Eintrag weiter verarbeiten
Identification of shared risk loci and pathways for bipolar disorder and schizophrenia
Gespeichert in:
| Veröffentlicht in: | PLOS ONE 12(2017,2), Artikel-Nummer e0171595, Seite 1-14 |
|---|---|
| Personen und Körperschaften: | , , |
| Titel: | Identification of shared risk loci and pathways for bipolar disorder and schizophrenia/ Andreas J. Forstner, Julian Hecker, Andrea Hofmann, Anna Maaser, Céline S. Reinbold, Thomas W. Mühleisen, Markus Leber, Jana Strohmaier, Franziska Degenhardt, Jens Treutlein, Manuel Mattheisen, Johannes Schumacher, Fabian Streit, Sandra Meier, Stefan Herms, Per Hoffmann, André Lacour, Stephanie H. Witt, Andreas Reif, Bertram Müller-Myhsok, Susanne Lucae, Wolfgang Maier, Markus Schwarz, Helmut Vedder, Jutta Kammerer-Ciernioch, Andrea Pfennig, Michael Bauer, Martin Hautzinger, Susanne Moebus, Lorena M. Schenk, Sascha B. Fischer, Sugirthan Sivalingam, Piotr M. Czerski, Joanna Hauser, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, Paul Brennan, James D. McKay, Adam Wright, Philip B. Mitchell, Janice M. Fullerton, Peter R. Schofield, Grant W. Montgomery, Sarah E. Medland, Scott D. Gordon, Nicholas G. Martin, Valery Krasnov, Alexander Chuchalin, Gulja Babadjanova, Galina Pantelejeva, Lilia I. Abramova, Alexander S. Tiganov, Alexey Polonikov, Elza Khusnutdinova, Martin Alda, Cristiana Cruceanu, Guy A. Rouleau, Gustavo Turecki, Catherine Laprise, Fabio Rivas, Fermin Mayoral, Manolis Kogevinas, Maria Grigoroiu-Serbanescu, Tim Becker, Thomas G. Schulze, Marcella Rietschel, Sven Cichon, Heide Fier, Markus M. Nöthen |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
February 6, 2017
|
| Gesamtaufnahme: |
: PLOS ONE, 12(2017,2), Artikel-Nummer e0171595, Seite 1-14
, volume:12 |
| Schlagwörter: | |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
| LEADER | 05593caa a2200709 4500 | ||
|---|---|---|---|
| 001 | 0-1572201991 | ||
| 003 | DE-627 | ||
| 005 | 20230814094255.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180420s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pone.0171595 |2 doi | |
| 035 | |a (DE-627)1572201991 | ||
| 035 | |a (DE-576)502201991 | ||
| 035 | |a (DE-599)BSZ502201991 | ||
| 035 | |a (OCoLC)1341007461 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 100 | 1 | |a Forstner, Andreas Josef |e VerfasserIn |0 (DE-588)1064967531 |0 (DE-627)815370296 |0 (DE-576)424653702 |4 aut | |
| 245 | 1 | 0 | |a Identification of shared risk loci and pathways for bipolar disorder and schizophrenia |c Andreas J. Forstner, Julian Hecker, Andrea Hofmann, Anna Maaser, Céline S. Reinbold, Thomas W. Mühleisen, Markus Leber, Jana Strohmaier, Franziska Degenhardt, Jens Treutlein, Manuel Mattheisen, Johannes Schumacher, Fabian Streit, Sandra Meier, Stefan Herms, Per Hoffmann, André Lacour, Stephanie H. Witt, Andreas Reif, Bertram Müller-Myhsok, Susanne Lucae, Wolfgang Maier, Markus Schwarz, Helmut Vedder, Jutta Kammerer-Ciernioch, Andrea Pfennig, Michael Bauer, Martin Hautzinger, Susanne Moebus, Lorena M. Schenk, Sascha B. Fischer, Sugirthan Sivalingam, Piotr M. Czerski, Joanna Hauser, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, Paul Brennan, James D. McKay, Adam Wright, Philip B. Mitchell, Janice M. Fullerton, Peter R. Schofield, Grant W. Montgomery, Sarah E. Medland, Scott D. Gordon, Nicholas G. Martin, Valery Krasnov, Alexander Chuchalin, Gulja Babadjanova, Galina Pantelejeva, Lilia I. Abramova, Alexander S. Tiganov, Alexey Polonikov, Elza Khusnutdinova, Martin Alda, Cristiana Cruceanu, Guy A. Rouleau, Gustavo Turecki, Catherine Laprise, Fabio Rivas, Fermin Mayoral, Manolis Kogevinas, Maria Grigoroiu-Serbanescu, Tim Becker, Thomas G. Schulze, Marcella Rietschel, Sven Cichon, Heide Fier, Markus M. Nöthen |
| 264 | 1 | |c February 6, 2017 | |
| 300 | |b Illustrationen | ||
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 20.04.2018 | ||
