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Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells
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| Zeitschriftentitel: | Cancer Epidemiology, Biomarkers & Prevention |
|---|---|
| Personen und Körperschaften: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| In: | Cancer Epidemiology, Biomarkers & Prevention, 19, 2010, 1, S. 80-88 |
| Format: | E-Article |
| Sprache: | Englisch |
| veröffentlicht: |
American Association for Cancer Research (AACR)
|
| Schlagwörter: |
| author_facet |
Zhang, Luoping Tang, Xiaojiang Rothman, Nathaniel Vermeulen, Roel Ji, Zhiying Shen, Min Qiu, Chuangyi Guo, Weihong Liu, Songwang Reiss, Boris Freeman, Laura Beane Ge, Yichen Hubbard, Alan E. Hua, Ming Blair, Aaron Galvan, Noe Ruan, Xiaolin Alter, Blanche P. Xin, Kerry X. Li, Senhua Moore, Lee E. Kim, Sungkyoon Xie, Yuxuan Hayes, Richard B. Azuma, Mariko Hauptmann, Michael Xiong, Jun Stewart, Patricia Li, Laiyu Rappaport, Stephen M. Huang, Hanlin Fraumeni, Joseph F. Smith, Martyn T. Lan, Qing Zhang, Luoping Tang, Xiaojiang Rothman, Nathaniel Vermeulen, Roel Ji, Zhiying Shen, Min Qiu, Chuangyi Guo, Weihong Liu, Songwang Reiss, Boris Freeman, Laura Beane Ge, Yichen Hubbard, Alan E. Hua, Ming Blair, Aaron Galvan, Noe Ruan, Xiaolin Alter, Blanche P. Xin, Kerry X. Li, Senhua Moore, Lee E. Kim, Sungkyoon Xie, Yuxuan Hayes, Richard B. Azuma, Mariko Hauptmann, Michael Xiong, Jun Stewart, Patricia Li, Laiyu Rappaport, Stephen M. Huang, Hanlin Fraumeni, Joseph F. Smith, Martyn T. Lan, Qing |
|---|---|
| author |
Zhang, Luoping Tang, Xiaojiang Rothman, Nathaniel Vermeulen, Roel Ji, Zhiying Shen, Min Qiu, Chuangyi Guo, Weihong Liu, Songwang Reiss, Boris Freeman, Laura Beane Ge, Yichen Hubbard, Alan E. Hua, Ming Blair, Aaron Galvan, Noe Ruan, Xiaolin Alter, Blanche P. Xin, Kerry X. Li, Senhua Moore, Lee E. Kim, Sungkyoon Xie, Yuxuan Hayes, Richard B. Azuma, Mariko Hauptmann, Michael Xiong, Jun Stewart, Patricia Li, Laiyu Rappaport, Stephen M. Huang, Hanlin Fraumeni, Joseph F. Smith, Martyn T. Lan, Qing |
| spellingShingle |
Zhang, Luoping Tang, Xiaojiang Rothman, Nathaniel Vermeulen, Roel Ji, Zhiying Shen, Min Qiu, Chuangyi Guo, Weihong Liu, Songwang Reiss, Boris Freeman, Laura Beane Ge, Yichen Hubbard, Alan E. Hua, Ming Blair, Aaron Galvan, Noe Ruan, Xiaolin Alter, Blanche P. Xin, Kerry X. Li, Senhua Moore, Lee E. Kim, Sungkyoon Xie, Yuxuan Hayes, Richard B. Azuma, Mariko Hauptmann, Michael Xiong, Jun Stewart, Patricia Li, Laiyu Rappaport, Stephen M. Huang, Hanlin Fraumeni, Joseph F. Smith, Martyn T. Lan, Qing Cancer Epidemiology, Biomarkers & Prevention Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells Oncology Epidemiology |
| author_sort |
zhang, luoping |
| spelling |
Zhang, Luoping Tang, Xiaojiang Rothman, Nathaniel Vermeulen, Roel Ji, Zhiying Shen, Min Qiu, Chuangyi Guo, Weihong Liu, Songwang Reiss, Boris Freeman, Laura Beane Ge, Yichen Hubbard, Alan E. Hua, Ming Blair, Aaron Galvan, Noe Ruan, Xiaolin Alter, Blanche P. Xin, Kerry X. Li, Senhua Moore, Lee E. Kim, Sungkyoon Xie, Yuxuan Hayes, Richard B. Azuma, Mariko Hauptmann, Michael Xiong, Jun Stewart, Patricia Li, Laiyu Rappaport, Stephen M. Huang, Hanlin Fraumeni, Joseph F. Smith, Martyn T. Lan, Qing 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-09-0762 <jats:title>Abstract</jats:title> <jats:p>There are concerns about the health effects of formaldehyde exposure, including carcinogenicity, in light of elevated indoor air levels in new homes and occupational exposures experienced by workers in health care, embalming, manufacturing, and other industries. Epidemiologic studies suggest that formaldehyde exposure is associated with an increased risk of leukemia. However, the biological plausibility of these findings has been questioned because limited