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ABO-Incompatible kidney transplantation
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Veröffentlicht in: | Frontiers in immunology 8(2017) Artikel-Nummer 234, 7 Seiten |
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Personen und Körperschaften: | , , , , |
Titel: | ABO-Incompatible kidney transplantation/ Christian Morath, Martin Zeier, Bernd Döhler, Gerhard Opelz, Caner Süsal |
Format: | E-Book-Kapitel |
Sprache: | Englisch |
veröffentlicht: |
06 March 2017
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Gesamtaufnahme: |
: Frontiers in immunology, 8(2017) Artikel-Nummer 234, 7 Seiten
, volume:8 |
Schlagwörter: | |
Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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520 | |a ABO incompatible (ABOi) kidney transplantation has long been considered a contraindication to successful kidney transplantation. During the last 25 years, increasing organ shortage enforced the development of strategies to overcome the ABO antibody barrier. In the meantime, ABOi kidney transplantation has become a routine procedure with death-censored graft survival rates comparable to the rates in compatible transplantations. Desensitization is usually achieved by apheresis and B cell-depleting therapies that are accompanied by powerful immunosuppression. Anti-A/B antibodies are aimed to be below a certain threshold at the time of ABOi kidney transplantation and during the first two weeks after surgery. Thereafter, even a rebound of anti-A/B antibodies does not appear to harm the kidney transplant, a phenomenon that is called accommodation, but is poorly understood. There is still concern, however, that infectious complications such as viral disease, Pneumocystis jirovecii pneumonia and severe urinary tract infections are increased after ABOi transplantations. Recent data from the Collaborative Transplant Study (CTS) show that during the first year after kidney transplantation, one additional patient death from an infectious complication occurs in 100 ABOi kidney transplant recipients. Herein, we review the recent evidence on ABOi kidney transplantation with a focus on desensitization strategies and respective outcomes. | ||
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author | Morath, Christian, Zeier, Martin, Döhler, Bernd, Opelz, Gerhard, Süsal, Caner |
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contents | ABO incompatible (ABOi) kidney transplantation has long been considered a contraindication to successful kidney transplantation. During the last 25 years, increasing organ shortage enforced the development of strategies to overcome the ABO antibody barrier. In the meantime, ABOi kidney transplantation has become a routine procedure with death-censored graft survival rates comparable to the rates in compatible transplantations. Desensitization is usually achieved by apheresis and B cell-depleting therapies that are accompanied by powerful immunosuppression. Anti-A/B antibodies are aimed to be below a certain threshold at the time of ABOi kidney transplantation and during the first two weeks after surgery. Thereafter, even a rebound of anti-A/B antibodies does not appear to harm the kidney transplant, a phenomenon that is called accommodation, but is poorly understood. There is still concern, however, that infectious complications such as viral disease, Pneumocystis jirovecii pneumonia and severe urinary tract infections are increased after ABOi transplantations. Recent data from the Collaborative Transplant Study (CTS) show that during the first year after kidney transplantation, one additional patient death from an infectious complication occurs in 100 ABOi kidney transplant recipients. Herein, we review the recent evidence on ABOi kidney transplantation with a focus on desensitization strategies and respective outcomes. |
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spelling | Morath, Christian 1973- VerfasserIn (DE-588)124036155 (DE-627)085595837 (DE-576)293989923 aut, ABO-Incompatible kidney transplantation Christian Morath, Martin Zeier, Bernd Döhler, Gerhard Opelz, Caner Süsal, 06 March 2017, 7, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 08.05.2018, ABO incompatible (ABOi) kidney transplantation has long been considered a contraindication to successful kidney transplantation. During the last 25 years, increasing organ shortage enforced the development of strategies to overcome the ABO antibody barrier. In the meantime, ABOi kidney transplantation has become a routine procedure with death-censored graft survival rates comparable to the rates in compatible