author_facet Pentchev, Konstantin
Ono, Keiichiro
Herwig, Ralf
Ideker, Trey
Kamburov, Atanas
Pentchev, Konstantin
Ono, Keiichiro
Herwig, Ralf
Ideker, Trey
Kamburov, Atanas
author Pentchev, Konstantin
Ono, Keiichiro
Herwig, Ralf
Ideker, Trey
Kamburov, Atanas
spellingShingle Pentchev, Konstantin
Ono, Keiichiro
Herwig, Ralf
Ideker, Trey
Kamburov, Atanas
Bioinformatics
Evidence mining and novelty assessment of protein–protein interactions with the ConsensusPathDB plugin for Cytoscape
Computational Mathematics
Computational Theory and Mathematics
Computer Science Applications
Molecular Biology
Biochemistry
Statistics and Probability
author_sort pentchev, konstantin
spelling Pentchev, Konstantin Ono, Keiichiro Herwig, Ralf Ideker, Trey Kamburov, Atanas 1367-4811 1367-4803 Oxford University Press (OUP) Computational Mathematics Computational Theory and Mathematics Computer Science Applications Molecular Biology Biochemistry Statistics and Probability http://dx.doi.org/10.1093/bioinformatics/btq522 <jats:title>Abstract</jats:title> <jats:p>Summary: Protein–protein interaction detection methods are applied on a daily basis by molecular biologists worldwide. After generating a set of potential interactions, biologists face the problem of highlighting the ones that are novel and collecting evidence with respect to literature and annotation. This task can be as tedious as searching for every predicted interaction in several interaction data repositories, or manually screening the scientific literature. To facilitate the task of evidence mining and novelty assessment of protein–protein interactions, we have developed a Cytoscape plugin that automatically mines publication references, database references, interaction detection method descriptions and pathway annotation for a user-supplied network of interactions. The basis for the annotation is ConsensusPathDB—a meta-database that integrates numerous protein–protein, signaling, metabolic and gene regulatory interaction repositories for currently three species: Homo sapiens, Saccharomyces cerevisiae and Mus musculus.</jats:p> <jats:p>Availability: The ConsensusPathDB plugin for Cytoscape (version 2.7.0 or later) can be installed within Cytoscape on a major operating system (Windows, Mac OS, Unix/Linux) with Sun Java 1.5 or later installed through Cytoscape's Plugin manager (category ‘Network and Attribute I/O’). The plugin is freely available for download on the ConsensusPathDB web site (http://cpdb.molgen.mpg.de).</jats:p> <jats:p>Supplementary information: Supplementary data are available at Bioinformatics online.</jats:p> <jats:p>Contact: kamburov@molgen.mpg.de</jats:p> Evidence mining and novelty assessment of protein–protein interactions with the ConsensusPathDB plugin for Cytoscape Bioinformatics
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title Evidence mining and novelty assessment of protein–protein interactions with the ConsensusPathDB plugin for Cytoscape
title_unstemmed Evidence mining and novelty assessment of protein–protein interactions with the ConsensusPathDB plugin for Cytoscape
title_full Evidence mining and novelty assessment of protein–protein interactions with the ConsensusPathDB plugin for Cytoscape
title_fullStr Evidence mining and novelty assessment of protein–protein interactions with the ConsensusPathDB plugin for Cytoscape
title_full_unstemmed Evidence mining and novelty assessment of protein–protein interactions with the ConsensusPathDB plugin for Cytoscape
title_short Evidence mining and novelty assessment of protein–protein interactions with the ConsensusPathDB plugin for Cytoscape
title_sort evidence mining and novelty assessment of protein–protein interactions with the consensuspathdb plugin for cytoscape
topic Computational Mathematics
Computational Theory and Mathematics
Computer Science Applications
Molecular Biology
Biochemistry
Statistics and Probability
url http://dx.doi.org/10.1093/bioinformatics/btq522
publishDate 2010