information is available on the ability of formaldehyde to disrupt hematopoietic function. Our objective was to determine if formaldehyde exposure disrupts hematopoietic function and produces leukemia-related chromosome changes in exposed humans. We examined the ability of formaldehyde to disrupt hematopoiesis in a study of 94 workers in China (43 exposed to formaldehyde and 51 frequency-matched controls) by measuring complete blood counts and peripheral stem/progenitor cell colony formation. Further, myeloid progenitor cells, the target for leukemogenesis, were cultured from the workers to quantify the level of leukemia-specific chromosome changes, including monosomy 7 and trisomy 8, in metaphase spreads of these cells. Among exposed workers, peripheral blood cell counts were significantly lowered in a manner consistent with toxic effects on the bone marrow and leukemia-specific chromosome changes were significantly elevated in myeloid blood progenitor cells. These findings suggest that formaldehyde exposure can have an adverse effect on the hematopoietic system and that leukemia induction by formaldehyde is biologically plausible, which heightens concerns about its leukemogenic potential from occupational and environmental exposures. Cancer Epidemiol Biomarkers Prev; 19(1); 80–8.</jats:p> Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells Cancer Epidemiology, Biomarkers & Prevention |
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| title |
Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells |
| title_unstemmed |
Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells |
| title_full |
Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells |
| title_fullStr |
Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells |
| title_full_unstemmed |
Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells |
| title_short |
Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells |
| title_sort |
occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells |
| topic |
Oncology Epidemiology |
| url |
http://dx.doi.org/10.1158/1055-9965.epi-09-0762 |
| publishDate |
2010 |
| physical |
80-88 |
| description |
<jats:title>Abstract</jats:title>
<jats:p>There are concerns about the health effects of formaldehyde exposure, including carcinogenicity, in light of elevated indoor air levels in new homes and occupational exposures experienced by workers in health care, embalming, manufacturing, and other industries. Epidemiologic studies suggest that formaldehyde exposure is associated with an increased risk of leukemia. However, the biological plausibility of these findings has been questioned because limited information is available on the ability of formaldehyde to disrupt hematopoietic function. Our objective was to determine if formaldehyde exposure disrupts hematopoietic function and produces leukemia-related chromosome changes in exposed humans. We examined the ability of formaldehyde to disrupt hematopoiesis in a study of 94 workers in China (43 exposed to formaldehyde and 51 frequency-matched controls) by measuring complete blood counts and peripheral stem/progenitor cell colony formation. Further, myeloid progenitor cells, the target for leukemogenesis, were cultured from the workers to quantify the level of leukemia-specific chromosome changes, including monosomy 7 and trisomy 8, in metaphase spreads of these cells. Among exposed workers, peripheral blood cell counts were significantly lowered in a manner consistent with toxic effects on the bone marrow and leukemia-specific chromosome changes were significantly elevated in myeloid blood progenitor cells. These findings suggest that formaldehyde exposure can have an adverse effect on the hematopoietic system and that leukemia induction by formaldehyde is biologically plausible, which heightens concerns about its leukemogenic potential from occupational and environmental exposures. Cancer Epidemiol Biomarkers Prev; 19(1); 80–8.</jats:p> |
