Eintrag weiter verarbeiten
Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry
Gespeichert in:
Zeitschriftentitel: | ACR Open Rheumatology |
---|---|
Personen und Körperschaften: | , , , , , |
In: | ACR Open Rheumatology, 1, 2019, 2, S. 119-124 |
Format: | E-Article |
Sprache: | Englisch |
veröffentlicht: |
Wiley
|
Schlagwörter: |
author_facet |
Wu, Eveline Y. Li, Suzanne C. Torok, Kathryn S. Virkud, Yamini V. Fuhlbrigge, Robert C. Rabinovich, C. Egla Wu, Eveline Y. Li, Suzanne C. Torok, Kathryn S. Virkud, Yamini V. Fuhlbrigge, Robert C. Rabinovich, C. Egla |
---|---|
author |
Wu, Eveline Y. Li, Suzanne C. Torok, Kathryn S. Virkud, Yamini V. Fuhlbrigge, Robert C. Rabinovich, C. Egla |
spellingShingle |
Wu, Eveline Y. Li, Suzanne C. Torok, Kathryn S. Virkud, Yamini V. Fuhlbrigge, Robert C. Rabinovich, C. Egla ACR Open Rheumatology Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry Rheumatology |
author_sort |
wu, eveline y. |
spelling |
Wu, Eveline Y. Li, Suzanne C. Torok, Kathryn S. Virkud, Yamini V. Fuhlbrigge, Robert C. Rabinovich, C. Egla 2578-5745 2578-5745 Wiley Rheumatology http://dx.doi.org/10.1002/acr2.1019 <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>Localized scleroderma (<jats:styled-content style="fixed-case">LS</jats:styled-content>) is a chronic inflammatory and fibrosing skin disorder. We present baseline data on the juvenile <jats:styled-content style="fixed-case">LS</jats:styled-content> (<jats:styled-content style="fixed-case">jLS</jats:styled-content>) cohort from the Childhood Arthritis and Rheumatology Research Alliance (<jats:styled-content style="fixed-case">CARRA</jats:styled-content>) Legacy Registry, a multicenter observational registry of pediatric rheumatologic disorders.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This is a cross‐sectional analysis of children with <jats:styled-content style="fixed-case">jLS</jats:styled-content> enrolled in the <jats:styled-content style="fixed-case">CARRA</jats:styled-content> Legacy Registry between May 2010 and April 2014. Descriptive statistics were used for demographic, clinical, and laboratory features. Data analysis included two‐sample <jats:italic>t</jats:italic> test, χ<jats:sup>2</jats:sup> test, Fisher's exact test, linear/logistic regression, and analysis of variance.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 381 children with <jats:styled-content style="fixed-case">jLS</jats:styled-content>, 76% were female and 80% Caucasian. Mean onset age was 8.2 years, with 17% having a 2‐year or greater delay to first pediatric rheumatology (<jats:styled-content style="fixed-case">PRH</jats:styled-content>) visit. Linear scleroderma was the most common subtype (54%). Antinuclear antibody (<jats:styled-content style="fixed-case">ANA</jats:styled-content>) positivity was associated with joint contracture (<jats:italic>P</jats:italic> = 0.04), muscle atrophy (<jats:italic>P</jats:italic> = 0.014), and extremity shortening (<jats:italic>P</jats:italic> = 0.007). Elevated aldolase was associated with joint contracture (<jats:italic>P</jats:italic> = 0.008) and elevated creatine kinase (<jats:styled-content style="fixed-case">CK</jats:styled-content>) with muscle atrophy (<jats:italic>P</jats:italic> = 0.028) and extremity shortening (<jats:italic>P</jats:italic> = 0.016). Children with functional limitation (27%) had earlier first <jats:styled-content style="fixed-case">PRH</jats:styled-content> visit compared with those without (<jats:italic>P</jats:italic> = 0.01). Poorer function correlated with muscle atrophy, joint contracture, and extremity shortening (<jats:italic>P</jats:italic> < 0.001). Methotrexate (97%) and corticosteroids (68%) were the most common medications used.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Children with <jats:styled-content style="fixed-case">jLS</jats:styled-content> without joint limitation are referred later, highlighting the insidious onset and need for educating referring providers. Poorer function correlated with muscle atrophy, joint contracture, and limb shortening. <jats:styled-content style="fixed-case">ANA</jats:styled-content> positivity and elevated <jats:styled-content style="fixed-case">CK</jats:styled-content> or aldolase were associated with muscle atrophy, joint contracture, and/or limb shortening, suggesting predictors of muscle involvement.</jats:p></jats:sec> Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry ACR Open Rheumatology |
