Eintrag weiter verarbeiten
Macrophages retain hematopoietic stem cells in the spleen via VCAM-1
Gespeichert in:
| Veröffentlicht in: | Journal of experimental medicine 212(2015), 4, Seite 497-512 |
|---|---|
| Personen und Körperschaften: | , |
| Titel: | Macrophages retain hematopoietic stem cells in the spleen via VCAM-1/ Partha Dutta, Friedrich Felix Hoyer, Lubov S. Grigoryeva, Hendrik B. Sager, Florian Leuschner, Gabriel Courties, Anna Borodovsky, Tatiana Novobrantseva, Vera M. Ruda, Kevin Fitzgerald, Yoshiko Iwamoto, Gregory Wojtkiewicz, Yuan Sun, Nicolas Da Silva, Peter Libby, Daniel G. Anderson, Filip K. Swirski, Ralph Weissleder, and Matthias Nahrendorf |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
6 April 2015
|
| Gesamtaufnahme: |
: Journal of experimental medicine, 212(2015), 4, Seite 497-512
, volume:212 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
| LEADER | 03435caa a2200469 4500 | ||
|---|---|---|---|
| 001 | 0-156078962X | ||
| 003 | DE-627 | ||
| 005 | 20220813193802.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 170712s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1084/jem.20141642 |2 doi | |
| 035 | |a (DE-627)156078962X | ||
| 035 | |a (DE-576)490789625 | ||
| 035 | |a (DE-599)BSZ490789625 | ||
| 035 | |a (OCoLC)1340977093 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 100 | 1 | |a Dutta, Partha |e VerfasserIn |0 (DE-588)1136687505 |0 (DE-627)89346449X |0 (DE-576)49078786X |4 aut | |
| 245 | 1 | 0 | |a Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 |c Partha Dutta, Friedrich Felix Hoyer, Lubov S. Grigoryeva, Hendrik B. Sager, Florian Leuschner, Gabriel Courties, Anna Borodovsky, Tatiana Novobrantseva, Vera M. Ruda, Kevin Fitzgerald, Yoshiko Iwamoto, Gregory Wojtkiewicz, Yuan Sun, Nicolas Da Silva, Peter Libby, Daniel G. Anderson, Filip K. Swirski, Ralph Weissleder, and Matthias Nahrendorf |
| 264 | 1 | |c 6 April 2015 | |
| 300 | |a 16 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 12.07.2017 | ||
| 520 | |a Dutta et al. show that targeting VACM-1 expression in splenic macrophages impairs extramedullary hematopoiesis, thus reducing inflammation in mouse ischemic heart and atherosclerotic plaques., Splenic myelopoiesis provides a steady flow of leukocytes to inflamed tissues, and leukocytosis correlates with cardiovascular mortality. Yet regulation of hematopoietic stem cell (HSC) activity in the spleen is incompletely understood. Here, we show that red pulp vascular cell adhesion molecule 1 (VCAM-1)+ macrophages are essential to extramedullary myelopoiesis because these macrophages use the adhesion molecule VCAM-1 to retain HSCs in the spleen. Nanoparticle-enabled in vivo RNAi silencing of the receptor for macrophage colony stimulation factor (M-CSFR) blocked splenic macrophage maturation, reduced splenic VCAM-1 expression and compromised splenic HSC retention. Both, depleting macrophages in CD169 iDTR mice or silencing VCAM-1 in macrophages released HSCs from the spleen. When we silenced either VCAM-1 or M-CSFR in mice with myocardial infarction or in ApoE−/− mice with atherosclerosis, nanoparticle-enabled in vivo RNAi mitigated blood leukocytosis, limited inflammation in the ischemic heart, and reduced myeloid cell numbers in atherosclerotic plaques. | ||
| 700 | 1 | |a Leuschner, Florian |e VerfasserIn |0 (DE-588)1072736144 |0 (DE-627)828165742 |0 (DE-576)189305347 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of experimental medicine |d New York, NY : Rockefeller Univ. Press, 1896 |g 212(2015), 4, Seite 497-512 |h Online-Ressource |w (DE-627)270425594 |w (DE-600)1477240-1 |w (DE-576)078590167 |x 1540-9538 |7 nnns |