transplantations. Desensitization is usually achieved by apheresis and B cell-depleting therapies that are accompanied by powerful immunosuppression. Anti-A/B antibodies are aimed to be below a certain threshold at the time of ABOi kidney transplantation and during the first two weeks after surgery. Thereafter, even a rebound of anti-A/B antibodies does not appear to harm the kidney transplant, a phenomenon that is called accommodation, but is poorly understood. There is still concern, however, that infectious complications such as viral disease, Pneumocystis jirovecii pneumonia and severe urinary tract infections are increased after ABOi transplantations. Recent data from the Collaborative Transplant Study (CTS) show that during the first year after kidney transplantation, one additional patient death from an infectious complication occurs in 100 ABOi kidney transplant recipients. Herein, we review the recent evidence on ABOi kidney transplantation with a focus on desensitization strategies and respective outcomes., ABO incompatible, Antibodies, Desensitization, Kidney Transplantation, Survival, Zeier, Martin VerfasserIn (DE-588)1026480302 (DE-627)726772356 (DE-576)371826438 aut, Döhler, Bernd VerfasserIn (DE-588)1121948634 (DE-627)875040691 (DE-576)481065997 aut, Opelz, Gerhard 1944- VerfasserIn (DE-588)1026480345 (DE-627)726772453 (DE-576)371826527 aut, Süsal, Caner VerfasserIn (DE-588)102648037X (DE-627)726772763 (DE-576)37182673X aut, Enthalten in Frontiers in immunology Lausanne : Frontiers Media, 2010 8(2017) Artikel-Nummer 234, 7 Seiten Online-Ressource (DE-627)657998354 (DE-600)2606827-8 (DE-576)343624834 1664-3224 nnns, volume:8 year:2017 extent:7, http://dx.doi.org/10.3389/fimmu.2017.00234 Verlag Resolving-System kostenfrei Volltext, https://www.frontiersin.org/articles/10.3389/fimmu.2017.00234/full Verlag kostenfrei Volltext, http://dx.doi.org/10.3389/fimmu.2017.00234 LFER, LFER 2018-05-17T00:00:00Z |
spellingShingle | Morath, Christian, Zeier, Martin, Döhler, Bernd, Opelz, Gerhard, Süsal, Caner, ABO-Incompatible kidney transplantation, ABO incompatible (ABOi) kidney transplantation has long been considered a contraindication to successful kidney transplantation. During the last 25 years, increasing organ shortage enforced the development of strategies to overcome the ABO antibody barrier. In the meantime, ABOi kidney transplantation has become a routine procedure with death-censored graft survival rates comparable to the rates in compatible transplantations. Desensitization is usually achieved by apheresis and B cell-depleting therapies that are accompanied by powerful immunosuppression. Anti-A/B antibodies are aimed to be below a certain threshold at the time of ABOi kidney transplantation and during the first two weeks after surgery. Thereafter, even a rebound of anti-A/B antibodies does not appear to harm the kidney transplant, a phenomenon that is called accommodation, but is poorly understood. There is still concern, however, that infectious complications such as viral disease, Pneumocystis jirovecii pneumonia and severe urinary tract infections are increased after ABOi transplantations. Recent data from the Collaborative Transplant Study (CTS) show that during the first year after kidney transplantation, one additional patient death from an infectious complication occurs in 100 ABOi kidney transplant recipients. Herein, we review the recent evidence on ABOi kidney transplantation with a focus on desensitization strategies and respective outcomes., ABO incompatible, Antibodies, Desensitization, Kidney Transplantation, Survival |
swb_id_str | 504242989 |
title | ABO-Incompatible kidney transplantation |
title_auth | ABO-Incompatible kidney transplantation |
title_full | ABO-Incompatible kidney transplantation Christian Morath, Martin Zeier, Bernd Döhler, Gerhard Opelz, Caner Süsal |
title_fullStr | ABO-Incompatible kidney transplantation Christian Morath, Martin Zeier, Bernd Döhler, Gerhard Opelz, Caner Süsal |
title_full_unstemmed | ABO-Incompatible kidney transplantation Christian Morath, Martin Zeier, Bernd Döhler, Gerhard Opelz, Caner Süsal |
title_in_hierarchy | ABO-Incompatible kidney transplantation / Christian Morath, Martin Zeier, Bernd Döhler, Gerhard Opelz, Caner Süsal, |
title_short | ABO-Incompatible kidney transplantation |
title_sort | abo incompatible kidney transplantation |
topic | ABO incompatible, Antibodies, Desensitization, Kidney Transplantation, Survival |
topic_facet | ABO incompatible, Antibodies, Desensitization, Kidney Transplantation, Survival |
url | http://dx.doi.org/10.3389/fimmu.2017.00234, https://www.frontiersin.org/articles/10.3389/fimmu.2017.00234/full |