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Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome
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Zeitschriftentitel: | Genome Research |
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Personen und Körperschaften: | , , , , , , , , , |
In: | Genome Research, 8, 1998, 4, S. 385-398 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Cold Spring Harbor Laboratory
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Schlagwörter: |
author_facet |
Groet, Jürgen Ives, Jane H. South, Andrew P. Baptista, Pedro R. Jones, Tania A. Yaspo, Marie-Laure Lehrach, Hans Potier, Marie-Claude Van Broeckhoven, Christine Nižetić, Dean Groet, Jürgen Ives, Jane H. South, Andrew P. Baptista, Pedro R. Jones, Tania A. Yaspo, Marie-Laure Lehrach, Hans Potier, Marie-Claude Van Broeckhoven, Christine Nižetić, Dean |
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author |
Groet, Jürgen Ives, Jane H. South, Andrew P. Baptista, Pedro R. Jones, Tania A. Yaspo, Marie-Laure Lehrach, Hans Potier, Marie-Claude Van Broeckhoven, Christine Nižetić, Dean |
spellingShingle |
Groet, Jürgen Ives, Jane H. South, Andrew P. Baptista, Pedro R. Jones, Tania A. Yaspo, Marie-Laure Lehrach, Hans Potier, Marie-Claude Van Broeckhoven, Christine Nižetić, Dean Genome Research Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome Genetics (clinical) Genetics |
author_sort |
groet, jürgen |
spelling |
Groet, Jürgen Ives, Jane H. South, Andrew P. Baptista, Pedro R. Jones, Tania A. Yaspo, Marie-Laure Lehrach, Hans Potier, Marie-Claude Van Broeckhoven, Christine Nižetić, Dean 1088-9051 1549-5469 Cold Spring Harbor Laboratory Genetics (clinical) Genetics http://dx.doi.org/10.1101/gr.8.4.385 <jats:p>We present a high-resolution bacterial contig map of 3.4 Mb of genomic DNA in human chromosome 21q11–q21, encompassing the region of elevated disomic homozygosity in Down Syndrome-associated abnormal myelopoiesis and leukemia, as well as the markers, which has shown a strong association with Alzheimer’s Disease that has never been explained. The map contains 89 overlapping PACs, BACs, or cosmids in three contigs (850, 850, and 1500 kb) with two gaps (one of 140–210 kb and the second <5 kb). To date, eight transcribed sequences derived by cDNA selection, exon trapping, and/or global EST sequencing have been positioned onto the map, and the only two genes so far mapped to this cytogenetic region, STCH and RIP140 have been precisely localized. This work converts a further 10% of chromosome 21q into a high-resolution bacterial contig map, which will be the physical basis for the long-range sequencing of this region. The map will also enable positional derivation of new transcribed sequences, as well as new polymorphic probes, that will help in elucidation of the role the genes in this region may play in abnormal myelopoiesis and leukemia associated with trisomy 21 and Alzheimer’s Disease.</jats:p> Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome Genome Research |
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10.1101/gr.8.4.385 |
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Cold Spring Harbor Laboratory, 1998 |
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1998 |
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Cold Spring Harbor Laboratory |
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Genome Research |
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title |
Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome |
title_unstemmed |
Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome |
title_full |
Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome |
title_fullStr |
Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome |
title_full_unstemmed |
Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome |
title_short |
Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome |
title_sort |
bacterial contig map of the 21q11 region associated with alzheimer’s disease and abnormal myelopoiesis in down syndrome |
topic |
Genetics (clinical) Genetics |
url |
http://dx.doi.org/10.1101/gr.8.4.385 |
publishDate |
1998 |
physical |
385-398 |
description |
<jats:p>We present a high-resolution bacterial contig map of 3.4 Mb of genomic DNA in human chromosome 21q11–q21, encompassing the region of elevated disomic homozygosity in Down Syndrome-associated abnormal myelopoiesis and leukemia, as well as the markers, which has shown a strong association with Alzheimer’s Disease that has never been explained. The map contains 89 overlapping PACs, BACs, or cosmids in three contigs (850, 850, and 1500 kb) with two gaps (one of 140–210 kb and the second <5 kb). To date, eight transcribed sequences derived by cDNA selection, exon trapping, and/or global EST sequencing have been positioned onto the map, and the only two genes so far mapped to this cytogenetic region, STCH and RIP140 have been precisely localized. This work converts a further 10% of chromosome 21q into a high-resolution bacterial contig map, which will be the physical basis for the long-range sequencing of this region. The map will also enable positional derivation of new transcribed sequences, as well as new polymorphic probes, that will help in elucidation of the role the genes in this region may play in abnormal myelopoiesis and leukemia associated with trisomy 21 and Alzheimer’s Disease.</jats:p> |
