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Information transfer in signaling pathways: a study using coupled simulated and experimental data
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| Veröffentlicht in: | BMC bioinformatics 9(2008) Artikel-Nummer 130, 14 Seiten |
|---|---|
| Personen und Körperschaften: | , |
| Titel: | Information transfer in signaling pathways: a study using coupled simulated and experimental data/ Jürgen Pahle, Anne K. Green, C. Jane Dixon and Ursula Kummer |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
4 March 2008
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| Gesamtaufnahme: |
: BMC bioinformatics, 9(2008) Artikel-Nummer 130, 14 Seiten
, volume:9 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 0 | |a Information transfer in signaling pathways |b a study using coupled simulated and experimental data |c Jürgen Pahle, Anne K. Green, C. Jane Dixon and Ursula Kummer |
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| 520 | |a The topology of signaling cascades has been studied in quite some detail. However, how information is processed exactly is still relatively unknown. Since quite diverse information has to be transported by one and the same signaling cascade (e.g. in case of different agonists), it is clear that the underlying mechanism is more complex than a simple binary switch which relies on the mere presence or absence of a particular species. Therefore, finding means to analyze the information transferred will help in deciphering how information is processed exactly in the cell. Using the information-theoretic measure transfer entropy, we studied the properties of information transfer in an example case, namely calcium signaling under different cellular conditions. Transfer entropy is an asymmetric and dynamic measure of the dependence of two (nonlinear) stochastic processes. We used calcium signaling since it is a well-studied example of complex cellular signaling. It has been suggested that specific information is encoded in the amplitude, frequency and waveform of the oscillatory Ca2+-signal. | ||
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| contents | The topology of signaling cascades has been studied in quite some detail. However, how information is processed exactly is still relatively unknown. Since quite diverse information has to be transported by one and the same signaling cascade (e.g. in case of different agonists), it is clear that the underlying mechanism is more complex than a simple binary switch which relies on the mere presence or absence of a particular species. Therefore, finding means to analyze the information transferred will help in deciphering how information is processed exactly in the cell. Using the information-theoretic measure transfer entropy, we studied the properties of information transfer in an example case, namely calcium signaling under different cellular conditions. Transfer entropy is an asymmetric and dynamic measure of the dependence of two (nonlinear) stochastic processes. We used calcium signaling since it is a well-studied example of complex cellular signaling. It has been suggested that specific information is encoded in the amplitude, frequency and waveform of the oscillatory Ca2+-signal. |
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| spelling | Pahle, Jürgen 1976- VerfasserIn (DE-588)136080243 (DE-627)577146467 (DE-576)300819382 aut, Information transfer in signaling pathways a study using coupled simulated and experimental data Jürgen Pahle, Anne K. Green, C. Jane Dixon and Ursula Kummer, 4 March 2008, 14, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 24.05.2017, The topology of signaling cascades has been studied in quite some detail. However, how information is processed exactly is still relatively unknown. Since quite diverse information has to be transported by one and the same signaling cascade (e.g. in case of different agonists), it is clear that the underlying mechanism is more complex than a simple binary switch which relies on the mere presence or absence of a particular species. Therefore, finding means to analyze the information transferred will help in deciphering how information is processed exactly in the cell. Using the information-theoretic measure transfer entropy, we studied the properties of information transfer in an example case, namely calcium signaling under different cellular conditions. Transfer entropy is an asymmetric and dynamic measure of the dependence of two (nonlinear) stochastic processes. We used calcium signaling since it is a well-studied example of complex cellular signaling. It has been suggested that specific information is encoded in the amplitude, frequency and waveform of the oscillatory Ca2+-signal., Kummer, Ursula 1967- VerfasserIn (DE-588)115411682 (DE-627)691297975 (DE-576)176480897 aut, Enthalten in BMC bioinformatics London : BioMed Central, 2000 9(2008) Artikel-Nummer 130, 14 Seiten Online-Ressource (DE-627)326644814 (DE-600)2041484-5 (DE-576)107014688 1471-2105 nnns, volume:9 year:2008 extent:14, http://dx.doi.org/10.1186/1471-2105-9-139 Verlag Resolving-System kostenfrei Volltext, http://dx.doi.org/10.1186/1471-2105-9-139 LFER, LFER 2017-06-08T00:00:00Z |
| spellingShingle | Pahle, Jürgen, Kummer, Ursula, Information transfer in signaling pathways: a study using coupled simulated and experimental data, The topology of signaling cascades has been studied in quite some detail. However, how information is processed exactly is still relatively unknown. Since quite diverse information has to be transported by one and the same signaling cascade (e.g. in case of different agonists), it is clear that the underlying mechanism is more complex than a simple binary switch which relies on the mere presence or absence of a particular species. Therefore, finding means to analyze the information transferred will help in deciphering how information is processed exactly in the cell. Using the information-theoretic measure transfer entropy, we studied the properties of information transfer in an example case, namely calcium signaling under different cellular conditions. Transfer entropy is an asymmetric and dynamic measure of the dependence of two (nonlinear) stochastic processes. We used calcium signaling since it is a well-studied example of complex cellular signaling. It has been suggested that specific information is encoded in the amplitude, frequency and waveform of the oscillatory Ca2+-signal. |
| swb_id_str | 488951119 |
| title | Information transfer in signaling pathways: a study using coupled simulated and experimental data |
| title_auth | Information transfer in signaling pathways a study using coupled simulated and experimental data |
| title_full | Information transfer in signaling pathways a study using coupled simulated and experimental data Jürgen Pahle, Anne K. Green, C. Jane Dixon and Ursula Kummer |
| title_fullStr | Information transfer in signaling pathways a study using coupled simulated and experimental data Jürgen Pahle, Anne K. Green, C. Jane Dixon and Ursula Kummer |
| title_full_unstemmed | Information transfer in signaling pathways a study using coupled simulated and experimental data Jürgen Pahle, Anne K. Green, C. Jane Dixon and Ursula Kummer |
| title_in_hierarchy | Information transfer in signaling pathways: a study using coupled simulated and experimental data / Jürgen Pahle, Anne K. Green, C. Jane Dixon and Ursula Kummer, |
| title_short | Information transfer in signaling pathways |
| title_sort | information transfer in signaling pathways a study using coupled simulated and experimental data |
| title_sub | a study using coupled simulated and experimental data |
| url | http://dx.doi.org/10.1186/1471-2105-9-139 |