author_facet Dreher, Felix
Kamburov, Atanas
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Kamburov, Atanas
Herwig, Ralf
spellingShingle Dreher, Felix
Kamburov, Atanas
Herwig, Ralf
Evolutionary Bioinformatics
Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome
Computer Science Applications
Genetics
Ecology, Evolution, Behavior and Systematics
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spelling Dreher, Felix Kamburov, Atanas Herwig, Ralf 1176-9343 1176-9343 SAGE Publications Computer Science Applications Genetics Ecology, Evolution, Behavior and Systematics http://dx.doi.org/10.4137/ebo.s8552 <jats:p> The analysis of interaction networks is crucial for understanding molecular function and has an essential impact for genome-wide studies. However, the interactomes of most species are largely incomplete and computational strategies that take into account sequence homology can help compensating for this lack of information using cross-species analysis. In this work we report the construction of a porcine interactome resource. We applied sequence homology matching and carried out bi-directional BLASTp searches for the currently available protein sequence collections of human and pig. Using this homology we were able to recover, on average, 71% of the proteins annotated for human pathways for the pig. Porcine protein-protein interactions were deduced from homologous proteins with known interactions in human. The result of this work is a resource comprising 204,699 predicted porcine interactions that can be used in genome analyses in order to enhance functional interpretation of data. The data can be visualized and downloaded from http://cpdb.molgen.mpg.de/pig . </jats:p> Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome Evolutionary Bioinformatics
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title Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome
title_unstemmed Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome
title_full Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome
title_fullStr Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome
title_full_unstemmed Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome
title_short Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome
title_sort construction of a pig physical interactome using sequence homology and a comprehensive reference human interactome
topic Computer Science Applications
Genetics
Ecology, Evolution, Behavior and Systematics
url http://dx.doi.org/10.4137/ebo.s8552
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description <jats:p> The analysis of interaction networks is crucial for understanding molecular function and has an essential impact for genome-wide studies. However, the interactomes of most species are largely incomplete and computational strategies that take into account sequence homology can help compensating for this lack of information using cross-species analysis. In this work we report the construction of a porcine interactome resource. We applied sequence homology matching and carried out bi-directional BLASTp searches for the currently available protein sequence collections of human and pig. Using this homology we were able to recover, on average, 71% of the proteins annotated for human pathways for the pig. Porcine protein-protein interactions were deduced from homologous proteins with known interactions in human. The result of this work is a resource comprising 204,699 predicted porcine interactions that can be used in genome analyses in order to enhance functional interpretation of data. The data can be visualized and downloaded from http://cpdb.molgen.mpg.de/pig . </jats:p>
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author Dreher, Felix, Kamburov, Atanas, Herwig, Ralf
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description <jats:p> The analysis of interaction networks is crucial for understanding molecular function and has an essential impact for genome-wide studies. However, the interactomes of most species are largely incomplete and computational strategies that take into account sequence homology can help compensating for this lack of information using cross-species analysis. In this work we report the construction of a porcine interactome resource. We applied sequence homology matching and carried out bi-directional BLASTp searches for the currently available protein sequence collections of human and pig. Using this homology we were able to recover, on average, 71% of the proteins annotated for human pathways for the pig. Porcine protein-protein interactions were deduced from homologous proteins with known interactions in human. The result of this work is a resource comprising 204,699 predicted porcine interactions that can be used in genome analyses in order to enhance functional interpretation of data. The data can be visualized and downloaded from http://cpdb.molgen.mpg.de/pig . </jats:p>
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spelling Dreher, Felix Kamburov, Atanas Herwig, Ralf 1176-9343 1176-9343 SAGE Publications Computer Science Applications Genetics Ecology, Evolution, Behavior and Systematics http://dx.doi.org/10.4137/ebo.s8552 <jats:p> The analysis of interaction networks is crucial for understanding molecular function and has an essential impact for genome-wide studies. However, the interactomes of most species are largely incomplete and computational strategies that take into account sequence homology can help compensating for this lack of information using cross-species analysis. In this work we report the construction of a porcine interactome resource. We applied sequence homology matching and carried out bi-directional BLASTp searches for the currently available protein sequence collections of human and pig. Using this homology we were able to recover, on average, 71% of the proteins annotated for human pathways for the pig. Porcine protein-protein interactions were deduced from homologous proteins with known interactions in human. The result of this work is a resource comprising 204,699 predicted porcine interactions that can be used in genome analyses in order to enhance functional interpretation of data. The data can be visualized and downloaded from http://cpdb.molgen.mpg.de/pig . </jats:p> Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome Evolutionary Bioinformatics
spellingShingle Dreher, Felix, Kamburov, Atanas, Herwig, Ralf, Evolutionary Bioinformatics, Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome, Computer Science Applications, Genetics, Ecology, Evolution, Behavior and Systematics
title Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome
title_full Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome
title_fullStr Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome
title_full_unstemmed Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome
title_short Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome
title_sort construction of a pig physical interactome using sequence homology and a comprehensive reference human interactome
title_unstemmed Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome
topic Computer Science Applications, Genetics, Ecology, Evolution, Behavior and Systematics
url http://dx.doi.org/10.4137/ebo.s8552