author_facet Groet, Jürgen
Ives, Jane H.
South, Andrew P.
Baptista, Pedro R.
Jones, Tania A.
Yaspo, Marie-Laure
Lehrach, Hans
Potier, Marie-Claude
Van Broeckhoven, Christine
Nižetić, Dean
Groet, Jürgen
Ives, Jane H.
South, Andrew P.
Baptista, Pedro R.
Jones, Tania A.
Yaspo, Marie-Laure
Lehrach, Hans
Potier, Marie-Claude
Van Broeckhoven, Christine
Nižetić, Dean
author Groet, Jürgen
Ives, Jane H.
South, Andrew P.
Baptista, Pedro R.
Jones, Tania A.
Yaspo, Marie-Laure
Lehrach, Hans
Potier, Marie-Claude
Van Broeckhoven, Christine
Nižetić, Dean
spellingShingle Groet, Jürgen
Ives, Jane H.
South, Andrew P.
Baptista, Pedro R.
Jones, Tania A.
Yaspo, Marie-Laure
Lehrach, Hans
Potier, Marie-Claude
Van Broeckhoven, Christine
Nižetić, Dean
Genome Research
Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome
Genetics (clinical)
Genetics
author_sort groet, jürgen
spelling Groet, Jürgen Ives, Jane H. South, Andrew P. Baptista, Pedro R. Jones, Tania A. Yaspo, Marie-Laure Lehrach, Hans Potier, Marie-Claude Van Broeckhoven, Christine Nižetić, Dean 1088-9051 1549-5469 Cold Spring Harbor Laboratory Genetics (clinical) Genetics http://dx.doi.org/10.1101/gr.8.4.385 <jats:p>We present a high-resolution bacterial contig map of 3.4 Mb of genomic DNA in human chromosome 21q11–q21, encompassing the region of elevated disomic homozygosity in Down Syndrome-associated abnormal myelopoiesis and leukemia, as well as the markers, which has shown a strong association with Alzheimer’s Disease that has never been explained. The map contains 89 overlapping PACs, BACs, or cosmids in three contigs (850, 850, and 1500 kb) with two gaps (one of 140–210 kb and the second &lt;5 kb). To date, eight transcribed sequences derived by cDNA selection, exon trapping, and/or global EST sequencing have been positioned onto the map, and the only two genes so far mapped to this cytogenetic region, STCH and RIP140 have been precisely localized. This work converts a further 10% of chromosome 21q into a high-resolution bacterial contig map, which will be the physical basis for the long-range sequencing of this region. The map will also enable positional derivation of new transcribed sequences, as well as new polymorphic probes, that will help in elucidation of the role the genes in this region may play in abnormal myelopoiesis and leukemia associated with trisomy 21 and Alzheimer’s Disease.</jats:p> Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome Genome Research
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title Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome
title_unstemmed Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome
title_full Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome
title_fullStr Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome
title_full_unstemmed Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome
title_short Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome
title_sort bacterial contig map of the 21q11 region associated with alzheimer’s disease and abnormal myelopoiesis in down syndrome
topic Genetics (clinical)
Genetics
url http://dx.doi.org/10.1101/gr.8.4.385
publishDate 1998
physical 385-398
description <jats:p>We present a high-resolution bacterial contig map of 3.4 Mb of genomic DNA in human chromosome 21q11–q21, encompassing the region of elevated disomic homozygosity in Down Syndrome-associated abnormal myelopoiesis and leukemia, as well as the markers, which has shown a strong association with Alzheimer’s Disease that has never been explained. The map contains 89 overlapping PACs, BACs, or cosmids in three contigs (850, 850, and 1500 kb) with two gaps (one of 140–210 kb and the second &lt;5 kb). To date, eight transcribed sequences derived by cDNA selection, exon trapping, and/or global EST sequencing have been positioned onto the map, and the only two genes so far mapped to this cytogenetic region, STCH and RIP140 have been precisely localized. This work converts a further 10% of chromosome 21q into a high-resolution bacterial contig map, which will be the physical basis for the long-range sequencing of this region. The map will also enable positional derivation of new transcribed sequences, as well as new polymorphic probes, that will help in elucidation of the role the genes in this region may play in abnormal myelopoiesis and leukemia associated with trisomy 21 and Alzheimer’s Disease.</jats:p>
