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Senna singueana: antioxidant, hepatoprotective, antiapoptotic properties and phytochemical profiling of a methanol bark extract
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| Veröffentlicht in: | Molecules 22(2017,9) Artikel-Nummer 1502, 15 Seiten |
|---|---|
| Personen und Körperschaften: | , , |
| Titel: | Senna singueana: antioxidant, hepatoprotective, antiapoptotic properties and phytochemical profiling of a methanol bark extract/ Mansour Sobeh, Mona F. Mahmoud, Rehab A. Hasan, Haroan Cheng, Assem M. El-Shazly and Michael Wink |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
8 September 2017
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| Gesamtaufnahme: |
: Molecules, 22(2017,9) Artikel-Nummer 1502, 15 Seiten
, volume:22 |
| Schlagwörter: | |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 0 | |a Senna singueana |b antioxidant, hepatoprotective, antiapoptotic properties and phytochemical profiling of a methanol bark extract |c Mansour Sobeh, Mona F. Mahmoud, Rehab A. Hasan, Haroan Cheng, Assem M. El-Shazly and Michael Wink |
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| 520 | |a Natural products are considered as an important source for the discovery of new drugs to treat aging-related degenerative diseases and liver injury. The present study profiled the chemical constituents of a methanol extract from Senna singueana bark using HPLC-PDA-ESI-MS/MS and 36 secondary metabolites were identified. Proanthocyanidins dominated the extract. Monomers, dimers, trimers of (epi)catechin, (epi)gallocatechin, (epi)guibourtinidol, (ent)cassiaflavan, and (epi)afzelechin represented the major constituents. The extract demonstrated notable antioxidant activities in vitro: In DPPH (EC50 of 20.8 µg/mL), FRAP (18.16 mM FeSO4/mg extract) assays, and total phenolic content amounted 474 mg gallic acid equivalent (GAE)/g extract determined with the Folin-Ciocalteu method. Also, in an in vivo model, the extract increased the survival rate of Caenorhabditis elegans worms pretreated with the pro-oxidant juglone from 43 to 64%, decreased intracellular ROS inside the wild-type nematodes by 47.90%, and induced nuclear translocation of the transcription factor DAF-16 in the transgenic strain TJ356. Additionally, the extract showed a remarkable hepatoprotective activity against d-galactosamine (d-GalN) induced hepatic injury in rats. It significantly reduced elevated AST (aspartate aminotransferase), and total bilirubin. Moreover, the extract induced a strong cytoplasmic Bcl-2 expression indicating suppression of apoptosis. In conclusion, the bark extract of S. sengueana represents an interesting candidate for further research in antioxidants and liver protection. | ||
| 650 | 4 | |a <i>Caenorhabditis elegans</i> | |
| 650 | 4 | |a <i>Senna singueana</i> | |
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| 650 | 4 | |a hepatoprotection | |
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| contents | Natural products are considered as an important source for the discovery of new drugs to treat aging-related degenerative diseases and liver injury. The present study profiled the chemical constituents of a methanol extract from Senna singueana bark using HPLC-PDA-ESI-MS/MS and 36 secondary metabolites were identified. Proanthocyanidins dominated the extract. Monomers, dimers, trimers of (epi)catechin, (epi)gallocatechin, (epi)guibourtinidol, (ent)cassiaflavan, and (epi)afzelechin represented the major constituents. The extract demonstrated notable antioxidant activities in vitro: In DPPH (EC50 of 20.8 µg/mL), FRAP (18.16 mM FeSO4/mg extract) assays, and total phenolic content amounted 474 mg gallic acid equivalent (GAE)/g extract