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GenomeCRISPR: a database for high-throughput CRISPR/Cas9 screens
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| Veröffentlicht in: | Nucleic acids research 45(2017), Database issue, Seite D679-D686 |
|---|---|
| Personen und Körperschaften: | , , , , |
| Titel: | GenomeCRISPR: a database for high-throughput CRISPR/Cas9 screens/ Benedikt Rauscher, Florian Heigwer, Marco Breinig, Jan Winter and Michael Boutros |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
2017
|
| Gesamtaufnahme: |
: Nucleic acids research, 45(2017), Database issue, Seite D679-D686
, volume:45 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 520 | |a Over the past years, CRISPR/Cas9 mediated genome editing has developed into a powerful tool for modifying genomes in various organisms. In high-throughput screens, CRISPR/Cas9 mediated gene perturbations can be used for the systematic functional analysis of whole genomes. Discoveries from such screens provide a wealth of knowledge about gene to phenotype relationships in various biological model systems. However, a database resource to query results efficiently has been lacking. To this end, we developed GenomeCRISPR (http://genomecrispr.org), a database for genome-scale CRISPR/Cas9 screens. Currently, GenomeCRISPR contains data on more than 550 000 single guide RNAs (sgRNA) derived from 84 different experiments performed in 48 different human cell lines, comprising all screens in human cells using CRISPR/Cas published to date. GenomeCRISPR provides data mining options and tools, such as gene or genomic region search. Phenotypic and genome track views allow users to investigate and compare the results of different screens, or the impact of different sgRNAs on the gene of interest. An Application Programming Interface (API) allows for automated data access and batch download. As more screening data will become available, we also aim at extending the database to include functional genomic data from other organisms and enable cross-species comparisons. | ||
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| contents | Over the past years, CRISPR/Cas9 mediated genome editing has developed into a powerful tool for modifying genomes in various organisms. In high-throughput screens, CRISPR/Cas9 mediated gene perturbations can be used for the systematic functional analysis of whole genomes. Discoveries from such screens provide a wealth of knowledge about gene to phenotype relationships in various biological model systems. However, a database resource to query results efficiently has been lacking. To this end, we developed GenomeCRISPR (http://genomecrispr.org), a database for genome-scale CRISPR/Cas9 screens. Currently, GenomeCRISPR contains data on more than 550 000 single guide RNAs (sgRNA) derived from 84 different experiments performed in 48 different human cell lines, comprising all screens in human cells using CRISPR/Cas published to date. GenomeCRISPR provides data mining options and tools, such as gene or genomic region search. Phenotypic and genome track views allow users to investigate and compare the results of different screens, or the impact of different sgRNAs on the gene of interest. An Application Programming Interface (API) allows for automated data access and batch download. As more screening data will become available, we also aim at extending the database to include functional genomic data from other organisms and enable cross-species comparisons. |
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| spelling | Rauscher, Benedikt 1990- VerfasserIn (DE-588)115648877X (DE-627)1019302666 (DE-576)502212357 aut, GenomeCRISPR a database for high-throughput CRISPR/Cas9 screens Benedikt Rauscher, Florian Heigwer, Marco Breinig, Jan Winter and Michael Boutros, 2017, 8, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Published online 26 October 2016, Gesehen am 20.04.2018, Over the past years, CRISPR/Cas9 mediated genome editing has developed into a powerful tool for modifying genomes in various organisms. In high-throughput screens, CRISPR/Cas9 mediated gene perturbations can be used for the systematic functional analysis of whole genomes. Discoveries from such screens provide a wealth of knowledge about gene to phenotype relationships in various biological model systems. However, a database resource to query results efficiently has been lacking. To this