| 520 | |a Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association study (GWAS) by the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). The present study investigated whether these SCZ-associated SNPs also contribute to BD development through the performance of association testing in a large BD GWAS dataset (9747 patients, 14278 controls). After re-imputation and correction for sample overlap, 22 of 107 investigated SCZ SNPs showed nominal association with BD. The number of shared SCZ-BD SNPs was significantly higher than expected (p = 1.46x10-8). This provides further evidence that SCZ-associated loci contribute to the development of BD. Two SNPs remained significant after Bonferroni correction. The most strongly associated SNP was located near TRANK1, which is a reported genome-wide significant risk gene for BD. Pathway analyses for all shared SCZ-BD SNPs revealed 25 nominally enriched gene-sets, which showed partial overlap in terms of the underlying genes. The enriched gene-sets included calcium- and glutamate signaling, neuropathic pain signaling in dorsal horn neurons, and calmodulin binding. The present data provide further insights into shared risk loci and disease-associated pathways for BD and SCZ. This may suggest new research directions for the treatment and prevention of these two major psychiatric disorders. | ||
| 650 | 4 | |a Bipolar disorder | |
| 650 | 4 | |a Genetic loci | |
| 650 | 4 | |a Genome-wide association studies | |
| 650 | 4 | |a Glutamate | |
| 650 | 4 | |a Meta-analysis | |
| 650 | 4 | |a Molecular genetics | |
| 650 | 4 | |a Schizophrenia | |
| 650 | 4 | |a Test statistics | |
| 700 | 1 | |a Witt, Stephanie |d 1970- |e VerfasserIn |0 (DE-588)132177897 |0 (DE-627)519022432 |0 (DE-576)298988399 |4 aut | |
| 700 | 1 | |a Rietschel, Marcella |d 1957- |e VerfasserIn |0 (DE-588)112785751 |0 (DE-627)505574020 |0 (DE-576)289742307 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t PLOS ONE |d San Francisco, California, US : PLOS, 2006 |g 12(2017,2), Artikel-Nummer e0171595, Seite 1-14 |h Online-Ressource |w (DE-627)523574592 |w (DE-600)2267670-3 |w (DE-576)281331979 |x 1932-6203 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:2017 |g number:2 |g extent:14 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1371/journal.pone.0171595 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171595 |x Verlag |z kostenfrei |3 Volltext |
| 936 | u | w | |d 12 |j 2017 |e 2 |g 14 |y 12(2017,2), Artikel-Nummer e0171595, Seite 1-14 |
| 951 | |a AR | ||
| 856 | 4 | 0 | |u http://dx.doi.org/10.1371/journal.pone.0171595 |9 LFER |
| 852 | |a LFER |z 2018-05-17T00:00:00Z | ||
| 970 | |c OD | ||
| 971 | |c EBOOK | ||
| 972 | |c EBOOK | ||
| 973 | |c Aufsatz | ||
| 935 | |a lfer | ||
| 900 | |a Forstner, Andreas J. | ||
| 900 | |a Forstner, A. J. | ||
| 900 | |a Forstner, Andreas | ||
| 900 | |a Witt, Stephanie H. | ||
| 900 | |a Witt, S. H. | ||
| 900 | |a Witt, S. | ||
| 900 | |a Michel, Marcella | ||
| 900 | |a Rietschel, M. | ||
| 900 | |a Rietschel, Marcela | ||
| 900 | |a Rietschel, Marcela D. C. | ||
| 951 | |b XA-DE | ||
| 980 | |a 1572201991 |b 0 |k 1572201991 |o 502201991 |c lfer | ||
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Identification+of+shared+risk+loci+and+pathways+for+bipolar+disorder+and+schizophrenia&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.creator=Forstner%2C+Andreas+Josef&rft.pub=&rft.format=Journal&rft.language=English&rft.issn=1932-6203 |
|---|
| _version_ | 1778848422725419008 |
|---|---|
| access_facet | Electronic Resources |
| author | Forstner, Andreas Josef, Witt, Stephanie, Rietschel, Marcella |
| author_facet | Forstner, Andreas Josef, Witt, Stephanie, Rietschel, Marcella |
| author_role | aut, aut, aut |
| author_sort | Forstner, Andreas Josef |
| author_variant | a j f aj ajf, s w sw, m r mr |
| callnumber-sort | |