determined with the Folin-Ciocalteu method. Also, in an in vivo model, the extract increased the survival rate of Caenorhabditis elegans worms pretreated with the pro-oxidant juglone from 43 to 64%, decreased intracellular ROS inside the wild-type nematodes by 47.90%, and induced nuclear translocation of the transcription factor DAF-16 in the transgenic strain TJ356. Additionally, the extract showed a remarkable hepatoprotective activity against d-galactosamine (d-GalN) induced hepatic injury in rats. It significantly reduced elevated AST (aspartate aminotransferase), and total bilirubin. Moreover, the extract induced a strong cytoplasmic Bcl-2 expression indicating suppression of apoptosis. In conclusion, the bark extract of S. sengueana represents an interesting candidate for further research in antioxidants and liver protection. |
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| spelling | Sobeh, Mansour VerfasserIn (DE-588)1099730058 (DE-627)859130444 (DE-576)469346434 aut, Senna singueana antioxidant, hepatoprotective, antiapoptotic properties and phytochemical profiling of a methanol bark extract Mansour Sobeh, Mona F. Mahmoud, Rehab A. Hasan, Haroan Cheng, Assem M. El-Shazly and Michael Wink, 8 September 2017, 15, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 01.12.2017, Natural products are considered as an important source for the discovery of new drugs to treat aging-related degenerative diseases and liver injury. The present study profiled the chemical constituents of a methanol extract from Senna singueana bark using HPLC-PDA-ESI-MS/MS and 36 secondary metabolites were identified. Proanthocyanidins dominated the extract. Monomers, dimers, trimers of (epi)catechin, (epi)gallocatechin, (epi)guibourtinidol, (ent)cassiaflavan, and (epi)afzelechin represented the major constituents. The extract demonstrated notable antioxidant activities in vitro: In DPPH (EC50 of 20.8 µg/mL), FRAP (18.16 mM FeSO4/mg extract) assays, and total phenolic content amounted 474 mg gallic acid equivalent (GAE)/g extract determined with the Folin-Ciocalteu method. Also, in an in vivo model, the extract increased the survival rate of Caenorhabditis elegans worms pretreated with the pro-oxidant juglone from 43 to 64%, decreased intracellular ROS inside the wild-type nematodes by 47.90%, and induced nuclear translocation of the transcription factor DAF-16 in the transgenic strain TJ356. Additionally, the extract showed a remarkable hepatoprotective activity against d-galactosamine (d-GalN) induced hepatic injury in rats. It significantly reduced elevated AST (aspartate aminotransferase), and total bilirubin. Moreover, the extract induced a strong cytoplasmic Bcl-2 expression indicating suppression of apoptosis. In conclusion, the bark extract of S. sengueana represents an interesting candidate for further research in antioxidants and liver protection., <i>Caenorhabditis elegans</i>, <i>Senna singueana</i>, antioxidant, hepatoprotection, HPLC-PDA-ESI-MS/MS, proanthocyanidins, Cheng, Haroan VerfasserIn (DE-588)1147656061 (DE-627)1006413669 (DE-576)495943118 aut, Wink, Michael 1951- VerfasserIn (DE-588)124618146 (DE-627)363448519 (DE-576)164659390 aut, Enthalten in Molecules Basel : MDPI, 1996 22(2017,9) Artikel-Nummer 1502, 15 Seiten Online-Ressource (DE-627)311313132 (DE-600)2008644-1 (DE-576)281192456 1420-3049 nnns, volume:22 year:2017 number:9 extent:15, http://dx.doi.org/10.3390/molecules22091502 Verlag Resolving-System kostenfrei Volltext, http://www.mdpi.com/1420-3049/22/9/1502 Verlag kostenfrei Volltext, http://dx.doi.org/10.3390/molecules22091502 LFER, LFER 2017-12-07T00:00:00Z |
