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Elm1 kinase activates the spindle position checkpoint kinase Kin4
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| Veröffentlicht in: | The journal of cell biology 190(2010), 6, Seite 975-989 |
|---|---|
| Personen und Körperschaften: | , , , |
| Titel: | Elm1 kinase activates the spindle position checkpoint kinase Kin4/ Ayse Koca Caydasi, Bahtiyar Kurtulmus, Maria I. L. Orrico, Astrid Hofmann, Bashar Ibrahim, and Gislene Pereira |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
September 20, 2010
|
| Gesamtaufnahme: |
: The journal of cell biology, 190(2010), 6, Seite 975-989
, volume:190 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 520 | |a Budding yeast asymmetric cell division relies upon the precise coordination of spindle orientation and cell cycle progression. The spindle position checkpoint (SPOC) is a surveillance mechanism that prevents cells with misoriented spindles from exiting mitosis. The cortical kinase Kin4 acts near the top of this network. How Kin4 kinase activity is regulated and maintained in respect to spindle positional cues remains to be established. Here, we show that the bud neck-associated kinase Elm1 participates in Kin4 activation and SPOC signaling by phosphorylating a conserved residue within the activation loop of Kin4. Blocking Elm1 function abolishes Kin4 kinase activity in vivo and eliminates the SPOC response to spindle misalignment. These findings establish a novel function for Elm1 in the coordination of spindle positioning with cell cycle progression via its control of Kin4. | ||
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| author | Caydasi, Ayse Koca, Kurtulmus, Bahtiyar, Hofmann, Astrid, Pereira, Gislene |
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| contents | Budding yeast asymmetric cell division relies upon the precise coordination of spindle orientation and cell cycle progression. The spindle position checkpoint (SPOC) is a surveillance mechanism that prevents cells with misoriented spindles from exiting mitosis. The cortical kinase Kin4 acts near the top of this network. How Kin4 kinase activity is regulated and maintained in respect to spindle positional cues remains to be established. Here, we show that the bud neck-associated kinase Elm1 participates in Kin4 activation and SPOC signaling by phosphorylating a conserved residue within the activation loop of Kin4. Blocking Elm1 function abolishes Kin4 kinase activity in vivo and eliminates the SPOC response to spindle misalignment. These findings establish a novel function for Elm1 in the coordination of spindle positioning with cell cycle progression via its control of Kin4. |
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| spelling | Caydasi, Ayse Koca VerfasserIn (DE-588)1019268204 (DE-627)684605791 (DE-576)357370236 aut, Elm1 kinase activates the spindle position checkpoint kinase Kin4 Ayse Koca Caydasi, Bahtiyar Kurtulmus, Maria I. L. Orrico, Astrid Hofmann, Bashar Ibrahim, and Gislene Pereira, September 20, 2010, 15, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 16.05.2017, Budding yeast asymmetric cell division relies upon the precise coordination of spindle orientation and cell cycle progression. The spindle position checkpoint (SPOC) is a surveillance mechanism that prevents cells with misoriented spindles from exiting mitosis. The cortical kinase Kin4 acts near the top of this network. How Kin4 kinase activity is regulated and maintained in respect to spindle positional cues remains to be established. Here, we show that the bud neck-associated kinase Elm1 participates in Kin4 activation and SPOC signaling by phosphorylating a conserved residue within the activation loop of Kin4. Blocking Elm1 function abolishes Kin4 kinase activity in vivo and eliminates the SPOC response to spindle misalignment. These findings establish a novel function for Elm1 in the coordination of spindle positioning with cell cycle progression via its control of Kin4., Kurtulmus, Bahtiyar VerfasserIn (DE-588)1132090040 (DE-627)887371213 (DE-576)488611911 aut, Hofmann, Astrid VerfasserIn (DE-588)1131901967 (DE-627)886951771 (DE-576)488571634 aut, Pereira, Gislene VerfasserIn (DE-588)1131901568 (DE-627)886950988 (DE-576)488570433 aut, Enthalten in The journal of cell biology New York, NY : Rockefeller Univ. Press, 1962 190(2010), 6, Seite 975-989 Online-Ressource (DE-627)242065244 (DE-600)1421310-2 (DE-576)065026527 1540-8140 nnns, volume:190 year:2010 number:6 pages:975-989 extent:15, http://dx.doi.org/10.1083/jcb.201006151 Verlag Resolving-System kostenfrei Volltext, http://jcb.rupress.org/content/190/6/975 Verlag kostenfrei Volltext, http://dx.doi.org/10.1083/jcb.201006151 LFER, LFER 2017-06-08T00:00:00Z |
| spellingShingle | Caydasi, Ayse Koca, Kurtulmus, Bahtiyar, Hofmann, Astrid, Pereira, Gislene, Elm1 kinase activates the spindle position checkpoint kinase Kin4, Budding yeast asymmetric cell division relies upon the precise coordination of spindle orientation and cell cycle progression. The spindle position checkpoint (SPOC) is a surveillance mechanism that prevents cells with misoriented spindles from exiting mitosis. The cortical kinase Kin4 acts near the top of this network. How Kin4 kinase activity is regulated and maintained in respect to spindle positional cues remains to be established. Here, we show that the bud neck-associated kinase Elm1 participates in Kin4 activation and SPOC signaling by phosphorylating a conserved residue within the activation loop of Kin4. Blocking Elm1 function abolishes Kin4 kinase activity in vivo and eliminates the SPOC response to spindle misalignment. These findings establish a novel function for Elm1 in the coordination of spindle positioning with cell cycle progression via its control of Kin4. |
| swb_id_str | 48863914X |
| title | Elm1 kinase activates the spindle position checkpoint kinase Kin4 |
| title_auth | Elm1 kinase activates the spindle position checkpoint kinase Kin4 |
| title_full | Elm1 kinase activates the spindle position checkpoint kinase Kin4 Ayse Koca Caydasi, Bahtiyar Kurtulmus, Maria I. L. Orrico, Astrid Hofmann, Bashar Ibrahim, and Gislene Pereira |
| title_fullStr | Elm1 kinase activates the spindle position checkpoint kinase Kin4 Ayse Koca Caydasi, Bahtiyar Kurtulmus, Maria I. L. Orrico, Astrid Hofmann, Bashar Ibrahim, and Gislene Pereira |
| title_full_unstemmed | Elm1 kinase activates the spindle position checkpoint kinase Kin4 Ayse Koca Caydasi, Bahtiyar Kurtulmus, Maria I. L. Orrico, Astrid Hofmann, Bashar Ibrahim, and Gislene Pereira |
| title_in_hierarchy | Elm1 kinase activates the spindle position checkpoint kinase Kin4 / Ayse Koca Caydasi, Bahtiyar Kurtulmus, Maria I. L. Orrico, Astrid Hofmann, Bashar Ibrahim, and Gislene Pereira, |
| title_short | Elm1 kinase activates the spindle position checkpoint kinase Kin4 |
| title_sort | elm1 kinase activates the spindle position checkpoint kinase kin4 |
| url | http://dx.doi.org/10.1083/jcb.201006151, http://jcb.rupress.org/content/190/6/975 |