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author | Groet, Jürgen, Ives, Jane H., South, Andrew P., Baptista, Pedro R., Jones, Tania A., Yaspo, Marie-Laure, Lehrach, Hans, Potier, Marie-Claude, Van Broeckhoven, Christine, Nižetić, Dean |
author_facet | Groet, Jürgen, Ives, Jane H., South, Andrew P., Baptista, Pedro R., Jones, Tania A., Yaspo, Marie-Laure, Lehrach, Hans, Potier, Marie-Claude, Van Broeckhoven, Christine, Nižetić, Dean, Groet, Jürgen, Ives, Jane H., South, Andrew P., Baptista, Pedro R., Jones, Tania A., Yaspo, Marie-Laure, Lehrach, Hans, Potier, Marie-Claude, Van Broeckhoven, Christine, Nižetić, Dean |
author_sort | groet, jürgen |
container_issue | 4 |
container_start_page | 385 |
container_title | Genome Research |
container_volume | 8 |
description | <jats:p>We present a high-resolution bacterial contig map of 3.4 Mb of genomic DNA in human chromosome 21q11–q21, encompassing the region of elevated disomic homozygosity in Down Syndrome-associated abnormal myelopoiesis and leukemia, as well as the markers, which has shown a strong association with Alzheimer’s Disease that has never been explained. The map contains 89 overlapping PACs, BACs, or cosmids in three contigs (850, 850, and 1500 kb) with two gaps (one of 140–210 kb and the second <5 kb). To date, eight transcribed sequences derived by cDNA selection, exon trapping, and/or global EST sequencing have been positioned onto the map, and the only two genes so far mapped to this cytogenetic region, STCH and RIP140 have been precisely localized. This work converts a further 10% of chromosome 21q into a high-resolution bacterial contig map, which will be the physical basis for the long-range sequencing of this region. The map will also enable positional derivation of new transcribed sequences, as well as new polymorphic probes, that will help in elucidation of the role the genes in this region may play in abnormal myelopoiesis and leukemia associated with trisomy 21 and Alzheimer’s Disease.</jats:p> |
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spelling | Groet, Jürgen Ives, Jane H. South, Andrew P. Baptista, Pedro R. Jones, Tania A. Yaspo, Marie-Laure Lehrach, Hans Potier, Marie-Claude Van Broeckhoven, Christine Nižetić, Dean 1088-9051 1549-5469 Cold Spring Harbor Laboratory Genetics (clinical) Genetics http://dx.doi.org/10.1101/gr.8.4.385 <jats:p>We present a high-resolution bacterial contig map of 3.4 Mb of genomic DNA in human chromosome 21q11–q21, encompassing the region of elevated disomic homozygosity in Down Syndrome-associated abnormal myelopoiesis and leukemia, as well as the markers, which has shown a strong association with Alzheimer’s Disease that has never been explained. The map contains 89 overlapping PACs, BACs, or cosmids in three contigs (850, 850, and 1500 kb) with two gaps (one of 140–210 kb and the second <5 kb). To date, eight transcribed sequences derived by cDNA selection, exon trapping, and/or global EST sequencing have been positioned onto the map, and the only two genes so far mapped to this cytogenetic region, STCH and RIP140 have been precisely localized. This work converts a further 10% of chromosome 21q into a high-resolution bacterial contig map, which will be the physical basis for the long-range sequencing of this region. The map will also enable positional derivation of new transcribed sequences, as well as new polymorphic probes, that will help in elucidation of the role the genes in this region may play in abnormal myelopoiesis and leukemia associated with trisomy 21 and Alzheimer’s Disease.</jats:p> Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome Genome Research |
spellingShingle | Groet, Jürgen, Ives, Jane H., South, Andrew P., Baptista, Pedro R., Jones, Tania A., Yaspo, Marie-Laure, Lehrach, Hans, Potier, Marie-Claude, Van Broeckhoven, Christine, Nižetić, Dean, Genome Research, Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome, Genetics (clinical), Genetics |
title | Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome |
title_full | Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome |
title_fullStr | Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome |
title_full_unstemmed | Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome |
title_short | Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome |
title_sort | bacterial contig map of the 21q11 region associated with alzheimer’s disease and abnormal myelopoiesis in down syndrome |
title_unstemmed | Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome |
topic | Genetics (clinical), Genetics |
url | http://dx.doi.org/10.1101/gr.8.4.385 |