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Temporal and compartment-specific signals coordinate mitotic exit with spindle position
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| Veröffentlicht in: | Nature Communications 8(2017) Artikel-Nummer 14129, 14 Seiten |
|---|---|
| Personen und Körperschaften: | , , , , , |
| Titel: | Temporal and compartment-specific signals coordinate mitotic exit with spindle position/ Ayse Koca Caydasi, Anton Khmelinskii, Rafael Duenas-Sanchez, Bahtiyar Kurtulmus, Michael Knop & Gislene Pereira |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
24 Jan 2017
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| Gesamtaufnahme: |
: Nature Communications, 8(2017) Artikel-Nummer 14129, 14 Seiten
, volume:8 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 0 | |a Temporal and compartment-specific signals coordinate mitotic exit with spindle position |c Ayse Koca Caydasi, Anton Khmelinskii, Rafael Duenas-Sanchez, Bahtiyar Kurtulmus, Michael Knop & Gislene Pereira |
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| 520 | |a The spatiotemporal control of mitotic exit is crucial for faithful chromosome segregation during mitosis. In budding yeast, the mitotic exit network (MEN) drives cells out of mitosis, whereas the spindle position checkpoint (SPOC) blocks MEN activity when the anaphase spindle is mispositioned. How the SPOC operates at a molecular level remains unclear. Here, we report novel insights into how mitotic signalling pathways orchestrate chromosome segregation in time and space. We establish that the key function of the central SPOC kinase, Kin4, is to counterbalance MEN activation by the cdc fourteen early anaphase release (FEAR) network in the mother cell compartment. Remarkably, Kin4 becomes dispensable for SPOC function in the absence of FEAR. Cells lacking both FEAR and Kin4 show that FEAR contributes to mitotic exit through regulation of the SPOC component Bfa1 and the MEN kinase Cdc15. Furthermore, we uncover controls that specifically promote mitotic exit in the daughter cell compartment., The mitotic exit network (MEN) triggers mitotic exit and can be blocked by the spindle position checkpoint (SPOC). Here the authors show that SPOC kinase Kin4 counterbalances MEN activation by the Cdc fourteen early anaphase release (FEAR) network in the mother cell and that in the absence of FEAR mitotic exit requires daughter cell-confined factors. | ||
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| contents | The spatiotemporal control of mitotic exit is crucial for faithful chromosome segregation during mitosis. In budding yeast, the mitotic exit network (MEN) drives cells out of mitosis, whereas the spindle position checkpoint (SPOC) blocks MEN activity when the anaphase spindle is mispositioned. How the SPOC operates at a molecular level remains unclear. Here, we report novel insights into how mitotic signalling pathways orchestrate chromosome segregation in time and space. We establish that the key function of the central SPOC kinase, Kin4, is to counterbalance MEN activation by the cdc fourteen early anaphase release (FEAR) network in the mother cell compartment. Remarkably, Kin4 becomes dispensable for SPOC function in the absence of FEAR. Cells lacking both FEAR and Kin4 show that FEAR contributes to mitotic exit through regulation of the SPOC component Bfa1 and the MEN kinase Cdc15. Furthermore, we uncover controls that specifically promote mitotic exit in the daughter cell compartment., The mitotic exit network (MEN) triggers mitotic exit and can be blocked by the spindle position checkpoint (SPOC). Here the authors show that SPOC kinase Kin4 counterbalances MEN activation by the Cdc fourteen early anaphase release (FEAR) network in the mother cell and that in the absence of FEAR mitotic exit requires daughter cell-confined factors. |
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| spelling | Caydasi, Ayse Koca VerfasserIn (DE-588)1019268204 (DE-627)684605791 (DE-576)357370236 aut, Temporal and compartment-specific signals coordinate mitotic exit with spindle position Ayse Koca Caydasi, Anton Khmelinskii, Rafael Duenas-Sanchez, Bahtiyar Kurtulmus, Michael Knop & Gislene Pereira, 24 Jan 2017, 14, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 04.08.2017, The spatiotemporal control of mitotic exit is crucial for faithful chromosome segregation during mitosis. In budding yeast, the mitotic exit network (MEN) drives cells out of mitosis, whereas the spindle position checkpoint (SPOC) blocks MEN activity when the anaphase spindle is mispositioned. How the SPOC operates at a molecular level remains unclear. Here, we report novel insights into how mitotic signalling pathways orchestrate chromosome segregation in time and space. We establish that the key