| spellingShingle | Sobeh, Mansour, Cheng, Haroan, Wink, Michael, Senna singueana: antioxidant, hepatoprotective, antiapoptotic properties and phytochemical profiling of a methanol bark extract, Natural products are considered as an important source for the discovery of new drugs to treat aging-related degenerative diseases and liver injury. The present study profiled the chemical constituents of a methanol extract from Senna singueana bark using HPLC-PDA-ESI-MS/MS and 36 secondary metabolites were identified. Proanthocyanidins dominated the extract. Monomers, dimers, trimers of (epi)catechin, (epi)gallocatechin, (epi)guibourtinidol, (ent)cassiaflavan, and (epi)afzelechin represented the major constituents. The extract demonstrated notable antioxidant activities in vitro: In DPPH (EC50 of 20.8 µg/mL), FRAP (18.16 mM FeSO4/mg extract) assays, and total phenolic content amounted 474 mg gallic acid equivalent (GAE)/g extract determined with the Folin-Ciocalteu method. Also, in an in vivo model, the extract increased the survival rate of Caenorhabditis elegans worms pretreated with the pro-oxidant juglone from 43 to 64%, decreased intracellular ROS inside the wild-type nematodes by 47.90%, and induced nuclear translocation of the transcription factor DAF-16 in the transgenic strain TJ356. Additionally, the extract showed a remarkable hepatoprotective activity against d-galactosamine (d-GalN) induced hepatic injury in rats. It significantly reduced elevated AST (aspartate aminotransferase), and total bilirubin. Moreover, the extract induced a strong cytoplasmic Bcl-2 expression indicating suppression of apoptosis. In conclusion, the bark extract of S. sengueana represents an interesting candidate for further research in antioxidants and liver protection., <i>Caenorhabditis elegans</i>, <i>Senna singueana</i>, antioxidant, hepatoprotection, HPLC-PDA-ESI-MS/MS, proanthocyanidins |
| swb_id_str | 495944750 |
| title | Senna singueana: antioxidant, hepatoprotective, antiapoptotic properties and phytochemical profiling of a methanol bark extract |
| title_auth | Senna singueana antioxidant, hepatoprotective, antiapoptotic properties and phytochemical profiling of a methanol bark extract |
| title_full | Senna singueana antioxidant, hepatoprotective, antiapoptotic properties and phytochemical profiling of a methanol bark extract Mansour Sobeh, Mona F. Mahmoud, Rehab A. Hasan, Haroan Cheng, Assem M. El-Shazly and Michael Wink |
| title_fullStr | Senna singueana antioxidant, hepatoprotective, antiapoptotic properties and phytochemical profiling of a methanol bark extract Mansour Sobeh, Mona F. Mahmoud, Rehab A. Hasan, Haroan Cheng, Assem M. El-Shazly and Michael Wink |
| title_full_unstemmed | Senna singueana antioxidant, hepatoprotective, antiapoptotic properties and phytochemical profiling of a methanol bark extract Mansour Sobeh, Mona F. Mahmoud, Rehab A. Hasan, Haroan Cheng, Assem M. El-Shazly and Michael Wink |
| title_in_hierarchy | Senna singueana: antioxidant, hepatoprotective, antiapoptotic properties and phytochemical profiling of a methanol bark extract / Mansour Sobeh, Mona F. Mahmoud, Rehab A. Hasan, Haroan Cheng, Assem M. El-Shazly and Michael Wink, |
| title_short | Senna singueana |
| title_sort | senna singueana antioxidant hepatoprotective antiapoptotic properties and phytochemical profiling of a methanol bark extract |
| title_sub | antioxidant, hepatoprotective, antiapoptotic properties and phytochemical profiling of a methanol bark extract |
| topic | <i>Caenorhabditis elegans</i>, <i>Senna singueana</i>, antioxidant, hepatoprotection, HPLC-PDA-ESI-MS/MS, proanthocyanidins |
| topic_facet | <i>Caenorhabditis elegans</i>, <i>Senna singueana</i>, antioxidant, hepatoprotection, HPLC-PDA-ESI-MS/MS, proanthocyanidins |
| url | http://dx.doi.org/10.3390/molecules22091502, http://www.mdpi.com/1420-3049/22/9/1502 |