Eintrag weiter verarbeiten
IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration
Gespeichert in:
| Veröffentlicht in: | Scientific reports 7(2017) Artikel-Nummer 16847, 9 Seiten |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , |
| Titel: | IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration/ Ilja Ovsiy, Vladimir Riabov, Ioannis Manousaridis, Julia Michel, Kondaiah Moganti, Shuiping Yin, Tengfei Liu, Carsten Sticht, Sergij Goerdt, Alexei Gratchev, Julia Kzhyshkowska |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
04 December 2017
|
| Gesamtaufnahme: |
: Scientific reports, 7(2017) Artikel-Nummer 16847, 9 Seiten
, volume:7 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
| LEADER | 04572caa a2200721 4500 | ||
|---|---|---|---|
| 001 | 0-1572408561 | ||
| 003 | DE-627 | ||
| 005 | 20220814124322.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180426s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41598-017-17307-z |2 doi | |
| 035 | |a (DE-627)1572408561 | ||
| 035 | |a (DE-576)502408561 | ||
| 035 | |a (DE-599)BSZ502408561 | ||
| 035 | |a (OCoLC)1341007394 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ovsiy, Ilja |d 1984- |e VerfasserIn |0 (DE-588)1037383893 |0 (DE-627)755553624 |0 (DE-576)391395963 |4 aut | |
| 245 | 1 | 0 | |a IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration |c Ilja Ovsiy, Vladimir Riabov, Ioannis Manousaridis, Julia Michel, Kondaiah Moganti, Shuiping Yin, Tengfei Liu, Carsten Sticht, Sergij Goerdt, Alexei Gratchev, Julia Kzhyshkowska |
| 264 | 1 | |c 04 December 2017 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 26.04.2018 | ||
| 520 | |a Monocytes are actively recruited at sites of chronic inflammation. However, molecular factors involved in this process are not fully elucidated. Here, we show that cytokine IL-4 which is implicated in the development of chronic inflammatory disease atopic dermatitis (AD) induces expression of transcription factor FoxQ1 in human monocytes and macrophages. FoxQ1 mRNA levels were elevated in monocytes of AD patients compared to healthy donors. Overexpression of FoxQ1 in RAW 264.7 monocytic cells facilitated their migration towards MCP-1 and was associated with decreased expression of migration-regulating genes (claudin 11 and plexin C1). Furthermore, FoxQ1 overexpression in RAW cells accelerated TNFα secretion after LPS challenge. Overall, our results indicate that FoxQ1 stimulates monocyte motility, increases pro-inflammatory potential, and directs monocyte migration towards MCP-1 that is crucial for monocyte influx into inflammatory sites. This mechanism could contribute to the pathogenesis of chronic inflammatory disorders such as AD. | ||
| 700 | 1 | |a Riabov, Vladimir |d 1983- |e VerfasserIn |0 (DE-588)1018515623 |0 (DE-627)690621361 |0 (DE-576)354034561 |4 aut | |
| 700 | 1 | |a Manousaridis, Ioannis |d 1983- |e VerfasserIn |0 (DE-588)140123148 |0 (DE-627)616035470 |0 (DE-576)314688749 |4 aut | |
| 700 | 1 | |a Michel, Julia |e VerfasserIn |0 (DE-588)1057943002 |0 (DE-627)795558546 |0 (DE-576)413947505 |4 aut | |
| 700 | 1 | |a Moganti, Kondaiah |d 1985- |e VerfasserIn |0 (DE-588)114079017X |0 (DE-627)898682355 |0 (DE-576)494041846 |4 aut | |
| 700 | 1 | |a Yin, Shuiping |d 1987- |e VerfasserIn |0 (DE-588)1140791230 |0 (DE-627)898684757 |0 (DE-576)494044128 |4 aut | |
| 700 | 1 | |a Liu, Tengfei |d 1987- |e VerfasserIn |0 (DE-588)1143873831 |0 (DE-627)1003436544 |0 (DE-576)495200980 |4 aut | |
| 700 | 1 | |a Sticht, Carsten |d 1972- |e VerfasserIn |0 (DE-588)1020115718 |0 (DE-627)691110077 |0 (DE-576)250042177 |4 aut | |
| 700 | 1 | |a Goerdt, Sergij |d 1954- |e VerfasserIn |0 (DE-588)1027602177 |0 (DE-627)729460010 |0 (DE-576)373451512 |4 aut | |
| 700 | 1 | |a Gratchev, Alexei |d 1972- |e VerfasserIn |0 (DE-588)1033448753 |0 (DE-627)741239019 |0 (DE-576)381048675 |4 aut | |
