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Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy
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| Veröffentlicht in: | Scientific reports 7(2017) Artikel-Nummer 6336, 9 Seiten |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , |
| Titel: | Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy/ Christina Doesch, Erol Tülümen, Ibrahim Akin, Boris Rudic, Juergen Kuschyk, Ibrahim El-Battrawy, Tobias Becher, Johannes Budjan, Arman Smakic, Stefan O. Schoenberg, Martin Borggrefe and Theano Papavassiliu |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
24 July 2017
|
| Gesamtaufnahme: |
: Scientific reports, 7(2017) Artikel-Nummer 6336, 9 Seiten
, volume:7 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 520 | |a Hypertrophic cardiomyopathy (HCM) has a low risk for sudden cardiac death (SCD). The ESC clinical risk prediction model estimates the risk of SCD using clinical and echocardiographical parameters without taking into account cardiac magnetic resonance (CMR) parameters. Therefore, we compared the CMR characteristics of 149 patients with low, intermediate and high ESC risk scores. In these patients left and right ventricular ejection fraction and volumes were comparable. Patients with a high ESC risk score revealed a significantly higher extent of late gadolinium enhancement (LGE) compared to patients with intermediate or a low risk scores. During follow-up of 4 years an extent of LGE ≥20% identified patients at a higher risk for major adverse cardiac arrhythmic events in the low and intermediate ESC risk group whereas an extent of LGE <20% was associated with a low risk of major adverse cardiac arrhythmic events despite a high ESC risk score ≥6%. Hence, we hypothesize that the extent of fibrosis might be an additional risk marker. | ||
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| contents | Hypertrophic cardiomyopathy (HCM) has a low risk for sudden cardiac death (SCD). The ESC clinical risk prediction model estimates the risk of SCD using clinical and echocardiographical parameters without taking into account cardiac magnetic resonance (CMR) parameters. Therefore, we compared the CMR characteristics of 149 patients with low, intermediate and high ESC risk scores. In these patients left and right ventricular ejection fraction and volumes were comparable. Patients with a high ESC risk score revealed a significantly higher extent of late gadolinium enhancement (LGE) compared to patients with intermediate or a low risk scores. During follow-up of 4 years an extent of LGE ≥20% identified patients at a higher risk for major adverse cardiac arrhythmic events in the low and intermediate ESC risk group whereas an extent of LGE <20% was associated with a low risk of major adverse cardiac arrhythmic events despite a high ESC risk score ≥6%. Hence, we hypothesize that the extent of fibrosis might be an additional risk marker. |
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| spelling | Dösch, Christina 1979- VerfasserIn (DE-588)132004100 (DE-627)516483846 (DE-576)298887207 aut, Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy Christina Doesch, Erol Tülümen, Ibrahim Akin, Boris Rudic, Juergen Kuschyk, Ibrahim El-Battrawy, Tobias Becher, Johannes Budjan, Arman Smakic, Stefan O. Schoenberg, Martin Borggrefe and Theano Papavassiliu, 24 July 2017, 9, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 22.05.2018, Hypertrophic cardiomyopathy (HCM) has a low risk for sudden cardiac death (SCD). The ESC clinical risk prediction model estimates the risk of SCD using clinical and echocardiographical parameters without taking into account cardiac magnetic resonance (CMR) parameters. Therefore, we compared the CMR characteristics of 149 patients with low, intermediate and high ESC risk scores. In these patients left and right ventricular ejection fraction and volumes were comparable. Patients with a high ESC risk score revealed a significantly higher extent of late gadolinium enhancement (LGE) compared to patients with intermediate or a low risk scores. During follow-up of 4 years an extent of LGE ≥20% identified patients at a higher risk for major adverse cardiac arrhythmic events in the low and intermediate ESC risk group whereas an extent of LGE <20% was associated with a low risk of major adverse cardiac arrhythmic events despite a high ESC risk score ≥6%. Hence, we hypothesize that the extent of fibrosis might be an additional