CAT25) in 223 colon cancer lesions. Beta2-Microglobulin mutation status was evaluated by exon-wise sequencing in all MSI-H lesions. Results: Patients with MSI-H (n=34) colon cancer presented with a significantly lower risk of relapse after 12 months of follow-up compared with MSS (n=189) colon cancer patients (5 year time to relapse: MSI-H 0.82 vs MSS 0.66, P=0.03). No significant difference in overall survival was detected. Beta2-Microglobulin mutations were identified in 10 (29.4%) out of 34 MSI-H colon cancers and were associated with a complete absence of disease relapse or tumour-related death events (P=0.09). Conclusion: The risk of late disease relapse was significantly lower in patients with MSI-H compared with MSS colon cancer. Moreover, B2M mutations may contribute to the favourable outcome of MSI-H colon cancer patients and should therefore be evaluated as a potential prognostic marker in future clinical trials. |
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| spelling | Schulz, Anna 1984- VerfasserIn (DE-588)1057967998 (DE-627)796229406 (DE-576)413967948 aut, Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer results of the FOGT-4 trial A. Tikidzhieva, A. Benner, S. Michel, A. Formentini, K.-H. Link, W. Dippold, M. von Knebel Doeberitz, M. Kornmann and M. Kloor, 21 February 2012, 7, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 30.05.2018, Background: High-level microsatellite instability (MSI-H) has been reported as a prognostic marker in colon cancer. We here analysed the prognostic significance of MSI and mutations of the Beta2-Microglobulin (B2M) gene, which occur in about 30% of MSI-H colon cancer, in the cohort of the prospective FOGT-4 (Forschungsruppe Onkologie Gastrointestinale Tumoren, FOGT) trial. Methods: Microsatellite instability status was determined using standard protocols (NCI/ICG-HNPCC panel and CAT25) in 223 colon cancer lesions. Beta2-Microglobulin mutation status was evaluated by exon-wise sequencing in all MSI-H lesions. Results: Patients with MSI-H (n=34) colon cancer presented with a significantly lower risk of relapse after 12 months of follow-up compared with MSS (n=189) colon cancer patients (5 year time to relapse: MSI-H 0.82 vs MSS 0.66, P=0.03). No significant difference in overall survival was detected. Beta2-Microglobulin mutations were identified in 10 (29.4%) out of 34 MSI-H colon cancers and were associated with a complete absence of disease relapse or tumour-related death events (P=0.09). Conclusion: The risk of late disease relapse was significantly lower in patients with MSI-H compared with MSS colon cancer. Moreover, B2M mutations may contribute to the favourable outcome of MSI-H colon cancer patients and should therefore be evaluated as a potential prognostic marker in future clinical trials., Knebel Doeberitz, Magnus von VerfasserIn (DE-588)1022165291 (DE-627)71693289X (DE-576)364934239 aut, Kloor, Matthias 1972- VerfasserIn (DE-588)124552803 (DE-627)363416609 (DE-576)294228616 aut, Enthalten in British journal of cancer Edinburgh : Nature Publ. Group, 1999 106(2012), 6, Seite 1239-1245 Online-Ressource (DE-627)320420094 (DE-600)2002452-6 (DE-576)103746854 1532-1827 nnns, volume:106 year:2012 number:6 pages:1239-1245 extent:7, http://dx.doi.org/10.1038/bjc.2012.53 Verlag Resolving-System kostenfrei Volltext, https://www.nature.com/articles/bjc201253 Verlag kostenfrei Volltext, https://www.nature.com/articles/bjc201253 LFER, LFER 2019-05-07T00:00:00Z |
| spellingShingle | Schulz, Anna, Knebel Doeberitz, Magnus von, Kloor, Matthias, Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer: results of the FOGT-4 trial, Background: High-level microsatellite instability (MSI-H) has been reported as a prognostic marker in colon cancer. We here analysed the prognostic significance of MSI and mutations of the Beta2-Microglobulin (B2M) gene, which occur in about 30% of MSI-H colon cancer, in the cohort of the prospective FOGT-4 (Forschungsruppe Onkologie Gastrointestinale Tumoren, FOGT) trial. Methods: Microsatellite instability status was determined using standard protocols (NCI/ICG-HNPCC panel and CAT25) in 223 colon cancer lesions. Beta2-Microglobulin mutation status was evaluated by exon-wise sequencing in all MSI-H lesions. Results: Patients with MSI-H (n=34) colon cancer presented with a significantly lower risk of relapse after 12 months of follow-up compared with MSS (n=189) colon cancer patients (5 year time to relapse: MSI-H 0.82 vs MSS 0.66, P=0.03). No significant difference in overall survival was detected. Beta2-Microglobulin mutations were identified in 10 (29.4%) out of 34 MSI-H colon cancers and were associated with a complete absence of disease relapse or tumour-related death events (P=0.09). Conclusion: The risk of late disease relapse was significantly lower in patients with MSI-H compared with MSS colon cancer. Moreover, B2M mutations may contribute to the favourable outcome of MSI-H colon cancer patients and should therefore be evaluated as a potential prognostic marker in future clinical trials. |
| swb_id_str | 505856409 |
| title | Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer: results of the FOGT-4 trial |
| title_auth | Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer results of the FOGT-4 trial |
| title_full | Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer results of the FOGT-4 trial A. Tikidzhieva, A. Benner, S. Michel, A. Formentini, K.-H. Link, W. Dippold, M. von Knebel Doeberitz, M. Kornmann and M. Kloor |
| title_fullStr | Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer results of the FOGT-4 trial A. Tikidzhieva, A. Benner, S. Michel, A. Formentini, K.-H. Link, W. Dippold, M. von Knebel Doeberitz, M. Kornmann and M. Kloor |
| title_full_unstemmed | Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer results of the FOGT-4 trial A. Tikidzhieva, A. Benner, S. Michel, A. Formentini, K.-H. Link, W. Dippold, M. von Knebel Doeberitz, M. Kornmann and M. Kloor |
| title_in_hierarchy | Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer: results of the FOGT-4 trial / A. Tikidzhieva, A. Benner, S. Michel, A. Formentini, K.-H. Link, W. Dippold, M. von Knebel Doeberitz, M. Kornmann and M. Kloor, |
| title_short | Microsatellite instability and Beta2-Microglobulin mutations as prognostic markers in colon cancer |
| title_sort | microsatellite instability and beta2 microglobulin mutations as prognostic markers in colon cancer results of the fogt 4 trial |
| title_sub | results of the FOGT-4 trial |
| url | http://dx.doi.org/10.1038/bjc.2012.53, https://www.nature.com/articles/bjc201253 |