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author Pentchev, Konstantin, Ono, Keiichiro, Herwig, Ralf, Ideker, Trey, Kamburov, Atanas
author_facet Pentchev, Konstantin, Ono, Keiichiro, Herwig, Ralf, Ideker, Trey, Kamburov, Atanas, Pentchev, Konstantin, Ono, Keiichiro, Herwig, Ralf, Ideker, Trey, Kamburov, Atanas
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spelling Pentchev, Konstantin Ono, Keiichiro Herwig, Ralf Ideker, Trey Kamburov, Atanas 1367-4811 1367-4803 Oxford University Press (OUP) Computational Mathematics Computational Theory and Mathematics Computer Science Applications Molecular Biology Biochemistry Statistics and Probability http://dx.doi.org/10.1093/bioinformatics/btq522 <jats:title>Abstract</jats:title> <jats:p>Summary: Protein–protein interaction detection methods are applied on a daily basis by molecular biologists worldwide. After generating a set of potential interactions, biologists face the problem of highlighting the ones that are novel and collecting evidence with respect to literature and annotation. This task can be as tedious as searching for every predicted interaction in several interaction data repositories, or manually screening the scientific literature. To facilitate the task of evidence mining and novelty assessment of protein–protein interactions, we have developed a Cytoscape plugin that automatically mines publication references, database references, interaction detection method descriptions and pathway annotation for a user-supplied network of interactions. The basis for the annotation is ConsensusPathDB—a meta-database that integrates numerous protein–protein, signaling, metabolic and gene regulatory interaction repositories for currently three species: Homo sapiens, Saccharomyces cerevisiae and Mus musculus.</jats:p> <jats:p>Availability: The ConsensusPathDB plugin for Cytoscape (version 2.7.0 or later) can be installed within Cytoscape on a major operating system (Windows, Mac OS, Unix/Linux) with Sun Java 1.5 or later installed through Cytoscape's Plugin manager (category ‘Network and Attribute I/O’). The plugin is freely available for download on the ConsensusPathDB web site (http://cpdb.molgen.mpg.de).</jats:p> <jats:p>Supplementary information: Supplementary data are available at Bioinformatics online.</jats:p> <jats:p>Contact: kamburov@molgen.mpg.de</jats:p> Evidence mining and novelty assessment of protein–protein interactions with the ConsensusPathDB plugin for Cytoscape Bioinformatics
spellingShingle Pentchev, Konstantin, Ono, Keiichiro, Herwig, Ralf, Ideker, Trey, Kamburov, Atanas, Bioinformatics, Evidence mining and novelty assessment of protein–protein interactions with the ConsensusPathDB plugin for Cytoscape, Computational Mathematics, Computational Theory and Mathematics, Computer Science Applications, Molecular Biology, Biochemistry, Statistics and Probability
title Evidence mining and novelty assessment of protein–protein interactions with the ConsensusPathDB plugin for Cytoscape
title_full Evidence mining and novelty assessment of protein–protein interactions with the ConsensusPathDB plugin for Cytoscape
title_fullStr Evidence mining and novelty assessment of protein–protein interactions with the ConsensusPathDB plugin for Cytoscape
title_full_unstemmed Evidence mining and novelty assessment of protein–protein interactions with the ConsensusPathDB plugin for Cytoscape
title_short Evidence mining and novelty assessment of protein–protein interactions with the ConsensusPathDB plugin for Cytoscape
title_sort evidence mining and novelty assessment of protein–protein interactions with the consensuspathdb plugin for cytoscape
title_unstemmed Evidence mining and novelty assessment of protein–protein interactions with the ConsensusPathDB plugin for Cytoscape
topic Computational Mathematics, Computational Theory and Mathematics, Computer Science Applications, Molecular Biology, Biochemistry, Statistics and Probability
url http://dx.doi.org/10.1093/bioinformatics/btq522