| collection | lfer |
| container_reference | 12(2017,2), Artikel-Nummer e0171595, Seite 1-14 |
| container_title | PLOS ONE |
| contents | Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association study (GWAS) by the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). The present study investigated whether these SCZ-associated SNPs also contribute to BD development through the performance of association testing in a large BD GWAS dataset (9747 patients, 14278 controls). After re-imputation and correction for sample overlap, 22 of 107 investigated SCZ SNPs showed nominal association with BD. The number of shared SCZ-BD SNPs was significantly higher than expected (p = 1.46x10-8). This provides further evidence that SCZ-associated loci contribute to the development of BD. Two SNPs remained significant after Bonferroni correction. The most strongly associated SNP was located near TRANK1, which is a reported genome-wide significant risk gene for BD. Pathway analyses for all shared SCZ-BD SNPs revealed 25 nominally enriched gene-sets, which showed partial overlap in terms of the underlying genes. The enriched gene-sets included calcium- and glutamate signaling, neuropathic pain signaling in dorsal horn neurons, and calmodulin binding. The present data provide further insights into shared risk loci and disease-associated pathways for BD and SCZ. This may suggest new research directions for the treatment and prevention of these two major psychiatric disorders. |
| ctrlnum | (DE-627)1572201991, (DE-576)502201991, (DE-599)BSZ502201991, (OCoLC)1341007461 |
| doi_str_mv | 10.1371/journal.pone.0171595 |
| facet_avail | Online, Free |
| finc_class_facet | not assigned |
| finc_id_str | 0021094323 |
| footnote | Gesehen am 20.04.2018 |
| format | ElectronicBookComponentPart |
| format_access_txtF_mv | Article, E-Article |
| format_de105 | Ebook |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_del152 | Buch |
| format_detail_txtF_mv | text-online-monograph-child |
| format_dezi4 | e-Book |
| format_finc | Article, E-Article |
| format_legacy | ElectronicBookPart |
| format_strict_txtF_mv | E-Article |
| geogr_code | not assigned |
| geogr_code_person | Germany |
| hierarchy_parent_id | 0-523574592 |
| hierarchy_parent_title | PLOS ONE |
| hierarchy_sequence | 12(2017,2), Artikel-Nummer e0171595, Seite 1-14 |
| hierarchy_top_id | 0-523574592 |
| hierarchy_top_title | PLOS ONE |
| id | 0-1572201991 |
| illustrated | Not Illustrated |
| imprint | February 6, 2017 |
| imprint_str_mv | February 6, 2017 |
| institution | DE-D117, DE-105, LFER, DE-Ch1, DE-15, DE-14, DE-Zwi2 |
| is_hierarchy_id | 0-1572201991 |
| is_hierarchy_title | Identification of shared risk loci and pathways for bipolar disorder and schizophrenia |
| isil_str_mv | LFER |
| issn | 1932-6203 |
| kxp_id_str | 1572201991 |
| language | English |
| last_indexed | 2023-10-04T17:54:12.428Z |
| local_heading_facet_dezwi2 | Bipolar disorder, Genetic loci, Genome-wide association studies, Glutamate, Meta-analysis, Molecular genetics, Schizophrenia, Test statistics |
| marc024a_ct_mv | 10.1371/journal.pone.0171595 |
| match_str | forstner2017identificationofsharedrisklociandpathwaysforbipolardisorderandschizophrenia |
| mega_collection | Verbunddaten SWB, Lizenzfreie Online-Ressourcen |
| misc_de105 | EBOOK |
| multipart_link | 281331979 |
| multipart_part | (281331979)12(2017,2), Artikel-Nummer e0171595, Seite 1-14 |
| names_id_str_mv | (DE-588)1064967531, (DE-627)815370296, (DE-576)424653702, (DE-588)132177897, (DE-627)519022432, (DE-576)298988399, (DE-588)112785751, (DE-627)505574020, (DE-576)289742307 |
| oclc_num | 1341007461 |
| physical | Illustrationen, 14 |
| publishDate | February 6, 2017 |
| publishDateSort | 2017 |
| publishPlace | |
| publisher | |
| record_format | marcfinc |
| record_id | 502201991 |
| recordtype | marcfinc |
