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Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report

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Veröffentlicht in: Malaria journal 15(2016) Artikel-Nummer 476, 11 Seiten
Personen und Körperschaften: Chêne, Arnaud (VerfasserIn), Houard, Sophie (VerfasserIn), Hundt, Sophia P. (VerfasserIn), D'Alessio, Flavia (VerfasserIn), Leroy, Odile (VerfasserIn)
Titel: Clinical development of placental malaria vaccines and immunoassays harmonization: a workshop report/ Arnaud Chêne, Sophie Houard, Morten A. Nielsen, Sophia Hundt, Flavia D’Alessio, Sodiomon B. Sirima, Adrian J.F. Luty, Patrick Duffy, Odile Leroy, Benoit Gamain and Nicola K. Viebig
Format: E-Book-Kapitel
Sprache: Englisch
veröffentlicht:
17 September 2016
Gesamtaufnahme: : Malaria journal, 15(2016) Artikel-Nummer 476, 11 Seiten
, volume:15
Schlagwörter:
Quelle: Verbunddaten SWB
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Zusammenfassung: Placental malaria caused by Plasmodium falciparum infection constitutes a major health problem manifesting as severe disease and anaemia in the mother, impaired fetal development, low birth weight or spontaneous abortion. Prevention of placental malaria currently relies on two key strategies that are losing efficacy due to spread of resistance: long-lasting insecticide-treated nets and intermittent preventive treatment during pregnancy. A placental malaria vaccine would be an attractive, cost-effective complement to the existing control tools. Two placental malaria vaccine candidates are currently in Phase Ia/b clinical trials. During two workshops hosted by the European Vaccine Initiative, one in Paris in April 2014 and the other in Brussels in November 2014, the main actors in placental malaria vaccine research discussed the harmonization of clinical development plans and of the immunoassays with a goal to define standards that will allow comparative assessment of different placental malaria vaccine candidates. The recommendations of these workshops should guide researchers and clinicians in the further development of placental malaria vaccines.
Beschreibung: Gesehen am 19.12.2017
ISSN: 1475-2875
DOI: 10.1186/s12936-016-1527-8