| 700 | 1 | |a Kzhyshkowska, Julia |d 1967- |e VerfasserIn |0 (DE-588)102414271X |0 (DE-627)719213754 |0 (DE-576)368002233 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Scientific reports |d [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 |g 7(2017) Artikel-Nummer 16847, 9 Seiten |h Online-Ressource |w (DE-627)663366712 |w (DE-600)2615211-3 |w (DE-576)346641179 |x 2045-2322 |7 nnns |
| 773 | 1 | 8 | |g volume:7 |g year:2017 |g extent:9 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41598-017-17307-z |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41598-017-17307-z |x Verlag |z kostenfrei |3 Volltext |
| 936 | u | w | |d 7 |j 2017 |g 9 |y 7(2017) Artikel-Nummer 16847, 9 Seiten |
| 951 | |a AR | ||
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41598-017-17307-z |9 LFER |
| 852 | |a LFER |z 2018-06-06T00:00:00Z | ||
| 970 | |c OD | ||
| 971 | |c EBOOK | ||
| 972 | |c EBOOK | ||
| 973 | |c Aufsatz | ||
| 935 | |a lfer | ||
| 900 | |a Tengfei, Liu | ||
| 900 | |a Kzhyshkowska, Julia G. | ||
| 900 | |a Kzhyshkovska, J. G. | ||
| 900 | |a Kzhyshkovska, Ju. G. | ||
| 900 | |a Kzhyshkowska, J. | ||
| 900 | |a Kzhyhskowska, Yu. G. | ||
| 900 | |a Kzhyshkowska, Yu. G. | ||
| 900 | |a Shuiping, Yin | ||
| 900 | |a Manousaridis, I. | ||
| 900 | |a Sticht, C. | ||
| 900 | |a Goerdt, S. | ||
| 900 | |a Michel, J. | ||
| 951 | |b XA-DE | ||
| 980 | |a 1572408561 |b 0 |k 1572408561 |o 502408561 |c lfer | ||
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=IL-4+driven+transcription+factor+FoxQ1+is+expressed+by+monocytes+in+atopic+dermatitis+and+stimulates+monocyte+migration&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.creator=Ovsiy%2C+Ilja&rft.pub=&rft.format=Journal&rft.language=English&rft.issn=2045-2322 |
|---|
| _version_ | 1757949477935644672 |
|---|---|
| access_facet | Electronic Resources |
| author | Ovsiy, Ilja, Riabov, Vladimir, Manousaridis, Ioannis, Michel, Julia, Moganti, Kondaiah, Yin, Shuiping, Liu, Tengfei, Sticht, Carsten, Goerdt, Sergij, Gratchev, Alexei, Kzhyshkowska, Julia |
| author_facet | Ovsiy, Ilja, Riabov, Vladimir, Manousaridis, Ioannis, Michel, Julia, Moganti, Kondaiah, Yin, Shuiping, Liu, Tengfei, Sticht, Carsten, Goerdt, Sergij, Gratchev, Alexei, Kzhyshkowska, Julia |
| author_role | aut, aut, aut, aut, aut, aut, aut, aut, aut, aut, aut |
| author_sort | Ovsiy, Ilja 1984- |
| author_variant | i o io, v r vr, i m im, j m jm, k m km, s y sy, t l tl, c s cs, s g sg, a g ag, j k jk |
| callnumber-sort | |
| collection | lfer |
| container_reference | 7(2017) Artikel-Nummer 16847, 9 Seiten |
| container_title | Scientific reports |
| contents | Monocytes are actively recruited at sites of chronic inflammation. However, molecular factors involved in this process are not fully elucidated. Here, we show that cytokine IL-4 which is implicated in the development of chronic inflammatory disease atopic dermatitis (AD) induces expression of transcription factor FoxQ1 in human monocytes and macrophages. FoxQ1 mRNA levels were elevated in monocytes of AD patients compared to healthy donors. Overexpression of FoxQ1 in RAW 264.7 monocytic cells facilitated their migration towards MCP-1 and was associated with decreased expression of migration-regulating genes (claudin 11 and plexin C1). Furthermore, FoxQ1 overexpression in RAW cells accelerated TNFα secretion after LPS challenge. Overall, our results indicate that FoxQ1 stimulates monocyte motility, increases pro-inflammatory potential, and directs monocyte migration towards MCP-1 that is crucial for monocyte influx into inflammatory sites. This mechanism could contribute to the pathogenesis of chronic inflammatory disorders such as AD. |
| ctrlnum | (DE-627)1572408561, (DE-576)502408561, (DE-599)BSZ502408561, (OCoLC)1341007394 |
| doi_str_mv | 10.1038/s41598-017-17307-z |
| facet_avail | Online, Free |
| finc_class_facet | not assigned |
| finc_id_str | 0021125657 |
| footnote | Gesehen am 26.04.2018 |
| format | ElectronicBookComponentPart |
| format_access_txtF_mv | Article, E-Article |
| format_de105 | Ebook |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_del152 | Buch |