doi_str_mv |
10.1002/acr2.1019 |
facet_avail |
Online Free |
finc_class_facet |
Medizin |
format |
ElectronicArticle |
fullrecord |
blob:ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9hY3IyLjEwMTk |
id |
ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9hY3IyLjEwMTk |
institution |
DE-D275 DE-Bn3 DE-Brt1 DE-D161 DE-Zwi2 DE-Gla1 DE-Zi4 DE-15 DE-Pl11 DE-Rs1 DE-105 DE-14 DE-Ch1 DE-L229 |
imprint |
Wiley, 2019 |
imprint_str_mv |
Wiley, 2019 |
issn |
2578-5745 |
issn_str_mv |
2578-5745 |
language |
English |
mega_collection |
Wiley (CrossRef) |
match_str |
wu2019baselinedescriptionofthejuvenilelocalizedsclerodermasubgroupfromthechildhoodarthritisandrheumatologyresearchalliancelegacyregistry |
publishDateSort |
2019 |
publisher |
Wiley |
recordtype |
ai |
record_format |
ai |
series |
ACR Open Rheumatology |
source_id |
49 |
title |
Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry |
title_unstemmed |
Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry |
title_full |
Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry |
title_fullStr |
Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry |
title_full_unstemmed |
Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry |
title_short |
Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry |
title_sort |
baseline description of the juvenile localized scleroderma subgroup from the childhood arthritis and rheumatology research alliance legacy registry |
topic |
Rheumatology |
url |
http://dx.doi.org/10.1002/acr2.1019 |
publishDate |
2019 |
physical |
119-124 |
description |
<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>Localized scleroderma (<jats:styled-content style="fixed-case">LS</jats:styled-content>) is a chronic inflammatory and fibrosing skin disorder. We present baseline data on the juvenile <jats:styled-content style="fixed-case">LS</jats:styled-content> (<jats:styled-content style="fixed-case">jLS</jats:styled-content>) cohort from the Childhood Arthritis and Rheumatology Research Alliance (<jats:styled-content style="fixed-case">CARRA</jats:styled-content>) Legacy Registry, a multicenter observational registry of pediatric rheumatologic disorders.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This is a cross‐sectional analysis of children with <jats:styled-content style="fixed-case">jLS</jats:styled-content> enrolled in the <jats:styled-content style="fixed-case">CARRA</jats:styled-content> Legacy Registry between May 2010 and April 2014. Descriptive statistics were used for demographic, clinical, and laboratory features. Data analysis included two‐sample <jats:italic>t</jats:italic> test, χ<jats:sup>2</jats:sup> test, Fisher's exact test, linear/logistic regression, and analysis of variance.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 381 children with <jats:styled-content style="fixed-case">jLS</jats:styled-content>, 76% were female and 80% Caucasian. Mean onset age was 8.2 years, with 17% having a 2‐year or greater delay to first pediatric rheumatology (<jats:styled-content style="fixed-case">PRH</jats:styled-content>) visit. Linear scleroderma was the most common subtype (54%). Antinuclear antibody (<jats:styled-content style="fixed-case">ANA</jats:styled-content>) positivity was associated with joint contracture (<jats:italic>P</jats:italic> = 0.04), muscle atrophy (<jats:italic>P</jats:italic> = 0.014), and extremity shortening (<jats:italic>P</jats:italic> = 0.007). Elevated aldolase was associated with joint contracture (<jats:italic>P</jats:italic> = 0.008) and elevated creatine kinase (<jats:styled-content style="fixed-case">CK</jats:styled-content>) with muscle atrophy (<jats:italic>P</jats:italic> = 0.028) and extremity shortening (<jats:italic>P</jats:italic> = 0.016). Children with functional limitation (27%) had earlier first <jats:styled-content style="fixed-case">PRH</jats:styled-content> visit compared with those without (<jats:italic>P</jats:italic> = 0.01). Poorer function correlated with muscle atrophy, joint contracture, and extremity shortening (<jats:italic>P</jats:italic> < 0.001). Methotrexate (97%) and corticosteroids (68%) were the most common medications used.