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Unexpected complexity of the Wnt gene family in a sea anemone
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| Veröffentlicht in: | Nature <London> 433(2005), 7022, Seite 156-160 |
|---|---|
| Personen und Körperschaften: | , |
| Titel: | Unexpected complexity of the Wnt gene family in a sea anemone/ Arne Kusserow, Kevin Pang, Carsten Sturm, Martina Hrouda, Jan Lentfer, Heiko A. Schmidt, Ulrich Technau, Arndt von Haeseler, Bert Hobmayer, Mark Q. Martindale & Thomas W. Holstein |
| Format: | E-Book-Kapitel |
| Sprache: | Englisch |
| veröffentlicht: |
13 January 2005
|
| Gesamtaufnahme: |
: Nature <London>, 433(2005), 7022, Seite 156-160
, volume:433 |
| Quelle: | Verbunddaten SWB Lizenzfreie Online-Ressourcen |
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| 245 | 1 | 0 | |a Unexpected complexity of the Wnt gene family in a sea anemone |c Arne Kusserow, Kevin Pang, Carsten Sturm, Martina Hrouda, Jan Lentfer, Heiko A. Schmidt, Ulrich Technau, Arndt von Haeseler, Bert Hobmayer, Mark Q. Martindale & Thomas W. Holstein |
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| 520 | |a The Wnt gene family encodes secreted signalling molecules that control cell fate in animal development and human diseases. Despite its significance, the evolution of this metazoan-specific protein family is unclear. In vertebrates, twelve Wnt subfamilies were defined, of which only six have counterparts in Ecdysozoa (for example, Drosophila and Caenorhabditis). Here, we report the isolation of twelve Wnt genes from the sea anemone Nematostella vectensis , a species representing the basal group within cnidarians. Cnidarians are diploblastic animals and the sister-group to bilaterian metazoans. Phylogenetic analyses of N. vectensis Wnt genes reveal a thus far unpredicted ancestral diversity within the Wnt family. Cnidarians and bilaterians have at least eleven of the twelve known Wnt gene subfamilies in common; five subfamilies appear to be lost in the protostome lineage. Expression patterns of Wnt genes during N. vectensis embryogenesis indicate distinct roles of Wnts in gastrulation, resulting in serial overlapping expression domains along the primary axis of the planula larva. This unexpectedly complex inventory of Wnt family signalling factors evolved in early multi-cellular animals about 650 million years (Myr) ago, predating the Cambrian explosion by at least 100 Myr (refs 5, 8). It emphasizes the crucial function of Wnt genes in the diversification of eumetazoan body plans. | ||
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| contents | The Wnt gene family encodes secreted signalling molecules that control cell fate in animal development and human diseases. Despite its significance, the evolution of this metazoan-specific protein family is unclear. In vertebrates, twelve Wnt subfamilies were defined, of which only six have counterparts in Ecdysozoa (for example, Drosophila and Caenorhabditis). Here, we report the isolation of twelve Wnt genes from the sea anemone Nematostella vectensis , a species representing the basal group within cnidarians. Cnidarians are diploblastic animals and the sister-group to bilaterian metazoans. Phylogenetic analyses of N. vectensis Wnt genes reveal a thus far unpredicted ancestral diversity within the Wnt family. Cnidarians and bilaterians have at least eleven of the twelve known Wnt gene subfamilies in common; five subfamilies appear to be lost in the protostome lineage. Expression patterns of Wnt genes during N. vectensis embryogenesis indicate distinct roles of Wnts in gastrulation, resulting in serial overlapping expression domains along the primary axis of the planula larva. This unexpectedly complex inventory of Wnt family signalling factors evolved in early multi-cellular animals about 650 million years (Myr) ago, predating the Cambrian explosion by at least 100 Myr (refs 5, 8). It emphasizes the crucial function of Wnt genes in the diversification of eumetazoan body plans. |
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| spelling | Kusserow, Arne 1967- VerfasserIn (DE-588)130469912 (DE-627)502216972 (DE-576)298215136 aut, Unexpected complexity of the Wnt gene family in a sea anemone Arne Kusserow, Kevin Pang, Carsten Sturm, Martina Hrouda, Jan Lentfer, Heiko A. Schmidt, Ulrich Technau, Arndt von Haeseler, Bert Hobmayer, Mark Q. Martindale & Thomas W. Holstein, 13 January 2005, 5, Text txt rdacontent, Computermedien c rdamedia, Online-Ressource cr rdacarrier, Gesehen am 10.05.2017, The Wnt gene family encodes secreted signalling molecules that control cell fate in animal development and human diseases. Despite its significance, the evolution of this metazoan-specific protein family is unclear. In vertebrates, twelve