| rvk_facet | No subject assigned |
| source_id | 0 |
| spelling | Forstner, Andreas Josef VerfasserIn (DE-588)1064967531 (DE-627)815370296 (DE-576)424653702 aut, Identification of shared risk loci and pathways for bipolar disorder and schizophrenia Andreas J. Forstner, Julian Hecker, Andrea Hofmann, Anna Maaser, Céline S. Reinbold, Thomas W. Mühleisen, Markus Leber, Jana Strohmaier, Franziska Degenhardt, Jens Treutlein, Manuel Mattheisen, Johannes Schumacher, Fabian Streit, Sandra Meier, Stefan Herms, Per Hoffmann, André Lacour, Stephanie H. Witt, Andreas Reif, Bertram Müller-Myhsok, Susanne Lucae, Wolfgang Maier, Markus Schwarz, Helmut Vedder, Jutta Kammerer-Ciernioch, Andrea Pfennig, Michael Bauer, Martin Hautzinger, Susanne Moebus, Lorena M. Schenk, Sascha B. Fischer, Sugirthan Sivalingam, Piotr M. Czerski, Joanna Hauser, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, Paul Brennan, James D. McKay, Adam Wright, Philip B. Mitchell, Janice M. Fullerton, Peter R. Schofield, Grant W. Montgomery, Sarah E. Medland, Scott D. Gordon, Nicholas G. Martin, Valery Krasnov, Alexander Chuchalin, Gulja Babadjanova, Galina Pantelejeva, Lilia I. Abramova, Alexander S. Tiganov, Alexey Polonikov, Elza Khusnutdinova, Martin Alda, Cristiana Cruceanu, Guy A. Rouleau, Gustavo Turecki, Catherine Laprise, Fabio Rivas, Fermin Mayoral, Manolis Kogevinas, Maria Grigoroiu-Serbanescu, Tim Becker, Thomas G. Schulze, Marcella Rietschel, Sven Cichon, Heide Fier, Markus M. Nöthen, February 6, 2017, Illustrationen, 14, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 20.04.2018, Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association study (GWAS) by the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). The present study investigated whether these SCZ-associated SNPs also contribute to BD development through the performance of association testing in a large BD GWAS dataset (9747 patients, 14278 controls). After re-imputation and correction for sample overlap, 22 of 107 investigated SCZ SNPs showed nominal association with BD. The number of shared SCZ-BD SNPs was significantly higher than expected (p = 1.46x10-8). This provides further evidence that SCZ-associated loci contribute to the development of BD. Two SNPs remained significant after Bonferroni correction. The most strongly associated SNP was located near TRANK1, which is a reported genome-wide significant risk gene for BD. Pathway analyses for all shared SCZ-BD SNPs revealed 25 nominally enriched gene-sets, which showed partial overlap in terms of the underlying genes. The enriched gene-sets included calcium- and glutamate signaling, neuropathic pain signaling in dorsal horn neurons, and calmodulin binding. The present data provide further insights into shared risk loci and disease-associated pathways for BD and SCZ. This may suggest new research directions for the treatment and prevention of these two major psychiatric disorders., Bipolar disorder, Genetic loci, Genome-wide association studies, Glutamate, Meta-analysis, Molecular genetics, Schizophrenia, Test statistics, Witt, Stephanie 1970- VerfasserIn (DE-588)132177897 (DE-627)519022432 (DE-576)298988399 aut, Rietschel, Marcella 1957- VerfasserIn (DE-588)112785751 (DE-627)505574020 (DE-576)289742307 aut, Enthalten in PLOS ONE San Francisco, California, US : PLOS, 2006 12(2017,2), Artikel-Nummer e0171595, Seite 1-14 Online-Ressource (DE-627)523574592 (DE-600)2267670-3 (DE-576)281331979 1932-6203 nnns, volume:12 year:2017 number:2 extent:14, http://dx.doi.org/10.1371/journal.pone.0171595 Verlag Resolving-System kostenfrei Volltext, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171595 Verlag kostenfrei Volltext, http://dx.doi.org/10.1371/journal.pone.0171595 LFER, LFER 2018-05-17T00:00:00Z |