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Children with <jats:styled-content style="fixed-case">jLS</jats:styled-content> without joint limitation are referred later, highlighting the insidious onset and need for educating referring providers. Poorer function correlated with muscle atrophy, joint contracture, and limb shortening. <jats:styled-content style="fixed-case">ANA</jats:styled-content> positivity and elevated <jats:styled-content style="fixed-case">CK</jats:styled-content> or aldolase were associated with muscle atrophy, joint contracture, and/or limb shortening, suggesting predictors of muscle involvement.</jats:p></jats:sec> |
container_issue |
2 |
container_start_page |
119 |
container_title |
ACR Open Rheumatology |
container_volume |
1 |
format_de105 |
Article, E-Article |
format_de14 |
Article, E-Article |
format_de15 |
Article, E-Article |
format_de520 |
Article, E-Article |
format_de540 |
Article, E-Article |
format_dech1 |
Article, E-Article |
format_ded117 |
Article, E-Article |
format_degla1 |
E-Article |
format_del152 |
Buch |
format_del189 |
Article, E-Article |
format_dezi4 |
Article |
format_dezwi2 |
Article, E-Article |
format_finc |
Article, E-Article |
format_nrw |
Article, E-Article |
_version_ |
1792344302073937923 |
geogr_code |
not assigned |
last_indexed |
2024-03-01T17:05:26.365Z |
geogr_code_person |
not assigned |
openURL |
url_ver=Z39.88-2004&ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fvufind.svn.sourceforge.net%3Agenerator&rft.title=Baseline+Description+of+the+Juvenile+Localized+Scleroderma+Subgroup+From+the+Childhood+Arthritis+and+Rheumatology+Research+Alliance+Legacy+Registry&rft.date=2019-04-01&genre=article&issn=2578-5745&volume=1&issue=2&spage=119&epage=124&pages=119-124&jtitle=ACR+Open+Rheumatology&atitle=Baseline+Description+of+the+Juvenile+Localized+Scleroderma+Subgroup+From+the+Childhood+Arthritis+and+Rheumatology+Research+Alliance+Legacy+Registry&aulast=Rabinovich&aufirst=C.+Egla&rft_id=info%3Adoi%2F10.1002%2Facr2.1019&rft.language%5B0%5D=eng |
SOLR | |
_version_ | 1792344302073937923 |
author | Wu, Eveline Y., Li, Suzanne C., Torok, Kathryn S., Virkud, Yamini V., Fuhlbrigge, Robert C., Rabinovich, C. Egla |
author_facet | Wu, Eveline Y., Li, Suzanne C., Torok, Kathryn S., Virkud, Yamini V., Fuhlbrigge, Robert C., Rabinovich, C. Egla, Wu, Eveline Y., Li, Suzanne C., Torok, Kathryn S., Virkud, Yamini V., Fuhlbrigge, Robert C., Rabinovich, C. Egla |
author_sort | wu, eveline y. |
container_issue | 2 |
container_start_page | 119 |
container_title | ACR Open Rheumatology |
container_volume | 1 |
description | <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>Localized scleroderma (<jats:styled-content style="fixed-case">LS</jats:styled-content>) is a chronic inflammatory and fibrosing skin disorder. We present baseline data on the juvenile <jats:styled-content style="fixed-case">LS</jats:styled-content> (<jats:styled-content style="fixed-case">jLS</jats:styled-content>) cohort from the Childhood Arthritis and Rheumatology Research Alliance (<jats:styled-content style="fixed-case">CARRA</jats:styled-content>) Legacy Registry, a multicenter observational registry of pediatric rheumatologic disorders.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This is a cross‐sectional analysis of children with <jats:styled-content style="fixed-case">jLS</jats:styled-content> enrolled in the <jats:styled-content style="fixed-case">CARRA</jats:styled-content> Legacy Registry between May 2010 and April 2014. Descriptive statistics were used for demographic, clinical, and laboratory features. Data analysis included two‐sample <jats:italic>t</jats:italic> test, χ<jats:sup>2</jats:sup> test, Fisher's exact test, linear/logistic regression, and analysis of variance.