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Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish
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| Veröffentlicht in: | Frontiers in neural circuits 7(2013) Artikel-Nummer 09, 7 Seiten |
|---|---|
| Personen und Körperschaften: | , |
| Titel: | Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish/ Idan Elbaz, Nicholas S. Foulkes, Yoav Gothilf and Lior Appelbaum |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
01February2013
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| Gesamtaufnahme: |
: Frontiers in neural circuits, 7(2013) Artikel-Nummer 09, 7 Seiten
, volume:7 |
| Schlagwörter: | |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 520 | |a The circadian clock and homeostatic processes are fundamental mechanisms that regulate sleep. Surprisingly, despite decades of research, we still do not know why we sleep. Intriguing hypotheses suggest that sleep regulates synaptic plasticity and consequently has a beneficial role in learning and memory. However, direct evidence is still limited and the molecular regulatory mechanisms remain unclear. The zebrafish provides a powerful vertebrate model system that enables simple genetic manipulation, imaging of neuronal circuits and synapses in living animals, and the monitoring of behavioral performance during day and night. Thus, the zebrafish has become an attractive model to study circadian and homeostatic processes that regulate sleep. Zebrafish clock- and sleep-related genes have been cloned, neuronal circuits that exhibit circadian rhythms of activity and synaptic plasticity have been studied, and rhythmic behavioral outputs have been characterized. Integration of this data could lead to a better understanding of sleep regulation. Here, we review the progress of circadian clock and sleep studies in zebrafish with special emphasis on the genetic and neuroendocrine mechanisms that regulate rhythms of melatonin secretion, structural synaptic plasticity, locomotor activity and sleep. | ||
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| contents | The circadian clock and homeostatic processes are fundamental mechanisms that regulate sleep. Surprisingly, despite decades of research, we still do not know why we sleep. Intriguing hypotheses suggest that sleep regulates synaptic plasticity and consequently has a beneficial role in learning and memory. However, direct evidence is still limited and the molecular regulatory mechanisms remain unclear. The zebrafish provides a powerful vertebrate model system that enables simple genetic manipulation, imaging of neuronal circuits and synapses in living animals, and the monitoring of behavioral performance during day and night. Thus, the zebrafish has become an attractive model to study circadian and homeostatic processes that regulate sleep. Zebrafish clock- and sleep-related genes have been cloned, neuronal circuits that exhibit circadian rhythms of activity and synaptic plasticity have been studied, and rhythmic behavioral outputs have been characterized. Integration of this data could lead to a better understanding of sleep regulation. Here, we review the progress of circadian clock and sleep studies in zebrafish with special emphasis on the genetic and neuroendocrine mechanisms that regulate rhythms of melatonin secretion, structural synaptic plasticity, locomotor activity and sleep. |
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| spelling | Elbaz, Idan VerfasserIn (DE-588)1135685614 (DE-627)890681783 (DE-576)490045634 aut, Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish Idan Elbaz, Nicholas S. Foulkes, Yoav Gothilf and Lior Appelbaum, 01February2013, 7, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 21.06.2017, The circadian clock and homeostatic processes are fundamental mechanisms that regulate sleep. Surprisingly, despite decades of research, we still do not know why we sleep. Intriguing hypotheses suggest that sleep regulates synaptic plasticity and consequently has a beneficial role in learning and memory. However, direct evidence is still limited and the molecular regulatory mechanisms remain unclear. The zebrafish provides a powerful vertebrate model system that enables simple genetic manipulation, imaging of neuronal circuits and synapses in living animals, and the monitoring of behavioral performance during day and night. Thus, the zebrafish has become an attractive model to study circadian and homeostatic processes that regulate sleep. Zebrafish clock- and sleep-related genes have been cloned, neuronal circuits that exhibit circadian rhythms of activity and synaptic plasticity have been studied, and rhythmic behavioral outputs have been characterized. Integration of this data could lead to a better understanding of sleep regulation. Here, we review the progress of circadian clock and sleep studies in zebrafish with special emphasis on the genetic and neuroendocrine mechanisms that regulate rhythms of melatonin secretion, structural synaptic plasticity, locomotor activity and sleep., Circadian clock, Circadian Rhythm, hypocretin, Melatonin, orexin, Sleep, synaptic plasticity, Zebrafish, Foulkes, Nicholas S. 1963- VerfasserIn (DE-588)1081431695 (DE-627)84611044X (DE-576)454404999 aut, Enthalten in Frontiers in neural circuits Lausanne : Frontiers Research Foundation, 2007 7(2013) Artikel-Nummer 09, 7 Seiten Online-Ressource (DE-627)579826457 (DE-600)2452968-0 (DE-576)286502275 1662-5110 nnns, volume:7 year:2013 extent:7, http://dx.doi.org/10.3389/fncir.2013.00009 Verlag Resolving-System kostenfrei Volltext, http://journal.frontiersin.org/article/10.3389/fncir.2013.00009/full Verlag kostenfrei Volltext, http://dx.doi.org/10.3389/fncir.2013.00009 LFER, LFER 2017-07-10T00:00:00Z |
| spellingShingle | Elbaz, Idan, Foulkes, Nicholas S., Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish, The circadian clock and homeostatic processes are fundamental mechanisms that regulate sleep. Surprisingly, despite decades of research, we still do not know why we sleep. Intriguing hypotheses suggest that sleep regulates synaptic plasticity and consequently has a beneficial role in learning and memory. However, direct evidence is still limited and the molecular regulatory mechanisms remain unclear. The zebrafish provides a powerful vertebrate model system that enables simple genetic manipulation, imaging of neuronal circuits and synapses in living animals, and the monitoring of behavioral performance during day and night. Thus, the zebrafish has become an attractive model to study circadian and homeostatic processes that regulate sleep. Zebrafish clock- and sleep-related genes have been cloned, neuronal circuits that exhibit circadian rhythms of activity and synaptic plasticity have been studied, and rhythmic behavioral outputs have been characterized. Integration of this data could lead to a better understanding of sleep regulation. Here, we review the progress of circadian clock and sleep studies in zebrafish with special emphasis on the genetic and neuroendocrine mechanisms that regulate rhythms of melatonin secretion, structural synaptic plasticity, locomotor activity and sleep., Circadian clock, Circadian Rhythm, hypocretin, Melatonin, orexin, Sleep, synaptic plasticity, Zebrafish |
| swb_id_str | 490047017 |
| title | Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish |
| title_auth | Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish |
| title_full | Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish Idan Elbaz, Nicholas S. Foulkes, Yoav Gothilf and Lior Appelbaum |
| title_fullStr | Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish Idan Elbaz, Nicholas S. Foulkes, Yoav Gothilf and Lior Appelbaum |
| title_full_unstemmed | Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish Idan Elbaz, Nicholas S. Foulkes, Yoav Gothilf and Lior Appelbaum |
| title_in_hierarchy | Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish / Idan Elbaz, Nicholas S. Foulkes, Yoav Gothilf and Lior Appelbaum, |
| title_short | Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish |
| title_sort | circadian clocks rhythmic synaptic plasticity and the sleep wake cycle in zebrafish |
| topic | Circadian clock, Circadian Rhythm, hypocretin, Melatonin, orexin, Sleep, synaptic plasticity, Zebrafish |
| topic_facet | Circadian clock, Circadian Rhythm, hypocretin, Melatonin, orexin, Sleep, synaptic plasticity, Zebrafish |
| url | http://dx.doi.org/10.3389/fncir.2013.00009, http://journal.frontiersin.org/article/10.3389/fncir.2013.00009/full |