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| author | Zhang, Luoping, Tang, Xiaojiang, Rothman, Nathaniel, Vermeulen, Roel, Ji, Zhiying, Shen, Min, Qiu, Chuangyi, Guo, Weihong, Liu, Songwang, Reiss, Boris, Freeman, Laura Beane, Ge, Yichen, Hubbard, Alan E., Hua, Ming, Blair, Aaron, Galvan, Noe, Ruan, Xiaolin, Alter, Blanche P., Xin, Kerry X., Li, Senhua, Moore, Lee E., Kim, Sungkyoon, Xie, Yuxuan, Hayes, Richard B., Azuma, Mariko, Hauptmann, Michael, Xiong, Jun, Stewart, Patricia, Li, Laiyu, Rappaport, Stephen M., Huang, Hanlin, Fraumeni, Joseph F., Smith, Martyn T., Lan, Qing |
| author_facet | Zhang, Luoping, Tang, Xiaojiang, Rothman, Nathaniel, Vermeulen, Roel, Ji, Zhiying, Shen, Min, Qiu, Chuangyi, Guo, Weihong, Liu, Songwang, Reiss, Boris, Freeman, Laura Beane, Ge, Yichen, Hubbard, Alan E., Hua, Ming, Blair, Aaron, Galvan, Noe, Ruan, Xiaolin, Alter, Blanche P., Xin, Kerry X., Li, Senhua, Moore, Lee E., Kim, Sungkyoon, Xie, Yuxuan, Hayes, Richard B., Azuma, Mariko, Hauptmann, Michael, Xiong, Jun, Stewart, Patricia, Li, Laiyu, Rappaport, Stephen M., Huang, Hanlin, Fraumeni, Joseph F., Smith, Martyn T., Lan, Qing, Zhang, Luoping, Tang, Xiaojiang, Rothman, Nathaniel, Vermeulen, Roel, Ji, Zhiying, Shen, Min, Qiu, Chuangyi, Guo, Weihong, Liu, Songwang, Reiss, Boris, Freeman, Laura Beane, Ge, Yichen, Hubbard, Alan E., Hua, Ming, Blair, Aaron, Galvan, Noe, Ruan, Xiaolin, Alter, Blanche P., Xin, Kerry X., Li, Senhua, Moore, Lee E., Kim, Sungkyoon, Xie, Yuxuan, Hayes, Richard B., Azuma, Mariko, Hauptmann, Michael, Xiong, Jun, Stewart, Patricia, Li, Laiyu, Rappaport, Stephen M., Huang, Hanlin, Fraumeni, Joseph F., Smith, Martyn T., Lan, Qing |
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| description | <jats:title>Abstract</jats:title> <jats:p>There are concerns about the health effects of formaldehyde exposure, including carcinogenicity, in light of elevated indoor air levels in new homes and occupational exposures experienced by workers in health care, embalming, manufacturing, and other industries. Epidemiologic studies suggest that formaldehyde exposure is associated with an increased risk of leukemia. However, the biological plausibility of these findings has been questioned because limited information is available on the ability of formaldehyde to disrupt hematopoietic function. Our objective was to determine if formaldehyde exposure disrupts hematopoietic function and produces leukemia-related chromosome changes in exposed humans. We examined the ability of formaldehyde to disrupt hematopoiesis in a study of 94 workers in China (43 exposed to formaldehyde and 51 frequency-matched controls) by measuring complete blood counts and peripheral stem/progenitor cell colony formation. Further, myeloid progenitor cells, the target for leukemogenesis, were cultured from the workers to quantify the level of leukemia-specific chromosome changes, including monosomy 7 and trisomy 8, in metaphase spreads of these cells. Among exposed workers, peripheral blood cell counts were significantly lowered in a manner consistent with toxic effects on the bone marrow and leukemia-specific chromosome changes were significantly elevated in myeloid blood progenitor cells. These findings suggest that formaldehyde exposure can have an adverse effect on the hematopoietic system and that leukemia induction by formaldehyde is biologically plausible, which heightens concerns about its leukemogenic potential from occupational and environmental exposures. Cancer Epidemiol Biomarkers Prev; 19(1); 80–8.</jats:p> |