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 381 children with <jats:styled-content style="fixed-case">jLS</jats:styled-content>, 76% were female and 80% Caucasian. Mean onset age was 8.2 years, with 17% having a 2‐year or greater delay to first pediatric rheumatology (<jats:styled-content style="fixed-case">PRH</jats:styled-content>) visit. Linear scleroderma was the most common subtype (54%). Antinuclear antibody (<jats:styled-content style="fixed-case">ANA</jats:styled-content>) positivity was associated with joint contracture (<jats:italic>P</jats:italic> = 0.04), muscle atrophy (<jats:italic>P</jats:italic> = 0.014), and extremity shortening (<jats:italic>P</jats:italic> = 0.007). Elevated aldolase was associated with joint contracture (<jats:italic>P</jats:italic> = 0.008) and elevated creatine kinase (<jats:styled-content style="fixed-case">CK</jats:styled-content>) with muscle atrophy (<jats:italic>P</jats:italic> = 0.028) and extremity shortening (<jats:italic>P</jats:italic> = 0.016). Children with functional limitation (27%) had earlier first <jats:styled-content style="fixed-case">PRH</jats:styled-content> visit compared with those without (<jats:italic>P</jats:italic> = 0.01). Poorer function correlated with muscle atrophy, joint contracture, and extremity shortening (<jats:italic>P</jats:italic> < 0.001). Methotrexate (97%) and corticosteroids (68%) were the most common medications used.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Children with <jats:styled-content style="fixed-case">jLS</jats:styled-content> without joint limitation are referred later, highlighting the insidious onset and need for educating referring providers. Poorer function correlated with muscle atrophy, joint contracture, and limb shortening. <jats:styled-content style="fixed-case">ANA</jats:styled-content> positivity and elevated <jats:styled-content style="fixed-case">CK</jats:styled-content> or aldolase were associated with muscle atrophy, joint contracture, and/or limb shortening, suggesting predictors of muscle involvement.</jats:p></jats:sec> |
doi_str_mv | 10.1002/acr2.1019 |
facet_avail | Online, Free |
finc_class_facet | Medizin |
format | ElectronicArticle |
format_de105 | Article, E-Article |
format_de14 | Article, E-Article |
format_de15 | Article, E-Article |
format_de520 | Article, E-Article |
format_de540 | Article, E-Article |
format_dech1 | Article, E-Article |
format_ded117 | Article, E-Article |
format_degla1 | E-Article |
format_del152 | Buch |
format_del189 | Article, E-Article |
format_dezi4 | Article |
format_dezwi2 | Article, E-Article |
format_finc | Article, E-Article |
format_nrw | Article, E-Article |
geogr_code | not assigned |
geogr_code_person | not assigned |
id | ai-49-aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9hY3IyLjEwMTk |
imprint | Wiley, 2019 |
imprint_str_mv | Wiley, 2019 |
institution | DE-D275, DE-Bn3, DE-Brt1, DE-D161, DE-Zwi2, DE-Gla1, DE-Zi4, DE-15, DE-Pl11, DE-Rs1, DE-105, DE-14, DE-Ch1, DE-L229 |
issn | 2578-5745 |
issn_str_mv | 2578-5745 |
language | English |
last_indexed | 2024-03-01T17:05:26.365Z |
match_str | wu2019baselinedescriptionofthejuvenilelocalizedsclerodermasubgroupfromthechildhoodarthritisandrheumatologyresearchalliancelegacyregistry |
mega_collection | Wiley (CrossRef) |
physical | 119-124 |
publishDate | 2019 |
publishDateSort | 2019 |
publisher | Wiley |
record_format | ai |
recordtype | ai |
series | ACR Open Rheumatology |
source_id | 49 |