function of the central SPOC kinase, Kin4, is to counterbalance MEN activation by the cdc fourteen early anaphase release (FEAR) network in the mother cell compartment. Remarkably, Kin4 becomes dispensable for SPOC function in the absence of FEAR. Cells lacking both FEAR and Kin4 show that FEAR contributes to mitotic exit through regulation of the SPOC component Bfa1 and the MEN kinase Cdc15. Furthermore, we uncover controls that specifically promote mitotic exit in the daughter cell compartment., The mitotic exit network (MEN) triggers mitotic exit and can be blocked by the spindle position checkpoint (SPOC). Here the authors show that SPOC kinase Kin4 counterbalances MEN activation by the Cdc fourteen early anaphase release (FEAR) network in the mother cell and that in the absence of FEAR mitotic exit requires daughter cell-confined factors., Khmelinskii, Anton VerfasserIn (DE-588)143067028 (DE-627)704379848 (DE-576)334857856 aut, Duenas-Sánchez, Rafael VerfasserIn (DE-588)1137714840 (DE-627)895079631 (DE-576)49171940X aut, Kurtulmus, Bahtiyar VerfasserIn (DE-588)1132090040 (DE-627)887371213 (DE-576)488611911 aut, Knop, Michael VerfasserIn (DE-588)1064187552 (DE-627)813076749 (DE-576)423832107 aut, Pereira, Gislene VerfasserIn (DE-588)1131901568 (DE-627)886950988 (DE-576)488570433 aut, Enthalten in Nature Communications [London] : Nature Publishing Group UK, 2010 8(2017) Artikel-Nummer 14129, 14 Seiten Online-Ressource (DE-627)626457688 (DE-600)2553671-0 (DE-576)331555905 2041-1723 nnns, volume:8 year:2017 pages:? extent:14, http://dx.doi.org/10.1038/ncomms14129 Verlag Resolving-System kostenfrei Volltext, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286211/ Verlag kostenfrei Volltext, http://dx.doi.org/10.1038/ncomms14129 LFER, LFER 2017-08-09T00:00:00Z |
| spellingShingle | Caydasi, Ayse Koca, Khmelinskii, Anton, Duenas-Sánchez, Rafael, Kurtulmus, Bahtiyar, Knop, Michael, Pereira, Gislene, Temporal and compartment-specific signals coordinate mitotic exit with spindle position, The spatiotemporal control of mitotic exit is crucial for faithful chromosome segregation during mitosis. In budding yeast, the mitotic exit network (MEN) drives cells out of mitosis, whereas the spindle position checkpoint (SPOC) blocks MEN activity when the anaphase spindle is mispositioned. How the SPOC operates at a molecular level remains unclear. Here, we report novel insights into how mitotic signalling pathways orchestrate chromosome segregation in time and space. We establish that the key function of the central SPOC kinase, Kin4, is to counterbalance MEN activation by the cdc fourteen early anaphase release (FEAR) network in the mother cell compartment. Remarkably, Kin4 becomes dispensable for SPOC function in the absence of FEAR. Cells lacking both FEAR and Kin4 show that FEAR contributes to mitotic exit through regulation of the SPOC component Bfa1 and the MEN kinase Cdc15. Furthermore, we uncover controls that specifically promote mitotic exit in the daughter cell compartment., The mitotic exit network (MEN) triggers mitotic exit and can be blocked by the spindle position checkpoint (SPOC). Here the authors show that SPOC kinase Kin4 counterbalances MEN activation by the Cdc fourteen early anaphase release (FEAR) network in the mother cell and that in the absence of FEAR mitotic exit requires daughter cell-confined factors. |
| swb_id_str | 491720173 |
| title | Temporal and compartment-specific signals coordinate mitotic exit with spindle position |
| title_auth | Temporal and compartment-specific signals coordinate mitotic exit with spindle position |
| title_full | Temporal and compartment-specific signals coordinate mitotic exit with spindle position Ayse Koca Caydasi, Anton Khmelinskii, Rafael Duenas-Sanchez, Bahtiyar Kurtulmus, Michael Knop & Gislene Pereira |
| title_fullStr | Temporal and compartment-specific signals coordinate mitotic exit with spindle position Ayse Koca Caydasi, Anton Khmelinskii, Rafael Duenas-Sanchez, Bahtiyar Kurtulmus, Michael Knop & Gislene Pereira |
| title_full_unstemmed | Temporal and compartment-specific signals coordinate mitotic exit with spindle position Ayse Koca Caydasi, Anton Khmelinskii, Rafael Duenas-Sanchez, Bahtiyar Kurtulmus, Michael Knop & Gislene Pereira |
| title_in_hierarchy | Temporal and compartment-specific signals coordinate mitotic exit with spindle position / Ayse Koca Caydasi, Anton Khmelinskii, Rafael Duenas-Sanchez, Bahtiyar Kurtulmus, Michael Knop & Gislene Pereira, |
| title_short | Temporal and compartment-specific signals coordinate mitotic exit with spindle position |
| title_sort | temporal and compartment specific signals coordinate mitotic exit with spindle position |
| url | http://dx.doi.org/10.1038/ncomms14129, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286211/ |