| format_detail_txtF_mv | text-online-monograph-child |
| format_dezi4 | e-Book |
| format_finc | Article, E-Article |
| format_legacy | ElectronicBookPart |
| format_strict_txtF_mv | E-Article |
| geogr_code | not assigned |
| geogr_code_person | Germany |
| hierarchy_parent_id | 0-663366712 |
| hierarchy_parent_title | Scientific reports |
| hierarchy_sequence | 7(2017) Artikel-Nummer 16847, 9 Seiten |
| hierarchy_top_id | 0-663366712 |
| hierarchy_top_title | Scientific reports |
| id | 0-1572408561 |
| illustrated | Not Illustrated |
| imprint | 04 December 2017 |
| imprint_str_mv | 04 December 2017 |
| institution | DE-D117, DE-105, LFER, DE-Ch1, DE-15, DE-14, DE-Zwi2 |
| is_hierarchy_id | 0-1572408561 |
| is_hierarchy_title | IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration |
| isil_str_mv | LFER |
| issn | 2045-2322 |
| kxp_id_str | 1572408561 |
| language | English |
| last_indexed | 2023-02-16T01:34:26.025Z |
| marc024a_ct_mv | 10.1038/s41598-017-17307-z |
| match_str | ovsiy2017il4driventranscriptionfactorfoxq1isexpressedbymonocytesinatopicdermatitisandstimulatesmonocytemigration |
| mega_collection | Verbunddaten SWB, Lizenzfreie Online-Ressourcen |
| misc_de105 | EBOOK |
| multipart_link | 346641179 |
| multipart_part | (346641179)7(2017) Artikel-Nummer 16847, 9 Seiten |
| names_id_str_mv | (DE-588)1037383893, (DE-627)755553624, (DE-576)391395963, (DE-588)1018515623, (DE-627)690621361, (DE-576)354034561, (DE-588)140123148, (DE-627)616035470, (DE-576)314688749, (DE-588)1057943002, (DE-627)795558546, (DE-576)413947505, (DE-588)114079017X, (DE-627)898682355, (DE-576)494041846, (DE-588)1140791230, (DE-627)898684757, (DE-576)494044128, (DE-588)1143873831, (DE-627)1003436544, (DE-576)495200980, (DE-588)1020115718, (DE-627)691110077, (DE-576)250042177, (DE-588)1027602177, (DE-627)729460010, (DE-576)373451512, (DE-588)1033448753, (DE-627)741239019, (DE-576)381048675, (DE-588)102414271X, (DE-627)719213754, (DE-576)368002233 |
| oclc_num | 1341007394 |
| physical | 9 |
| publishDate | 04 December 2017 |
| publishDateSort | 2017 |
| publishPlace | |
| publisher | |
| record_format | marcfinc |
| record_id | 502408561 |
| recordtype | marcfinc |
| rvk_facet | No subject assigned |
| source_id | 0 |
| spelling | Ovsiy, Ilja 1984- VerfasserIn (DE-588)1037383893 (DE-627)755553624 (DE-576)391395963 aut, IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration Ilja Ovsiy, Vladimir Riabov, Ioannis Manousaridis, Julia Michel, Kondaiah Moganti, Shuiping Yin, Tengfei Liu, Carsten Sticht, Sergij Goerdt, Alexei Gratchev, Julia Kzhyshkowska, 04 December 2017, 9, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 26.04.2018, Monocytes are actively recruited at sites of chronic inflammation. However, molecular factors involved in this process are not fully elucidated. Here, we show that cytokine IL-4 which is implicated in the development of chronic inflammatory disease atopic dermatitis (AD) induces expression of transcription factor FoxQ1 in human monocytes and macrophages. FoxQ1 mRNA levels were elevated in monocytes of AD patients compared to healthy donors. Overexpression of FoxQ1 in RAW 264.7 monocytic cells facilitated their migration towards MCP-1 and was associated with decreased expression of migration-regulating genes (claudin 11 and plexin C1). Furthermore, FoxQ1 overexpression in RAW cells accelerated TNFα secretion after LPS challenge. Overall, our results indicate that FoxQ1 stimulates monocyte motility, increases pro-inflammatory potential, and directs monocyte migration towards MCP-1 that is crucial for monocyte influx into inflammatory sites. This mechanism could contribute to the pathogenesis of chronic inflammatory disorders such as AD., Riabov, Vladimir 1983- VerfasserIn (DE-588)1018515623 (DE-627)690621361 (DE-576)354034561 aut, Manousaridis, Ioannis 1983- VerfasserIn (DE-588)140123148 (DE-627)616035470 (DE-576)314688749 aut, Michel, Julia VerfasserIn (DE-588)1057943002 (DE-627)795558546 (DE-576)413947505 