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author Groet, Jürgen, Ives, Jane H., South, Andrew P., Baptista, Pedro R., Jones, Tania A., Yaspo, Marie-Laure, Lehrach, Hans, Potier, Marie-Claude, Van Broeckhoven, Christine, Nižetić, Dean
author_facet Groet, Jürgen, Ives, Jane H., South, Andrew P., Baptista, Pedro R., Jones, Tania A., Yaspo, Marie-Laure, Lehrach, Hans, Potier, Marie-Claude, Van Broeckhoven, Christine, Nižetić, Dean, Groet, Jürgen, Ives, Jane H., South, Andrew P., Baptista, Pedro R., Jones, Tania A., Yaspo, Marie-Laure, Lehrach, Hans, Potier, Marie-Claude, Van Broeckhoven, Christine, Nižetić, Dean
author_sort groet, jürgen
container_issue 4
container_start_page 385
container_title Genome Research
container_volume 8
description <jats:p>We present a high-resolution bacterial contig map of 3.4 Mb of genomic DNA in human chromosome 21q11–q21, encompassing the region of elevated disomic homozygosity in Down Syndrome-associated abnormal myelopoiesis and leukemia, as well as the markers, which has shown a strong association with Alzheimer’s Disease that has never been explained. The map contains 89 overlapping PACs, BACs, or cosmids in three contigs (850, 850, and 1500 kb) with two gaps (one of 140–210 kb and the second &lt;5 kb). To date, eight transcribed sequences derived by cDNA selection, exon trapping, and/or global EST sequencing have been positioned onto the map, and the only two genes so far mapped to this cytogenetic region, STCH and RIP140 have been precisely localized. This work converts a further 10% of chromosome 21q into a high-resolution bacterial contig map, which will be the physical basis for the long-range sequencing of this region. The map will also enable positional derivation of new transcribed sequences, as well as new polymorphic probes, that will help in elucidation of the role the genes in this region may play in abnormal myelopoiesis and leukemia associated with trisomy 21 and Alzheimer’s Disease.</jats:p>
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spelling Groet, Jürgen Ives, Jane H. South, Andrew P. Baptista, Pedro R. Jones, Tania A. Yaspo, Marie-Laure Lehrach, Hans Potier, Marie-Claude Van Broeckhoven, Christine Nižetić, Dean 1088-9051 1549-5469 Cold Spring Harbor Laboratory Genetics (clinical) Genetics http://dx.doi.org/10.1101/gr.8.4.385 <jats:p>We present a high-resolution bacterial contig map of 3.4 Mb of genomic DNA in human chromosome 21q11–q21, encompassing the region of elevated disomic homozygosity in Down Syndrome-associated abnormal myelopoiesis and leukemia, as well as the markers, which has shown a strong association with Alzheimer’s Disease that has never been explained. The map contains 89 overlapping PACs, BACs, or cosmids in three contigs (850, 850, and 1500 kb) with two gaps (one of 140–210 kb and the second &lt;5 kb). To date, eight transcribed sequences derived by cDNA selection, exon trapping, and/or global EST sequencing have been positioned onto the map, and the only two genes so far mapped to this cytogenetic region, STCH and RIP140 have been precisely localized. This work converts a further 10% of chromosome 21q into a high-resolution bacterial contig map, which will be the physical basis for the long-range sequencing of this region. The map will also enable positional derivation of new transcribed sequences, as well as new polymorphic probes, that will help in elucidation of the role the genes in this region may play in abnormal myelopoiesis and leukemia associated with trisomy 21 and Alzheimer’s Disease.</jats:p> Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome Genome Research
spellingShingle Groet, Jürgen, Ives, Jane H., South, Andrew P., Baptista, Pedro R., Jones, Tania A., Yaspo, Marie-Laure, Lehrach, Hans, Potier, Marie-Claude, Van Broeckhoven, Christine, Nižetić, Dean, Genome Research, Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome, Genetics (clinical), Genetics
title Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome
title_full Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome
title_fullStr Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome
title_full_unstemmed Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome
title_short Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome
title_sort bacterial contig map of the 21q11 region associated with alzheimer’s disease and abnormal myelopoiesis in down syndrome
title_unstemmed Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome
topic Genetics (clinical), Genetics
url http://dx.doi.org/10.1101/gr.8.4.385