| spellingShingle | Forstner, Andreas Josef, Witt, Stephanie, Rietschel, Marcella, Identification of shared risk loci and pathways for bipolar disorder and schizophrenia, Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association study (GWAS) by the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). The present study investigated whether these SCZ-associated SNPs also contribute to BD development through the performance of association testing in a large BD GWAS dataset (9747 patients, 14278 controls). After re-imputation and correction for sample overlap, 22 of 107 investigated SCZ SNPs showed nominal association with BD. The number of shared SCZ-BD SNPs was significantly higher than expected (p = 1.46x10-8). This provides further evidence that SCZ-associated loci contribute to the development of BD. Two SNPs remained significant after Bonferroni correction. The most strongly associated SNP was located near TRANK1, which is a reported genome-wide significant risk gene for BD. Pathway analyses for all shared SCZ-BD SNPs revealed 25 nominally enriched gene-sets, which showed partial overlap in terms of the underlying genes. The enriched gene-sets included calcium- and glutamate signaling, neuropathic pain signaling in dorsal horn neurons, and calmodulin binding. The present data provide further insights into shared risk loci and disease-associated pathways for BD and SCZ. This may suggest new research directions for the treatment and prevention of these two major psychiatric disorders., Bipolar disorder, Genetic loci, Genome-wide association studies, Glutamate, Meta-analysis, Molecular genetics, Schizophrenia, Test statistics |
| swb_id_str | 502201991 |
| title | Identification of shared risk loci and pathways for bipolar disorder and schizophrenia |
| title_auth | Identification of shared risk loci and pathways for bipolar disorder and schizophrenia |
| title_full | Identification of shared risk loci and pathways for bipolar disorder and schizophrenia Andreas J. Forstner, Julian Hecker, Andrea Hofmann, Anna Maaser, Céline S. Reinbold, Thomas W. Mühleisen, Markus Leber, Jana Strohmaier, Franziska Degenhardt, Jens Treutlein, Manuel Mattheisen, Johannes Schumacher, Fabian Streit, Sandra Meier, Stefan Herms, Per Hoffmann, André Lacour, Stephanie H. Witt, Andreas Reif, Bertram Müller-Myhsok, Susanne Lucae, Wolfgang Maier, Markus Schwarz, Helmut Vedder, Jutta Kammerer-Ciernioch, Andrea Pfennig, Michael Bauer, Martin Hautzinger, Susanne Moebus, Lorena M. Schenk, Sascha B. Fischer, Sugirthan Sivalingam, Piotr M. Czerski, Joanna Hauser, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, Paul Brennan, James D. McKay, Adam Wright, Philip B. Mitchell, Janice M. Fullerton, Peter R. Schofield, Grant W. Montgomery, Sarah E. Medland, Scott D. Gordon, Nicholas G. Martin, Valery Krasnov, Alexander Chuchalin, Gulja Babadjanova, Galina Pantelejeva, Lilia I. Abramova, Alexander S. Tiganov, Alexey Polonikov, Elza Khusnutdinova, Martin Alda, Cristiana Cruceanu, Guy A. Rouleau, Gustavo Turecki, Catherine Laprise, Fabio Rivas, Fermin Mayoral, Manolis Kogevinas, Maria Grigoroiu-Serbanescu, Tim Becker, Thomas G. Schulze, Marcella Rietschel, Sven Cichon, Heide Fier, Markus M. Nöthen |
| title_fullStr | Identification of shared risk loci and pathways for bipolar disorder and schizophrenia Andreas J. Forstner, Julian Hecker, Andrea Hofmann, Anna Maaser, Céline S. Reinbold, Thomas W. Mühleisen, Markus Leber, Jana Strohmaier, Franziska Degenhardt, Jens Treutlein, Manuel Mattheisen, Johannes Schumacher, Fabian Streit, Sandra Meier, Stefan Herms, Per Hoffmann, André Lacour, Stephanie H. Witt, Andreas Reif, Bertram Müller-Myhsok, Susanne Lucae, Wolfgang Maier, Markus Schwarz, Helmut Vedder, Jutta Kammerer-Ciernioch, Andrea Pfennig, Michael Bauer, Martin Hautzinger, Susanne Moebus, Lorena M. Schenk, Sascha B. Fischer, Sugirthan Sivalingam, Piotr M. Czerski, Joanna Hauser, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, Paul Brennan, James D. McKay, Adam Wright, Philip B. Mitchell, Janice M. Fullerton, Peter R. Schofield, Grant W. Montgomery, Sarah E. Medland, Scott D. Gordon, Nicholas G. Martin, Valery Krasnov, Alexander Chuchalin, Gulja Babadjanova, Galina Pantelejeva, Lilia I. Abramova, Alexander S. Tiganov, Alexey Polonikov, Elza Khusnutdinova, Martin Alda, Cristiana Cruceanu, Guy A. Rouleau, Gustavo Turecki, Catherine Laprise, Fabio Rivas, Fermin Mayoral, Manolis Kogevinas, Maria Grigoroiu-Serbanescu, Tim Becker, Thomas G. Schulze, Marcella Rietschel, Sven Cichon, Heide Fier, Markus M. Nöthen |
