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Control of regulatory T cell differentiation by the transcription factors Thpok and LRF
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| Veröffentlicht in: | The journal of immunology 199(2017), 5, Seite 1716-1728 |
|---|---|
| Personen und Körperschaften: | , |
| Titel: | Control of regulatory T cell differentiation by the transcription factors Thpok and LRF/ Andrea C. Carpenter, Elizabeth Wohlfert, Laura B. Chopp, Melanie S. Vacchio, Jia Nie, Yongmei Zhao, Jyoti Shetty, Qi Xiao, Callie Deng, Bao Tran, Margaret Cam, Matthias M. Gaida, Yasmine Belkaid, Rémy Bosselut |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
September 1, 2017
|
| Gesamtaufnahme: |
: The journal of immunology, 199(2017), 5, Seite 1716-1728
, volume:199 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 0 | |a Control of regulatory T cell differentiation by the transcription factors Thpok and LRF |c Andrea C. Carpenter, Elizabeth Wohlfert, Laura B. Chopp, Melanie S. Vacchio, Jia Nie, Yongmei Zhao, Jyoti Shetty, Qi Xiao, Callie Deng, Bao Tran, Margaret Cam, Matthias M. Gaida, Yasmine Belkaid, Rémy Bosselut |
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| 520 | |a The CD4+ lineage-specific transcription factor Thpok is required for intrathymic CD4+ T cell differentiation and, together with its homolog LRF, supports CD4+ T cell helper effector responses. However, it is not known whether these factors are needed for the regulatory T cell (Treg) arm of MHC class II responses. In this study, by inactivating in mice the genes encoding both factors in differentiated Tregs, we show that Thpok and LRF are redundantly required to maintain the size and functions of the postthymic Treg pool. They support IL-2-mediated gene expression and the functions of the Treg-specific factor Foxp3. Accordingly, Treg-specific disruption of Thpok and Lrf causes a lethal inflammatory syndrome similar to that resulting from Treg deficiency. Unlike in conventional T cells, Thpok and LRF functions in Tregs are not mediated by their repression of the transcription factor Runx3. Additionally, we found that Thpok is needed for the differentiation of thymic Treg precursors, an observation in line with the fact that Foxp3+ Tregs are CD4+ cells. Thus, a common Thpok-LRF node supports both helper and regulatory arms of MHC class II responses. | ||
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| contents | The CD4+ lineage-specific transcription factor Thpok is required for intrathymic CD4+ T cell differentiation and, together with its homolog LRF, supports CD4+ T cell helper effector responses. However, it is not known whether these factors are needed for the regulatory T cell (Treg) arm of MHC class II responses. In this study, by inactivating in mice the genes encoding both factors in differentiated Tregs, we show that Thpok and LRF are redundantly required to maintain the size and functions of the postthymic Treg pool. They support IL-2-mediated gene expression and the functions of the Treg-specific factor Foxp3. Accordingly, Treg-specific disruption of Thpok and Lrf causes a lethal inflammatory syndrome similar to that resulting from Treg deficiency. Unlike in conventional T cells, Thpok and LRF functions in Tregs are not mediated by their repression of the transcription factor Runx3. Additionally, we found that Thpok is needed for the differentiation of thymic Treg precursors, an observation in line with the fact that Foxp3+ Tregs are CD4+ cells. Thus, a common Thpok-LRF node supports both helper and regulatory arms of MHC class II responses. |
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| spelling | Carpenter, Andrea C. VerfasserIn (DE-588)1156658799 (DE-627)1020125624 (DE-576)502353627 aut, Control of regulatory T cell differentiation by the transcription factors Thpok and LRF Andrea C. Carpenter, Elizabeth Wohlfert, Laura B. Chopp, Melanie S. Vacchio, Jia Nie, Yongmei Zhao, Jyoti Shetty, Qi Xiao, Callie Deng, Bao Tran, Margaret Cam, Matthias M. Gaida, Yasmine Belkaid, Rémy Bosselut, September 1, 2017, 13, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 25.04.2018, The CD4+ lineage-specific transcription factor Thpok is required for intrathymic CD4+ T cell differentiation and, together with its homolog LRF, supports CD4+ T cell helper effector responses. However, it is not known whether these factors are needed for the regulatory T cell (Treg) arm of MHC class II responses. In this study, by inactivating in