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Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality: 20 years follow-up in patients after hip or knee replacement
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| Veröffentlicht in: | Scientific reports 8(2018) Artikel-Nummer 5253, 8 Seiten |
|---|---|
| Personen und Körperschaften: | , |
| Titel: | Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality: 20 years follow-up in patients after hip or knee replacement/ G. Büchele, K. P. Günther, H. Brenner, W. Puhl, T. Stürmer, D. Rothenbacher & R. E. Brenner |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
27 March 2018
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| Gesamtaufnahme: |
: Scientific reports, 8(2018) Artikel-Nummer 5253, 8 Seiten
, volume:8 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 520 | |a Osteoarthritis (OA) is a common musculoskeletal disorder and occur in different patterns. However, its impact on long-term all-cause-mortality is inconclusive. Study aims: Investigate 20-year all-cause-mortality in patients with hip/knee arthroplasty (recruited 1995/1996, N = 809) from the Ulm Osteoarthritis Study-cohort, in comparison to general population. Furthermore, to enlighten the triangle between baseline life-style and cardio-metabolic risk factors, phenotypic OA-patterns (laterality, generalization, cause) and all-cause-mortality. Mortality was assessed during 20 years follow-up. Standardized mortality ratios (SMR), adjusted odds ratios and hazard ratios (aHR) were calculated. After five years cohort-mortality was reduced compared to the general population, however 20 years later assimilated (SMR = 1.11; 95%-CI 0.73-1.49). OA-patterns were associated with age, cholesterol, and overweight/obesity. In comparison to primary OA decreased mortality was observed for patients with secondary OA (aHR = 0.76; 95%-CI 0.61-0.95) adjusted for age, smoking, overweight/obesity, diabetes, hypertension, cardiac insufficiency, uric acid, and lower cholesterol. There was no increased mortality in patients after 20 years follow-up compared to general population. Significantly decreased mortality in secondary compared to primary OA suggests a subtype-specific involvement of systemic co-factors in determination of all-cause-mortality. Because cardio-metabolic risk factors were associated with increased risk of bilateral OA and lower long-term survival, those risk factors should be consequently targeted in OA-patients. | ||
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| contents | Osteoarthritis (OA) is a common musculoskeletal disorder and occur in different patterns. However, its impact on long-term all-cause-mortality is inconclusive. Study aims: Investigate 20-year all-cause-mortality in patients with hip/knee arthroplasty (recruited 1995/1996, N = 809) from the Ulm Osteoarthritis Study-cohort, in comparison to general population. Furthermore, to enlighten the triangle between baseline life-style and cardio-metabolic risk factors, phenotypic OA-patterns (laterality, generalization, cause) and all-cause-mortality. Mortality was assessed during 20 years follow-up. Standardized mortality ratios (SMR), adjusted odds ratios and hazard ratios (aHR) were calculated. After five years cohort-mortality was reduced compared to the general population, however 20 years later assimilated (SMR = 1.11; 95%-CI 0.73-1.49). OA-patterns were associated with age, cholesterol, and overweight/obesity. In comparison to primary OA decreased mortality was observed for patients with secondary OA (aHR = 0.76; 95%-CI 0.61-0.95) adjusted for age, smoking, overweight/obesity, diabetes, hypertension, cardiac insufficiency, uric acid, and lower cholesterol. There was no increased mortality in patients after 20 years follow-up compared to general population. Significantly decreased mortality in secondary compared to primary OA suggests a subtype-specific involvement of systemic co-factors in determination of all-cause-mortality. Because cardio-metabolic risk factors were associated with increased risk of bilateral OA and lower long-term survival, those risk factors should be consequently targeted in OA-patients. |
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| spelling | Büchele, Gisela VerfasserIn (DE-588)142154350 (DE-627)634412337 (DE-576)185387780 aut, Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality 20 years follow-up in patients after hip or knee replacement G. Büchele, K. P. Günther, H. Brenner, W. Puhl, T. Stürmer, D. Rothenbacher & R. E. Brenner, 27 March 2018, 8, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 05.04.2018, Osteoarthritis (OA) is a common musculoskeletal disorder and occur in different patterns. However, its impact on long-term all-cause-mortality is inconclusive. Study aims: Investigate 20-year all-cause-mortality in patients with hip/knee arthroplasty (recruited 1995/1996, N = 809) from the Ulm Osteoarthritis Study-cohort, in comparison to general population. Furthermore, to enlighten the triangle between baseline life-style and cardio-metabolic risk factors, phenotypic OA-patterns (laterality, generalization, cause) and