| title_full_unstemmed | Identification of shared risk loci and pathways for bipolar disorder and schizophrenia Andreas J. Forstner, Julian Hecker, Andrea Hofmann, Anna Maaser, Céline S. Reinbold, Thomas W. Mühleisen, Markus Leber, Jana Strohmaier, Franziska Degenhardt, Jens Treutlein, Manuel Mattheisen, Johannes Schumacher, Fabian Streit, Sandra Meier, Stefan Herms, Per Hoffmann, André Lacour, Stephanie H. Witt, Andreas Reif, Bertram Müller-Myhsok, Susanne Lucae, Wolfgang Maier, Markus Schwarz, Helmut Vedder, Jutta Kammerer-Ciernioch, Andrea Pfennig, Michael Bauer, Martin Hautzinger, Susanne Moebus, Lorena M. Schenk, Sascha B. Fischer, Sugirthan Sivalingam, Piotr M. Czerski, Joanna Hauser, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, Paul Brennan, James D. McKay, Adam Wright, Philip B. Mitchell, Janice M. Fullerton, Peter R. Schofield, Grant W. Montgomery, Sarah E. Medland, Scott D. Gordon, Nicholas G. Martin, Valery Krasnov, Alexander Chuchalin, Gulja Babadjanova, Galina Pantelejeva, Lilia I. Abramova, Alexander S. Tiganov, Alexey Polonikov, Elza Khusnutdinova, Martin Alda, Cristiana Cruceanu, Guy A. Rouleau, Gustavo Turecki, Catherine Laprise, Fabio Rivas, Fermin Mayoral, Manolis Kogevinas, Maria Grigoroiu-Serbanescu, Tim Becker, Thomas G. Schulze, Marcella Rietschel, Sven Cichon, Heide Fier, Markus M. Nöthen |
| title_in_hierarchy | Identification of shared risk loci and pathways for bipolar disorder and schizophrenia / Andreas J. Forstner, Julian Hecker, Andrea Hofmann, Anna Maaser, Céline S. Reinbold, Thomas W. Mühleisen, Markus Leber, Jana Strohmaier, Franziska Degenhardt, Jens Treutlein, Manuel Mattheisen, Johannes Schumacher, Fabian Streit, Sandra Meier, Stefan Herms, Per Hoffmann, André Lacour, Stephanie H. Witt, Andreas Reif, Bertram Müller-Myhsok, Susanne Lucae, Wolfgang Maier, Markus Schwarz, Helmut Vedder, Jutta Kammerer-Ciernioch, Andrea Pfennig, Michael Bauer, Martin Hautzinger, Susanne Moebus, Lorena M. Schenk, Sascha B. Fischer, Sugirthan Sivalingam, Piotr M. Czerski, Joanna Hauser, Jolanta Lissowska, Neonila Szeszenia-Dabrowska, Paul Brennan, James D. McKay, Adam Wright, Philip B. Mitchell, Janice M. Fullerton, Peter R. Schofield, Grant W. Montgomery, Sarah E. Medland, Scott D. Gordon, Nicholas G. Martin, Valery Krasnov, Alexander Chuchalin, Gulja Babadjanova, Galina Pantelejeva, Lilia I. Abramova, Alexander S. Tiganov, Alexey Polonikov, Elza Khusnutdinova, Martin Alda, Cristiana Cruceanu, Guy A. Rouleau, Gustavo Turecki, Catherine Laprise, Fabio Rivas, Fermin Mayoral, Manolis Kogevinas, Maria Grigoroiu-Serbanescu, Tim Becker, Thomas G. Schulze, Marcella Rietschel, Sven Cichon, Heide Fier, Markus M. Nöthen, |
| title_short | Identification of shared risk loci and pathways for bipolar disorder and schizophrenia |
| title_sort | identification of shared risk loci and pathways for bipolar disorder and schizophrenia |
| topic | Bipolar disorder, Genetic loci, Genome-wide association studies, Glutamate, Meta-analysis, Molecular genetics, Schizophrenia, Test statistics |
| topic_facet | Bipolar disorder, Genetic loci, Genome-wide association studies, Glutamate, Meta-analysis, Molecular genetics, Schizophrenia, Test statistics |
| url | http://dx.doi.org/10.1371/journal.pone.0171595, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171595 |