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Pre- and post-diagnostic β-blocker use and lung cancer survival: a population-based cohort study
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| Veröffentlicht in: | Scientific reports 7(2017) Artikel-Nummer 2911, 11 Seiten |
|---|---|
| Personen und Körperschaften: | , , |
| Titel: | Pre- and post-diagnostic β-blocker use and lung cancer survival: a population-based cohort study/ Janick Weberpals, Lina Jansen, Walter E. Haefeli, Michael Hoffmeister, Martin Wolkewitz, Myrthe P. P. van Herk-Sukel, Pauline A. J. Vissers & Hermann Brenner |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
06 June 2017
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| Gesamtaufnahme: |
: Scientific reports, 7(2017) Artikel-Nummer 2911, 11 Seiten
, volume:7 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 0 | |a Pre- and post-diagnostic β-blocker use and lung cancer survival |b a population-based cohort study |c Janick Weberpals, Lina Jansen, Walter E. Haefeli, Michael Hoffmeister, Martin Wolkewitz, Myrthe P. P. van Herk-Sukel, Pauline A. J. Vissers & Hermann Brenner |
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| 520 | |a Beta-blockers have been associated with decreased cancer mortality. However, evidence for lung cancer is sparse and reported beneficial effects might be based on biased analyses. In this so far largest study we investigated the association between β-blocker use and lung cancer survival. Therefore, patients with a lung cancer diagnosis between April 1998 and December 2011 were selected from a database linkage of the Netherlands Cancer Registry and the PHARMO Database Network. After matching eligible patients on the propensity score, adjusted hazard ratios (HRs) and corresponding 95% confidence intervals (CI) were calculated using Cox proportional hazards regression to investigate the association between pre-diagnostic and time-dependent β-blocker use and overall survival. Duration and dose-response analyses and stratified analyses by β-blocker type, histological subgroups and stage were conducted. Of 3,340 eligible lung cancer patients, 1437 (43%) took β-blockers four months prior to diagnosis. Pre-diagnostic β-blocker use was not associated with overall survival (HR 1.00 (0.92-1.08)) in the adjusted model. Time-dependent post-diagnostic analysis showed similar results with a HR of 1.03 (0.94-1.11). Trend analyses showed no association for cumulative dose (HR 0.99 (0.97-1.02)) and cumulative duration (HR 1.00 (0.96-1.05)). In conclusion, β-blocker use is not associated with reduced mortality among lung cancer patients. | ||
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| contents | Beta-blockers have been associated with decreased cancer mortality. However, evidence for lung cancer is sparse and reported beneficial effects might be based on biased analyses. In this so far largest study we investigated the association between β-blocker use and lung cancer survival. Therefore, patients with a lung cancer diagnosis between April 1998 and December 2011 were selected from a database linkage of the Netherlands Cancer Registry and the PHARMO Database Network. After matching eligible patients on the propensity score, adjusted hazard ratios (HRs) and corresponding 95% confidence intervals (CI) were calculated using Cox proportional hazards regression to investigate the association between pre-diagnostic and time-dependent β-blocker use and overall survival. Duration and dose-response analyses and stratified analyses by β-blocker type, histological subgroups and stage were conducted. Of 3,340 eligible lung cancer patients, 1437 (43%) took β-blockers four months prior to diagnosis. Pre-diagnostic β-blocker use was not associated with overall survival (HR 1.00 (0.92-1.08)) in the adjusted model. Time-dependent post-diagnostic analysis showed similar results with a HR of 1.03 (0.94-1.11). Trend analyses showed no association for cumulative dose (HR 0.99 (0.97-1.02)) and cumulative duration (HR 1.00 (0.96-1.05)). In conclusion, β-blocker use is not associated with reduced mortality among lung cancer patients. |
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| spelling | Weberpals, Janick 1989- VerfasserIn (DE-588)1135927847 (DE-627)890933855 (DE-576)470039663 aut, Pre- and post-diagnostic β-blocker use and lung cancer survival a population-based cohort study Janick Weberpals, Lina Jansen, Walter E. Haefeli, Michael Hoffmeister, Martin Wolkewitz, Myrthe P. P. van Herk-Sukel, Pauline A. J. Vissers & Hermann Brenner, 06 June 2017, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 26.06.2017, Beta-blockers have been associated with decreased cancer mortality. However, evidence for lung cancer is sparse and reported beneficial effects might be based on biased analyses. In this so far largest study we investigated the association between β-blocker use and lung cancer survival. Therefore, patients with a lung cancer diagnosis between April 1998 and December 2011 were selected