aut, Moganti, Kondaiah 1985- VerfasserIn (DE-588)114079017X (DE-627)898682355 (DE-576)494041846 aut, Yin, Shuiping 1987- VerfasserIn (DE-588)1140791230 (DE-627)898684757 (DE-576)494044128 aut, Liu, Tengfei 1987- VerfasserIn (DE-588)1143873831 (DE-627)1003436544 (DE-576)495200980 aut, Sticht, Carsten 1972- VerfasserIn (DE-588)1020115718 (DE-627)691110077 (DE-576)250042177 aut, Goerdt, Sergij 1954- VerfasserIn (DE-588)1027602177 (DE-627)729460010 (DE-576)373451512 aut, Gratchev, Alexei 1972- VerfasserIn (DE-588)1033448753 (DE-627)741239019 (DE-576)381048675 aut, Kzhyshkowska, Julia 1967- VerfasserIn (DE-588)102414271X (DE-627)719213754 (DE-576)368002233 aut, Enthalten in Scientific reports [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 7(2017) Artikel-Nummer 16847, 9 Seiten Online-Ressource (DE-627)663366712 (DE-600)2615211-3 (DE-576)346641179 2045-2322 nnns, volume:7 year:2017 extent:9, http://dx.doi.org/10.1038/s41598-017-17307-z Verlag Resolving-System kostenfrei Volltext, https://www.nature.com/articles/s41598-017-17307-z Verlag kostenfrei Volltext, http://dx.doi.org/10.1038/s41598-017-17307-z LFER, LFER 2018-06-06T00:00:00Z |
| spellingShingle | Ovsiy, Ilja, Riabov, Vladimir, Manousaridis, Ioannis, Michel, Julia, Moganti, Kondaiah, Yin, Shuiping, Liu, Tengfei, Sticht, Carsten, Goerdt, Sergij, Gratchev, Alexei, Kzhyshkowska, Julia, IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration, Monocytes are actively recruited at sites of chronic inflammation. However, molecular factors involved in this process are not fully elucidated. Here, we show that cytokine IL-4 which is implicated in the development of chronic inflammatory disease atopic dermatitis (AD) induces expression of transcription factor FoxQ1 in human monocytes and macrophages. FoxQ1 mRNA levels were elevated in monocytes of AD patients compared to healthy donors. Overexpression of FoxQ1 in RAW 264.7 monocytic cells facilitated their migration towards MCP-1 and was associated with decreased expression of migration-regulating genes (claudin 11 and plexin C1). Furthermore, FoxQ1 overexpression in RAW cells accelerated TNFα secretion after LPS challenge. Overall, our results indicate that FoxQ1 stimulates monocyte motility, increases pro-inflammatory potential, and directs monocyte migration towards MCP-1 that is crucial for monocyte influx into inflammatory sites. This mechanism could contribute to the pathogenesis of chronic inflammatory disorders such as AD. |
| swb_id_str | 502408561 |
| title | IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration |
| title_auth | IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration |
| title_full | IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration Ilja Ovsiy, Vladimir Riabov, Ioannis Manousaridis, Julia Michel, Kondaiah Moganti, Shuiping Yin, Tengfei Liu, Carsten Sticht, Sergij Goerdt, Alexei Gratchev, Julia Kzhyshkowska |
| title_fullStr | IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration Ilja Ovsiy, Vladimir Riabov, Ioannis Manousaridis, Julia Michel, Kondaiah Moganti, Shuiping Yin, Tengfei Liu, Carsten Sticht, Sergij Goerdt, Alexei Gratchev, Julia Kzhyshkowska |
| title_full_unstemmed | IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration Ilja Ovsiy, Vladimir Riabov, Ioannis Manousaridis, Julia Michel, Kondaiah Moganti, Shuiping Yin, Tengfei Liu, Carsten Sticht, Sergij Goerdt, Alexei Gratchev, Julia Kzhyshkowska |
| title_in_hierarchy | IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration / Ilja Ovsiy, Vladimir Riabov, Ioannis Manousaridis, Julia Michel, Kondaiah Moganti, Shuiping Yin, Tengfei Liu, Carsten Sticht, Sergij Goerdt, Alexei Gratchev, Julia Kzhyshkowska, |
| title_short | IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration |
| title_sort | il 4 driven transcription factor foxq1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration |
| url | http://dx.doi.org/10.1038/s41598-017-17307-z, https://www.nature.com/articles/s41598-017-17307-z |