mice the genes encoding both factors in differentiated Tregs, we show that Thpok and LRF are redundantly required to maintain the size and functions of the postthymic Treg pool. They support IL-2-mediated gene expression and the functions of the Treg-specific factor Foxp3. Accordingly, Treg-specific disruption of Thpok and Lrf causes a lethal inflammatory syndrome similar to that resulting from Treg deficiency. Unlike in conventional T cells, Thpok and LRF functions in Tregs are not mediated by their repression of the transcription factor Runx3. Additionally, we found that Thpok is needed for the differentiation of thymic Treg precursors, an observation in line with the fact that Foxp3+ Tregs are CD4+ cells. Thus, a common Thpok-LRF node supports both helper and regulatory arms of MHC class II responses., Gaida, Matthias 1982- VerfasserIn (DE-588)139102620 (DE-627)703207377 (DE-576)309804523 aut, Enthalten in The journal of immunology Bethesda, Md. : Soc., 1916 199(2017), 5, Seite 1716-1728 Online-Ressource (DE-627)269535217 (DE-600)1475085-5 (DE-576)079963838 1550-6606 nnns, volume:199 year:2017 number:5 pages:1716-1728 extent:13, http://dx.doi.org/10.4049/jimmunol.1700181 Verlag Resolving-System kostenfrei Volltext, http://www.jimmunol.org/content/199/5/1716 Verlag kostenfrei Volltext, http://dx.doi.org/10.4049/jimmunol.1700181 LFER, LFER 2018-05-17T00:00:00Z |
| spellingShingle | Carpenter, Andrea C., Gaida, Matthias, Control of regulatory T cell differentiation by the transcription factors Thpok and LRF, The CD4+ lineage-specific transcription factor Thpok is required for intrathymic CD4+ T cell differentiation and, together with its homolog LRF, supports CD4+ T cell helper effector responses. However, it is not known whether these factors are needed for the regulatory T cell (Treg) arm of MHC class II responses. In this study, by inactivating in mice the genes encoding both factors in differentiated Tregs, we show that Thpok and LRF are redundantly required to maintain the size and functions of the postthymic Treg pool. They support IL-2-mediated gene expression and the functions of the Treg-specific factor Foxp3. Accordingly, Treg-specific disruption of Thpok and Lrf causes a lethal inflammatory syndrome similar to that resulting from Treg deficiency. Unlike in conventional T cells, Thpok and LRF functions in Tregs are not mediated by their repression of the transcription factor Runx3. Additionally, we found that Thpok is needed for the differentiation of thymic Treg precursors, an observation in line with the fact that Foxp3+ Tregs are CD4+ cells. Thus, a common Thpok-LRF node supports both helper and regulatory arms of MHC class II responses. |
| swb_id_str | 502351810 |
| title | Control of regulatory T cell differentiation by the transcription factors Thpok and LRF |
| title_auth | Control of regulatory T cell differentiation by the transcription factors Thpok and LRF |
| title_full | Control of regulatory T cell differentiation by the transcription factors Thpok and LRF Andrea C. Carpenter, Elizabeth Wohlfert, Laura B. Chopp, Melanie S. Vacchio, Jia Nie, Yongmei Zhao, Jyoti Shetty, Qi Xiao, Callie Deng, Bao Tran, Margaret Cam, Matthias M. Gaida, Yasmine Belkaid, Rémy Bosselut |
| title_fullStr | Control of regulatory T cell differentiation by the transcription factors Thpok and LRF Andrea C. Carpenter, Elizabeth Wohlfert, Laura B. Chopp, Melanie S. Vacchio, Jia Nie, Yongmei Zhao, Jyoti Shetty, Qi Xiao, Callie Deng, Bao Tran, Margaret Cam, Matthias M. Gaida, Yasmine Belkaid, Rémy Bosselut |
| title_full_unstemmed | Control of regulatory T cell differentiation by the transcription factors Thpok and LRF Andrea C. Carpenter, Elizabeth Wohlfert, Laura B. Chopp, Melanie S. Vacchio, Jia Nie, Yongmei Zhao, Jyoti Shetty, Qi Xiao, Callie Deng, Bao Tran, Margaret Cam, Matthias M. Gaida, Yasmine Belkaid, Rémy Bosselut |
| title_in_hierarchy | Control of regulatory T cell differentiation by the transcription factors Thpok and LRF / Andrea C. Carpenter, Elizabeth Wohlfert, Laura B. Chopp, Melanie S. Vacchio, Jia Nie, Yongmei Zhao, Jyoti Shetty, Qi Xiao, Callie Deng, Bao Tran, Margaret Cam, Matthias M. Gaida, Yasmine Belkaid, Rémy Bosselut, |
| title_short | Control of regulatory T cell differentiation by the transcription factors Thpok and LRF |
| title_sort | control of regulatory t cell differentiation by the transcription factors thpok and lrf |
| url | http://dx.doi.org/10.4049/jimmunol.1700181, http://www.jimmunol.org/content/199/5/1716 |