| 773 | 1 | 8 | |g volume:212 |g year:2015 |g number:4 |g pages:497-512 |g extent:16 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1084/jem.20141642 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387283/ |x Verlag |z kostenfrei |3 Volltext |
| 936 | u | w | |d 212 |j 2015 |e 4 |h 497-512 |g 16 |
| 951 | |a AR | ||
| 856 | 4 | 0 | |u http://dx.doi.org/10.1084/jem.20141642 |9 LFER |
| 852 | |a LFER |z 2017-08-09T00:00:00Z | ||
| 970 | |c OD | ||
| 971 | |c EBOOK | ||
| 972 | |c EBOOK | ||
| 973 | |c Aufsatz | ||
| 935 | |a lfer | ||
| 951 | |b XD-US | ||
| 980 | |a 156078962X |b 0 |k 156078962X |o 490789625 |c lfer | ||
| openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Macrophages+retain+hematopoietic+stem+cells+in+the+spleen+via+VCAM-1&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.creator=Dutta%2C+Partha&rft.pub=&rft.format=Journal&rft.language=English&rft.issn=1540-9538 |
|---|
| _version_ | 1757948516518330368 |
|---|---|
| access_facet | Electronic Resources |
| author | Dutta, Partha, Leuschner, Florian |
| author_facet | Dutta, Partha, Leuschner, Florian |
| author_role | aut, aut |
| author_sort | Dutta, Partha |
| author_variant | p d pd, f l fl |
| callnumber-sort | |
| collection | lfer |
| container_reference | 212(2015), 4, Seite 497-512 |
| container_title | Journal of experimental medicine |
| contents | Dutta et al. show that targeting VACM-1 expression in splenic macrophages impairs extramedullary hematopoiesis, thus reducing inflammation in mouse ischemic heart and atherosclerotic plaques., Splenic myelopoiesis provides a steady flow of leukocytes to inflamed tissues, and leukocytosis correlates with cardiovascular mortality. Yet regulation of hematopoietic stem cell (HSC) activity in the spleen is incompletely understood. Here, we show that red pulp vascular cell adhesion molecule 1 (VCAM-1)+ macrophages are essential to extramedullary myelopoiesis because these macrophages use the adhesion molecule VCAM-1 to retain HSCs in the spleen. Nanoparticle-enabled in vivo RNAi silencing of the receptor for macrophage colony stimulation factor (M-CSFR) blocked splenic macrophage maturation, reduced splenic VCAM-1 expression and compromised splenic HSC retention. Both, depleting macrophages in CD169 iDTR mice or silencing VCAM-1 in macrophages released HSCs from the spleen. When we silenced either VCAM-1 or M-CSFR in mice with myocardial infarction or in ApoE−/− mice with atherosclerosis, nanoparticle-enabled in vivo RNAi mitigated blood leukocytosis, limited inflammation in the ischemic heart, and reduced myeloid cell numbers in atherosclerotic plaques. |
| ctrlnum | (DE-627)156078962X, (DE-576)490789625, (DE-599)BSZ490789625, (OCoLC)1340977093 |
| doi_str_mv | 10.1084/jem.20141642 |
| facet_avail | Online, Free |
| finc_class_facet | not assigned |
| finc_id_str | 0019177575 |
| footnote | Gesehen am 12.07.2017 |
| format | ElectronicBookComponentPart |
| format_access_txtF_mv | Article, E-Article |
| format_de105 | Ebook |
| format_de14 | Article, E-Article |
| format_de15 | Article, E-Article |
| format_del152 | Buch |
| format_detail_txtF_mv | text-online-monograph-child |
| format_dezi4 | e-Book |
| format_finc | Article, E-Article |
| format_legacy | ElectronicBookPart |
| format_strict_txtF_mv | E-Article |
| geogr_code | not assigned |
| geogr_code_person | USA |
| hierarchy_parent_id | 0-270425594 |
| hierarchy_parent_title | Journal of experimental medicine |
| hierarchy_sequence | 212(2015), 4, Seite 497-512 |
