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Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia
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Veröffentlicht in: | Nature Communications 9(2018) Artikel-Nummer 1340, 9 Seiten |
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Personen und Körperschaften: | , , , , , , |
Titel: | Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia/ Jayaram Vijayakrishnan, James Studd, Peter Broderick, Ben Kinnersley, Amy Holroyd, Philip J. Law, Rajiv Kumar, James M. Allan, Christine J. Harrison, Anthony V. Moorman, Ajay Vora, Eve Roman, Sivaramakrishna Rachakonda, Sally E. Kinsey, Eamonn Sheridan, Pamela D. Thompson, Julie A. Irving, Rolf Koehler, Per Hoffmann, Markus M. Nöthen, Stefanie Heilmann-Heimbach, Karl-Heinz Jöckel, Douglas F. Easton, Paul D.P. Pharaoh, Alison M. Dunning, Julian Peto, Frederico Canzian, Anthony Swerdlow, Rosalind A. Eeles, ZSofia Kote-Jarai, Kenneth Muir, Nora Pashayan, the PRACTICAL consortium, Mel Greaves, Martin Zimmerman, Claus R. Bartram, Martin Schrappe, Martin Stanulla, Kari Hemminki & Richard S. Houlston |
Format: | E-Book-Kapitel |
Sprache: | Englisch |
veröffentlicht: |
2018
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Gesamtaufnahme: |
: Nature Communications, 9(2018) Artikel-Nummer 1340, 9 Seiten
, volume:9 |
Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
Errata: |
Vijayakrishnan, Jayaram: Author correction |
Zusammenfassung: | Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology. |
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Beschreibung: |
Gesehen am 07.03.2019 Hermann Brenner is a member of the PRACTICAL consortium |
Umfang: | 9 |
ISSN: |
2041-1723
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DOI: | 10.1038/s41467-018-03178-z |