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Construction of a Pig Physical Interactome Using Sequence Homology and a Comprehensive Reference Human Interactome
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Zeitschriftentitel: | Evolutionary Bioinformatics |
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Personen und Körperschaften: | , , |
In: | Evolutionary Bioinformatics, 8, 2012, S. EBO.S8552 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
SAGE Publications
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Schlagwörter: |
Zusammenfassung: | <jats:p> The analysis of interaction networks is crucial for understanding molecular function and has an essential impact for genome-wide studies. However, the interactomes of most species are largely incomplete and computational strategies that take into account sequence homology can help compensating for this lack of information using cross-species analysis. In this work we report the construction of a porcine interactome resource. We applied sequence homology matching and carried out bi-directional BLASTp searches for the currently available protein sequence collections of human and pig. Using this homology we were able to recover, on average, 71% of the proteins annotated for human pathways for the pig. Porcine protein-protein interactions were deduced from homologous proteins with known interactions in human. The result of this work is a resource comprising 204,699 predicted porcine interactions that can be used in genome analyses in order to enhance functional interpretation of data. The data can be visualized and downloaded from http://cpdb.molgen.mpg.de/pig . </jats:p> |
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Umfang: | EBO.S8552 |
ISSN: |
1176-9343
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DOI: | 10.4137/ebo.s8552 |