| hierarchy_top_id | 0-270425594 |
| hierarchy_top_title | Journal of experimental medicine |
| id | 0-156078962X |
| illustrated | Not Illustrated |
| imprint | 6 April 2015 |
| imprint_str_mv | 6 April 2015 |
| institution | DE-D117, DE-105, LFER, DE-Ch1, DE-15, DE-14, DE-Zwi2 |
| is_hierarchy_id | 0-156078962X |
| is_hierarchy_title | Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 |
| isil_str_mv | LFER |
| issn | 1540-9538 |
| kxp_id_str | 156078962X |
| language | English |
| last_indexed | 2023-02-16T01:19:08.111Z |
| marc024a_ct_mv | 10.1084/jem.20141642 |
| match_str | dutta2015macrophagesretainhematopoieticstemcellsinthespleenviavcam1 |
| mega_collection | Verbunddaten SWB, Lizenzfreie Online-Ressourcen |
| misc_de105 | EBOOK |
| multipart_link | 078590167 |
| multipart_part | (078590167)212(2015), 4, Seite 497-512 |
| names_id_str_mv | (DE-588)1136687505, (DE-627)89346449X, (DE-576)49078786X, (DE-588)1072736144, (DE-627)828165742, (DE-576)189305347 |
| oclc_num | 1340977093 |
| physical | 16 |
| publishDate | 6 April 2015 |
| publishDateSort | 2015 |
| publishPlace | |
| publisher | |
| record_format | marcfinc |
| record_id | 490789625 |
| recordtype | marcfinc |
| rvk_facet | No subject assigned |
| source_id | 0 |
| spelling | Dutta, Partha VerfasserIn (DE-588)1136687505 (DE-627)89346449X (DE-576)49078786X aut, Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 Partha Dutta, Friedrich Felix Hoyer, Lubov S. Grigoryeva, Hendrik B. Sager, Florian Leuschner, Gabriel Courties, Anna Borodovsky, Tatiana Novobrantseva, Vera M. Ruda, Kevin Fitzgerald, Yoshiko Iwamoto, Gregory Wojtkiewicz, Yuan Sun, Nicolas Da Silva, Peter Libby, Daniel G. Anderson, Filip K. Swirski, Ralph Weissleder, and Matthias Nahrendorf, 6 April 2015, 16, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 12.07.2017, Dutta et al. show that targeting VACM-1 expression in splenic macrophages impairs extramedullary hematopoiesis, thus reducing inflammation in mouse ischemic heart and atherosclerotic plaques., Splenic myelopoiesis provides a steady flow of leukocytes to inflamed tissues, and leukocytosis correlates with cardiovascular mortality. Yet regulation of hematopoietic stem cell (HSC) activity in the spleen is incompletely understood. Here, we show that red pulp vascular cell adhesion molecule 1 (VCAM-1)+ macrophages are essential to extramedullary myelopoiesis because these macrophages use the adhesion molecule VCAM-1 to retain HSCs in the spleen. Nanoparticle-enabled in vivo RNAi silencing of the receptor for macrophage colony stimulation factor (M-CSFR) blocked splenic macrophage maturation, reduced splenic VCAM-1 expression and compromised splenic HSC retention. Both, depleting macrophages in CD169 iDTR mice or silencing VCAM-1 in macrophages released HSCs from the spleen. When we silenced either VCAM-1 or M-CSFR in mice with myocardial infarction or in ApoE−/− mice with atherosclerosis, nanoparticle-enabled in vivo RNAi mitigated blood leukocytosis, limited inflammation in the ischemic heart, and reduced myeloid cell numbers in atherosclerotic plaques., Leuschner, Florian VerfasserIn (DE-588)1072736144 (DE-627)828165742 (DE-576)189305347 aut, Enthalten in Journal of experimental medicine New York, NY : Rockefeller Univ. Press, 1896 212(2015), 4, Seite 497-512 Online-Ressource (DE-627)270425594 (DE-600)1477240-1 (DE-576)078590167 1540-9538 nnns, volume:212 year:2015 number:4 pages:497-512 extent:16, http://dx.doi.org/10.1084/jem.20141642 Verlag Resolving-System kostenfrei Volltext, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387283/ Verlag kostenfrei Volltext, http://dx.doi.org/10.1084/jem.20141642 LFER, LFER 2017-08-09T00:00:00Z |
