Late effects following isoniazid therapy.

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Bibliographische Detailangaben
Zeitschriftentitel:	American Journal of Public Health
Personen und Körperschaften:	Boice, J D, Fraumeni, J F
In:	American Journal of Public Health, 70, 1980, 9, S. 987-989
Format:	E-Article
Sprache:	Englisch
veröffentlicht:	American Public Health Association
Schlagwörter:	Public Health, Environmental and Occupational Health

Details
Zusammenfassung:	<jats:p> Amont 338 women treated in Massachusetts with isoniazid (isonicotinic acid hydrazide = INH) for pulmonary tuberculosis, no excess cancer deaths occurred (8 observed vs 8.3 expected) after 23 years (12.9 mean) of follow-up. There was an excess of cancer deaths (54 vs 35.7) among 1,090 patients who did not receive INH, partly due to radiogenic breast cancer resulting from multiple chest fluoroscopies to monitor pneumothorax. Increased deaths from liver cirrhosis (5 vs 0.8) were observed following INH use, suggesting that chronic as well as acute liver disease complicate this treatment. </jats:p>
Umfang:	987-989
ISSN:	0090-0036 1541-0048
DOI:	10.2105/ajph.70.9.987