end, we developed GenomeCRISPR (http://genomecrispr.org), a database for genome-scale CRISPR/Cas9 screens. Currently, GenomeCRISPR contains data on more than 550 000 single guide RNAs (sgRNA) derived from 84 different experiments performed in 48 different human cell lines, comprising all screens in human cells using CRISPR/Cas published to date. GenomeCRISPR provides data mining options and tools, such as gene or genomic region search. Phenotypic and genome track views allow users to investigate and compare the results of different screens, or the impact of different sgRNAs on the gene of interest. An Application Programming Interface (API) allows for automated data access and batch download. As more screening data will become available, we also aim at extending the database to include functional genomic data from other organisms and enable cross-species comparisons., Heigwer, Florian VerfasserIn (DE-588)1110981589 (DE-627)865935963 (DE-576)475858867 aut, Breinig, Marco VerfasserIn (DE-588)141226749 (DE-627)703917579 (DE-576)322839637 aut, Winter, Jan 1986- VerfasserIn (DE-588)1156489164 (DE-627)1019303050 (DE-576)502212500 aut, Boutros, Michael VerfasserIn (DE-588)1023031132 (DE-627)717350045 (DE-576)366291831 aut, Enthalten in Nucleic acids research Oxford : Oxford Univ. Press, 1974 45(2017), Database issue, Seite D679-D686 Online-Ressource (DE-627)26813250X (DE-600)1472175-2 (DE-576)07760878X 1362-4962 nnns, volume:45 year:2017 number:Database issue pages:D679-D686 extent:8, http://dx.doi.org/10.1093/nar/gkw997 Verlag Resolving-System kostenfrei Volltext, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210668/ Verlag kostenfrei Volltext, http://dx.doi.org/10.1093/nar/gkw997 LFER, LFER 2018-05-17T00:00:00Z |
| spellingShingle | Rauscher, Benedikt, Heigwer, Florian, Breinig, Marco, Winter, Jan, Boutros, Michael, GenomeCRISPR: a database for high-throughput CRISPR/Cas9 screens, Over the past years, CRISPR/Cas9 mediated genome editing has developed into a powerful tool for modifying genomes in various organisms. In high-throughput screens, CRISPR/Cas9 mediated gene perturbations can be used for the systematic functional analysis of whole genomes. Discoveries from such screens provide a wealth of knowledge about gene to phenotype relationships in various biological model systems. However, a database resource to query results efficiently has been lacking. To this end, we developed GenomeCRISPR (http://genomecrispr.org), a database for genome-scale CRISPR/Cas9 screens. Currently, GenomeCRISPR contains data on more than 550 000 single guide RNAs (sgRNA) derived from 84 different experiments performed in 48 different human cell lines, comprising all screens in human cells using CRISPR/Cas published to date. GenomeCRISPR provides data mining options and tools, such as gene or genomic region search. Phenotypic and genome track views allow users to investigate and compare the results of different screens, or the impact of different sgRNAs on the gene of interest. An Application Programming Interface (API) allows for automated data access and batch download. As more screening data will become available, we also aim at extending the database to include functional genomic data from other organisms and enable cross-species comparisons. |
| swb_id_str | 502212594 |
| title | GenomeCRISPR: a database for high-throughput CRISPR/Cas9 screens |
| title_auth | GenomeCRISPR a database for high-throughput CRISPR/Cas9 screens |
| title_full | GenomeCRISPR a database for high-throughput CRISPR/Cas9 screens Benedikt Rauscher, Florian Heigwer, Marco Breinig, Jan Winter and Michael Boutros |
| title_fullStr | GenomeCRISPR a database for high-throughput CRISPR/Cas9 screens Benedikt Rauscher, Florian Heigwer, Marco Breinig, Jan Winter and Michael Boutros |
| title_full_unstemmed | GenomeCRISPR a database for high-throughput CRISPR/Cas9 screens Benedikt Rauscher, Florian Heigwer, Marco Breinig, Jan Winter and Michael Boutros |
| title_in_hierarchy | GenomeCRISPR: a database for high-throughput CRISPR/Cas9 screens / Benedikt Rauscher, Florian Heigwer, Marco Breinig, Jan Winter and Michael Boutros, |
| title_short | GenomeCRISPR |
| title_sort | genomecrispr a database for high throughput crispr cas9 screens |
| title_sub | a database for high-throughput CRISPR/Cas9 screens |
| url | http://dx.doi.org/10.1093/nar/gkw997, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210668/ |