| spellingShingle | Dutta, Partha, Leuschner, Florian, Macrophages retain hematopoietic stem cells in the spleen via VCAM-1, Dutta et al. show that targeting VACM-1 expression in splenic macrophages impairs extramedullary hematopoiesis, thus reducing inflammation in mouse ischemic heart and atherosclerotic plaques., Splenic myelopoiesis provides a steady flow of leukocytes to inflamed tissues, and leukocytosis correlates with cardiovascular mortality. Yet regulation of hematopoietic stem cell (HSC) activity in the spleen is incompletely understood. Here, we show that red pulp vascular cell adhesion molecule 1 (VCAM-1)+ macrophages are essential to extramedullary myelopoiesis because these macrophages use the adhesion molecule VCAM-1 to retain HSCs in the spleen. Nanoparticle-enabled in vivo RNAi silencing of the receptor for macrophage colony stimulation factor (M-CSFR) blocked splenic macrophage maturation, reduced splenic VCAM-1 expression and compromised splenic HSC retention. Both, depleting macrophages in CD169 iDTR mice or silencing VCAM-1 in macrophages released HSCs from the spleen. When we silenced either VCAM-1 or M-CSFR in mice with myocardial infarction or in ApoE−/− mice with atherosclerosis, nanoparticle-enabled in vivo RNAi mitigated blood leukocytosis, limited inflammation in the ischemic heart, and reduced myeloid cell numbers in atherosclerotic plaques. |
| swb_id_str | 490789625 |
| title | Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 |
| title_auth | Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 |
| title_full | Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 Partha Dutta, Friedrich Felix Hoyer, Lubov S. Grigoryeva, Hendrik B. Sager, Florian Leuschner, Gabriel Courties, Anna Borodovsky, Tatiana Novobrantseva, Vera M. Ruda, Kevin Fitzgerald, Yoshiko Iwamoto, Gregory Wojtkiewicz, Yuan Sun, Nicolas Da Silva, Peter Libby, Daniel G. Anderson, Filip K. Swirski, Ralph Weissleder, and Matthias Nahrendorf |
| title_fullStr | Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 Partha Dutta, Friedrich Felix Hoyer, Lubov S. Grigoryeva, Hendrik B. Sager, Florian Leuschner, Gabriel Courties, Anna Borodovsky, Tatiana Novobrantseva, Vera M. Ruda, Kevin Fitzgerald, Yoshiko Iwamoto, Gregory Wojtkiewicz, Yuan Sun, Nicolas Da Silva, Peter Libby, Daniel G. Anderson, Filip K. Swirski, Ralph Weissleder, and Matthias Nahrendorf |
| title_full_unstemmed | Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 Partha Dutta, Friedrich Felix Hoyer, Lubov S. Grigoryeva, Hendrik B. Sager, Florian Leuschner, Gabriel Courties, Anna Borodovsky, Tatiana Novobrantseva, Vera M. Ruda, Kevin Fitzgerald, Yoshiko Iwamoto, Gregory Wojtkiewicz, Yuan Sun, Nicolas Da Silva, Peter Libby, Daniel G. Anderson, Filip K. Swirski, Ralph Weissleder, and Matthias Nahrendorf |
| title_in_hierarchy | Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 / Partha Dutta, Friedrich Felix Hoyer, Lubov S. Grigoryeva, Hendrik B. Sager, Florian Leuschner, Gabriel Courties, Anna Borodovsky, Tatiana Novobrantseva, Vera M. Ruda, Kevin Fitzgerald, Yoshiko Iwamoto, Gregory Wojtkiewicz, Yuan Sun, Nicolas Da Silva, Peter Libby, Daniel G. Anderson, Filip K. Swirski, Ralph Weissleder, and Matthias Nahrendorf, |
| title_short | Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 |
| title_sort | macrophages retain hematopoietic stem cells in the spleen via vcam 1 |
| url | http://dx.doi.org/10.1084/jem.20141642, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387283/ |