Wnt subfamilies were defined, of which only six have counterparts in Ecdysozoa (for example, Drosophila and Caenorhabditis). Here, we report the isolation of twelve Wnt genes from the sea anemone Nematostella vectensis , a species representing the basal group within cnidarians. Cnidarians are diploblastic animals and the sister-group to bilaterian metazoans. Phylogenetic analyses of N. vectensis Wnt genes reveal a thus far unpredicted ancestral diversity within the Wnt family. Cnidarians and bilaterians have at least eleven of the twelve known Wnt gene subfamilies in common; five subfamilies appear to be lost in the protostome lineage. Expression patterns of Wnt genes during N. vectensis embryogenesis indicate distinct roles of Wnts in gastrulation, resulting in serial overlapping expression domains along the primary axis of the planula larva. This unexpectedly complex inventory of Wnt family signalling factors evolved in early multi-cellular animals about 650 million years (Myr) ago, predating the Cambrian explosion by at least 100 Myr (refs 5, 8). It emphasizes the crucial function of Wnt genes in the diversification of eumetazoan body plans., Holstein, Thomas W. 1953- VerfasserIn (DE-588)1057984620 (DE-627)796251053 (DE-576)413989178 aut, Enthalten in Nature <London> London [u.a.] : Nature Publ. Group, 1869 433(2005), 7022, Seite 156-160 Online-Ressource (DE-627)240151402 (DE-600)1413423-8 (DE-576)079718426 1476-4687 nnns, volume:433 year:2005 number:7022 pages:156-160 extent:5, http://dx.doi.org/10.1038/nature03158 Verlag Resolving-System kostenfrei Volltext, https://www.nature.com/nature/journal/v433/n7022/full/nature03158.html Verlag kostenfrei Volltext, http://dx.doi.org/10.1038/nature03158 LFER, LFER 2017-06-08T00:00:00Z |
| spellingShingle | Kusserow, Arne, Holstein, Thomas W., Unexpected complexity of the Wnt gene family in a sea anemone, The Wnt gene family encodes secreted signalling molecules that control cell fate in animal development and human diseases. Despite its significance, the evolution of this metazoan-specific protein family is unclear. In vertebrates, twelve Wnt subfamilies were defined, of which only six have counterparts in Ecdysozoa (for example, Drosophila and Caenorhabditis). Here, we report the isolation of twelve Wnt genes from the sea anemone Nematostella vectensis , a species representing the basal group within cnidarians. Cnidarians are diploblastic animals and the sister-group to bilaterian metazoans. Phylogenetic analyses of N. vectensis Wnt genes reveal a thus far unpredicted ancestral diversity within the Wnt family. Cnidarians and bilaterians have at least eleven of the twelve known Wnt gene subfamilies in common; five subfamilies appear to be lost in the protostome lineage. Expression patterns of Wnt genes during N. vectensis embryogenesis indicate distinct roles of Wnts in gastrulation, resulting in serial overlapping expression domains along the primary axis of the planula larva. This unexpectedly complex inventory of Wnt family signalling factors evolved in early multi-cellular animals about 650 million years (Myr) ago, predating the Cambrian explosion by at least 100 Myr (refs 5, 8). It emphasizes the crucial function of Wnt genes in the diversification of eumetazoan body plans. |
| swb_id_str | 488380359 |
| title | Unexpected complexity of the Wnt gene family in a sea anemone |
| title_auth | Unexpected complexity of the Wnt gene family in a sea anemone |
| title_full | Unexpected complexity of the Wnt gene family in a sea anemone Arne Kusserow, Kevin Pang, Carsten Sturm, Martina Hrouda, Jan Lentfer, Heiko A. Schmidt, Ulrich Technau, Arndt von Haeseler, Bert Hobmayer, Mark Q. Martindale & Thomas W. Holstein |
| title_fullStr | Unexpected complexity of the Wnt gene family in a sea anemone Arne Kusserow, Kevin Pang, Carsten Sturm, Martina Hrouda, Jan Lentfer, Heiko A. Schmidt, Ulrich Technau, Arndt von Haeseler, Bert Hobmayer, Mark Q. Martindale & Thomas W. Holstein |
| title_full_unstemmed | Unexpected complexity of the Wnt gene family in a sea anemone Arne Kusserow, Kevin Pang, Carsten Sturm, Martina Hrouda, Jan Lentfer, Heiko A. Schmidt, Ulrich Technau, Arndt von Haeseler, Bert Hobmayer, Mark Q. Martindale & Thomas W. Holstein |
| title_in_hierarchy | Unexpected complexity of the Wnt gene family in a sea anemone / Arne Kusserow, Kevin Pang, Carsten Sturm, Martina Hrouda, Jan Lentfer, Heiko A. Schmidt, Ulrich Technau, Arndt von Haeseler, Bert Hobmayer, Mark Q. Martindale & Thomas W. Holstein, |
| title_short | Unexpected complexity of the Wnt gene family in a sea anemone |
| title_sort | unexpected complexity of the wnt gene family in a sea anemone |
| url | http://dx.doi.org/10.1038/nature03158, https://www.nature.com/nature/journal/v433/n7022/full/nature03158.html |