spelling | Wu, Eveline Y. Li, Suzanne C. Torok, Kathryn S. Virkud, Yamini V. Fuhlbrigge, Robert C. Rabinovich, C. Egla 2578-5745 2578-5745 Wiley Rheumatology http://dx.doi.org/10.1002/acr2.1019 <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>Localized scleroderma (<jats:styled-content style="fixed-case">LS</jats:styled-content>) is a chronic inflammatory and fibrosing skin disorder. We present baseline data on the juvenile <jats:styled-content style="fixed-case">LS</jats:styled-content> (<jats:styled-content style="fixed-case">jLS</jats:styled-content>) cohort from the Childhood Arthritis and Rheumatology Research Alliance (<jats:styled-content style="fixed-case">CARRA</jats:styled-content>) Legacy Registry, a multicenter observational registry of pediatric rheumatologic disorders.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This is a cross‐sectional analysis of children with <jats:styled-content style="fixed-case">jLS</jats:styled-content> enrolled in the <jats:styled-content style="fixed-case">CARRA</jats:styled-content> Legacy Registry between May 2010 and April 2014. Descriptive statistics were used for demographic, clinical, and laboratory features. Data analysis included two‐sample <jats:italic>t</jats:italic> test, χ<jats:sup>2</jats:sup> test, Fisher's exact test, linear/logistic regression, and analysis of variance.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Of 381 children with <jats:styled-content style="fixed-case">jLS</jats:styled-content>, 76% were female and 80% Caucasian. Mean onset age was 8.2 years, with 17% having a 2‐year or greater delay to first pediatric rheumatology (<jats:styled-content style="fixed-case">PRH</jats:styled-content>) visit. Linear scleroderma was the most common subtype (54%). Antinuclear antibody (<jats:styled-content style="fixed-case">ANA</jats:styled-content>) positivity was associated with joint contracture (<jats:italic>P</jats:italic> = 0.04), muscle atrophy (<jats:italic>P</jats:italic> = 0.014), and extremity shortening (<jats:italic>P</jats:italic> = 0.007). Elevated aldolase was associated with joint contracture (<jats:italic>P</jats:italic> = 0.008) and elevated creatine kinase (<jats:styled-content style="fixed-case">CK</jats:styled-content>) with muscle atrophy (<jats:italic>P</jats:italic> = 0.028) and extremity shortening (<jats:italic>P</jats:italic> = 0.016). Children with functional limitation (27%) had earlier first <jats:styled-content style="fixed-case">PRH</jats:styled-content> visit compared with those without (<jats:italic>P</jats:italic> = 0.01). Poorer function correlated with muscle atrophy, joint contracture, and extremity shortening (<jats:italic>P</jats:italic> < 0.001). Methotrexate (97%) and corticosteroids (68%) were the most common medications used.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Children with <jats:styled-content style="fixed-case">jLS</jats:styled-content> without joint limitation are referred later, highlighting the insidious onset and need for educating referring providers. Poorer function correlated with muscle atrophy, joint contracture, and limb shortening. <jats:styled-content style="fixed-case">ANA</jats:styled-content> positivity and elevated <jats:styled-content style="fixed-case">CK</jats:styled-content> or aldolase were associated with muscle atrophy, joint contracture, and/or limb shortening, suggesting predictors of muscle involvement.</jats:p></jats:sec> Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry ACR Open Rheumatology |
spellingShingle | Wu, Eveline Y., Li, Suzanne C., Torok, Kathryn S., Virkud, Yamini V., Fuhlbrigge, Robert C., Rabinovich, C. Egla, ACR Open Rheumatology, Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry, Rheumatology |
title | Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry |
title_full | Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry |
title_fullStr | Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry |
title_full_unstemmed | Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry |
title_short | Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry |
title_sort | baseline description of the juvenile localized scleroderma subgroup from the childhood arthritis and rheumatology research alliance legacy registry |
title_unstemmed | Baseline Description of the Juvenile Localized Scleroderma Subgroup From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry |
topic | Rheumatology |
url | http://dx.doi.org/10.1002/acr2.1019 |