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| spelling | Zhang, Luoping Tang, Xiaojiang Rothman, Nathaniel Vermeulen, Roel Ji, Zhiying Shen, Min Qiu, Chuangyi Guo, Weihong Liu, Songwang Reiss, Boris Freeman, Laura Beane Ge, Yichen Hubbard, Alan E. Hua, Ming Blair, Aaron Galvan, Noe Ruan, Xiaolin Alter, Blanche P. Xin, Kerry X. Li, Senhua Moore, Lee E. Kim, Sungkyoon Xie, Yuxuan Hayes, Richard B. Azuma, Mariko Hauptmann, Michael Xiong, Jun Stewart, Patricia Li, Laiyu Rappaport, Stephen M. Huang, Hanlin Fraumeni, Joseph F. Smith, Martyn T. Lan, Qing 1055-9965 1538-7755 American Association for Cancer Research (AACR) Oncology Epidemiology http://dx.doi.org/10.1158/1055-9965.epi-09-0762 <jats:title>Abstract</jats:title> <jats:p>There are concerns about the health effects of formaldehyde exposure, including carcinogenicity, in light of elevated indoor air levels in new homes and occupational exposures experienced by workers in health care, embalming, manufacturing, and other industries. Epidemiologic studies suggest that formaldehyde exposure is associated with an increased risk of leukemia. However, the biological plausibility of these findings has been questioned because limited information is available on the ability of formaldehyde to disrupt hematopoietic function. Our objective was to determine if formaldehyde exposure disrupts hematopoietic function and produces leukemia-related chromosome changes in exposed humans. We examined the ability of formaldehyde to disrupt hematopoiesis in a study of 94 workers in China (43 exposed to formaldehyde and 51 frequency-matched controls) by measuring complete blood counts and peripheral stem/progenitor cell colony formation. Further, myeloid progenitor cells, the target for leukemogenesis, were cultured from the workers to quantify the level of leukemia-specific chromosome changes, including monosomy 7 and trisomy 8, in metaphase spreads of these cells. Among exposed workers, peripheral blood cell counts were significantly lowered in a manner consistent with toxic effects on the bone marrow and leukemia-specific chromosome changes were significantly elevated in myeloid blood progenitor cells. These findings suggest that formaldehyde exposure can have an adverse effect on the hematopoietic system and that leukemia induction by formaldehyde is biologically plausible, which heightens concerns about its leukemogenic potential from occupational and environmental exposures. Cancer Epidemiol Biomarkers Prev; 19(1); 80–8.</jats:p> Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells Cancer Epidemiology, Biomarkers & Prevention |
| spellingShingle | Zhang, Luoping, Tang, Xiaojiang, Rothman, Nathaniel, Vermeulen, Roel, Ji, Zhiying, Shen, Min, Qiu, Chuangyi, Guo, Weihong, Liu, Songwang, Reiss, Boris, Freeman, Laura Beane, Ge, Yichen, Hubbard, Alan E., Hua, Ming, Blair, Aaron, Galvan, Noe, Ruan, Xiaolin, Alter, Blanche P., Xin, Kerry X., Li, Senhua, Moore, Lee E., Kim, Sungkyoon, Xie, Yuxuan, Hayes, Richard B., Azuma, Mariko, Hauptmann, Michael, Xiong, Jun, Stewart, Patricia, Li, Laiyu, Rappaport, Stephen M., Huang, Hanlin, Fraumeni, Joseph F., Smith, Martyn T., Lan, Qing, Cancer Epidemiology, Biomarkers & Prevention, Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells, Oncology, Epidemiology |
| title | Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells |
| title_full | Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells |
| title_fullStr | Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells |
| title_full_unstemmed | Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells |
| title_short | Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells |
| title_sort | occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells |
| title_unstemmed | Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells |
| topic | Oncology, Epidemiology |
| url | http://dx.doi.org/10.1158/1055-9965.epi-09-0762 |