risk marker., Tueluemen, Erol VerfasserIn (DE-588)1035228955 (DE-627)746999585 (DE-576)382840534 aut, Akın, Ibrahim 1978- VerfasserIn (DE-588)132322293 (DE-627)521039010 (DE-576)299074366 aut, Rudic, Boris 1982- VerfasserIn (DE-588)1024726789 (DE-627)720427134 (DE-576)369410599 aut, Kuschyk, Jürgen 1968- VerfasserIn (DE-588)122441850 (DE-627)081944993 (DE-576)293272212 aut, El-Battrawy, Ibrahim 1987- VerfasserIn (DE-588)1033436917 (DE-627)741219549 (DE-576)38084673X aut, Becher, Tobias 1983- VerfasserIn (DE-588)1026789605 (DE-627)727387510 (DE-576)37211105X aut, Budjan, Johannes 1984- VerfasserIn (DE-588)1020241047 (DE-627)691154244 (DE-576)359777821 aut, Smakic, Arman 1987- VerfasserIn (DE-588)1159934339 (DE-627)1023018500 (DE-576)505404672 aut, Schönberg, Stefan 1969- VerfasserIn (DE-588)131557912 (DE-627)510700624 (DE-576)298584891 aut, Borggrefe, Martin VerfasserIn (DE-588)1025920546 (DE-627)725574232 (DE-576)370913426 aut, Papavassiliu, Theano VerfasserIn (DE-588)1028853440 (DE-627)731667417 (DE-576)376292849 aut, Enthalten in Scientific reports [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 7(2017) Artikel-Nummer 6336, 9 Seiten Online-Ressource (DE-627)663366712 (DE-600)2615211-3 (DE-576)346641179 2045-2322 nnns, volume:7 year:2017 extent:9, http://dx.doi.org/10.1038/s41598-017-06533-0 Verlag Resolving-System kostenfrei Volltext, https://www.nature.com/articles/s41598-017-06533-0 Verlag kostenfrei Volltext, http://dx.doi.org/10.1038/s41598-017-06533-0 LFER, LFER 2018-05-24T00:00:00Z |
| spellingShingle | Dösch, Christina, Tueluemen, Erol, Akın, Ibrahim, Rudic, Boris, Kuschyk, Jürgen, El-Battrawy, Ibrahim, Becher, Tobias, Budjan, Johannes, Smakic, Arman, Schönberg, Stefan, Borggrefe, Martin, Papavassiliu, Theano, Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy, Hypertrophic cardiomyopathy (HCM) has a low risk for sudden cardiac death (SCD). The ESC clinical risk prediction model estimates the risk of SCD using clinical and echocardiographical parameters without taking into account cardiac magnetic resonance (CMR) parameters. Therefore, we compared the CMR characteristics of 149 patients with low, intermediate and high ESC risk scores. In these patients left and right ventricular ejection fraction and volumes were comparable. Patients with a high ESC risk score revealed a significantly higher extent of late gadolinium enhancement (LGE) compared to patients with intermediate or a low risk scores. During follow-up of 4 years an extent of LGE ≥20% identified patients at a higher risk for major adverse cardiac arrhythmic events in the low and intermediate ESC risk group whereas an extent of LGE <20% was associated with a low risk of major adverse cardiac arrhythmic events despite a high ESC risk score ≥6%. Hence, we hypothesize that the extent of fibrosis might be an additional risk marker. |
| swb_id_str | 505405792 |
| title | Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy |
| title_auth | Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy |
| title_full | Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy Christina Doesch, Erol Tülümen, Ibrahim Akin, Boris Rudic, Juergen Kuschyk, Ibrahim El-Battrawy, Tobias Becher, Johannes Budjan, Arman Smakic, Stefan O. Schoenberg, Martin Borggrefe and Theano Papavassiliu |
| title_fullStr | Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy Christina Doesch, Erol Tülümen, Ibrahim Akin, Boris Rudic, Juergen Kuschyk, Ibrahim El-Battrawy, Tobias Becher, Johannes Budjan, Arman Smakic, Stefan O. Schoenberg, Martin Borggrefe and Theano Papavassiliu |
| title_full_unstemmed | Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy Christina Doesch, Erol Tülümen, Ibrahim Akin, Boris Rudic, Juergen Kuschyk, Ibrahim El-Battrawy, Tobias Becher, Johannes Budjan, Arman Smakic, Stefan O. Schoenberg, Martin Borggrefe and Theano Papavassiliu |
| title_in_hierarchy | Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy / Christina Doesch, Erol Tülümen, Ibrahim Akin, Boris Rudic, Juergen Kuschyk, Ibrahim El-Battrawy, Tobias Becher, Johannes Budjan, Arman Smakic, Stefan O. Schoenberg, Martin Borggrefe and Theano Papavassiliu, |
| title_short | Incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy |
| title_sort | incremental benefit of late gadolinium cardiac magnetic resonance imaging for risk stratification in patients with hypertrophic cardiomyopathy |
| url | http://dx.doi.org/10.1038/s41598-017-06533-0, https://www.nature.com/articles/s41598-017-06533-0 |