from a database linkage of the Netherlands Cancer Registry and the PHARMO Database Network. After matching eligible patients on the propensity score, adjusted hazard ratios (HRs) and corresponding 95% confidence intervals (CI) were calculated using Cox proportional hazards regression to investigate the association between pre-diagnostic and time-dependent β-blocker use and overall survival. Duration and dose-response analyses and stratified analyses by β-blocker type, histological subgroups and stage were conducted. Of 3,340 eligible lung cancer patients, 1437 (43%) took β-blockers four months prior to diagnosis. Pre-diagnostic β-blocker use was not associated with overall survival (HR 1.00 (0.92-1.08)) in the adjusted model. Time-dependent post-diagnostic analysis showed similar results with a HR of 1.03 (0.94-1.11). Trend analyses showed no association for cumulative dose (HR 0.99 (0.97-1.02)) and cumulative duration (HR 1.00 (0.96-1.05)). In conclusion, β-blocker use is not associated with reduced mortality among lung cancer patients., Haefeli, Walter E. 1958- VerfasserIn (DE-588)124572359 (DE-627)656806141 (DE-576)340514221 aut, Brenner, Hermann VerfasserIn (DE-588)1020516445 (DE-627)691247005 (DE-576)360642136 aut, Enthalten in Scientific reports [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 7(2017) Artikel-Nummer 2911, 11 Seiten Online-Ressource (DE-627)663366712 (DE-600)2615211-3 (DE-576)346641179 2045-2322 nnns, volume:7 year:2017, http://dx.doi.org/10.1038/s41598-017-02913-8 Verlag Resolving-System kostenfrei Volltext, https://www.nature.com/articles/s41598-017-02913-8 Verlag kostenfrei Volltext, http://dx.doi.org/10.1038/s41598-017-02913-8 LFER, LFER 2017-07-10T00:00:00Z |
| spellingShingle | Weberpals, Janick, Haefeli, Walter E., Brenner, Hermann, Pre- and post-diagnostic β-blocker use and lung cancer survival: a population-based cohort study, Beta-blockers have been associated with decreased cancer mortality. However, evidence for lung cancer is sparse and reported beneficial effects might be based on biased analyses. In this so far largest study we investigated the association between β-blocker use and lung cancer survival. Therefore, patients with a lung cancer diagnosis between April 1998 and December 2011 were selected from a database linkage of the Netherlands Cancer Registry and the PHARMO Database Network. After matching eligible patients on the propensity score, adjusted hazard ratios (HRs) and corresponding 95% confidence intervals (CI) were calculated using Cox proportional hazards regression to investigate the association between pre-diagnostic and time-dependent β-blocker use and overall survival. Duration and dose-response analyses and stratified analyses by β-blocker type, histological subgroups and stage were conducted. Of 3,340 eligible lung cancer patients, 1437 (43%) took β-blockers four months prior to diagnosis. Pre-diagnostic β-blocker use was not associated with overall survival (HR 1.00 (0.92-1.08)) in the adjusted model. Time-dependent post-diagnostic analysis showed similar results with a HR of 1.03 (0.94-1.11). Trend analyses showed no association for cumulative dose (HR 0.99 (0.97-1.02)) and cumulative duration (HR 1.00 (0.96-1.05)). In conclusion, β-blocker use is not associated with reduced mortality among lung cancer patients. |
| swb_id_str | 490166040 |
| title | Pre- and post-diagnostic β-blocker use and lung cancer survival: a population-based cohort study |
| title_auth | Pre- and post-diagnostic β-blocker use and lung cancer survival a population-based cohort study |
| title_full | Pre- and post-diagnostic β-blocker use and lung cancer survival a population-based cohort study Janick Weberpals, Lina Jansen, Walter E. Haefeli, Michael Hoffmeister, Martin Wolkewitz, Myrthe P. P. van Herk-Sukel, Pauline A. J. Vissers & Hermann Brenner |
| title_fullStr | Pre- and post-diagnostic β-blocker use and lung cancer survival a population-based cohort study Janick Weberpals, Lina Jansen, Walter E. Haefeli, Michael Hoffmeister, Martin Wolkewitz, Myrthe P. P. van Herk-Sukel, Pauline A. J. Vissers & Hermann Brenner |
| title_full_unstemmed | Pre- and post-diagnostic β-blocker use and lung cancer survival a population-based cohort study Janick Weberpals, Lina Jansen, Walter E. Haefeli, Michael Hoffmeister, Martin Wolkewitz, Myrthe P. P. van Herk-Sukel, Pauline A. J. Vissers & Hermann Brenner |
| title_in_hierarchy | Pre- and post-diagnostic β-blocker use and lung cancer survival: a population-based cohort study / Janick Weberpals, Lina Jansen, Walter E. Haefeli, Michael Hoffmeister, Martin Wolkewitz, Myrthe P. P. van Herk-Sukel, Pauline A. J. Vissers & Hermann Brenner, |
| title_short | Pre- and post-diagnostic β-blocker use and lung cancer survival |
| title_sort | pre and post diagnostic β blocker use and lung cancer survival a population based cohort study |
| title_sub | a population-based cohort study |
| url | http://dx.doi.org/10.1038/s41598-017-02913-8, https://www.nature.com/articles/s41598-017-02913-8 |