all-cause-mortality. Mortality was assessed during 20 years follow-up. Standardized mortality ratios (SMR), adjusted odds ratios and hazard ratios (aHR) were calculated. After five years cohort-mortality was reduced compared to the general population, however 20 years later assimilated (SMR = 1.11; 95%-CI 0.73-1.49). OA-patterns were associated with age, cholesterol, and overweight/obesity. In comparison to primary OA decreased mortality was observed for patients with secondary OA (aHR = 0.76; 95%-CI 0.61-0.95) adjusted for age, smoking, overweight/obesity, diabetes, hypertension, cardiac insufficiency, uric acid, and lower cholesterol. There was no increased mortality in patients after 20 years follow-up compared to general population. Significantly decreased mortality in secondary compared to primary OA suggests a subtype-specific involvement of systemic co-factors in determination of all-cause-mortality. Because cardio-metabolic risk factors were associated with increased risk of bilateral OA and lower long-term survival, those risk factors should be consequently targeted in OA-patients., Brenner, Hermann VerfasserIn (DE-588)1020516445 (DE-627)691247005 (DE-576)360642136 aut, Enthalten in Scientific reports [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 8(2018) Artikel-Nummer 5253, 8 Seiten Online-Ressource (DE-627)663366712 (DE-600)2615211-3 (DE-576)346641179 2045-2322 nnns, volume:8 year:2018 extent:8, http://dx.doi.org/10.1038/s41598-018-23573-2 Verlag Resolving-System kostenfrei Volltext, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869736/ Verlag kostenfrei Volltext, http://dx.doi.org/10.1038/s41598-018-23573-2 LFER, LFER 2018-05-17T00:00:00Z |
| spellingShingle | Büchele, Gisela, Brenner, Hermann, Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality: 20 years follow-up in patients after hip or knee replacement, Osteoarthritis (OA) is a common musculoskeletal disorder and occur in different patterns. However, its impact on long-term all-cause-mortality is inconclusive. Study aims: Investigate 20-year all-cause-mortality in patients with hip/knee arthroplasty (recruited 1995/1996, N = 809) from the Ulm Osteoarthritis Study-cohort, in comparison to general population. Furthermore, to enlighten the triangle between baseline life-style and cardio-metabolic risk factors, phenotypic OA-patterns (laterality, generalization, cause) and all-cause-mortality. Mortality was assessed during 20 years follow-up. Standardized mortality ratios (SMR), adjusted odds ratios and hazard ratios (aHR) were calculated. After five years cohort-mortality was reduced compared to the general population, however 20 years later assimilated (SMR = 1.11; 95%-CI 0.73-1.49). OA-patterns were associated with age, cholesterol, and overweight/obesity. In comparison to primary OA decreased mortality was observed for patients with secondary OA (aHR = 0.76; 95%-CI 0.61-0.95) adjusted for age, smoking, overweight/obesity, diabetes, hypertension, cardiac insufficiency, uric acid, and lower cholesterol. There was no increased mortality in patients after 20 years follow-up compared to general population. Significantly decreased mortality in secondary compared to primary OA suggests a subtype-specific involvement of systemic co-factors in determination of all-cause-mortality. Because cardio-metabolic risk factors were associated with increased risk of bilateral OA and lower long-term survival, those risk factors should be consequently targeted in OA-patients. |
| swb_id_str | 501720758 |
| title | Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality: 20 years follow-up in patients after hip or knee replacement |
| title_auth | Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality 20 years follow-up in patients after hip or knee replacement |
| title_full | Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality 20 years follow-up in patients after hip or knee replacement G. Büchele, K. P. Günther, H. Brenner, W. Puhl, T. Stürmer, D. Rothenbacher & R. E. Brenner |
| title_fullStr | Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality 20 years follow-up in patients after hip or knee replacement G. Büchele, K. P. Günther, H. Brenner, W. Puhl, T. Stürmer, D. Rothenbacher & R. E. Brenner |
| title_full_unstemmed | Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality 20 years follow-up in patients after hip or knee replacement G. Büchele, K. P. Günther, H. Brenner, W. Puhl, T. Stürmer, D. Rothenbacher & R. E. Brenner |
| title_in_hierarchy | Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality: 20 years follow-up in patients after hip or knee replacement / G. Büchele, K. P. Günther, H. Brenner, W. Puhl, T. Stürmer, D. Rothenbacher & R. E. Brenner, |
| title_short | Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality |
| title_sort | osteoarthritis patterns cardio metabolic risk factors and risk of all cause mortality 20 years follow up in patients after hip or knee replacement |
| title_sub | 20 years follow-up in patients after hip or knee replacement |
| url | http://dx.doi.org/10.1038/s41598-018-23573-2, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869736/ |